Review
Immunology
George Sideris-Lampretsas, Marzia Malcangio
Summary: This review summarizes the existing preclinical evidence on how the CNS compartment and sex impact microglia functions in health, emphasizing recent advances in transcriptomics analyses for characterizing disease-associated microglial states. The specific scenario of peripheral nerve or tissue injury inducing expression of a specific subset of genes in microglia in the dorsal horn of the spinal cord is discussed, along with the possibility of a unique microglia transcriptional profile associated with chronic pain conditions. The evidence also suggests microglial activation in pain-related areas of the brain can be observed in models of neuropathic pain, highlighting the potential for future studies to further explore neuroimmune interactions in chronic pain using novel approaches like scRNA-seq and CYTOF.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Xue Bai, Gerard Batalle, Olga Pol
Summary: The study demonstrates the anxiolytic and antidepressant properties of DADS and GYY4137 during neuropathic pain, revealing their analgesic actions through inhibition of inflammatory, apoptotic, and oxidative responses. These findings support the use of these treatments for managing affective disorders accompanying chronic neuropathic pain.
Article
Immunology
Tahmineh Mokhtari, Min Lu, Ayman El-Meghawry El-Kenawy
Summary: This study aimed to investigate the effects of luteolin on chronic neuropathic pain-induced mood disorders by regulating oxidative stress, neurotrophic factors, and neuroinflammation. The results showed that luteolin treatment reversed the behavioral alterations and improved chronic pain-induced anxiety and depressive-like symptoms through its antioxidant, anti-inflammatory, and neuroprotective properties. This study highlights the potential of luteolin as a therapeutic agent for mood disorders associated with chronic pain.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Jonathan Niranjan Rajan, Katharine Ireland, Richard Johnson, Karolina M. Stepien
Summary: Fabry disease is a progressive X-linked lysosomal storage disease caused by a mutation in the GLA gene, leading to toxic accumulation of glycosphingolipids. Neuropathic pain is the most common manifestation of Fabry disease, with small fibre neuropathy being a key component. Pharmacological management is recommended as the first-line treatment, while interdisciplinary rehabilitation approach is suggested for refractory cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anesthesiology
Matthew Lyes, Kevin H. Yang, Joel Castellanos, Timothy Furnish
Summary: This article presents the experiences of three individuals using low-dose psilocybin to manage chronic neuropathic pain. They achieved significant pain relief and reduced reliance on traditional analgesics through self-administration of psilocybin. These commonalities highlight the therapeutic potential of psilocybin in the treatment of chronic pain.
Article
Pharmacology & Pharmacy
Qianqian Liu, Rui Li, Wei Yang, Ranji Cui, Bingjin Li
Summary: This study summarized the role of neuroglia in neuropathic pain and depression, revealing a bridging role of neuroglia in both conditions.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Chemistry, Medicinal
Marion Voute, Veronique Morel, Gisele Pickering
Summary: Topical lidocaine is a safe and effective option for pain management, with proven efficacy in various pain conditions. It can be used alone or in conjunction with systemic drugs and non-pharmacological approaches for optimized pain management and multimodal analgesia.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Dermatology
Mathilde HAYOUN-VIGOUROUX, Laurent MISERY
Summary: Pain is a common problem in dermatology, with various skin diseases and treatments potentially causing pain. Understanding the situations that cause pain can help provide suitable analgesic solutions.
ACTA DERMATO-VENEREOLOGICA
(2022)
Review
Biochemistry & Molecular Biology
Alessandra Bennici, Carmen Mannucci, Fabrizio Calapai, Luigi Cardia, Ilaria Ammendolia, Sebastiano Gangemi, Gioacchino Calapai, Daniel Griscti Soler
Summary: Products derived from Cannabis sativa are commonly used for treating chronic neuropathic pain, with nabiximols being the only product approved by regulatory authorities for neuropathic pain and spasticity in European countries and Canada. Safety and risk-benefit profiles of other cannabis preparations widely used for medical purposes remain unclear, highlighting the need for further research on adverse reactions.
