Article
Urology & Nephrology
Fabiola G. Gianella, Victor E. Prado, John R. Poindexter, Beverley Adams-Huet, Xilong Li, R. Tyler Miller, Khashayar Sakhaee, Naim M. Maalouf, Orson W. Moe
Summary: Serum bicarbonate concentration is not a sensitive marker, especially in CKD patients, while urinary citrate excretion rate may be a better indicator of acid-base status. In patients receiving potassium citrate therapy, an increase in urinary citrate-to-creatinine ratio may be a superior parameter for monitoring alkali therapy compared to serum bicarbonate concentration. Additional studies are needed before implementing a clinical test.
KIDNEY INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Young Su Joo, Hyung Woo Kim, Sangmi Lee, Ki Heon Nam, Hae-Ryong Yun, Jong Hyun Jhee, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Jung Tak Park
Summary: This study used data from the Korean Genome and Epidemiology Study to show that low dietary zinc intake may increase the risk of chronic kidney disease in individuals with normal renal function.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Sofia Cecchi, Silvio Di Stante, Sara Belcastro, Veronica Bertuzzi, Assunta Cardillo, Laura Diotallevi, Xhensila Grabocka, Hrissa Kulurianu, Mauro Martello, Valentina Nastasi, Osmy Paci Della Costanza, Francesca Pizzolante, Marina Di Luca
Summary: Supplemented very low-protein diet (sVLPD) has been effective in delaying the start of dialysis treatment for stage 5 chronic renal failure patients, but it may increase the risk of malnutrition and is difficult to implement. By prescribing sVLPD supplemented with essential amino acids instead of keto-analogues, the progression of chronic kidney disease was slowed down and the start of dialysis treatment was delayed without evidence of malnutrition.
Article
Chemistry, Medicinal
Katsunori Yanai, Keiji Hirai, Shohei Kaneko, Yuko Mutsuyoshi, Taisuke Kitano, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Susumu Ookawara, Yoshiyuki Morishita
Summary: We retrospectively analyzed the efficacy and safety of dotinurad, a selective urate reabsorption inhibitor, in hyperuricemic patients with advanced CKD. The results showed that dotinurad was able to decrease uric acid levels and might attenuate renal function decline.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Nutrition & Dietetics
M. Kyla Shea, Kathryn Barger, Sarah L. Booth, Jifan Wang, Harold Feldman, Raymond R. Townsend, Jing Chen, John Flack, Jiang He, Bernard G. Jaar, Mayank Kansal, Sylvia E. Rosas, Daniel E. Weiner
Summary: The study found that individuals with better vitamin K status in chronic kidney disease have a lower risk of all-cause mortality, but there is no significant difference in the risk of atherosclerotic cardiovascular disease events.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Ashish Verma, Anand Vaidya, Sonu Subudhi, Sushrut S. Waikar
Summary: The study found that higher serum aldosterone levels are independently associated with an increased risk for kidney disease progression in individuals with chronic kidney disease, regardless of concomitant diabetes. This suggests a potential role for mineralocorticoid receptor antagonists in delaying CKD progression even in those without diabetes.
EUROPEAN HEART JOURNAL
(2022)
Article
Multidisciplinary Sciences
Peder Berg, Jesper Frank Andersen, Mads Vaarby Sorensen, Tobias Wang, Hans Malte, Jens Leipziger
Summary: The lungs and kidneys play a crucial role in regulating the body's acid-base balance. In cystic fibrosis, impaired renal excretion of HCO3- leads to metabolic alkalosis, which can contribute to reduced lung function by suppressing ventilatory drive.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Nutrition & Dietetics
Angela Vidal, Rafael Rios, Carmen Pineda, Ignacio Lopez, Ana I. Raya, Escolastico Aguilera-Tejero, Mariano Rodriguez
Summary: This paper reviews the impact of calorie intake on mineral metabolism, highlighting its role in phosphate balance and bone density regulation, as well as the direct influence of calorie content on FGF23 and calcitriol synthesis and secretion.
