Article
Chemistry, Multidisciplinary
Jia-Bin Wang, Qing-Zhu Qiu, Qiao-Ling Zheng, Ya-Jun Zhao, Yu Xu, Tao Zhang, Shuan-Hu Wang, Quan Wang, Qin-Wen Jin, Yin-Hua Ye, Ping Li, Jian-Wei Xie, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Ying-Hong Yang, Chao-Hui Zheng, Chang-Ming Huang
Summary: In this study, a gastric cancer immunophenotypic score (IPS) was constructed based on the tumor microenvironment classification, which can predict the effectiveness of immune checkpoint inhibitor therapy. The IPS provides a practical reference for implementing neoadjuvant ICI therapy for patients with gastric cancer.
Article
Oncology
Chongyuan Sun, Penghui Niu, Xiaojie Zhang, Lulu Zhao, Wanqing Wang, Xiaoyi Luan, Xue Han, Yingtai Chen, Dongbing Zhao
Summary: This study aimed to compare the effect of clinical and pathological response on the prognosis of patients with gastric cancer. The results showed that concurrent clinical and pathological response might predict a favorable prognosis of patients with gastric cancer after neoadjuvant therapy.
Article
Oncology
Ataollah Rajabnejad, Florin Vaida, Mark Valasek, Saqib Razzaque, Paul Fanta, Santiago Horgan, Michael Bouvet, Andrew M. Lowy, Kaitlyn J. Kelly
Summary: This study found that 46% of patients with locally advanced gastric cancer did not have a histologic response to therapy. Histology of signet ring cell carcinoma and possibly race were associated with treatment effect grade.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Qifei He, Jiahui Chen, Kai Zhou, Chenggen Jin, Anqiang Wang, Ke Ji, Xin Ji, Ji Zhang, Xiaojiang Wu, Xia Li, Zhaode Bu, Jiafu Ji
Summary: This study compared the efficacy of chemotherapy with trastuzumab in HER2-positive gastric cancer patients in the AT and NAT settings, showing that AT patients benefited from the combination with trastuzumab in terms of overall survival, while NAT patients showed improvements in tumor pathological regression and staging.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Juan Sun, Xianze Wang, Zimu Zhang, Ziyang Zeng, Siwen Ouyang, Weiming Kang
Summary: Research on predicting the sensitivity of NACT for gastric cancer spans multiple aspects including biomarkers, inflammatory indicators, and imaging assessments. While numerous studies have been conducted on biomarkers, a unified conclusion has not yet been reached. Inflammatory indicators have been shown to be associated with the survival and prognosis of patients undergoing NACT, and imaging assessments such as CT, MRI, and PET may offer unique advantages in early screening for NACT-sensitive patients through careful integration and optimization.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Meng Zhang, Heli Yang, Tao Fu, Meizhu Meng, Yi Feng, Changda Qu, Zhongwu Li, Xiaofang Xing, Wenmei Li, Meiying Ye, Sisi Li, Zhaode Bu, Shuqin Jia
Summary: Circulating tumor DNA (ctDNA) testing can be used to monitor the response to neoadjuvant chemotherapy (NACT) and predict prognosis in gastric cancer (GC) patients. The concentration of ctDNA and the number of genomic alterations decreased gradually during NACT, and patients with a good response to NACT had favorable outcomes.
MOLECULAR ONCOLOGY
(2023)
Article
Oncology
Chase J. Wehrle, Caleb N. Seavey, Jenny Chang, Katherine Stackhouse, Kimberly Woo, Toms Augustin, Daniel Joyce, Robert Simon, R. Matthew Walsh, Samer A. Naffouje
Summary: The study aimed to assess whether the Neoadjuvant Rectal score (NAR) can be used to predict 5-year overall survival (OS) and guide the allocation of adjuvant therapy in locally advanced gastric adenocarcinoma patients. The results showed that NAR score can be repurposed as a prognostic tool in gastric adenocarcinoma to predict 5-year OS and guide the decision-making regarding adjuvant therapy. Further studies are needed to validate these findings.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Jung Kyong Shin, Jung Wook Huh, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Yong Beom Cho, Yoon Ah Park
Summary: This study analyzed the predictive factors, recurrence patterns, oncologic outcomes, and prognostic factors of patients with pathologic complete response (pCR) in rectal cancer who underwent radical surgery after neoadjuvant chemoradiotherapy (nCRT). The study found that clinical node negativity, tumor size < 4 cm, and well differentiation were significant independent clinical predictors for achieving pCR. Patients with pCR had better long-term outcomes compared to those without pCR.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Alina Desiree Sando, Reidun Fougner, Elin Synnove Royset, Hong Yan Dai, Jon Erik Gronbech, Erling Audun Bringeland
Summary: Evaluation of response following neoadjuvant chemotherapy (NAC) in gastric cancer has been widely debated. The aim of this study was to investigate downsizing and downstaging as methods of response evaluation. The findings suggest that comparing the baseline radiological CT stage to the pathological stage following NAC is a useful method for stratifying patients based on their long-term survival rates.
