Review
Chemistry, Analytical
Yichen Zhao, Kayvan Yavari, Juewen Liu
Summary: Over the past three decades, aptamer-based biosensors have been extensively studied. This article reviews recent papers that question the binding ability of popular aptamers and provides insights into the reasons for false positive results. It also highlights the importance of carefully designed controls and immobilized libraries for obtaining high-quality aptamers. The findings emphasize the need for validated aptamers in order to achieve meaningful results in biosensor design.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Dilara Basat Dereli, Abbase Guleren Alsancak
Summary: This study calculated the ionization constants of sulfonylurea group antidiabetic drugs using potentiometric titration and reverse-phase liquid chromatography methods, providing valuable information for researchers studying the physicochemical properties of these drugs. The aqueous pK(a) values of the compounds were determined using Yasuda-Shedlovsky equation and mole fraction-pK(a) extrapolation methods, with results obtained for different drugs using different calculation techniques.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Medicinal
Xue Li, Zhaofang Shi, Tiezheng Jia
Summary: By characterizing the acid dissociation constants of four polyamides, the pharmacological properties of an anticancer polyamide can be optimized. The acidities of the polyamides tested were similar, while the pK(a) of the N-methylimidazole moieties varied with the peptide sequence and molecular architecture.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Emil Bjorklund, Anna du Rietz, Patrik Lundstrom
Summary: PLIS is an open-source software for determination of protein-ligand dissociation constants, which can be used to characterize biological processes or to shed light on biophysical aspects of interactions. In addition to analyzing experimental data, PLIS includes functionality for generating synthetic data, useful for understanding how different parameters affect the data in order to better analyze experiments.
Article
Biochemical Research Methods
Veronika Solinova, Sille Stepanova, Andrej Jancarik, Jiri Klivar, Michal Samal, Irena G. Stara, Jana Vacek Chocholousova, Jaroslav Vacek, Ivo Stary, Vaclav Kasicka
Summary: Nonaqueous capillary electrophoresis combined with density functional theory has been used to determine the thermodynamic acidity constants of mono- and diaza[5]helicenes in methanol and water. The experimental results were found to be in good agreement with the theoretical calculations.
Article
Chemistry, Multidisciplinary
Guoao Li, Yaling Wang, Chengyi Sun, Fei Liu
Summary: The acid dissociation constant (pKa) of piperacillin was determined using potentiometric titration and electrospray ionization mass spectrometry (ESI-MS), which revealed two microscopic pKa values (3.37 and 8.96) corresponding to direct dissociation of the carboxylic acid group and one secondary amide group, respectively. Unlike other beta-lactam antibiotics, piperacillin undergoes direct dissociation instead of protonation dissociation. Additionally, the degradation tendency of piperacillin in alkaline solution can alter the dissociation pattern or eliminate the corresponding pKa values of amphoteric beta-lactam antibiotics. This study provides reliable determination of piperacillin's acid dissociation constant and a clear interpretation of how antibiotic stability affects the dissociation process.
FRONTIERS IN CHEMISTRY
(2023)
Article
Chemistry, Analytical
Giacomo Russo, Ardiana Kajtazi, Maura Vallaro, Pieter Surmont, Giuseppe Ermondi, Scott Anderson, Lucia Grumetto, Giulia Caron, Frederic Lynen
Summary: The charge state of a molecule determines its interaction with the environment. Acid retention on the CelerisTM Arginine column is driven by electrostatics and charge state. The analytical retention was found to have a significant relationship with the pKa of acidic solutes, showing either a linear or quadratic trend. The developed LC mass spectrometry method is fast, reliable, accurate, easily automatized, and has broad applicability.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Maria C. Carrasco, Katherine J. Dezarn, Firoz Shah Tuglak Khan, Shabnam Hematian
Summary: This study synthesized a new mu-oxo-heme/Cu complex and investigated the protonation events of three mu-oxo-heme/Cu complexes, reporting the pK(a) values for the first protonation event. The mu-aquo-heme/Cu complexes described were the first examples of such systems.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Energy & Fuels
Jiaqi Wang, Xinyu Zhang, Kun Ge, Wei Yu, Haoqi Wei, Jiaxing Liu
Summary: The commercial development of natural gas hydrates (NGH) is crucial for meeting future energy demands. Analyzing the efficiency of different production methods under various well configurations is essential for NGH exploitation. A simulation model was established based on the physical properties of hydrate reservoirs in the South China Sea. By comparing and analyzing natural gas production behavior using rapid depressurization and stepwise depressurization with a horizontal well, it was found that gravity enhances heat and mass transfer capacities in a horizontal well configuration, reducing water yield. Stepwise depressurization with a horizontal well is advantageous, as it significantly reduces water production, increases external energy input, and allows for quick reservoir heating.
