Analysis of glycoforms on the glycosylation site and the glycans in monoclonal antibody biopharmaceuticals

Rapid High-Resolution Characterization of Functionally Important Monoclonal AntibodyN-Glycans by Capillary Electrophoresis

(2011) Zoltan Szabo et al.   ANALYTICAL CHEMISTRY

HILIC analysis of fluorescence-labeled N-glycans from recombinant biopharmaceuticals

(2010) Michael Melmer et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Glycan profiling of monoclonal antibodies using zwitterionic-type hydrophilic interaction chromatography coupled with electrospray ionization mass spectrometry detection

(2010) Lea Mauko et al.   ANALYTICAL BIOCHEMISTRY

Methods to Determine the Level of Afucosylation in Recombinant Monoclonal Antibodies

(2010) Yang Shen et al.   ANALYTICAL CHEMISTRY

Structure and function of immunoglobulins

(2010) Harry W. Schroeder et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Impact of Product-Related Factors on Immunogenicity of Biotherapeutics

(2010) Satish Kumar Singh   JOURNAL OF PHARMACEUTICAL SCIENCES

Mass Spectrometric Analysis of Intact Human Monoclonal Antibody Aggregates Fractionated by Size-Exclusion Chromatography

(2010) Başak Kükrer et al.   PHARMACEUTICAL RESEARCH

Analysis of 3-(acetylamino)-6-aminoacridine-derivatized oligosaccharides from recombinant monoclonal antibodies by liquid chromatography–mass spectrometry

(2009) Ambrose Clarke et al.   ANALYTICAL BIOCHEMISTRY

Investigation of Sample Preparation Artifacts Formed during the Enzymatic Release of N-Linked Glycans prior to Analysis by Capillary Electrophoresis

(2009) Yong Liu et al.   ANALYTICAL CHEMISTRY

Characterization of IgG N-Glycans Employing a Microfluidic Chip that Integrates Glycan Cleavage, Sample Purification, LC Separation, and MS Detection

(2009) Maggie A. Bynum et al.   ANALYTICAL CHEMISTRY

Determination of glycosylation sites and site-specific heterogeneity in glycoproteins

(2009) Hyun Joo An et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Development of a high performance anion exchange chromatography analysis for mapping of oligosaccharides

(2009) Carl Grey et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab

(2009) Carola W. N. Damen et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Profile of native N-linked glycan structures from human serum using high performance liquid chromatography on a microfluidic chip and time-of-flight mass spectrometry

(2009) Caroline S. Chu et al.   PROTEOMICS

Glycosylation profiling of a therapeutic recombinant monoclonal antibody with two N-linked glycosylation sites using liquid chromatography coupled to a hybrid quadrupole time-of-flight mass spectrometer

(2008) Amareth Lim et al.   ANALYTICAL BIOCHEMISTRY

High-throughput immunoglobulin G N-glycan characterization using rapid resolution reverse-phase chromatography tandem mass spectrometry

(2008) Bradley D. Prater et al.   ANALYTICAL BIOCHEMISTRY

On-Line CE−LIF−MS Technology for the Direct Characterization of N-Linked Glycans from Therapeutic Antibodies

(2008) Lynn A. Gennaro et al.   ANALYTICAL CHEMISTRY

Evaluation of glycosylation for quality assurance of antibody pharmaceuticals by capillary electrophoresis

(2008) Satoru Kamoda et al.   ELECTROPHORESIS

Capillary electrophoresis-electrospray ionization mass spectrometry for rapid and sensitive N-glycan analysis of glycoproteins as 9-fluorenylmethyl derivatives

(2008) M. Nakano et al.   GLYCOBIOLOGY

The way forward, enhanced characterization of therapeutic antibody glycosylation: Comparison of three level mass spectrometry-based strategies

(2008) Elsa Wagner-Rousset et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Evaluation of oligosaccharide methods for carbohydrate analysis in a fully human monoclonal antibody and comparison of the results to the monosaccharide composition determination by a novel calculation

(2008) Michael Adamo et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Analytical Performance of Immobilized Pronase for Glycopeptide Footprinting and Implications for Surpassing Reductionist Glycoproteomics

(2008) Eric D. Dodds et al.   JOURNAL OF PROTEOME RESEARCH

Comparison of LC and LC/MS methods for quantifying N-glycosylation in recombinant IgGs

(2008) Sandipan Sinha et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Analysis of immunoglobulin glycosylation by LC-ESI-MS of glycopeptides and oligosaccharides

(2008) Johannes Stadlmann et al.   PROTEOMICS

Standardization, evaluation and early-phase method validation of an analytical scheme for batch-consistency N-glycosylation analysis of recombinant produced glycoproteins

(2007) S ZIETZE   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Determination of N-glycosylation sites and site heterogeneity in a monoclonal antibody by electrospray quadrupole ion-mobility time-of-flight mass spectrometry

(2007) Petra Olivova et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Glycosylation of Recombinant Antibody Therapeutics

(2005) Royston Jefferis   BIOTECHNOLOGY PROGRESS