Article
Urology & Nephrology
Max Traeger, Christian Leiber-Caspers, Francesco Chierigo, Omer Onur Cakir, Christian Gratzke, Daniel Schlager
Summary: This study compared the differences in measuring penile curvature between at-home self-photography and in-office penile drug injection. It found that at-home self-photography underestimated the extent of penile curvature. The study also showed that men with erectile dysfunction have a larger difference in the measured degree of penile curvature between at-home self-photography and in-office penile drug injection.
EUROPEAN UROLOGY FOCUS
(2023)
Article
Acoustics
Ahmed Mohamed Hassanin, Ramzy Elnabarawy, Hatem El-Azizi, Sameh Fayek Gamal El Din, Mahmoud Fawzy Ghaly
Summary: This study aims to investigate the value of penile elastography in assessing fibrotic changes in the corpora cavernosa. The results indicate that penile shear wave elastography can effectively assess fibrotic changes in the corpora cavernosa and can be used as a modality for diagnosing patients with erectile dysfunction.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Wende Yang, Chen Qiu, Jiancheng Zhai, Wei Zhang, Chengwu Huang, Jun Shao, Jingke Zhang, Shigao Chen, Xiaoyan Miao, Peng Chen, Bo Wei, Jie Ren, Hongbo Wei
Summary: In this study, an innovative liposomal microbubble (MB) loaded with both Sildenafil (one of PDE5i) and NO was designed. Ultrasound-targeted MB destruction (UTMD)-mediated efficient release and integration erectogenic agents into corpus cavernosum with high biosafety. The coordinated intervention of the multifunctional MB-cooperated UTMD reversed the abnormal structural remodeling and promoted the recovery of functional erection.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ana Claudia Vincenzi Raduan Uski, Luciana Maksoud Piccolo, Carolina Pereira Abud, Maria Helena Naves Inacio Pedroso, Kamila Seidel Albuquerque, Natalia Borges Nunes Gomes, Jose de Avila Fernandes
Summary: Penile implants are surgically inserted devices used to treat erectile dysfunction. Advances in surgical techniques and implant manufacturing have reduced complications and increased the popularity of this therapy. Routine imaging before surgery is not recommended. MRI plays a crucial role in detecting and managing postoperative complications, allowing evaluation of implant positioning and function.
Article
Urology & Nephrology
Amanda R. Swanton, Ricardo M. Munarriz, Martin S. Gross
Summary: This retrospective study investigated the association between preoperative partner involvement and deviation from a standardized postoperative care pathway in patients undergoing inflatable penile prosthesis placement. The results showed that involving partners during preoperative visits significantly reduced the number of unanticipated follow-up visits.
Article
Urology & Nephrology
Amir Toussi, Matthew Ziegelmann, David Yang, Madeleine Manka, Igor Frank, Stephen A. Boorjian, Matthew Tollefson, Tobias Kohler, Landon Trost
Summary: The study investigates the effects of using a novel penile traction therapy device on erectile function and penile length post prostatectomy. Results demonstrate significant improvements in penile length, erectile function, intercourse satisfaction, and overall sexual satisfaction in the penile traction therapy group compared to controls.
JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Asif Muneer, Sarah Fowler, David J. Ralph, Duncan J. Summerton, Rowland W. Rees
Summary: This study is the largest prospective registry analysis of penile prosthesis procedures in the UK to date, showing trends over a 3-year collection period such as a decrease in the number of surgeons performing the procedure, fewer peri-operative complications, and recorded postoperative complications in patients.
Article
Andrology
Alberto Costa Silva, Vasco Rodrigues, Carlos Martins Silva, Afonso Morgado
Summary: Surgical correction of penile fractures can restore sexual function and improve body image satisfaction, with rare need for specific treatment of complications.
