Article
Immunology
Hui Hua, Qi Zhao, Jing Xia, Qian-long Dai, Shi-rui Bai, Xiao-bo Wang, Min Zhou
Summary: This study investigated whether ASP015K could attenuate DOX-induced cardiotoxicity through its anti-ageing effects and whether it would affect the tumour treatment effect of DOX. ASP015K was found to antagonise senescence induced by various factors, including hydrogen peroxide and DOX. Additionally, ASP015K treatment significantly alleviated cardiac function damage, histopathological deterioration, myocardial fibrosis, and oxidative damage in acute injury mouse models. ASP015K also enhanced the sensitivity of tumour cells to DOX therapy and significantly slowed down tumour growth in the xenograft mouse model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Vivekananda Budamagunta, Thomas C. Foster, Daohong Zhou
Summary: Immunosenescence is a complex phenomenon that leads to age-related immune dysfunction, resulting in various pathologies such as decreased ability to clear senescent and cancerous cells, increased autoimmune response, reduced ability to combat pathogens, and diminished response to vaccination. Cellular senescence and immunosenescence have not been extensively explored in terms of their relationship, yet in the context of the ongoing pandemic, immunosenescence has become a topic of great importance.
Article
Chemistry, Multidisciplinary
Ye Zhao, Shan Sun, Yan Lyu, Mengyao Gao, Hengwei Lin, Cheng Yang
Summary: A near-infrared fluorescent nanoprobe based on semiconducting polymer nanoparticles (SPNs) is developed for detecting senescence-associated beta-gal (SA-beta-gal). This probe can visualize SA-beta-gal in living cells due to its inherent lysosome-locating feature.
CHEMICAL COMMUNICATIONS
(2023)
Article
Agronomy
Kexin Li, Chaofan Zhang, Jiankang Cao, Guiqin Qu
Summary: This study investigated the morphological and physiological changes of daylily buds during postharvest senescence. The results showed that the external tissues of daylily buds turned yellow and wrinkled, while the internal tissues underwent autolysis and collapse. Phytohormone analysis revealed that abscisic acid (ABA) was the most abundant hormone and positively correlated with the senescence of daylily buds. The study also demonstrated the cross-talk between hormones in regulating the senescence of daylily buds.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2022)
Article
Geriatrics & Gerontology
Tianyue Sun, Lanxin Zhang, Jiali Feng, Lingyuan Bao, Jiqun Wang, Zhouzhi Song, Zhifan Mao, Jian Li, Zelan Hu
Summary: By studying a mouse model of doxorubicin-induced aging, we found that a dose of 5 mg/kg of doxorubicin was optimal for inducing cellular senescence in mice. This dose led to an increase in senescent cells and the accumulation of lipofuscin in the kidney and liver, respectively. These preliminary findings support the use of doxorubicin-induced aging mice as an animal model for evaluating potential anti-aging drug candidates.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Cell Biology
Wenzheng Xia, Bowen Chang, Liqun Li, Tingting Hu, Jiaqi Ye, Hanbin Chen, Wenfeng Li, Tao Zan, Meng Hou
Summary: The study revealed that the expression of miR-199a-3p in cardiomyocytes was downregulated in response to Dox treatment. The upregulation of miR-199a-3p promoted cell cycle re-entry and cell proliferation in cardiomyocytes, alleviating cardiac senescence.
Review
Immunology
Gonzalo Soto-Heredero, Manuel M. Gomez De las Heras, J. Ignacio Escrig-Larena, Maria Mittelbrunn
Summary: There are significant changes in the T cell compartment during aging, including the reduction of naive T cells and the accumulation of memory-like T cells. Memory-like T cells in older individuals exhibit characteristics of terminally differentiated and senescent cells. This review focuses on different subsets of age-associated T cells, such as highly cytotoxic T cells with natural killer properties, exhausted T cells with altered cytokine production, and regulatory T cells with proinflammatory features. Importantly, these subsets lose their ability to home to lymph nodes and preferentially migrate to nonlymphoid tissues, contributing to tissue deterioration and inflammaging.
