Article
Medicine, Research & Experimental
Yong-Qing Zhang, Hyun Kyu Min, Eunchong Hong, Eunhye Yu, Sun Mi Gu, Seong Shoon Yoon, Dohyun Lee, Jaejun Lee, Jin Tae Hong, Jaesuk Yun
Summary: The ICSS model was used to evaluate the abuse potential of 18 drugs in mice, and it was found that DAT availability and extracellular dopamine levels in the mPFC and NAc correlated with the ICSS threshold. These findings suggest a relationship between DAT availability-mediated dopamine levels and drug-induced reward-seeking behavior.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Anatomy & Morphology
Imre Kallo, Azar Omrani, Frank J. Meye, Han de Jong, Zsolt Liposits, Roger A. H. Adan
Summary: Orexin neurons play a role in homeostatic regulatory processes and provide input to VTA, a central hub processing reward and motivation. This study found that the VTA neurons projecting to the mNAcs receive more input from orexin neurons compared to those projecting to the mPFC. Orexin exerts facilitatory effects on both clusters of dopamine neurons.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Clinical Neurology
Greg C. Bristow, Tory Eisenlohr-Moul, Krista Lotesto, Monsheel S. Sodhi
Summary: This study found gender differences in the transcription of monoaminergic genes in the DLPFC in MDD patients, indicating that abnormalities in the expression of monoaminergic genes may contribute to alterations in DLPFC activity observed in major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Multidisciplinary Sciences
Daniel J. Christoffel, Jessica J. Walsh, Paul Hoerbelt, Boris D. Heifets, Pierre Llorach, Ricardo C. Lopez, Charu Ramakrishnan, Karl Deisseroth, Robert C. Malenka
Summary: The study reveals that dopamine and serotonin modulate excitatory synaptic transmission in the nucleus accumbens in input-specific ways, influencing motivated behaviors differently. Endogenous release of DA and 5-HT, as well as optogenetic inhibition, alter the behavioral effects of drugs in distinct manners.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Behavioral Sciences
Lola Kaukas, Joshua L. Holmes, Freshta Rahimi, Lyndsey Collins-Praino, Frances Corrigan
Summary: Adolescents who experience mild traumatic brain injury (mTBI) are more likely to exhibit chronic symptoms in adulthood, with sex-specific effects on executive functions related to subtle changes in the developmental trajectory of the mesocortical limbic pathway in males only. In an experimental study with Sprague Dawley rats, mTBI during mid-adolescence led to different behavioral deficits in males and females, as well as an imbalance in dopaminergic innervation post-injury.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
Marisela Hernandez-Gonzalez, Francisco Javier Barrera-Cobos, Enrique Hernandez-Arteaga, Ignacio Gonzalez-Burgos, Mario Flores-Soto, Miguel Angel Guevara, Pedro Manuel Cortes
Summary: Sexual experience improves copulatory performance in male rats by promoting changes in the density of dendritic spines in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAcc). Specifically, sexually experienced rats exhibited higher total dendritic density and increased numerical density of certain types of dendritic spines in the mPFC and NAcc. Furthermore, there was a shift in the proportional density of different types of dendritic spines towards a higher proportion of mushroom spines. These findings suggest that sexual experience can lead to consolidation of synaptic information in the brain regions involved in sexual behavior.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Xiao-Bo Wu, Qian Zhu, Ming-Hui Gao, Sheng-Xiang Yan, Pan-Yang Gu, Peng-Fei Zhang, Meng-Lin Xu, Yong-Jing Gao
Summary: Itch is a complex sensation regulated by neural circuits involving the nucleus accumbens (NAc) and excitatory afferents from the medial prefrontal cortex (mPFC), amygdala, and hippocampus. This study reveals that acute itch decreases the intrinsic membrane excitability in dopamine receptor D1-expressing medium spiny neurons (Drd1-MSNs) in the NAc core, and that chemogenetic activation of Drd1-MSNs alleviates itch-induced scratching behaviors. Furthermore, it was found that excitatory synaptic afferents from the mPFC play a crucial role in itch modulation.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Lucia Caffino, Francesca Mottarlini, Gianmaria Zita, Dawid Gawlinski, Kinga Gawlinska, Karolina Wydra, Edmund Przegalinski, Fabio Fumagalli
Summary: Drug addiction is a devastating disorder that poses a huge economic and social burden on modern society, with adolescents being particularly vulnerable. Research has shown that exposure to cocaine during adolescence confers a vulnerable endophenotype primarily by inducing changes in neuroplasticity.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Neurosciences
Barbara Ziolkowska
Summary: This article highlights the involvement of the nigrostriatal and mesolimbic dopamine systems in chronic pain modulation. Dopamine exerts analgesic effects in persistent pain by stimulating D2 receptors in the dorsal striatum and nucleus accumbens, while hampered dopaminergic neurotransmission in the mesostriatal pathways exacerbates pain. The interaction between dopaminergic and glutamatergic inputs plays a crucial role in pain modulation.