Article
Nutrition & Dietetics
I-Hsin Lin, Te-Chih Wong, Tuyen Van Duong, Shih-Wei Nien, I-Hsin Tseng, Hsu-Han Wang, Yang-Jen Chiang, Shwu-Huey Yang
Summary: This study investigated the association between dietary quality indices and recurrent chronic kidney disease (rCKD) in Taiwanese post-renal transplant recipients (RTRs). The results showed that RTRs with higher dietary quality indices were older, had higher eGFRs, and had lower odds of rCKD.
FRONTIERS IN NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Ramesh Kumar, Rajeev Nayan Priyadarshi, Utpal Anand
Summary: In recent years, there has been a sharp increase in the diagnosis of CKD among patients with liver cirrhosis, mainly attributed to risk factors such as diabetes, hypertension, and nonalcoholic fatty liver disease. A significant proportion of acute kidney injury in patients with decompensated cirrhosis turns into CKD, which can be either structural or functional. Limited literature exists on combined cirrhosis-CKD, presenting challenges for clinicians in diagnosing and treating CKD in cirrhosis patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiawen Li, Min Liang, Tao Zeng, Minzi Qiu, Mengbi Zhang, Shaoling Jiang, Lishan Tan, Aiqing Li
Summary: The study showed that inhibition of central PRR expression can ameliorate salt-induced renal injury in CKD rats by reducing sympathetic nerve activity, inflammation, and oxidative stress, as well as by blocking central MAPK/ERK1/2 and PI3K/Akt signaling pathways and ACE1-Ang II-AT1R axis. This suggests that targeting central PRR or PRR-mediated signaling pathway may be a novel strategy for CKD treatment.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Pharmacology & Pharmacy
Chun-fung Sin, Ka-ping Wong, Tsz-fu Wong, Chung-wah Siu, Desmond Y. H. Yap
Summary: This study investigated the plasma levels of apixaban in patients with chronic kidney disease (CKD) and found that the levels increased with worsening renal function, and the increase was associated with an increased risk of bleeding complications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Hiroki Muramatsu, Naoe Akimoto, Michio Hashimoto, Kenji Sugibayashi, Masanori Katakura
Summary: This study demonstrated that feeding diets containing ARA and DHA has positive effects on the progression of chronic kidney disease, slowing down the occurrence of proteinuria and reducing oxidative stress levels in the kidneys.
Article
Physiology
Thomas Verissimo, Delal Dalga, Gregoire Arnoux, Imene Sakhi, Anna Faivre, Hannah Auwerx, Soline Bourgeois, Deborah Paolucci, Quentin Gex, Joseph M. Rutkowski, David Legouis, Carsten A. Wagner, Andrew M. Hall, Sophie de Seigneux
Summary: Phosphoenolpyruvate carboxykinase 1 (PCK1) plays an important role in maintaining normal tubular physiology, lactate, and glucose homeostasis in the kidney. It regulates acid-base balance and ammoniagenesis. Downregulation of PCK1 during renal injury impairs renal function, making it a potential therapeutic target in renal disease.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Chun-Fung Sin, Ka-Ping Wong, Hoi-Man Wong, Chung-Wah Siu, Desmond Y. H. Yap
Summary: This study investigated the plasma levels of rivaroxaban in early CKD patients and its relationship with clinical events. The results showed that plasma trough levels of rivaroxaban were higher in CKD patients and inversely correlated with renal function. Additionally, there was an association between plasma trough levels of rivaroxaban and the rate of bleeding complications.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Marcia Ribeiro, Larissa Fonseca, Juliana S. Anjos, Jean C. C. Capo-chichi, Natalia A. Borges, Jerrilynn Burrowes, Denise Mafra
Summary: Patients with chronic kidney disease often experience anemia, with oral or intravenous iron supplementation being the main treatment. Recent studies have shown that oral iron supplementation may disrupt gut microbiota and cause oxidative stress, affecting the composition of intestinal flora.
