Article
Sport Sciences
Christian Fugl Hansen, Jonas Jensen, John Brodersen, Volkert Siersma, Jonathan D. Comins, Michael R. Krogsgaard
Summary: The majority of RCTs did not use the most appropriate PROM as the primary outcome, but studies that did were more likely to show significant differences between interventions. The high prevalence of unavailable protocols was surprising.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Article
Health Care Sciences & Services
Tim Mathes, Tanja Rombey, Oliver Kuss, Dawid Pieper
Summary: The study compared treatment effect estimates between nonrandomized controlled studies based on real-world data and randomized controlled trials, finding that in most cases there was overlap, with disagreements mainly attributed to bias risk in NRCS-RWDs.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2021)
Article
Multidisciplinary Sciences
Runalika Roy, Gautham Melur Sukumar, Mariamma Philip, Gururaj Gopalakrishna
Summary: This study aims to test the face, content, criterion, and construct validity of the work-stress assessment tool TAWS-16. The results showed that TAWS-16 has good face and content validity, and appropriate construct validity. Overall, it measures work-stressors, coping abilities, and psycho-somatic symptoms associated with work-stress. The study recommends the use of TAWS-16 for periodic screening and classification of work-stress among employees.
Review
Clinical Neurology
Aaron Schokman, Yu Sun Bin, Diana Naehrig, Janet M. Y. Cheung, Kristina Kairaitis, Nick Glozier
Summary: This study aims to evaluate outcome measures used to assess the efficacy of narcolepsy interventions, finding that there is limited evidence for the validity, reliability, and responsiveness of frequently used PROMs. Further research is needed to establish clinically important differences from a patient-centered perspective.
Article
Dermatology
Kevin S. Kim, An-Wen Chan, Emilie P. Belley-Cote, Aaron M. Drucker
Summary: Noninferiority trials, which assess the comparability of a new treatment with the standard of care, have increased significantly in publication from 2005 to 2015. These trials differ from superiority trials in various aspects of trial design and have unique considerations.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Tammi R. A. Kral, Kaley Davis, Cole Korponay, Matthew J. Hirshberg, Rachel Hoel, Lawrence Y. Tello, Robin Goldman, Melissa A. Rosenkranz, Antoine Lutz, Richard J. Davidson
Summary: In this study, a large combined dataset from two controlled trials was used to examine the effects of an 8-week mindfulness-based stress reduction course on brain structure. The results showed no evidence of neuroplastic changes compared to control groups, contradicting previous findings.
Article
Cardiac & Cardiovascular Systems
Tariq Jamal Siddiqi, Izza Shahid, Muhammad Sameer Arshad, Stephen J. Greene, Ambarish Pandey, Muthiah Vaduganathan, Harriette G. c. Van Spall, Robert J. Mentz, Shahzeb Khan
Summary: This study investigated the prevalence and characteristics of heart failure RCTs that report outcomes different from those prespecified. The results showed that more than 10% of trials reported inconsistent outcomes, with various types of inconsistencies including omission, changes in order, and addition of new outcomes. These findings suggest the need for action to reduce selective reporting and improve transparency.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Rheumatology
George A. Wells, Peter Tugwell, Gunnar Tomasson, Francis Guillemin, Lara J. Maxwell, Beverley J. Shea, Shawna Grosskleg, Peter A. Merkel, Lyn March, Dorcas E. Beaton
Summary: This article discusses the concepts of multioutcome domain (MOD) and composite outcome domain (COD), as well as their applications in core outcome sets. It also provides specific steps and training plans on how to develop MOD or COD tools.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Health Care Sciences & Services
Aristea Missiou, Eleni Ntalaouti, Christos Lionis, Evangelos Evangelou, Athina Tatsioni
Summary: The study aimed to assess the reporting of applicability in randomized controlled trials (RCTs) conducted in primary care (PC). A random sample of PC RCTs published between 2000 and 2020 was used to evaluate applicability. Data related to setting, population, intervention, comparator, outcomes, and context were extracted. Findings revealed underreporting of contextual factors in PC RCTs, which compromises the assessment of applicability.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Editorial Material
Health Care Sciences & Services
Daniel Kotz, Robert West
Summary: Randomized controlled trials are considered the most robust design for evaluating clinical interventions. The revised Cochrane risk-of-bias tool (RoB 2) helps researchers mitigate bias and ensure transparency in reporting.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Review
Health Care Sciences & Services
Adi Turjeman, Itamar Poran, Vered Daitch, Noam Tau, Irit Ayalon-Dangur, Jeries Nashashibi, Dafna Yahav, Mical Paul, Leonard Leibovici
Summary: Among 360 RCTs, only two-thirds reported the number of patients assessed for eligibility. Trials reporting eligibility data had better methodology, reported on the tested hypothesis, included a placebo arm, evaluated soft outcomes, published their findings in higher impact journals, and recruited a higher number of randomized patients. Recruitment rates were significantly higher in trials sponsored by industry, conducted in multiple centers and countries, including inpatients, testing non-inferiority hypothesis, including a placebo arm, and evaluating surrogate outcomes.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Megha L. Mehrotra, Daniel Westreich, M. Maria Glymour, Elvin Geng, David Glidden
Summary: The process of transporting subgroup analyses from highly selected study populations to external target populations can provide target-specific subgroup effect estimates and numbers needed to treat, ultimately leading to more tailored and accurate guidance for resource allocation and cost-effectiveness analyses.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Multidisciplinary Sciences
Marijn Mulder, Rinske H. M. Nijland, Judith D. M. Vloothuis, Maayken van den Berg, Maria Crotty, Gert Kwakkel, Erwin E. H. van Wegen
Summary: This study compared two randomized controlled trials conducted in the Netherlands and Australia, revealing differences in patient characteristics and treatment outcomes across countries.