ANNUAL REVIEW OF IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kamil Rudolf, Emil Rudolf
Summary: The mechanisms and outcomes of DOX-dependent toxicity in cardiomyocytes were investigated in this study. It was found that DOX induced a concentration-dependent loss of viability, autophagy activation, cell death, and senescence, preceded by oxidative burst, DNA damage, and loss of mitochondrial and lysosomal integrity. Proinflammatory and stress kinase signaling were upregulated in DOX-treated cells upon the loss of free intracellular Zn pools. Increased free Zn concentrations had both inhibitory and stimulatory effects on DOX-related molecular mechanisms and signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Yuko Yamaguchi, Marta Zampino, Toshiko Tanaka, Stefania Bandinelli, Yusuke Osawa, Luigi Ferrucci, Richard D. Semba
Summary: The study found that circulating GDF-15 is associated with the development of anemia in older adults, and higher levels of GDF-15 are linked to an increased risk of anemia.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Araceli Lerida-Viso, Alejandra Estepa-Fernandez, Angela Morella-Aucejo, Beatriz Lozano-Torres, Maria Alfonso, Juan F. Blandez, Viviana Bisbal, Pilar Sepulveda, Alba Garcia-Fernandez, Mar Orzaez, Ramon Martinez-Manez
Summary: Many anticancer drugs can cause premature aging in healthy tissues, resulting in accelerated aging processes and adverse effects in patients. Cardiotoxicity is a major limiting factor in the use of doxorubicin as a cancer treatment, leading to long-term morbidity and mortality. In this study, it was demonstrated that induction of senescence in the heart contributes to impaired cardiac function in mice treated with doxorubicin. Elimination of senescent cells using the senolytic Navitoclax significantly reduced senescence and cardiotoxicity markers, and restored cardiac function in mice. These results suggest the potential clinical use of senolytic therapies to alleviate cardiotoxicities induced by chemotherapy.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Francesco Demetrio Lofaro, Barbara Cisterna, Maria Assunta Lacavalla, Federico Boschi, Manuela Malatesta, Daniela Quaglino, Carlo Zancanaro, Federica Boraldi
Summary: This study characterized the matrisome in the aging skeletal muscle for the first time, demonstrating significant statistical differences in several matrisome proteins between aged and adult muscle. The findings provide new insights into the mechanisms regulating myocellular behavior in aging and their contribution to age-related muscle dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Genni Enza Marcovecchio, Francesca Ferrua, Elena Fontana, Stefano Beretta, Marco Genua, Ileana Bortolomai, Anastasia Conti, Davide Montin, Maria Teresa Cascarano, Sonia Bergante, Veronica D'Oria, Alessandro Giamberti, Donato Amodio, Caterina Cancrini, Adriano Carotti, Raffaella Di Micco, Ivan Merelli, Marita Bosticardo, Anna Villa
Summary: Down syndrome (DS) patients exhibit clinical manifestations associated with aging earlier than usual, with their immune system declining prematurely. Cellular senescence is hypothesized to contribute to early thymic involution and immune dysregulation in DS. Thymic tissue analysis in DS patients showed signs of accelerated thymic aging, with gene expression alterations related to stress response, epigenetic regulation, and senescence. Senescence markers and oxidative stress were detected in DS thymic epithelial cells, thymocytes, and T cells, highlighting the role of cellular senescence in immune dysfunction.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Yong Gao, Xia Shi, Yongyuan Chang, Yingbo Li, Xuehang Xiong, Hongmei Liu, Mengyuan Li, Weihua Li, Xuehai Zhang, Zhiyuan Fu, Yadong Xue, Jihua Tang
Summary: Narrowing down a single putative target gene and constructing the regulation network by proteomic method for a leaf senescence mutant. Leaf senescence mutant is an important resource for exploring molecular mechanism of aging. Proteomics analysis of the mutant and its wild type revealed differentially accumulated proteins mainly enriched in regulation pathways such as photosynthesis, ribosome, and chlorophyll metabolism. The interaction networks constructed by transcriptome data showed that ZmELS5 likely repaired several key factors in the photosynthesis system. These results provide a fundamental basis and new insights for further research on the molecular mechanism of leaf senescence in maize.
