Article
Endocrinology & Metabolism
Zixi Chen, Jinpeng Li, Wenjuan Xu, Xiaomei Wu, Fenfen Xiang, Xiaoxiao Li, Mengzhe Zhang, Jin Zheng, Xiangdong Kang, Rong Wu
Summary: The study found that TLR4 expression on CD14+ maternal blood monocytes was significantly higher in the third trimester compared to the first and second trimesters. Maternal serum concentrations of TLR4 and cytokines were significantly higher in the term labor group compared to the term non-labor group.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Lizhong Sun, Libang He, Wei Wu, Li Luo, Mingyue Han, Yifang Liu, Shijie Shi, Kaijing Zhong, Jiaojiao Yang, Jiyao Li
Summary: The study investigated the prophylactic and therapeutic efficacy of fibroblast membrane-camouflaged nanoparticles for early inflammation treatment. The nanoparticles act as sentinels to detect and neutralize invasive E. coli LPS, reducing secretion of inflammatory cytokines for multitargeted anti-inflammatory effects. This work expands the potential cell types for inflammation regulation.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Dahu Qi, Hui Liu, Xuying Sun, Danni Luo, Meipeng Zhu, Tenghui Tao, Chenghao Gao, Chuankun Zhou, Wei Zhou, Jun Xiao
Summary: Pristimerin exerts potential therapeutic effects on osteoporosis by inhibiting NF-kappa B and MAPK signaling pathways, reducing ROS production, activating Nrf2/HO-1 signaling pathway, and affecting osteoclast differentiation and function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guobin Qi, Zengxin Jiang, Wei Lu, Defang Li, Weibing Chen, Xiuying Yang, Lei Ding, Hengfeng Yuan
Summary: Berbamine, a natural product from Berberis amurensis Rupr, was found to have a protective effect against osteoporosis by inhibiting osteoclastogenesis and bone resorption without affecting osteogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Food Science & Technology
Manuel Adrian Picos-Salas, Luis Angel Cabanillas-Bojorquez, Cristina Alicia Elizalde-Romero, Nayely Leyva-Lopez, Luis Aurelio Montoya-Inzunza, J. Basilio Heredia, Erick P. Gutierrez-Grijalva
Summary: This review summarizes the current knowledge on the protective effects of naringenin against oxidative stress and inflammation and its mechanisms of action.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Wei Liu, Hao Zhang, Yun-yi Hou, Rui-yi Hu, Jun-jie Zhang, Xuan Chen, Shuang Wang, Jun-nan Hu, Zi Wang, Wei Li
Summary: This study evaluates the protective effects of arginyl-fructosyl-glucose (AFG), a major Maillard reaction product of red ginseng, against cisplatin-induced intestinal toxicity. The results showed that AFG can alleviate cisplatin-induced gastrointestinal damage and inhibit cell apoptosis by regulating the Wnt/beta-catenin signaling pathway.
Article
Biochemistry & Molecular Biology
Donghui Bai, Tianxiao Sun, Fang Lu, Yancheng Shen, Yan Zhang, Bo Zhang, Guangli Yu, Haihua Li, Jiejie Hao
Summary: The study showed that Eupatilin can attenuate the inflammatory response in OVA-induced asthma by regulating NF-kappa B, MAPK, and Nrf2 signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Runsen Chen, Yuxi Zhang, Nishant Patel, Kede Wu, Manman Li, Xuming Mo, Zhaocong Yang
Summary: This study identified biomarkers for septic hepatitis and proposed CARD9 and TIS as potential treatment targets. The results suggested that CARD9 may serve as an important molecular target for septic hepatitis, while TIS can protect against septic hepatitis by regulating the CARD9-mediated signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Yongxian Li, Sipeng Lin, Panjie Liu, Jianbin Huang, Junxiong Qiu, Zhenkang Wen, Jinbo Yuan, Heng Qiu, Yuhao Liu, Qian Liu, Tengpeng Zhou, Peijie Luo, Huizhi Guo, Yanhuai Ma, Danqing Guo, Guoye Mo, Yongchao Tang, Liangliang Xu, De Liang, Jiake Xu, Yue Ding, Shuncong Zhang
Summary: The study found that Carnosol has a strong inhibitory effect on osteoclast differentiation induced by RANKL, potentially serving as a therapeutic supplementary in the prevention or treatment of osteolysis by suppressing the formation and function of RANKL-induced osteoclasts.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Thanasekaran Jayakumar, Ming-Ping Wu, Joen-Rong Sheu, Chih-Wei Hsia, Periyakali Saravana Bhavan, Manjunath Manubolu, Chi-Li Chung, Chih-Hsuan Hsia
Summary: Pterostilbene (PTE), a natural stilbenoid found in grapes and berries, exhibits anti-inflammatory properties by attenuating NF-kappa B/ERK signaling pathways and enhancing antioxidant defense mechanisms. It significantly reduces NO production and expression of inflammatory factors, while inhibiting ERK activation and blocking phosphorylation and nuclear translocation of p65NF-kappa B.
