Article
Medicine, Research & Experimental
Ruben Martin-Escolano, Ana Virseda-Berdices, Juan Berenguer, Juan Gonzalez-Garcia, Oscar Brochado-Kith, Amanda Fernandez-Rodriguez, Cristina Diez, Victor Hontanon, Salvador Resino, Maria Angeles Jimenez-Sousa
Summary: This study aimed to evaluate the association between plasma immune checkpoint proteins at baseline with hepatic steatosis index increase at the end of follow-up in HIV/HCV-coinfected patients. The results showed that higher levels of immune checkpoint proteins BTLA, CD137, CD80, GITR, LAG-3, and PD-L1 before HCV therapy were associated with a long-term increase in hepatic steatosis index after successful HCV therapy, suggesting a potential predictive role for early detection of progression towards steatosis in HIV/HCV-coinfected patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Marcio Nahum Lobo, Susan Denice Flores Irias, Pedro Leao Fontes Neto, Maria Eduarda Sousa Avelino, Maria Karoliny da Silva Torres, Marlinda de Carvalho Souza, Ricardo Roberto Souza Fonseca, Pedro Eduardo Bonfim Freitas, Heloisa Marceliano Nunes, Jose Raul Rocha de Araujo Junior, Dickson Ciro Nascimento de Brito, Aldemir Branco Oliveira-Filho, Luiz Fernando Almeida Machado
Summary: This study aimed to investigate the prevalence and genotypes of hepatitis C virus (HCV) among people living with HIV (PLWH) in the Amazon region. The study found a low prevalence of HCV infection and identified the presence of HCV genotype 2 for the first time among PLWH in the area.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ashraf Y. Elfert, Amel Salem, Amr M. Abdelhamid, Ahmad Salama, Doaa A. Sourour, Olfat Shaker, Mofida Keshk
Summary: The expression profiles of miRNA-122, miR-483, and miR-335 were studied in the serum of HCV-related hepatocellular carcinoma (HCC) patients. miR-122 and miR-483 were upregulated in HCC patients, while miR-335 was downregulated. These miRNAs could serve as potential non-invasive early diagnostic biomarkers for HCC, with miR-483 showing the highest diagnostic accuracy and sensitivity.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Medicine, Research & Experimental
Sergio Salguero, Oscar Brochado-Kith, Ana Virseda Verdices, Juan Berenguer, Juan Gonzalez-Garcia, Isidoro Martinez, Cristina Diez, Victor Hontanon, Leire Perez-Latorre, Amanda Fernandez-Rodriguez, Maria Angeles Jimenez-Sousa, Salvador Resino
Summary: We identified a gene expression signature associated with advanced cirrhosis with high risk for clinically significant portal hypertension (CSPH) in HIV/HCV coinfected patients through analyzing the gene expression profile of peripheral blood mononuclear cells (PBMCs). A cross-sectional study on 68 patients was conducted, and liver stiffness measurement (LSM) was used for stratification. We found 60 differentially expressed transcripts between patients with LSM < 12.5 kPa and >= 25 kPa, and two of them were validated in a different cohort.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Oscar Brochado-Kith, Isidoro Martinez, Juan Berenguer, Juan Gonzalez-Garcia, Sergio Salguero, Daniel Sepulveda-Crespo, Cristina Diez, Victor Hontanon, Luis Ibanez-Samaniego, Leire Perez-Latorre, Amanda Fernandez-Rodriguez, Maria angeles Jimenez-Sousa, Salvador Resino
Summary: In HIV/HCV coinfected patients with advanced HCV-related cirrhosis, eradication of HCV following DAA therapy resulted in improved liver disease markers, decreased plasma biomarkers, and reduced gene expression related to antiviral/inflammatory responses, particularly in levels of chemokines and ISGs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andrea Da Fonseca Ferreira, Jianqin Wei, Lukun Zhang, Conrad J. Macon, Bernard Degnan, Dushyantha Jayaweera, Joshua M. Hare, Michael A. Kolber, Michael Bellio, Aisha Khan, Yue Pan, Derek M. Dykxhoorn, Liyong Wang, Chunming Dong
Summary: HIV infection impairs the functionality of vascular repairing cells, leading to an increased risk of cerebrocardiovascular diseases in PLHIV.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Amin Ullah, Xiaojie Yu, Margarete Odenthal, Sonja Meemboor, Bashir Ahmad, Irshad ur Rehman, Jamshaid Ahmad, Qurban Ali, Tariq Nadeem
Summary: This study investigated the circulating levels of miR-122 in HCV chronic liver disease patients and found that these levels were significantly upregulated in patients with cirrhosis, particularly in those with mild cirrhosis. Additionally, miR-122 showed a positive correlation with ALT values in patients with mild cirrhosis.