Article
Clinical Neurology
Pei Liu, Jianjun Chen, Shuai Ma, Jianjun Zhang, Jianyu Zhou
Summary: The activation of the NLRP3 inflammasome is crucial in the pathogenesis of neuropathic pain, anxiety, and depression. Albiflorin may alleviate these symptoms by inhibiting NLRP3 inflammasome activity. Albiflorin could be a potential therapeutic agent to improve overall symptoms of neuropathic pain.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Neurosciences
Fan-He Song, Dai-Qiang Liu, Ya-Qun Zhou, Wei Mei
Summary: This article summarizes the role and mechanisms of SIRT1 in chronic pain, exploring its regulation of inflammation, oxidative stress, and mitochondrial function, suggesting that SIRT1 agonists may serve as potential therapeutic drugs for chronic pain.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Ming Tatt Lee, Wei-Hao Peng, Cheng-Chun Wu, Hung-Wei Kan, Deng-Wu Wang, Yu-Ning Teng, Yu-Cheng Ho
Summary: Chronic pain and depression often occur together in clinical populations. Chronic pain worsens the prevalence of depression, and depression increases the risk of chronic pain. The mechanisms underlying the comorbidity of chronic pain and depression remain unknown.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Anesthesiology
Jami L. Saloman, Darwin L. Conwell, Evan Fogel, Santhi Swaroop Vege, Liang Li, Shuang Li, Dana K. Andersen, William E. Fisher, Christopher E. Forsmark, Phil A. Hart, Stephen J. Pandol, Walter G. Park, Anna Evans Phillips, Mark Topazian, Stephen K. Van den Eeden, Jose Serrano, Dhiraj Yadav
Summary: Pain is common and significantly reduces quality of life in patients with chronic pancreatitis. This study aimed to classify the pain types in these patients, finding that patients with multiple pain types have worse health and quality of life scores. Further research is needed to identify biomarkers associated with specific pain types and predict responses to interventions.
Article
Biology
Marcin Kolacz, Dariusz Kosson, Ewa Puchalska-Kowalczyk, Malgorzata Mikaszewska-Sokolewicz, Barbara Lisowska, Malgorzata Malec-Milewska
Summary: Depression, anxiety, and aggression are closely associated with neuropathic pain. Effective treatment of these comorbidities can enhance pain management outcomes. The study examined the impact of antidepressants, benzodiazepine anxiolytics, and hypnotics on the intensity of depression, anxiety, and aggression in patients with neuropathic pain. The findings indicated that depression was well managed, but anxiety remained a potential treatment problem for these patients.
Review
Biochemistry & Molecular Biology
Masaru Tanaka, Nora Torok, Fanni Toth, Agnes Szabo, Laszlo Vecsei
Summary: Chronic pain is a persistent or recurrent, unpleasant sensory and emotional experience lasting more than three months. Recent classifications by the International Association for the Study of Pain will come into effect in 2022, emphasizing neurological pathology in chronic pain while downplaying psychological or social factors. This review delves into the pain pathway, mechanisms of pain, sensitization, chronic inflammation, and the role of metabolites, exploring how psychosocial and behavioral factors contribute to the development of chronic pain.
Review
Pharmacology & Pharmacy
Immaculate M. Langmia, Katja S. Just, Sabrina Yamoune, Julian Peter Mueller, Julia C. Stingl
Summary: The long-term use of ketamine and esketamine as antidepressants requires further research to improve safety, dosing, and identification of individuals at risk of drug-drug interactions.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Respiratory System
Ingmar Bergs, Katja S. Just, Annegret Mueller, Julia C. Stingl, Michael Dreher
Summary: The study found that 41% of COPD patients in the emergency department received therapy that was underdosed according to current guidelines. Dyspnea was the most common symptom in this group and occurred more frequently in patients who received underdosed inhalation therapy.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Genetics & Heredity
Carina M. Mathey, Carlo Maj, Annika B. Scheer, Julia Fazaal, Bettina Wedi, Dorothea Wieczorek, Philipp M. Amann, Harald Loffler, Lukas Koch, Clemens Schoffl, Heinrich Dickel, Nomun Ganjuur, Thorsten Hornung, Susann Forkel, Jens Greve, Gerda Wurpts, Par Hallberg, Anette Bygum, Christian Von Buchwald, Malgorzata Karawajczyk, Michael Steffens, Julia Stingl, Per Hoffmann, Stefanie Heilmann-Heimbach, Elisabeth Mangold, Kerstin U. Ludwig, Eva R. Rasmussen, Mia Wadelius, Bernhardt Sachs, Markus M. Nothen, Andreas J. Forstner
Summary: This study investigated the possible association between ACEi/ARB-induced angioedema and HAE genes through molecular genetic screening. The results suggest that HAE-associated mutations are, at best, a rare cause of ACEi/ARB-induced angioedema, and there was no significant association found between ACEi/ARB-induced angioedema and other variants in the investigated genes.