Review
Biochemistry & Molecular Biology
Philip W. Gold
Summary: The PPARg system plays a crucial role in depression by increasing BDNF levels and activity in specific brain areas, promoting neuroplasticity and neurogenesis, and influencing behavioral and physiological processes in patients with depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Jessica Hayes, Bettina Laursen, Elin Eneberg, Jan Kehler, Lars Kyhn Rasmussen, Morten Langgard, Jesper F. Bastlund, Todor V. Gerdjikov
Summary: Positive modulation of cAMP signaling by PDE inhibitors is a potential target for cognitive and behavioral deficits involving the corticoaccumbal circuit. Studies suggest that PDE1B inhibition may improve memory function in rodent models, but its effects on impulsivity, attention, motivation, and neurophysiology require further investigation.
Article
Biochemistry & Molecular Biology
James W. M. Kang, Kevin A. A. Keay, Michael D. D. Kendig, Laura H. H. Corbit, David Mor
Summary: The ability to adaptively guide behavior requires integration of external information with internal motivational factors. Acute stress and chronic pain can impair decision-making, including cognitive dysfunction. This study investigated the relationship between dopamine, serotonin, and their metabolites in brain regions regulating motivated behavior and decision-making.
NEUROCHEMICAL RESEARCH
(2023)
Article
Behavioral Sciences
Evelyn Ordones Sanchez, Debra A. Bangasser
Summary: Impulsivity is a common symptom in various psychiatric disorders, and early life stress has been found to affect impulsive behaviors and brain circuits associated with impulsivity, which is essential for developing treatments aimed at reducing impulsivity symptoms in psychiatric disorders.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Biology
Rawan AlSubaie, Ryan W. S. Wee, Anne Ritoux, Karyna Mishchanchuk, Jessica Passlack, Daniel Regester, Andrew F. MacAskill
Summary: Projections from the basal amygdala to the ventral hippocampus provide information about rewarding or threatening stimuli to support appropriate behavior. These projections consist of both excitatory and inhibitory inputs that control the activity of downstream neurons, ultimately affecting goal-directed behavior.
Article
Chemistry, Medicinal
Romina Vargiu, Francesca Broccia, Carla Lobina, Daniele Lecca, Alessandro Capra, Pier Paolo Bassareo, Valentina Bassareo
Summary: Energy drinks like Red Bull can increase dopamine levels in the brain, leading to addictive properties similar to drugs of abuse. While chronic consumption of RB did not affect cardiac mechanical parameters, it may impact the contraction of the left-ventricular papillary muscle in rats.