Review
Clinical Neurology
Scout McWilliams, Ted Zhou, Sylvia Stockler, Dean Elbe, Osman S. Ipsiroglu
Summary: Sleep disturbances are common among children with ADHD, but there is a lack of standardized sleep measures for assessing and treating ADHD. Sleep should be included as a core outcome measure in future clinical trials.
SLEEP MEDICINE REVIEWS
(2022)
Review
Multidisciplinary Sciences
Hanna M. Ollila, Markku Partinen, Jukka Koskela, John Borghi, Riikka Savolainen, Anna Rotkirch, Liisa T. Laine
Summary: This study is a systematic review and meta-analysis that examines the use of face mask intervention in mitigating the risk of spreading respiratory infections. The findings suggest that wearing face masks, particularly in a community setting and for adults, can reduce the occurrence of respiratory infections.
Letter
Rheumatology
Sofia Ramiro, Remy L. M. Mostard, Robert B. M. Landewe
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Robert B. M. Landewe, Sofia Ramiro, Remy L. M. Mostard
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Laure Gossec, Jessica A. Walsh, Kaleb Michaud, Steve Peterson, Elizabeth A. Holdsworth, Chetan S. Karyekar, Nicola Booth, Soumya D. Chakravarty, Alexis Ogdie
Summary: This study found that sex differences exist in clinical characteristics, disability, quality of life (QOL), and work productivity in patients with PsA. Women experienced worse QOL, higher disability, and greater work activity impairment compared to men. However, women had a lower burden of comorbidities. These findings have important implications for the therapeutic management of PsA.
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Rheumatology
Enrico De Lorenzis, Gerlando Natalello, David Simon, Georg Schett, Maria Antonietta D'Agostino
Summary: Pain is the main symptom in entheseal diseases. Eicosanoids, cytokines, and neuropeptides released during inflammation and mechanical challenge stimulate nerves and blood vessels to invade the enthesis. Nociceptive pseudounipolar neurons support this process by releasing neurotransmitters that induce neovascularization and sensitization, which may explain the dissociation between pain and imaging findings.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Surgery
N. J. Preston, G. A. McHugh, E. M. A. Hensor, A. J. Grainger, P. J. O'Connor, P. G. Conaghan, M. H. Stone, S. R. Kingsbury
Summary: This study evaluated the feasibility and acceptability of a standardized virtual clinic (VC) approach for the follow-up of hip and knee total joint arthroplasty (TJA) patients. The results suggest that a standardized VC is a feasible alternative for TJA patients and is acceptable to key stakeholders.
ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
(2023)
Article
Rheumatology
Lotte van Ouwerkerk, Maarten Boers, Paul Emery, Pascal H. P. de Jong, Robert B. M. Landewe, Willem Lems, Josef S. Smolen, Patrick Verschueren, Tom W. J. Huizinga, Cornelia F. Allaart, Sytske Anne Bergstra
Summary: This study investigated whether patients with rheumatoid arthritis (RA) can discontinue glucocorticoids (GC) after GC 'bridging' in the initial treatment step and identified factors that may affect this. The probability of using GC decreased over time after bridging therapy ended, while the probability of continuous GC use increased. In oral GC bridging studies, the probabilities of later and continuous GC use and the cumulative GC doses were higher compared to studies that included parenteral GC bridging.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Andreas Kerschbaumer, Alexandre Sepriano, Sytske Anne Bergstra, Josef S. Smolen, Desiree van der Heijde, Roberto Caporali, Christopher John Edwards, Patrick Verschueren, Savia de Souza, Janet E. Pope, Tsutomu Takeuchi, Kimme L. Hyrich, Kevin L. Winthrop, Daniel Aletaha, Tanja A. Stamm, Jan W. Schoones, Robert B. M. Landewe
Summary: This study aimed to update the evidence on the efficacy of DMARDs and provide information for the 2022 update of EULAR recommendations for RA management. A systematic literature review was conducted to investigate the efficacy of cs, b, biosimilar, and tsDMARDs in RA patients. The results showed that csDMARDs combined with short-term glucocorticoids in early RA were as effective as bDMARD+MTX combination therapy. JAK inhibitors were effective in different patient populations. Tapering of DMARDs was feasible for some patients who could maintain low disease activity or achieve remission.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Orthopedics
Alan Brett, Michael A. Bowes, Philip G. Conaghan
Summary: This study aimed to compare CT and MRI assessments of 3D imaging biomarkers. The results showed a strong correlation between CT and MRI measurements of B-scores, but there were some biases in area measurements. Additionally, there were different biases in 3D joint space width between the lateral and medial compartments.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Editorial Material
Rheumatology
Zakaria El Ouali, Laure Gossec
Correction
Rheumatology
Bernard G. Combe, Yoshiya Tanaka, Maya H. Buch, Peter Nash, Gerd R. Burmester, Alan J. Kivitz, Beatrix Bartok, Alena Pechonkina, Katrina Xia, Kahaku Emoto, Shungo Kano, Thijs K. Hendrikx, Robert B. M. Landewe, Daniel Aletaha
RHEUMATOLOGY AND THERAPY
(2023)
Letter
Rheumatology
Sofia Ramiro, Elena Nikiphorou, Alexandre Sepriano, Augusta Ortolan, Casper Webers, Xenofon Baraliakos, Robert B. M. Landewe, Desiree van der Heijde
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Victoria Navarro-Compan, Diego Benavent, Dafne Capelusnik, Desiree van der Heijde, Robert B. M. Landewe, Denis Poddubnyy, Astrid van Tubergen, Xenofon Baraliakos, Filip E. van den Bosch, Floris A. van Gaalen, Lianne Gensler, Clementina Lopez-Medina, Helena Marzo-Ortega, Anna Molto, Rodolfo Perez-Alamino, Martin Rudwaleit, Marleen van de Sande, Raj Sengupta, Ulrich Weber, Sofia Ramiro
Summary: This study developed a consensual definition for 'early axial spondyloarthritis-axSpA' and 'early peripheral spondyloarthritis-pSpA' through a systematic literature review and Delphi survey. The results indicated that early axSpA should be based on symptom duration only, without considering the presence of radiographic damage.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Agata Burska, Javier Rodriguez-Carrio, Robert Biesen, Willem A. Dik, Maija-Leena Eloranta, Giulio Cavalli, Marianne Visser, Dimitrios T. Boumpas, George Bertsias, Marie Wahren-Herlenius, Jan Rehwinkel, Marie-Louise Fremond, Mary K. Crow, Lars Ronnblom, P. G. Conaghan, Marjan Versnel, Ed Vital
Summary: This study systematically reviewed the literature on assay methods for evaluating type I interferon (IFN-I) pathway activation and aimed to harmonize related terminology. Data from 276 papers on 412 methods were extracted and summarized. Consensus terminology was developed to define different aspects of IFN-I research and practice.
Review
Rheumatology
Javier Rodriguez-Carrio, Agata Burska, P. G. Conaghan, Willem A. Dik, Robert Biesen, Maija-Leena Eloranta, Giulio Cavalli, Marianne Visser, Dimitrios T. Boumpas, George Bertsias, Marie Wahren-Herlenius, Jan Rehwinkel, Marie-Louise Fremond, Mary K. Crow, Lars Ronnblom, Ed Vital, Marjan Versnel
Summary: This article provides a systematic review of assays measuring IFN-I pathway activation and summarizes the potential clinical utility in various rheumatic and musculoskeletal diseases. The results show that IFN-I pathway activation is associated with disease diagnosis, disease activity assessment, prognosis, response to treatment, and assay responsiveness. However, the heterogeneity in techniques and technical conditions are major limitations.
Review
Health Care Sciences & Services
Mohammed Mujaab Kamso, Jordi Pardo Pardo, Samuel L. Whittle, Rachelle Buchbinder, George Wells, Vanessa Glennon, Peter Tugwell, Rob Deardon, Tolulope Sajobi, George Tomlinson, Jesse Elliott, Shannon E. Kelly, Glen S. Hazlewood
Summary: This study evaluated an approach that combines automation and crowdsourcing to identify and classify randomized controlled trials (RCTs) for rheumatoid arthritis (RA) in a living systematic review (LSR). The results showed that this approach can significantly reduce the workload for expert reviewers and has high sensitivity.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