Article
Infectious Diseases
Yu Wang, Xin Chen, Mei Ye, Wei Pang, Chiyu Zhang, Si-Dong Xiong, Yong-Tang Zheng
Summary: The study conducted in Yingjiang and Kaiyuan, Yunnan Province, China, with 310 HIV-1/HCV coinfected drug users, identified multiple HCV subtypes and HIV-1 subtypes, demonstrating a high consistency in the spatial dynamics of HIV-1 and HCV among coinfected individuals. This provides theoretical evidence for the simultaneous prevention of HIV-1 and HCV.
BMC INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Anila Duni, Marta Greco, Pierangela Presta, Roberta Arena, Ethymios Pappas, Lampros Lakkas, Katerina K. Naka, Antonio Brunetti, Daniela Patrizia Foti, Michele Andreucci, Giuseppe Coppolino, Evangelia Dounousi, Davide Bolignano
Summary: Patients undergoing chronic hemodialysis (HD) are at high risk of cardiovascular (CV) events, but risk prediction in this population is challenging. Recent research has shown that circulating miRNA 122-5p is related to the onset and progression of CV disease. This study found that HD patients had lower levels of circulating miRNA 122-5p compared to healthy controls. ALT, E/e', and CRP were identified as independent predictors of miRNA 122-5p levels. Additionally, higher baseline levels of circulating miRNA 122-5p predicted a significantly increased risk of composite endpoint occurrence in HD patients.
Article
Medicine, Research & Experimental
Daniel Sepulveda-Crespo, Maria Belen Yelamos, Cristina Diez, Julian Gomez, Victor Hontanon, Francisco Torresano-Felipe, Juan Berenguer, Juan Gonzalez-Garcia, Luis Ibanez-Samaniego, Elva Llop, Antonio Olveira, Javier Martinez, Salvador Resino, Isidoro Martinez
Summary: HIV/HCV-coinfected patients produce lower levels of broad-spectrum anti-HCV antibodies compared to HCV-monoinfected patients. After sustained virological response (SVR), the HCV-group has higher antibody levels than the HIV/HCV-group, but the levels decrease in both groups at 36 weeks post-SVR.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Genetics & Heredity
Victoria Cairoli, Daniel Valle-Millares, Maria C. Terron-Orellano, Daniel Luque, Pablo Ryan, Lourdes Dominguez, Luz Martin-Carbonero, Ignacio De los Santos, Elena De Matteo, Beatriz Ameigeiras, Veronica Briz, Paola Casciato, Maria Victoria Preciado, Pamela Valva, Amanda Fernandez-Rodriguez
Summary: This study characterizes the plasma-derived extracellular vesicles miRNA signature of chronic HCV infected and HIV coinfected patients, revealing potential molecular mechanisms of coinfection. The study identifies differentially expressed miRNAs that regulate biological pathways related to HCV and HIV pathogenesis, which may assist in the development of new biomarkers and treatment strategies.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Cell Biology
Oscar Brochado, Isidoro Martinez, Juan Berenguer, Luz Medrano, Juan Gonzalez-Garcia, Maria Angeles Jimenez-Sousa, Ana Carrero, Victor Hontanon, Jordi Navarro, Josep M. Guardiola, Amanda Fernandez-Rodriguez, Salvador Resino
Summary: Eliminating hepatitis C virus through interferon-based therapy leads to significant changes in gene expression profiles in HIV/HCV-coinfected patients, particularly in pathways related to inflammation and liver-related complications.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Adam Palayew, Alexandra M. Schmidt, Sahar Saeed, Curtis L. Cooper, Alexander Wong, Valerie Martel-Laferriere, Sharon Walmsley, Joseph Cox, Marina B. Klein
Summary: The study developed an individual-level deprivation index for assessing social deprivation among HIV-HCV coinfected individuals, which identified different deprivation profiles across provinces.
