Emergent biological properties of arrestin pathway-selective biased agonism

Functional Signaling Biases in G Protein-Coupled Receptors: Game Theory and Receptor Dynamics

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Deciphering biased-agonism complexity reveals a new active AT1 receptor entity

(2012) Aude Saulière et al.   Nature Chemical Biology

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

The β-Arrestin Pathway-selective Type 1A Angiotensin Receptor (AT1A) Agonist [Sar1,Ile4,Ile8]Angiotensin II Regulates a Robust G Protein-independent Signaling Network

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Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Quantitative Phosphoproteomics Dissection of Seven-transmembrane Receptor Signaling Using Full and Biased Agonists

(2010) Gitte L. Christensen et al.   MOLECULAR & CELLULAR PROTEOMICS

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

(2010) T. Kenakin et al.   PHARMACOLOGICAL REVIEWS

Beyond Desensitization: Physiological Relevance of Arrestin-Dependent Signaling

(2010) L. M. Luttrell et al.   PHARMACOLOGICAL REVIEWS

Sympathetic Activation in Congestive Heart Failure: Evidence, Consequences and Therapeutic Implications

(2009) Guido Grassi et al.   Current Vascular Pharmacology

The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

(2009) X. J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A  -Arrestin-Biased Agonist of the Parathyroid Hormone Receptor (PTH1R) Promotes Bone Formation Independent of G Protein Activation

(2009) D. Gesty-Palmer et al.   Science Translational Medicine

‘7TM Receptor Allostery: Putting Numbers to Shapeshifting Proteins

(2009) Terry P. Kenakin   TRENDS IN PHARMACOLOGICAL SCIENCES

Differential effects of intermittent PTH(1–34) and PTH(7–34) on bone microarchitecture and aortic calcification in experimental renal failure

(2008) Ely M. Sebastian et al.   BONE

Subcellular Imaging of Dynamic Protein Interactions by Bioluminescence Resonance Energy Transfer

(2007) Vincent Coulon et al.   BIOPHYSICAL JOURNAL

Regulation of osteogenic differentiation during skeletal development

(2007) Zhong-Liang Deng   Frontiers in Bioscience-Landmark