Article
Nutrition & Dietetics
Jian-Xian Lin, Yi-Hui Tang, Wen-Xing Zhou, Jacopo Desiderio, Amilcare Parisi, Jian-Wei Xie, Jia-Bin Wang, Fabio Cianchi, Lorenzo Antonuzzo, Felice Borghi, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Fabio Staderini, Alessandra Marano, Chiara Peluso, Ping Li, Chao-Hui Zheng, Yu-Bin Ma, Chang-Ming Huang
Summary: The study revealed that body composition parameters did not significantly change in patients with locally advanced gastric cancer after neoadjuvant treatment. Changes in skeletal muscle radiodensity and muscle index can accurately predict pathological response and prognosis, indicating a potential need for additional supportive treatment.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Xuejun Gan, Shen Li, Yiding Wang, Hong Du, Ying Hu, Xiaofang Xing, Xiaojing Cheng, Yan Yan, Ziyu Li
Summary: The expression of ASPH was found to be higher in gastric cancer patients undergoing neoadjuvant chemotherapy (NACT), and was associated with prognosis. In vitro and in vivo experiments showed that ASPH knockout enhanced the inhibitory effects of chemotherapeutic drugs on cell proliferation, migration, and invasion. Therefore, ASPH may serve as a candidate biomarker to predict prognosis and a novel therapeutic target for gastric cancer patients treated with NACT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
C. Denkert, M. Untch, S. Benz, A. Schneeweiss, K. E. Weber, S. Schmatloch, C. Jackisch, H. P. Sinn, J. Golovato, T. Karn, F. Marme, T. Link, J. Budczies, V Nekljudova, W. D. Schmitt, E. Stickeler, V Mueller, P. Jank, R. Parulkar, E. Heinmoeller, J. Z. Sanborn, C. Schem, B. Sinn, P. Soon-Shiong, M. van Mackelenbergh, P. A. Fasching, S. Rabizadeh, S. Loibl
Summary: Different mutational signatures in breast cancer, including HRD and APOBEC-related patterns, are associated with chemotherapy response and survival outcomes. These signatures can potentially be used to predict treatment response and define therapy-resistant subgroups for future interventions.
ANNALS OF ONCOLOGY
(2021)
Article
Pathology
Ayaka Katayama, Islam M. Miligy, Sho Shiino, Michael S. Toss, Karim Eldib, Sasagu Kurozumi, Cecily M. Quinn, Nahla Badr, Ciara Murray, Elena Provenzano, Grace Callagy, Cian Martyn, Rebecca Millican-Slater, Colin Purdie, Dave Purnell, Sarah E. Pinder, Tetsunari Oyama, Abeer M. Shaaban, Ian Ellis, Andrew H. S. Lee, Emad A. Rakha
Summary: The response of HER2-positive breast cancer patients to anti-HER2 targeted therapy varies, with HER2 status discordance potentially occurring after neoadjuvant treatment. Results indicate that HER2 IHC 3+ and histological grade 3 are independent predictors of pathological complete response following neoadjuvant anti-HER2 therapy.
Article
Multidisciplinary Sciences
Sunghoon Joo, Eun Sook Ko, Soonhwan Kwon, Eunjoo Jeon, Hyungsik Jung, Ji-Yeon Kim, Myung Jin Chung, Young-Hyuck Im
Summary: The study developed a deep learning model that integrates clinical information and MRI images to predict pathologic complete response to neoadjuvant chemotherapy in breast cancer patients. The model trained on all datasets showed better performance compared to using only clinical information.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Ming Cui, Sami Shoucair, Quan Liao, Xiaoyan Qiu, Benedict Kinny-Koster, Joseph R. Habib, Elie M. Ghabi, Junke Wang, Eun Ji Shin, Sean X. Leng, Syed Z. Ali, Elizabeth D. Thompson, Jacquelyn W. Zimmerman, Christopher R. Shubert, Kelly J. Lafaro, Richard A. Burkhart, William R. Burns, Lei Zheng, Jin He, Yupei Zhao, Christopher L. Wolfgang, Jun Yu