APPLIED SCIENCES-BASEL
(2021)
Article
Food Science & Technology
Ga Eun Woo, Min Ji Kim, Dong-Hyun Ahn
Summary: This study found that ethanolic extract of Sargassum confusum has anti-inflammatory activity without cytotoxicity. The extract can suppress the production of inflammatory factors by inhibiting the expression of COX-2 and iNOS, as well as the phosphorylation of transcription factors.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Bingfeng Lin, Pingcui Xu, Juan Zheng, Xuehui Deng, Qitao Ye, Zhongping Huang, Nani Wang
Summary: This review discusses the use of natural alkaloids in the prevention and treatment of osteoporosis. Anti-osteoporosis alkaloids can promote mesenchymal stem cells differentiation, improve osteoblast proliferation, suppress osteoclast formation, and regulate multiple signaling pathways. These findings provide evidence and support for the development of novel drugs and clinical treatment of osteoporosis using natural alkaloids.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Jun-ming Huang, Chen-zhong Wang, Shun-yi Lu, Zhe Wang, Zuo-qin Yan
Summary: The study demonstrated that Oroxin B may act as an anti-osteoporosis agent by inhibiting osteoclast maturation and attenuating bone resorption.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Xiaodi Zhang, Zhengfang Sun, Ying Zhang, Liuzhu Pan, Wei Jiang, Hui Dong, Zhengxin Jin, Jianning Kang, Ronghan Liu, Bin Ning
Summary: This study demonstrates that Periplocin can reduce inflammation and attenuate bone resorption in osteoporosis by inhibiting MAPK and NF-kappa B signaling pathways. It also exerts anti-inflammatory and anti-osteoclastic effects by binding to LRP4. These findings provide new possibilities for the treatment of osteoporosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Minjun Yao, Caihua Zhang, Lingzhi Ni, Xiaoxiao Ji, Jianqiao Hong, Yazhou Chen, Jie Wang, Congsun Li, Jiyan Lin, Tingting Lu, Yihao Sheng, Menghao Sun, Mingmin Shi, Chenhe Zhou, Xunzi Cai
Summary: This study demonstrated for the first time the protective medicinal efficacy of cepharanthine (CEP) in osteoarthritis. CEP suppressed inflammation and increased protein expression in joint tissues while restoring cellular autophagy. The mouse model confirmed the therapeutic potential of CEP in osteoarthritis treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Wei-ting Zhong, Yi-chun Wu, Xian-xing Xie, Xuan Zhou, Miao-miao Wei, Lanan-Wassy Soromou, Xin-xin Ci, Da-cheng Wang
Article
Pharmacology & Pharmacy
Na Chen, Dianfeng Liu, Lanan Wassy Soromou, Jingjing Sun, Weiting Zhong, Weixiao Guo, Meixia Huo, Hongyu Li, Shuang Guan, Zhenwen Chen, Haihua Feng
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2014)
Article
Immunology
Qianchao Wu, Guoquan Sun, Xue Yuan, Lanan Wassy Soromou, Na Chen, Ying Xiong, Haihua Feng
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2013)
Article
Cell Biology
Weiting Zhong, Gefu Chi, Lanxiang Jiang, Lanan Wassy Soromou, Na Chen, Meixia Huo, Weixiao Guo, Xuming Deng, Haihua Feng
Article
Cell Biology
Qianchao Wu, Ruisheng Li, Lanan Wassy Soromou, Na Chen, Xue Yuan, Guoquan Sun, Beibei Li, Haihua Feng
INFLAMMATION RESEARCH
(2014)
Article
Immunology
Lanan Wassy Soromou, Xiao Chu, Lanxiang Jiang, Miaomiao Wei, Meixia Huo, Na Chen, Shuang Guan, Xiaofeng Yang, Chengzhen Chen, Haihua Feng, Xuming Deng
INTERNATIONAL IMMUNOPHARMACOLOGY
(2012)
Article
Immunology
Jingjing Sun, Gefu Chi, Lanan Wassy Soromou, Na Chen, Mingfeng Guan, Qianchao Wu, Dacheng Wang, Hongyu Li
INTERNATIONAL IMMUNOPHARMACOLOGY
(2012)
Article
Immunology
Na Chen, Qianchao Wu, Gefu Chi, Lanan Wassy Soromou, Jinli Hou, Yanhong Deng, Haihua Feng
INTERNATIONAL IMMUNOPHARMACOLOGY
(2013)
Article
Immunology
Meixia Huo, Ruijie Gao, Lanxiang Jiang, Xiurui Cui, Lingxin Duan, Xuming Deng, Shuang Guan, Jingyuan Wei, Lanan Wassy Soromou, Haihua Feng, Gefu Chi
INTERNATIONAL IMMUNOPHARMACOLOGY
(2013)
Article
Immunology
Xianxing Xie, Shicheng Sun, Weiting Zhong, Lanan Wassy Soromou, Xuan Zhou, Miaomiao Wei, Yanling Ren, Yu Ding
INTERNATIONAL IMMUNOPHARMACOLOGY
(2014)
Article
Immunology
Qianchao Wu, Lijun Yu, Jiaming Qiu, Bingyu Shen, Di Wang, Lanan Wassy Soromou, Haihua Feng
INTERNATIONAL IMMUNOPHARMACOLOGY
(2014)
Article
Toxicology
Lanan Wassy Soromou, Lanxiang Jiang, Miaomiao Wei, Na Chen, Meixia Huo, Xiao Chu, Weiting Zhong, Qianchao Wu, Abdourahmane Balde, Xuming Deng, Haihua Feng
JOURNAL OF IMMUNOTOXICOLOGY
(2014)
Article
Surgery
Wei-ting Zhong, Lan-xiang Jiang, Jing-yuan Wei, An-na Qiao, Miao-miao Wei, Lanan-Wassy Soromou, Xian-xing Xie, Xuan Zhou, Xin-xin Ci, Da-cheng Wang
JOURNAL OF SURGICAL RESEARCH
(2013)
Article
Surgery
Meixia Huo, Xiurui Cui, Jiangdong Xue, Gefu Chi, Ruijie Gao, Xuming Deng, Shuang Guan, Jingyuan Wei, Lanan Wassy Soromou, Haihua Feng, Dacheng Wang
JOURNAL OF SURGICAL RESEARCH
(2013)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)