Article
Plant Sciences
Yingbo Li, Yingjie Zong, Wenrui Li, Guimei Guo, Longhua Zhou, Hongwei Xu, Runhong Gao, Chenghong Liu
Summary: This study investigated the effects of cold stress on microspore totipotency in rice cultivar Zhonghua 11, revealing important molecular events occurring during this process through transcriptomics and metabolomics analyses. Pathways related to amino acid and carbohydrate metabolism may play crucial roles in rice microspore totipotency, with stearidonic acid identified as potentially participating in microspore embryogenesis initiation.
Article
Biotechnology & Applied Microbiology
A. Klajmon, K. Makowska, J. Zimny, S. Oleszczuk, M. Libik-Konieczny, M. Sebela, I. Gasparikova, W. Baba, R. Konieczny
Summary: This study investigates the antioxidant activity of gum Arabic (GA) in barley anthers during androgenesis. The results show that GA enhances the activity of antioxidant enzymes in the anthers, leading to effective ROS scavenging and successful androgenesis. The presence of GA does not directly contribute to the total antioxidant capacity, but rather affects the activity of the anther antioxidant system.
PLANT CELL TISSUE AND ORGAN CULTURE
(2023)
Review
Food Science & Technology
Ewa Dubas, Iwona Zur, Jana Moravcikova, Jozsef Fodor, Monika Krzewska, Ewa Surowka, Anna Nowicka, Zuzana Gersi
Summary: This study reviews the signaling role of proteins and peptides in the stress-induced microspore embryogenesis processes, providing insights into microspore reprogramming and embryo development. It discusses the potential impact on DHs production and emphasizes the advancements in synthetic peptides for genome-editing techniques in plant science and breeding.
FRONTIERS IN SUSTAINABLE FOOD SYSTEMS
(2021)
Article
Biotechnology & Applied Microbiology
Iwona Zur, Ewa Dubas, Monika Krzewska, Przemyslaw Kopec, Anna Nowicka, Ewa Surowka, Katarzyna Gawronska, Gabriela Golebiowska, Katarzyna Juzon, Sabina Malaga
Summary: Microspore reprogramming towards embryogenic development is initiated by the genotype-specific threshold of reactive oxygen species accumulation, which requires an efficient antioxidative defence system for high effectiveness. The effectiveness of microspore embryogenesis is influenced by a complex network of internal and environmental factors, with a strong seasonal effect on microspore physiological status. Variations in response to ME-inducing stress tiller pre-treatment exist between different genotypes and cultivars, suggesting the importance of antioxidant molecules in influencing ME effectiveness.
PLANT CELL TISSUE AND ORGAN CULTURE
(2021)
Article
Biochemistry & Molecular Biology
Zhihua Dou, Chen Liu, Xinhuan Feng, Yutong Xie, Haitao Yue, Jing Dong, Zhongkai Zhao, Gangliang Chen, Jie Yang
Summary: The study demonstrated that camel whey protein (CWP) treatment could improve weight loss, dyslipidemia reversal, inflammatory response inhibition, and liver protection in type 2 diabetes mellitus (T2DM) rats. Additionally, CWP was shown to up-regulate key factors related to insulin signaling pathways, suggesting a potential regulatory role in glucose and lipid metabolism.
Review
Pharmacology & Pharmacy
Issa Sadeghian, Reza Heidari, Mohammad Javad Raee, Manica Negahdaripour
Summary: Cell-penetrating peptides (CPPs) have the potential to deliver peptides and proteins into cells, offering promise for treating diseases involving oxidative stress, inflammatory response, and apoptosis. However, the clinical usage of CPPs is limited by several issues that need to be addressed through further research.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chun-Yan Kong, Zhen Guo, Peng Song, Xin Zhang, Yu-Pei Yuan, Teng Teng, Ling Yan, Qi-Zhu Tang
Summary: This review provides a comprehensive overview of the mechanisms underlying the oxidative stress and cell death pathways induced by doxorubicin, which are the major factors responsible for the acute cardiotoxicity. The authors aim to offer new insights for researchers to discover potential therapeutic strategies to prevent or reverse doxorubicin-induced cardiotoxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biophysics
Maria Chiarpotti, Gabriel S. Longo, Mario G. Del Popolo
Summary: In this study, the adsorption of nanoparticles coated with CPP on membranes containing acidic lipids was characterized using a molecular theory. The results show that electrostatic interactions, modulated by entropic effects, provide the driving force and regulate the adsorption kinetics of CPP-coated particles on acidic membranes. Adsorption free energy profiles allow to quantify the adsorption energy, and reveal that nanoparticles attachment and detachment from the membrane surface are restrained by free energy barriers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Environmental Sciences
Carlos Villaorduna, Mariano Mendoza-Carlos, Manuel Chuyma, Jhon Aviles, Ayda Avalos-Diaz, Ronald Lozano-Reategui, Juan Garcia-Ruiz, Nadia Panduro-Tenazoa, Jessy Vargas, Ysabel Moran-Quintanilla, Jose-Luis Rodriguez
Summary: Ipconazole, an antifungal agrochemical, poses a hazard to human, animal, and environmental health due to its widespread use in agriculture and easy accumulation in the environment. Our study investigated the cytotoxic effects of ipconazole on SH-SY5Y neuroblastoma cells, revealing a dose-dependent reduction in cell viability, increased ROS production, and induction of cell death. These findings suggest that ipconazole exposure may contribute to neurotoxicity or neurodegeneration.