Article
Multidisciplinary Sciences
Sandra Franco, Josep M. Llibre, Toni Jou, Cristina Tural, Miguel Angel Martinez
Summary: In a previous study, three plasma circulating miRNAs (miR-100-5p_iso3p:-2, miR-122-5p, and miR-192-5p) that correlate with liver fibrosis evolution in HIV-1/HCV co-infected patients were identified. This study investigated whether the levels of these miRNAs are associated with liver disease progression in HIV-1/HCV co-infected patients who achieved sustained virologic response (SVR) after treatment. The results showed significant reductions in the levels of these miRNAs in SVR patients, indicating their potential as biomarkers for liver damage progression in these individuals.
Article
Cell Biology
Emiliano Dalla, Michela Bulfoni, Daniela Cesselli, Riccardo Pravisani, Masaaki Hidaka, Susumu Eguchi, Umberto Baccarani
Summary: Liver biopsies obtained from HCV/HIV co-infected patients after transplantation show a distinct miRNA profile compared to HCV mono-infected patients, with differences in immune and apoptotic processes and extracellular matrix remodeling. These early miRNA changes are associated with liver reinfection processes and further studies are needed to determine their prognostic significance.
Article
Gastroenterology & Hepatology
Benedikt Silvester Hofer, Benedikt Simbrunner, Lukas Hartl, Mathias Jachs, David Josef Maria Bauer, Lorenz Balcar, Rafael Paternostro, Philipp Schwabl, Georg Semmler, Bernhard Scheiner, Albert Friedrich Staettermayer, Michael Trauner, Mattias Mandorfer, Thomas Reiberger
Summary: This study investigates the impact of alcohol abstinence on the natural progression of alcohol-related cirrhosis across different stages of portal hypertension. The results showed that alcohol abstinence is significantly associated with reduced risks of hepatic decompensation, liver-related mortality, and all-cause mortality. Importantly, alcohol abstinence also reduces the cumulative incidence of hepatic decompensation in patients with both low-risk and high-risk portal hypertension.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Mattias Mandorfer, Katharina Pomej, Bernhard Scheiner, Lorenz Balcar, Thomas Reiberger
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Multidisciplinary Sciences
Nadine Bachtler, Sandra Torres, Cristina Ortiz, Robert Schierwagen, Olaf Tyc, Christoph Hieber, Marie-Luise Berres, Caroline Meier, Nico Kraus, Stefan Zeuzem, Bart Nijmeijer, Sebas Pronk, Jonel Trebicka, Sabine Klein
Summary: The ROCK inhibitors Y-33075 and Y-27632 can significantly reduce contraction, fibrogenesis, and proliferation of activated hepatic stellate cells (HSC). However, they also increase the migration of HSC. Y-33075 is more potent than Y-27632 in inhibiting HSC contraction.
Article
Cell Biology
Cristina Ortiz, Sabine Klein, Winfried H. Reul, Fernando Magdaleno, Stefanie Groeschl, Peter Dietrich, Robert Schierwagen, Frank E. Uschner, Sandra Torres, Christoph Hieber, Caroline Meier, Nico Kraus, Olaf Tyc, Maximilian Brol, Stefan Zeuzem, Christoph Welsch, Marco Poglitsch, Claus Hellerbrand, Mercedes Alfonso-Prieto, Fabio Mira, Ulrich auf dem Keller, Anja Tetzner, Andrew Moore, Thomas Walther, Jonel Trebicka
Summary: The development of liver fibrosis is associated with the contraction of hepatic stellate cells (HSC), but the interaction between neprilysin (NEP) and its substrate neuropeptide Y (NPY) in liver fibrosis is not well understood.NEP is derived from HSCs while NPY mainly comes from the splanchnic region and is cleaved by NEP to terminate contraction. NEP deficiency leads to less fibrosis but portal hypertension in mice models of liver injury. Combining NEP inhibitor with angiotensin II type 1 receptor blocker (ARB) or ACE inhibitor provides incremental benefits for fibrosis and portal hypertension. Administration of Entresto, a combination of ARB and NEP inhibitor, reduces hepatic fibrosis and portal pressure in mice.
Article
Infectious Diseases
David Chromy, David Bauer, Benedikt Simbrunner, Mathias Jachs, Lukas Hartl, Philipp Schwabl, Teresa Binter, Lisa Steininger, Caroline Schwarz, Armin Rieger, Katharina Grabmeier-Pfistershammer, Michael Trauner, Peter Ferenci, Markus Peck-Radosavljevic, Mattias Mandorfer, Thomas Reiberger
Summary: HCV cure rates in Viennese HIV patients increased significantly from 49% in the IFN era to 88-95% in the DAA era. However, MSM-related risk behavior and reinfections have become the key challenges towards HCV elimination in HIV/HCV-coinfected patients.