NUTRITION IN CLINICAL PRACTICE
(2022)
Article
Urology & Nephrology
Jean Christ Cedras Capo-Chichi, Natalia Alvarenga Borges, Drielly Cristhiny Mendes de Vargas Reis, Lia S. Nakao, Denise Mafra
Summary: In chronic kidney disease patients undergoing hemodialysis, although levels of uremic toxins such as IS, IAA, and p-CS were elevated, there was no correlation found between uremic toxins plasma levels and anemia parameters. Only in patients with Hb < 11 g/dL, there was a negative correlation between hematocrit and IAA plasma levels.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Review
Food Science & Technology
Marcia Ribeiro, Livia Alvarenga, Ludmila F. M. F. Cardozo, Julie A. Kemp, Ligia S. Lima, Jonatas S. de Almeida, Viviane de O. Leal, Peter Stenvinkel, Paul G. Shiels, Denise Mafra
Summary: Coffee, a globally consumed beverage, is rich in caffeine, antioxidants, and phenolic compounds. It can modulate the composition of the gut microbiota and mitigate inflammation and oxidative stress. It has beneficial effects on diseases such as depression, diabetes, cardiovascular disease, and obesity.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Denise Mafra, Stephanie Ariemu Ugochukwu, Natalia A. Borges, Ludmila F. M. F. Cardozo, Peter Stenvinkel, Paul G. Shiels
Summary: Inflammageing is a persistent low-level inflammatory burden that accompanies age-related dysregulation of the immune system. A healthy diet, containing a balanced amount of macronutrients, vitamins, minerals, and poly(phenols), plays an essential role in mitigating the effects of inflammageing and extending healthspan by modulating the activity of various factors.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Nutrition & Dietetics
Isabelle C. V. S. Martins, Michel G. Maciel, Jose L. M. do Nascimento, Denise Mafra, Alexsandro F. Santos, Camila S. Padilha
Summary: The aim of this systematic review and meta-analysis was to evaluate the effects of anthocyanins-interventions on oxidative stress, inflammation, and lipid profile in patients undergoing hemodialysis. The results showed that anthocyanin intervention can reduce oxidative stress and inflammatory parameters, and improve lipid metabolism by increasing HDL cholesterol levels.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
D. Mafra, L. Cardozo, M. Ribeiro-Alves, P. Bergman, P. G. Shiels, P. Stenvinkel
Summary: This cross-sectional pilot study aimed to investigate the possible relationship between plasma choline levels and transcriptional expression of nuclear factor-erythroid 2-related factor 2 (Nrf2) in patients with chronic kidney disease (CKD). The study found a positive correlation between choline plasma levels and Nrf2 expression.
CLINICAL NUTRITION ESPEN
(2022)
Review
Nutrition & Dietetics
D. Mafra, B. A. Baptista, E. Sahiun, S. Abuznada, V. O. Leal, N. A. Borges
Summary: This article discusses the potential benefits of polydextrose on gut health, specifically its impact on constipation, in patients with chronic kidney disease.
CLINICAL NUTRITION ESPEN
(2022)
Article
Urology & Nephrology
Denise Mafra, Livia Alvarenga, Marcia Ribeiro, Beatriz G. Baptista, Susane Fanton, Bruna R. Paiva, Liana Trugilho, Julie Ann Kemp, Marcelo Alves-Ribeiro, Ludmila F. M. F. Cardozo
Summary: This study aimed to evaluate the expression of Bach1 mRNA in different treatments for chronic kidney disease (CKD). The results showed that Bach1 mRNA expression was significantly higher in patients undergoing hemodialysis compared to peritoneal dialysis and nondialysis patients. This suggests that Bach1 may be a therapeutic target for regulating inflammation in CKD patients.