Article
Chemistry, Analytical
Sayed S. Badawy, Yomna M. Ahmed, Fatehy M. Abdel-Haleem, Ahmed Barhoum
Summary: In this study, an ionophore-based nanosphere emulsion was developed for the determination of daclatasvir dihydrochloride (DAC) in various samples. The method exhibited a wide linear dynamic range, high recovery values, and excellent selectivity.
Article
Agronomy
Tho Nguyen, Man Ba Duong
Summary: Developing lime requirement (LR) methods for routine use is important in saving time, labor, and cost. This paper examined the effects of testing conditions on LR and tested a single base addition method. Optimal conditions were determined for LR estimation on Acrisols in Southeastern Vietnam. The single base addition method estimated 85.8% of LR by the reference method and can be suitable for routine use with further testing and validation.
ARCHIVES OF AGRONOMY AND SOIL SCIENCE
(2023)
Article
Chemistry, Physical
Anze Bozic, Rudolf Podgornik
Summary: This study extends the Kirkwood-Shumaker theory to proteins with anisotropic distributions of dissociable charges, showing that the fluctuations of the total charge and total dipole moment depend on the same proton occupancy correlator and exhibit similar dependencies on solution pH. This has significant implications for the Kirkwood-Shumaker interaction and its sensitivity to solution conditions.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Chemistry, Physical
Ryo Kanzaki, Tomoya Hidaka, Hitoshi Kodamatani, Takashi Tomiyasu
Summary: Gran's plot is a clever tool for finding endpoints in potentiometric neutralization titrations. It can also determine the formal potential of electrodes and autoprotolysis constants with high accuracy. This technique is fundamental for investigating the properties of solvents such as protic ionic liquids.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Medicinal
Robert Fraczkiewicz, Marvin Waldman
Summary: In this study, it is shown that the apparent pKa measured through standard titration experiments is not sufficient to accurately assess the acidity/basicity of organic functional groups in multiprotic compounds, which is a common situation in pharmaceutical research. The use of apparent pKa in such cases may lead to costly errors. To address this issue, the authors propose pK50 as a single-proton midpoint measure, derived from a statistical thermodynamics treatment of multiprotic ionization. The study demonstrates that pK50, which can be directly measured using specialized NMR titration experiments, is superior in tracking the acidity/basicity of the functional groups across related compounds and converges to the ionization constant in the monoprotic case.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Chemistry, Multidisciplinary
Mirjam Patricia Margarete Poschmann, Karl Petter Lillerud, Norbert Stock
Summary: In this paper, two new COOH-functionalized metal-organic frameworks (MOFs) were synthesized, with highly stable microporous framework structures lined with -COOH groups. The proton exchange of different acidic protons in the MOFs was studied, and Zr-CAU-61 membranes were prepared and tested for permeation of dyes and ions in aqueous solutions.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Analytical
Y. Surme, A. T. Bisgin, M. Ucan, I. Narin
JOURNAL OF ANALYTICAL CHEMISTRY
(2018)
Article
Chemistry, Analytical
A. T. Bisgin, Y. Surme, M. Ucan, I. Narin
JOURNAL OF ANALYTICAL CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Sema Karabel Ocal, Sami Pekdemir, Murat Serhatlioglu, Hasan H. Ipekci, Ertugrul Sahmetlioglu, Ibrahim Narin, Fatih Duman, Caglar Elbuken, Gokhan Demirel, M. Serdar Onses