Summary: This study aimed to explore whether the expression of cancer-cell-derived sialylated immunoglobulin G (SIA-IgG) in treatment-naive fine needle aspirate (FNA) biopsy specimens could predict the pathological response (PR) to neoadjuvant therapy (NAT) for pancreatic ductal adenocarcinoma (PDAC). The results showed that positive SIA-IgG expression in FNA specimens was associated with unfavorable PR and could serve as an independent predictor of PR. In addition, both positive SIA-IgG expression in FNA specimens and high SIA-IgG expression in surgically resected primary tumor specimens were significantly associated with shorter survival.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Felix Berlth, Stefan Moenig, Berit Pinther, Peter Grimminger, Martin Maus, Hans Schloesser, Patrick Plum, Ute Warnecke-Eberz, Olivier Harismendy, Uta Drebber, Elfriede Bollschweiler, Arnulf Hoelscher, Hakan Alakus
ANNALS OF SURGICAL ONCOLOGY
(2015)
Article
Oncology
Hans Anton Schloesser, Uta Drebber, Alexander Urbanski, Simon Haase, Christoph Baltin, Felix Berlth, Susanne Neiss, Michael von Bergwelt-Baildon, Ulrich Klaus Fetzner, Ute Warnecke-Eberz, Elfriede Bollschweiler, Arnulf Heinrich Hoelscher, Stefan Paul Moenig, Hakan Alakus
Article
Oncology
Ute Warnecke-Eberz, Ralf Metzger, Arnulf H. Hoelscher, Uta Drebber, Elfriede Bollschweiler
Article
Oncology
Ute Warnecke-Eberz, Seung-Hun Chon, Arnulf H. Holscher, Uta Drebber, Elfriede Bollschweiler
Article
Surgery
Elfriede Bollschweiler, Arnulf H. Hoelscher, Till Herbold, Ralf Metzger, Hakan Alakus, Henner Schmidt, Uta Drebber, Ute Warnecke-Eberz
Article
Computer Science, Interdisciplinary Applications
Okyaz Eminaga, Axel Semjonow, Elke Eltze, Olaf Bettendorf, Anne Schultheis, Ute Warnecke-Eberz, Ilgar Akbarov, Sebastian Wille, Udo Engelmann
JOURNAL OF BIOMEDICAL INFORMATICS
(2016)
Article
Oncology
Hakan Alakus, Elfriede Bollschweiler, Arnulf H. Hoelscher, Ute Warnecke-Eberz, Kelly A. Frazer, Olivier Harismendy, Andrew M. Lowy, Stefan P. Moenig, Pascal M. Eberz, Martin Maus, Uta Drebber, Winfried Siffert, Ralf Metzger
ANNALS OF SURGICAL ONCOLOGY
(2014)
Article
Multidisciplinary Sciences
Christian Jansen, Thomas Reiberger, Jia Huang, Hannah Eischeid, Robert Schierwagen, Mattias Mandorfer, Evrim Anadol, Philipp Schwabl, Carolynne Schwarze-Zander, Ute Warnecke-Eberz, Christian P. Strassburg, Juergen K. Rockstroh, Markus Peck-Radosavljevic, Margarete Odenthal, Jonel Trebicka
Article
Genetics & Heredity
Okyaz Eminaga, Jochen Fries, Susanne Neiss, Michaela Heitmann, Fabian Woetzel, Axel Heidenreich, Christiane Bruns, Hakan Alakus, Ute Warnecke-Eberz
Article
Multidisciplinary Sciences
Patrick Sven Plum, Ute Warnecke-Eberz, Uta Drebber, Seung-Hun Chon, Hakan Alakus, Arnulf Heinrich Hoelscher, Alexander Quaas, Christiane Josephine Bruns, Ines Gockel, Dietmar Lorenz, Ralf Metzger, Elfriede Bollschweiler
SCIENTIFIC REPORTS
(2019)
Article
Oncology
Kosuke Narumiya, Elfriede Bollschweiler, Arnulf H. Hoelscher, Masakazu Yamamoto, Uta Drebber, Hakan Alakus, Ralf Metzger, Ute Warnecke-Eberz
Article
Gastroenterology & Hepatology
Ute Warnecke-Eberz, Patrick Plum, Viola Schweinsberg, Uta Drebber, Christiane J. Bruns, Dolores T. Mueller, Arnulf H. Hoelscher, Elfriede Bollschweiler
WORLD JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Cell Biology
Patrick S. Plum, Ute Warnecke-Eberz, Oulfa Dhaouadi, Hakan Alakus, Uta Drebber, Ralf Metzger, Klaus L. Prenzel, Arnulf H. Hoelscher, Elfriede Bollschweiler
HISTOLOGY AND HISTOPATHOLOGY
(2015)
Article
Oncology
Robert Kleinert, Klaus Prenzel, Nikolas Stoecklein, Hakan Alakus, Elfriede Bollschweiler, Arnulf Hoelscher, Ute Warnecke-Eberz
ANTICANCER RESEARCH
(2015)
Review
Oncology
Elfriede Bollschweiler, Arnulf H. Hoelscher, Matthias Schmidt, Ute Warnecke-Eberz
CHINESE JOURNAL OF CANCER RESEARCH
(2015)