Correction
Clinical Neurology
E. Dremencov, K. Csatlosova, B. Durisova, L. Moravcikova, L. Lacinova, D. Jezova
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Clinical Neurology
Eliyahu Dremencov, Kristina Csatlosova, Barbora Durisova, Lucia Moravcikova, Lubica Lacinova, Daniela Jezova
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Behavioral Sciences
Enrico Ullmann, Seth W. Perry, Julio Licinio, Ma-Li Wong, Eliyahu Dremencov, Evgenii L. Zavjalov, Oleg B. Shevelev, Nikita Khotskin, Galina Koncevaya, Anna S. Khotshkina, Mikhail P. Moshkin, Maxim S. Lapshin, Maria Komelkova, Inna Feklicheva, Olga B. Tseilikman, Olga P. Cherkasova, Kamaldeep S. Bhui, Edgar Jones, Clemens Kirschbaum, Stefan R. Bornstein, Vadim Tseilikman
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2019)
Review
Behavioral Sciences
Vadim Tseilikman, Eliyahu Dremencov, Olga Tseilikman, Michaela Pavlovicova, Lubica Lacinova, Daniela Jezova
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2020)
Article
Endocrinology & Metabolism
Vadim Tseilikman, Eliyahu Dremencov, Ekaterina Maslennikova, Alla Ishmatova, Eugenia Manukhina, H. Fred Downey, Igor Klebanov, Olga Tseilikman, Mariya Komelkova, Maxim S. Lapshin, Mariya V. Vasilyeva, Stefan R. Bornstein, Seth W. Perry, Ma-Li Wong, Julio Licinio, Rachel Yehuda, Enrico Ullmann
HORMONE AND METABOLIC RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Romana Koprdova, Kristina Csatlosova, Barbora Durisova, Eszter Bogi, Magdalena Majekova, Eliyahu Dremencov, Mojmir Mach
Article
Behavioral Sciences
Eszter Bogi, Kristina Belovicova, Lucia Moravcikova, Kristina Csatlosova, Eliyahu Dremencov, Lubica Lacinova, Michal Dubovicky
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Behavioral Sciences
Alexey Sarapultsev, Petr Sarapultsev, Eliyahu Dremencov, Maria Komelkova, Olga Tseilikman, Vadim Tseilikman
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2020)
Article
Endocrinology & Metabolism
Vadim Tseilikman, Maria Komelkova, Maxim Lapshin, Anatoli Alliluev, Olga Tseilikman, Marina Karpenko, Nina Pestereva, Eugenia Manukhina, H. Fred Downey, Marina Kondashevskaya, Alexey Sarapultsev, Eliyahu Dremencov
PSYCHONEUROENDOCRINOLOGY
(2020)
Article
Clinical Neurology
Kristina Csatlosova, Eszter Bogi, Barbora Durisova, Daniil Grinchii, Ruslan Paliokha, Lucia Moravcikova, Lubica Lacinova, Daniela Jezova, Eliyahu Dremencov
Summary: There is a higher risk of depression and schizophrenia in the descendants of mothers who experienced acute infection during pregnancy, possibly due to the altered excitability of serotonin (5-HT) and dopamine neurons. Maternal immune activation suppressed the firing rate of 5-HT neurons and stimulated the firing rate of dopamine neurons in male offspring. This alteration in neuronal excitability may contribute to the psychopathologies induced by infectious disease during pregnancy.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Daniil Grinchii, Eliyahu Dremencov
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Lucia Moravcikova, Roman Moravcik, Daniela Jezova, Lubica Lacinova, Eliyahu Dremencov
Summary: The study investigated the effects of DOR agonist and antagonist on the excitability of hippocampal neurons, showing that they affect sodium, calcium, and potassium currents differently, possibly through DOR mediation. These findings suggest that the behavioral effects of the ligands observed in previous studies may be partially mediated by their modulatory effects on hippocampal neuron excitability.
PHARMACOLOGICAL REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Daniil Grinchii, Ruslan Paliokha, Vadim Tseilikman, Eliyahu Dremencov
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2018)
Article
Biochemistry & Molecular Biology
Eliyahu Dremencov, Lubica Lacinova, Gunnar Flik, Joost H. A. Folgering, Thomas I. F. H. Cremers, Ben H. C. Westerink
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2017)
Meeting Abstract
Physiology
L. Lapinova, E. Dremencov, L. Lacinova