Review
Biochemistry & Molecular Biology
Mai Nguyen, Clodia Osipo
Summary: Breast cancer therapies have improved survival rates, but recurrence and drug resistance remain challenging. Phytoestrogens have been found to target breast cancer stem cells and may complement conventional therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Wurood Hantoosh Neamah, Alex Rutkovsky, Osama Abdullah, Kiesha Wilson, Ryan Bloomquist, Prakash Nagarkatti, Mitzi Nagarkatti
Summary: This study demonstrates that Resveratrol (RSV), an AhR antagonist, reduces the induction and function of murine myeloid-derived suppressor cells (MDSCs) induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). RSV reverses the effects of TCDD on macrophages and dendritic cells, as well as the upregulation of critical molecules involved in TCDD-mediated induction and immunosuppressive functions of MDSCs. RSV treatment decreases the energetic demands induced by TCDD. These findings suggest the potential use of RSV to attenuate the immunosuppressive properties of MDSCs.
Review
Biochemistry & Molecular Biology
Cord Naujokat, Dwight L. McKee
Summary: Cancer stem cells (CSCs) possess resistance mechanisms to current cancer therapies and pathways for survival. Certain phytochemicals can interfere with these pathways and eliminate CSCs, offering a potential novel therapeutic strategy against cancer.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Environmental Sciences
Xiaona Gao, Shuhui Liu, Chenchen Ding, Yufan Miao, Zhangshan Gao, Mengcong Li, Wentao Fan, Zhihui Tang, Nobuhle Hyacinth Mhlambi, Liping Yan, Suquan Song
Summary: The study found that genistein (GEN) can alleviate the pathological damage, hepatic steatosis, and insulin resistance induced by a high-energy low-protein diet in laying hens, while bisphenol A (BPA) can exacerbate NAFLD symptoms and suppress ER alpha levels in the liver, with GEN being able to reverse this effect.
ENVIRONMENTAL POLLUTION
(2021)
Review
Geriatrics & Gerontology
Sara Abudahab, E. T. Price, M. G. Dozmorov, L. S. Deshpande, J. L. McClay
Summary: This article mainly discusses the role of aryl hydrocarbon receptor (AhR) in aging and longevity, as well as several AhR ligands with potential anti-aging properties. The article suggests that AhR-driven expression of xenobiotic metabolism genes into old age may be a key mechanism through which moderate induction of AhR elicits positive benefits on longevity and healthspan. Additionally, the article shows that liver-specific AhR target genes are enriched among genes subject to epigenetic aging through integration of publicly available datasets. Hence, the interplay between AhR and epigenetic aging should be the subject of future research, and a broad range of non-toxic AhR ligands should be investigated for their potential to promote healthspan and longevity.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Review
Biochemistry & Molecular Biology
Dominika Komorowska, Tomasz Radzik, Sebastian Kalenik, Aleksandra Rodacka
Summary: Conventional cancer treatment methods may not always be successful due to the radioresistance of cancer cells. Using radiosensitizers to enhance the radiosensitivity of cancer cells is an important approach to improve the effectiveness of radiotherapy. Natural products have been increasingly studied as adjuvants in radiotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Helga Caputo Nunes, Samara Costa Tavares, Heloisa Vicente Garcia, Maira Smaniotto Cucielo, Sergio Alexandre Alcantara dos Santos, Mirian Carolini Esgoti Aal, Marjorie Assis de Golim, Luis Antonio Justulin Jr, Amanda Oliveira Ribeiro, Elenice Deffune, Wellerson Rodrigo Scarano, Flavia Karina Delella
Summary: Chemical contamination is an important factor to consider in cell therapy strategy design. This study found that BPA and TCDD can significantly reduce cell viability and affect adipogenic differentiation and DNA damage.
ENVIRONMENTAL TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lukasz Huminiecki
Summary: This paper presents an updated and contextualized literature review on functional genomic studies of natural phenols in the context of cancer. It suggests the multilevel chemopreventive and anticancer mechanisms of action shared by multiple dietary natural phenols. Specifically, evidence is cited for the multilevel anti-cancer effects of curcumin and resveratrol.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Zhenglun Yang, Yihui Chen, Jianggang Jia, Chunyan Hou, Rongrong Xuan, Tingting Wang
Summary: In this study, C18-modified halloysite was successfully fabricated and applied in matrix solid-phase dispersion (MSPD) for the extraction of bisphenol A and diethylstilbestrol from human placenta. The developed method showed high sensitivity, accuracy, and reliability, with the average recoveries ranging from 91.0 to 106.0% and the relative standard deviations less than 10.6%.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Fabia de Oliveira Andrade, Fang Liu, Xiyuan Zhang, Mariana Papaleo Rosim, Caroline Dani, Idalia Cruz, Thomas T. Y. Wang, William Helferich, Robert W. Li, Leena Hilakivi-Clarke
Summary: The risk of recurrence of estrogen receptor-positive breast cancer remains constant, even 20 years after diagnosis. Maternal obesity can alter offspring's gut microbiota and increase the risk of mammary cancer recurrence. Genistein supplementation can prevent local recurrence in offspring of obese dams by reversing changes in gut microbiota and metabolites.