Article
Urology & Nephrology
David W. Barham, Nikolaos Pyrgidis, Martin S. Gross, Muhammed Hammad, Daniel Swerdloff, Jake Miller, Abdullah Alkhayal, Khalid A. Alrabeeah, Robert Andrianne, Arthur L. Burnett, Kelli Gross, Georgios Hatzichristodoulou, James M. Hotaling, Tung-Chin Hsieh, Adam Jones, James M. Jones, Aaron Lentz, Jason Levy, Vaibhav Modgil, Daniar Osmonov, Sung Hun Park, Ian Pearce, Paul Perito, Hossein Sadeghi-Nejad, Maxime Sempels, Alfredo Suarez-Sarmiento, Jay Simhan, Koenraad van Renterghem, J. Nicholas Warner, Matthew Ziegelmann, Faysal A. Yafi
Summary: The aim of this study was to compare the infection risk between the AUA-recommended prophylaxis (vancomycin and gentamicin alone) and nonstandard regimens for primary inflatable penile prosthesis surgery. The results showed that the infection rate was similar between the two groups, but the vancomycin and gentamicin regimen was associated with a higher infection risk. Therefore, further research is needed to evaluate the recommended antimicrobial prophylactic regimens and determine best practices for inflatable penile prosthesis surgery.
JOURNAL OF UROLOGY
(2023)
Review
Cell Biology
Sheng Wang, Songsen Gao, Dexi Zhou, Xueyi Qian, Jiajie Luan, Xiongwen Lv
Summary: Extracellular ATP serves as a danger signal released by dying and damaged cells, promoting inflammation as an immunostimulatory signal. CD39 and CD73 play critical roles in liver disease by breaking down ATP into adenosine, shifting from a proinflammatory to an anti-inflammatory environment. The modification of the CD39-CD73-adenosine pathway alters the liver's response to injury and adenosine exerts different effects on liver pathophysiology through different receptors.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Urology & Nephrology
Eusebio Luna, Bradley Garden, Dayron Rodriguez, Luanda Y. Perez, Dailianys Barrios, Fernando J. Bianco, Edward Gheiler
Summary: This study describes the technique and early results of inflatable penile prosthesis (IPP) deactivation via puncture and drainage in the office setting, aiming to avoid penile explanting interventions in high-risk surgical patients. The findings indicate that this procedure is safe and reliable, with no reported complications. The authors strongly recommend puncturing implants in patients with severe cognitive decline to prevent potential complications.
Review
Nursing
Francesc Rogers, Amineh Rashidi, Beverley Ewens
Summary: Men with prostate cancer do not receive sufficient education and support to initiate penile rehabilitation post-prostatectomy. There is particularly a lack of knowledge regarding the needs of gay, bisexual, and single men. Nurses and nurse practitioners can contribute positively to meeting educational needs.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2022)
Article
Biology
David Allard, Isabelle Cousineau, Eric H. Ma, Bertrand Allard, Yacine Bareche, Hubert Fleury, John Stagg
Summary: CD73 is overexpressed on tumor cells and suppresses anti-tumor immunity. It promotes tumor cell metabolism by enhancing mitochondrial respiration and aspartate biosynthesis. Targeting CD73 decreases tumor cell metabolic fitness, increases genomic instability, and suppresses PARP activity. This study uncovers an important immune-independent function of CD73 in promoting tumor cell metabolism and provides rationale for previously unforeseen combination therapies incorporating CD73 inhibition.
Article
Urology & Nephrology
Leonardo L. Monteiro, Rodrigo Skowronski, Fadi Brimo, Paulo da C. Carvalho Neto, Romulo A. L. de Vasconcelos, Charley R. C. Pacheco, Adriano A. Calado, Wassim Kassouf
Summary: This study evaluated erectile function in patients who underwent partial penectomy and found that older age, shorter penile shaft length, and clinically positive lymph nodes were significantly associated with erectile dysfunction.
INTERNATIONAL BRAZ J UROL
(2021)
Review
Biochemistry & Molecular Biology
Jianlei Xing, Jinhua Zhang, Jinyan Wang
Summary: Adenosine, an immunosuppressive metabolite, plays a crucial role in tumor progression by promoting tumor cell activities and down-regulating anti-tumor immune responses. This review summarizes the role of the adenosine/adenosine receptor pathway in regulating tumor-infiltrating immune cells and provides insights into adenosine-targeted tumor immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)