FRONTIERS IN GENETICS
(2022)
Article
Clinical Neurology
Maurice M. Ohayon, Maggie McCue, Andrew Krystal, Katherine J. Selzler, Lambros Chrones, Debra Lawrence, Marie-Lise Cote
Summary: This study aimed to understand the evolution of depression and treatment satisfaction over a 3-year period in primary care settings. Results showed a high prevalence of depression and low rates of remission. Dissatisfaction with treatment, frequent switching of antidepressants, and changing care providers were identified as challenges that need to be addressed in future research.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Pharmacology & Pharmacy
Ingmar Bergs, Katja S. Just, Catharina Scholl, Michael Dreher, Julia C. Stingl
Summary: This study aimed to analyze the association between inhaled therapy and adverse drug reactions (ADRs) in COPD patients, with a focus on the impact of overdose. The results showed that overdose of inhaled therapies led to severe ADRs and affected emergency room presentations. These ADRs are rarely associated with inhaled therapy by healthcare professionals or patients. Due to the high volume of prescriptions for inhaled drugs, greater attention should be paid to pharmacovigilance and patient education in COPD patients.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pediatrics
Sarah Leitzen, Diana Dubrall, Irmgard Toni, Julia Stingl, Patrick Christ, Ursula Koberle, Matthias Schmid, Antje Neubert, Bernhardt Sachs
Summary: The study compares the differences between ADRs reported in the KiDSafe project and the spontaneous ADR reports sent to EudraVigilance. The results show underreporting of ADRs in the spontaneous reports compared to the systematically collected KiDSafe reports. The two approaches yield different results in terms of reported drugs, ADRs, and medication errors.
Article
Clinical Neurology
Luisa da Costa Lopes, Dalva Lucia Rollemberg Poyares, Sergio Tufik, Sophia La Banca de Oliveira, Julia Ribeiro da Silva Vallim, Vanessa Kiyomi Ota, Maria Isabel Melaragno, Maurice Ohayon, Claudia Berlim de Mello
Summary: This study aimed to evaluate the effect of the BDNF Val66Met polymorphism on the performance of adolescents in attentional tests, circadian preferences, and activity-rest rhythm. The results showed that the time that the students attended school had an impact on all types of attention, regardless of chronotype. The presence of the BDNF Val66Met polymorphism was only associated with alternate attention performance.
Meeting Abstract
Clinical Neurology
Maurice Ohayon, Marie-Lise Cote
Meeting Abstract
Clinical Neurology
Maurice Ohayon, Marie-Lise Cote
Meeting Abstract
Clinical Neurology
Michael Thorpy, Colin Shapiro, Clete Kushida, Maurice Ohayon, Jordan Dubow, Jennifer Gudeman
Meeting Abstract
Obstetrics & Gynecology
F. Heitz, K. Weber-Lassalle, C. Ernst, K. Moellenhoff, N. De Gregorio, J. Hauke, D. Dietrich, J. Borde, C. Jackisch, T-W Park-Simon, L. C. Hanker, E. Pohl-Rescigno, K. Prieske, S. Kommoss, F. Marme, J. C. Stingl, S. Rita, P. Harter, E. Hahnen
GEBURTSHILFE UND FRAUENHEILKUNDE
(2022)
Meeting Abstract
Clinical Neurology
Maurice Ohayon, Amir Pakpour, Marie Lise Cote
Meeting Abstract
Clinical Neurology
Maurice Ohayon, Amir Pakpour, Marie Lise Cote
Meeting Abstract
Clinical Neurology
M. M. Ohayon, S. Dave, A. Shah, T. Swick, M. -L. Cote
Meeting Abstract
Respiratory System
I Bergs, S. K. Just, J. Stingl, M. Dreher
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)