Article
Medicine, Research & Experimental
Thalles Fernando Rocha Ruiz, Simone Jacovaci Colleta, Debora Aparecida Pires de Campos Zuccari, Patricia Simone Leite Vilamaior, Ellen Cristina Rivas Leonel, Sebastiao Roberto Taboga
Summary: This study used Mongolian gerbils as an experimental model to investigate the effects of exposure to BPA during pregnancy and lactation on the hormone receptor status in aged female individuals. The results showed that BPA exposure led to increased expression of ER alpha and decreased expression of ER beta, PR, and PRL-R, with an association between enhanced EZH2 expression and poor cancer prognosis, indicating a potential role of BPA in promoting tumorigenesis through HER2/ErbB2.
Article
Biochemistry & Molecular Biology
Alessandra Ferramosca, Stefano Lorenzetti, Mariangela Di Giacomo, Paola Lunetti, Francesco Murrieri, Loredana Capobianco, Vincenza Dolce, Lamberto Coppola, Vincenzo Zara
Summary: Plant bioactives, such as polyphenols, can have differential effects on sperm quality depending on their concentration, with some compounds improving mitochondrial function in asthenozoospermic samples. This study highlights the potential of natural antioxidants in nutraceutical supplementation for male infertility treatment.
Article
Cell Biology
Pablo Torres-Alamilla, Rocio Castillo-Sanchez, Pedro Cortes-Reynosa, Rocio Gomez, Eduardo Perez Salazar
Summary: Triple negative breast cancer (TNBC) is characterized by the absence of estrogen and progesterone receptors and low HER2/neu expression. BPA, an endocrine disrupting chemical, has been associated with increased rates of breast cancer. In TNBC cells, BPA induces migration and invasion through the activation of GPER expression.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhangshan Gao, Xiaona Gao, Wentao Fan, Shuhui Liu, Mengcong Li, Yufan Miao, Chenchen Ding, Zhihui Tang, Liping Yan, Guangliang Liu, Xizhi Shi, Suquan Song
Summary: The study showed that typical environmental estrogens BPA and GEN have different toxicological mechanisms on adult ovary. BPA at a lower dose reduced egg production and disrupted redox homeostasis, while GEN significantly improved ovary antioxidant capacity. Furthermore, BPA and GEN have opposite regulatory effects on the Nrf2-Keap1 pathway through ERα modulation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Medicine, Research & Experimental
Karolina Banys, Joanna Giebultowicz, Marcin Sobczak, Rafal Wyrebiak, Wojciech Bielecki, Robert Wrzesien, Barbara Bobrowska-Korczak
Summary: The study found that dietary supplementation of genistein led to an increase in the excretion of methylated derivatives in the urine of rats. Animals on the control diet showed increasing or relatively low levels of methyl derivatives throughout the study, while those on diets supplemented with genistein had consistently high levels of methylated derivatives. High levels of methyl derivatives may have an influence on carcinogenesis.
Article
Biochemistry & Molecular Biology
Maruf Hasan, Henry Reyer, Michael Oster, Nares Trakooljul, Siriluck Ponsuksilli, Elizabeth Magowan, Dagmar -Christiane Fischer, Klaus Wimmers
Summary: UVB exposure can increase the supply of vitamin D in pig husbandry and does not affect the growth performance of the pigs. After exposure, there are changes in gene expression in the liver, with the pathways for vitamin D synthesis being preferentially initiated.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu-ying Yi, Yuan-ying Zhang, Yu-di Wang, Han-lin Chen, Yi-jie Guo, Xin-ming Wei, Du-xiao Yang
Summary: Vitamin D can reverse S1P-induced cell death and alleviate EAE symptoms by regulating S1P levels and related signaling pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Correction
Biochemistry & Molecular Biology
Haixiao Chen, Xing Ji, Xinhua Hu, Lihua Chen, Haiyan Lv, Chengyun Xu, Dun Hong, Ximei Wu
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)