HEMODIALYSIS INTERNATIONAL
(2023)
Review
Food Science & Technology
Denise Mafra, Julie A. Kemp, Viviane de O. Leal, Ludmila Cardozo, Natalia A. Borges, Livia Alvarenga, Karla T. R. Teixeira, Peter Stenvinkel
Summary: Fish is a valuable source of nutrients and intake is associated with reduced cardiovascular risk, but recent studies have shown that it also contains TMAO, a toxin associated with cardiovascular diseases. TMAO levels are increased in patients with CKD, but the effects of a fish-rich diet on TMAO levels and cardiovascular outcomes have not been studied yet. This review explores the pros and cons of a fish-rich diet in CKD patients, an area that requires further research.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Nutrition & Dietetics
Karen S. Coutinho-Wolino, Manuela F. S. Melo, Jessica C. Mota, Denise Mafra, Jonas T. Guimaraes, Milena B. Stockler-Pinto
Summary: Gut dysbiosis, a common condition in chronic kidney disease (CKD) patients, can lead to uremic toxin production, inflammation, oxidative stress, and cardiovascular disease. Consuming berry fruits, rich in polyphenols and nutrients, has shown promise in positively influencing the gut microbiota and improving clinical outcomes in CKD. However, more research is needed to understand the mechanisms and determine the optimal amount of berries for these effects. Clinical studies are encouraged to further evaluate the potential benefits of berry fruits in CKD patients.
Article
Plant Sciences
Beatriz Germer Baptista, Susane Fanton, Marcia Ribeiro, Ludmila F. M. F. Cardozo, Bruna Regis, Livia Alvarenga, Marcelo Ribeiro-Alves, Andresa A. Berretta, Paul G. Shiels, Denise Mafra
Summary: The study aimed to evaluate the effects of propolis supplementation on inflammatory markers in peritoneal dialysis patients with chronic kidney disease. The results showed that propolis supplementation significantly reduced tumor necrosis factor-alpha levels and had a trend to increase the expression of nuclear factor erythroid-2-related factor 2.
Review
Nutrition & Dietetics
Lu Dai, Denise Mafra, Paul G. Shiels, Tilman M. Hackeng, Peter Stenvinkel, Leon J. Schurgers
Summary: Vitamin K and vitamin K-dependent proteins are associated with age-related diseases. The direct impact of vitamin K on cellular senescence is yet to be proven, but its status reflects the complex interactions between dietary intake, gut microbiome activity, and health. It is proposed to emphasize food quality and explore healthy eating patterns containing vitamin K rather than focusing on a single nutrient for dietary recommendations.
Review
Food Science & Technology
Denise Mafra, Julie A. Kemp, Natalia A. Borges, Michelle Wong, Peter Stenvinkel
Summary: Residual kidney function is associated with better quality of life and outcome for patients with chronic kidney disease (CKD), and strategies should be implemented to preserve kidney function. Gut dysbiosis due to increased uremic toxin production and endotoxemia is a major cause of kidney damage, and various strategies, including diet, medications, and faecal transplantation, have been proposed to modulate the gut microbiota in these patients. Modifying gut microbiota composition may mitigate chronic kidney damage and preserve residual kidney function, but the effects of diet on residual kidney function remain limited.
Review
Medicine, General & Internal
Beatriz G. Baptista, Ligia S. Lima, Marcia Ribeiro, Isadora K. Britto, Livia Alvarenga, Julie A. Kemp, Ludmila F. M. F. Cardozo, Andresa A. Berretta, Denise Mafra
Summary: Royal jelly is a bee product rich in bioactive components with therapeutic properties, such as antioxidants and anti-inflammatory compounds. It has been shown to have preventive effects on complications related to non-communicable diseases (NCDs) through its role in reducing inflammation, oxidative stress, and intestinal dysbiosis. Personalized use of royal jelly as a non-pharmacological therapy is recommended.
Review
Urology & Nephrology
Laiis de Souza Gouveia Moreira, Isabela de Souza da Costa Brum, Drielly C. M. de Vargas Reis, Liana Trugilho, Tuany R. Chermut, Marta Esgalhado, Ludmila F. M. F. Cardozo, Peter Stenvinkel, Paul G. Shiels, Denise Mafra
Summary: Cinnamon, a widely used spice and traditional herbal medicine, may have beneficial effects on cardiovascular disease, obesity, and diabetes. However, its effectiveness for chronic kidney disease (CKD) remains uncertain. Bioactive compounds in cinnamon can mitigate common complications in CKD patients, such as oxidative stress, inflammation, hyperglycemia, gut dysbiosis, and dyslipidemia. This narrative review explores the mechanisms by which cinnamon may alleviate CKD complications and its potential role as an additional nutritional strategy for this patient group.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2023)