INFECTIOUS DISEASES
(2023)
Review
Medicine, General & Internal
Tilman Sauerbruch, Martin Hennenberg, Jonel Trebicka, Robert Schierwagen
Summary: Despite vasoconstrictor activation, patients with liver cirrhosis experience hyperdynamic circulatory disturbance. Non-selective beta-blockers have been established as a therapy to lower portal pressure and protect against variceal hemorrhage. The beneficial effect of the alpha and beta receptor blocking medication, carvedilol, and its consequences in liver cirrhosis patients have not been sufficiently investigated.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Georg Semmler, Bernhard Scheiner, Lorenz Balcar, Rafael Paternostro, Benedikt Simbrunner, Matthias Pinter, Michael Trauner, Marta Bofill Roig, Elias Laurin Meyer, Benedikt Silvester Hofer, Mattias Mandorfer, David James Pinato, Christian Zauner, Thomas Reiberger, Georg-Christian Funk
Summary: This study confirms the association between hypochloremia and prognosis in patients with cirrhosis, both in clinically stable patients and critically ill cases.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Nikolaus Pfisterer, Michael Schwarz, Mathias Jachs, Florian Putre, Lukas Ritt, Mattias Mandorfer, Christian Madl, Michael Trauner, Thomas Reiberger
Summary: Prophylactic endoscopic band ligation (EBL) is a safe procedure to prevent variceal bleeding in cirrhotic patients, even in the presence of thrombocytopenia or high INR. The risk of EBL-related bleeding is mainly associated with high MELD and bilirubin levels, but not with platelet count, INR, or non-selective beta-blocker use.
HEPATOLOGY INTERNATIONAL
(2023)
Editorial Material
Gastroenterology & Hepatology
Rafael Paternostro, Mathias Jachs, Thomas Reiberger, Mattias Mandorfer
Summary: This article is linked to the papers by Paternostro et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Mathias Jachs, Rafael Paternostro, Thomas Reiberger, Mattias Mandorfer
Summary: This article is linked to the papers by Paternostro et al, providing links to view these papers.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Mathias Jachs, Mattias Mandorfer, Thomas Reiberger
JOURNAL OF HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Bernhar Schener, Lorenz Balcar, Ton Lisman, Mattias Mandorfer
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Benedikt Silvester Hofer, Benedikt Simbrunner, Lukas Hartl, Mathias Jachs, Lorenz Balcar, Rafael Paternostro, Philipp Schwabl, Georg Semmler, Bernhard Scheiner, Michael Trauner, Mattias Mandorfer, Thomas Reiberger
Summary: This study found that alcohol abstinence can lead to recompensation of hepatic function and significantly reduce liver-related mortality in patients with decompensated alcohol-related cirrhosis.
LIVER INTERNATIONAL
(2023)
Article
Hematology
Ksenia Brusilovskaya, Benedikt Silvester Hofer, Benedikt Simbrunner, Beate Eichelberger, Silvia Lee, David J. M. Bauer, Mattias Mandorfer, Philipp Schwabl, Simon Panzer, Thomas Reiberger, Thomas Gremmel
Summary: Platelet responsiveness decreases with increasing severity of liver cirrhosis and portal hypertension, potentially counterbalanced by lower antithrombin-III levels.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Katharina Lampichler, Georg Semmler, Katharina Woeran, Benedikt Simbrunner, Mathias Jachs, Lukas Hartl, David Josef Maria Bauer, Lorenz Balcar, Lukas Burghart, Michael Trauner, Dietmar Tamandl, Ahmed Ba-Ssalamah, Mattias Mandorfer, Thomas Reiberger, Bernhard Scheiner, Martina Scharitzer
Summary: This study aimed to compare the radiological features between PSVD and cirrhosis. The results showed that compared to cirrhosis, patients with PSVD were younger and had lower HVPG, liver stiffness, and MELD. CT/MRI results revealed that PSVD patients had more intrahepatic portal tract abnormalities, FNH-like lesions, and abnormal liver morphology. A specific radiological feature of PSVD identified in gadoxetic acid-enhanced MRI was periportal hyperintensity in the HBP.
EUROPEAN RADIOLOGY
(2023)