☆ 4.2 Article

Protection of mice against lipopolysaccharide-induced endotoxic shock by pinocembrin is correlated with regulation of cytokine secretion

JOURNAL OF IMMUNOTOXICOLOGY (2014)

Journal

JOURNAL OF IMMUNOTOXICOLOGY

Volume 11, Issue 1, Pages 56-61

Publisher

TAYLOR & FRANCIS LTD

DOI: 10.3109/1547691X.2013.792886

Keywords

Cytokine; endotoxemia; lipopolysaccharide; mice; pinocembrin

Categories

Toxicology

Funding

National Nature Science Foundation of China [31172172]
Chinese postdoctoral station of Jilin University [20090461034]

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Abstract

Natural products have been used as potentially important sources of anti-inflammatory drugs. This study examined the effects of pinocembrin against lipopolysaccharide (LPS)-induced endotoxemia to ascertain whether pinocembrin could protect mice from ensuing death. Cytokine responses were also assessed in serum isolated from blood collected at 0, 2, 4, 6, 8, and 24 h after LPS administration of the mice (with or without drug treatment). The results showed that there was a lower production of TNF alpha, IL-6, and IL-1 beta in the serum of LPS-challenged mice that had been pre-treated with pinocembrin. In addition, pre-treatment with pinocembrin improved host survival against the LPS-induced lethal endotoxemia. These results suggest that this new flavonoid could potentially be a novel candidate for preventing development/mitigation progression of septic shock.

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