Article
Plant Sciences
Eduardo Berenguer, Elena Carneros, Yolanda Perez-Perez, Carmen Gil, Ana Martinez, Pilar S. Testillano
Summary: The use of synthetic small molecule inhibitors of mammalian GSK-3 beta has been shown to improve in vitro embryogenesis efficiency in plants, promoting somatic embryogenesis by activating the BR pathway.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Chemistry, Medicinal
Xiao-Lu Wang, Ren-Wang Jiang
Summary: Superoxide dismutase (SOD) is an antioxidant enzyme that cannot effectively protect tissues from oxidative damage. However, cell-penetrating peptides (CPPs) can cross the cell membrane and when fused with SOD protein, forming a recombinant fusion protein (CPP-SOD), can penetrate various tissues and organs as well as the blood-brain barrier. CPP-SODs can alleviate severe oxidative damage in different tissues caused by radiation, ischemia, inflammation, and chemotherapy.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ly Porosk, Heleri Heike Hark, Renata Naporano Bicev, Ilja Gaidutsik, Jekaterina Nebogatova, Eger-Jasper Armolik, Piret Arukuusk, Emerson Rodrigo da Silva, Ulo Langel
Summary: Alzheimer's disease (AD) is a common neurodegenerative disease that causes dementia, and its pathophysiological dynamics are driven by genetics with high heterogeneity in biological alterations and causes. The disease is characterized by the progression of aggregated amyloid-beta (A beta) or Tau neurofibrillary tangles. Current treatments for AD are not efficient, but recent breakthroughs have led to the discovery of potential therapeutic targets such as reducing brain inflammation and limiting A beta aggregation. This study demonstrates the successful use of A beta interacting protein sequences, particularly derived from Transthyretin, to reduce or target amyloid aggregation, and also predicts anti-inflammatory properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Ulo Langel
Summary: In the past 25-30 years, multiple novel mechanisms and applications of cell-penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery systems. Research in the author's own laboratories has led to the development of multiple CPPs, paving the way for delivering bio-functional materials.
Article
Plant Sciences
Carolina Camacho-Fernandez, Jose M. Segui-Simarro, Ricardo Mir, Kim Boutilier, Patricia Corral-Martinez
Summary: Different types of embryogenic structures exhibit specific cell wall characteristics that determine their developmental fate. Highly embryogenic structures have thin walls rich in specific components, while less embryogenic structures have thick walls and lower values of cell wall components.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Immunology
Danieli F. Buccini, Marlon H. Cardoso, Octavio L. Franco
Summary: Bacterial infections caused by intracellular pathogens are difficult to control with conventional antibiotic therapies, leading to increased interest in antimicrobial peptides and cell-penetrating peptides as potential alternative treatments.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Plant Sciences
Rakesh K. Sinha, Pavel Pospisil, Priti Maheshwari, Francois Eudes
FRONTIERS IN PLANT SCIENCE
(2016)
Article
Plant Sciences
Rakesh Kumar Sinha, Shiv Narayan Sharma, Shiv S. Verma, Jenu Zha
ACTA PHYSIOLOGIAE PLANTARUM
(2018)
Article
Biochemistry & Molecular Biology
Deepak Kumar Yadav, Jerzy Kruk, Rakesh Kumar Sinha, Pavel Pospisil
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2010)
Article
Biophysics
Rakesh Kumar Sinha, Arjun Tiwari, Pavel Pospisil
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2010)
Article
Plant Sciences
Shiv Narayan Sharma, Zenu Jha, Rakesh Kumar Sinha, Arvind Kumar Geda
PHYSIOLOGIA PLANTARUM
(2015)
Article
Plant Sciences
Rakesh Kumar Sinha, Josef Komenda, Jana Knoppova, Michaela Sedlarova, Pavel Pospisil
PLANT CELL AND ENVIRONMENT
(2012)
Meeting Abstract
Cell Biology
Rakesh Kumar Sinha, Francois Eudes
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2013)
Article
Multidisciplinary Sciences
Shiv Narayan Sharma, Rakesh Kumar Sinha, D. K. Sharma, Zenu Jha
Article
Chemistry, Medicinal
Shiv Narayan Sharma, Zenu Jha, Rakesh Kumar Sinha
NATURAL PRODUCT COMMUNICATIONS
(2013)