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2019)
Article
Biotechnology & Applied Microbiology
Zeliha Duygu Ozdal, Ertugrul Sahmetlioglu, Ibrahim Narin, Ahmet Cumaoglu
Article
Environmental Sciences
Burcu Unlu Endirlik, Elcin Bakir, Iffet Ipek Bosgelmez, Ayse Eken, Ibrahim Narin, Aylin Gurbay
Article
Chemistry, Analytical
Donay Yuvali, Ibrahim Narin, Mustafa Soylak, Erkan Yilmaz
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2020)
Article
Multidisciplinary Sciences
Abdullah Taner Bisgin, Yavuz Surme, Mustafa Ucan, Ibrahim Narin
IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A-SCIENCE
(2020)
Article
Chemistry, Analytical
Yeliz Camci, Abdullah Taner Bisgin, Yavuz Surme, Mustafa Ucan, Ibrahim Narin
JOURNAL OF ANALYTICAL CHEMISTRY
(2020)
Article
Spectroscopy
Donay Yuvali, Muslum Seyhaneyildizi, Mustafa Soylak, Ibrahim Narin, Erkan Yilmaz
Summary: A new deep eutectic solvent (DES) composed of tetrabuthylammonium bromide (TBABr) and 1-octanol at a 1:2 molar ratio was prepared and characterized, and used as an extraction solvent for E127 in blood, urine, pharmaceutical tablet, and syrup samples. The combination of DES-UA-LLME and UV-Vis spectrophotometric detection allows for accurate determination of E127 in various sample matrices.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Harun Sener, Beril Anilanmert, Murat Emrah Mavis, Gokce Goksu Gursu, Salih Cengiz
Summary: A fast LC-APCI-MS/MS screening/confirmation method was developed and validated for trace analyses of explosives and organic gun shot residues in soil and on hands. Tape-lifting was chosen as the best residue collection method and a gradient elution system was developed. The method was validated and applied to real samples for quantitative analysis.
ACTA CHROMATOGRAPHICA
(2022)
Article
Biochemical Research Methods
Fatma Cavus Yonar, Gulten Rayimoglu, Beril Anilanmert, Emel Hulya Yukseloglu, Salih Cengiz
Summary: A new collective strategy was developed to extract touch DNA from questioned documents, achieving quantifiable amounts of DNA and high-quality DNA profiles with a success rate up to 1 week. The study also demonstrated the successful application of this strategy in different types of documents.
Article
Chemistry, Analytical
Fatma Cidem, Donay Yuvali, Mustafa Soylak, Ibrahim Narin, Erkan Yilmaz
Summary: In this study, a method combining deep eutectic solvent-based ultrasound-assisted liquid-liquid microextraction (DES-UA-LLME) and high-performance liquid chromatography-ultraviolet visible detection system was developed for accurate and sensitive determination of ibuprofen in various samples. The developed method offers the advantage of determining ibuprofen without interfering with the matrix environment of different samples.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Beril Anilanmert, Fatma Cavus Yonar
Summary: A 15 min dilute-and-shoot analysis method was developed for the simultaneous confirmation and quantification of sertraline, zolpidem and fentanyl in fruit juice residues. The method used liquid chromatography tandem mass spectrometry and a C-18 phenomenex column. The method is important for emergency-toxicology cases and drug facilitated crimes, as it can determine the combined or single use of these drugs and identify reasons for related deaths.
ANALYTICAL SCIENCES
(2023)
Article
Chemistry, Analytical
Donay Yuvali, Erkan Yilmaz, Ibrahim Narin
JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Beril Anilanmert, Ibrahim Narin, Ibrahim Aydin, Munevver Acikkol
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2018)
