Creatinine metabolite, HMH (5-hydroxy-1-methylhydantoin; NZ-419), modulates bradykinin-induced changes in vascular smooth muscle cells

Protective effect of an intrinsic antioxidant, HMH (5-hydroxy-1-methylhydantoin; NZ-419), against cellular damage of kidney tubules

(2012) Kazuharu Ienaga et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Connective Tissue Growth Factor Regulates Retinal Neovascularization through p53 Protein-dependent Transactivation of the Matrix Metalloproteinase (MMP)-2 Gene

(2012) Hembindu Chintala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum accumulation of a creatinine oxidative metabolite (NZ-419: 5-hydroxy-1- methylhydatoin) as an intrinsic antioxidant in diabetic patients with or without chronic kidney disease

(2011) G. Hasegawa et al.   CLINICAL NEPHROLOGY

Treatment with NZ-419 (5-Hydroxy-1-methylimidazoline-2,4-dione), a Novel Intrinsic Antioxidant, against the Progression of Chronic Kidney Disease at Stages 3 and 4 in Rats

(2010) Kazuharu Ienaga et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

First Indications Demonstrating the Preventive Effects of NZ-419, a Novel Intrinsic Antioxidant, on the Initiation and/or Progression of Chronic Renal Failure in Rats

(2009) Kazuharu Ienaga et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Connective Tissue Growth Factor Overexpression in Cardiomyocytes Promotes Cardiac Hypertrophy and Protection against Pressure Overload

(2009) Anna N. Panek et al.   PLoS One

Connective tissue growth factor and cardiac fibrosis

(2008) A. Daniels et al.   Acta Physiologica

Plasma Connective Tissue Growth Factor Is an Independent Predictor of End-Stage Renal Disease and Mortality in Type 1 Diabetic Nephropathy

(2008) T. Q. Nguyen et al.   DIABETES CARE

Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure

(2008) Norimichi Koitabashi et al.   EUROPEAN JOURNAL OF HEART FAILURE

Connective Tissue Growth Factor and Susceptibility to Renal and Vascular Disease Risk in Type 1 Diabetes

(2008) Ayad A. Jaffa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Connective Tissue Growth Factor Is Necessary for Retinal Capillary Basal Lamina Thickening in Diabetic Mice

(2008) Esther J. Kuiper et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice

(2007) H. Yokoi et al.   KIDNEY INTERNATIONAL