PLANT CELL REPORTS
(2023)
Article
Fisheries
Yeke Wang, Feng Chen, Jun He, Jun Chen, Ge Xue, Yan Zhao, Yanghui Peng, Ping Xie
Summary: This study reveals significant differences in the structure and protein composition of the egg envelopes of common carp adhesive eggs and grass carp semi-buoyant eggs, with common carp eggs having a thicker egg envelope and adhesive layer. Proteomic changes in common carp adhesive eggs after fertilization suggest a role in cell and fish egg morphology maintenance. Proteins upregulated in common carp adhesive eggs after fertilization, such as coagulation factor XIII A, zona pellucida proteins, and cystatin, may play a role in egg envelope hardening and embryonic development protection. Additionally, higher levels of alpha-2-macroglobulin-like protein in fertilized common carp eggs indicate potential for effective immune defense.
Article
Plant Sciences
Kanjana Kirasak, Sutin Kunyamee, Saichol Ketsa
Summary: Ethylene is a plant hormone that can cause flower senescence. Dendrobium flowers are highly sensitive to ethylene, and the concentration of ethylene can determine if premature senescence occurs. The cultivar 'Lucky Duan' is particularly sensitive to ethylene exposure. The study found that ethylene treatment induced color fading, drooping, and venation in the petals of 'Lucky Duan' flowers, while pre-treatment with 1-MCP counteracted these changes. The ultrastructural changes induced by ethylene, such as membrane damage and disorganization of different organelles, were also observed and were mitigated by 1-MCP pre-treatment.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Neurosciences
Chiara Lanzillotta, Ilaria Zuliani, Antonella Tramutola, Eugenio Barone, Carla Blarzino, Valentina Folgiero, Matteo Caforio, Diletta Valentini, Alberto Villani, Franco Locatelli, D. Allan Butterfield, Elizabeth Head, Marzia Perluigi, Jose F. Abisambra, Fabio Di Domenico
Summary: Abnormal activation of the PERK pathway in neurodegenerative disorders is associated with reduced protein synthesis, cell death, and altered antioxidant response. In Down syndrome, PERK activation is linked to the early development of Alzheimer's disease, suggesting that dysregulation of the PERK pathway may play a key role in DS pathology.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shon A. Koren, Matthew J. Hamm, Ryan Cloyd, Sarah N. Fontaine, Emad Chishti, Chiara Lanzillotta, Jennifer Rodriguez-Rivera, Alexandria Ingram, Michelle Bell, Sara M. Galvis-Escobar, Nicholas Zulia, Fabio Di Domenico, Duc Duong, Nicholas T. Seyfried, David Powell, Moriel Vandsburger, Tal Frolinger, Anika M. S. Hartz, John Koren, Jeffrey M. Axten, Nicholas J. Laping, Jose F. Abisambra
Summary: Tauopathies are a group of disorders involving neurodegeneration and cognitive decline, with limited therapeutic options due to lack of understanding of molecular mechanisms. Treating early stage tau transgenic mice with a multi-target kinase inhibitor improved brain atrophy and cognitive function, despite unchanged levels of hyperphosphorylated tau. Proteomics data identified potential therapeutic targets for tauopathy treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Ilaria Zuliani, Chiara Lanzillotta, Antonella Tramutola, Antonio Francioso, Sara Pagnotta, Eugenio Barone, Marzia Perluigi, Fabio Di Domenico
Summary: Protein O-GlcNAcylation plays a crucial role in neurodegenerative diseases, particularly in the pathogenesis of Alzheimer's disease. Although Down syndrome (DS) and AD share similar pathological features, the impact of O-GlcNAcylation in DS pathology has not been investigated. This study sheds light on the role of O-GlcNAcylation in DS brain alterations and its significance in AD hallmarks.
Article
Biochemistry & Molecular Biology
Chiara Lanzillotta, Antonella Tramutola, Graziella Di Giacomo, Federico Marini, D. Allan Butterfield, Fabio Di Domenico, Marzia Perluigi, Eugenio Barone
Summary: Research has shown that Down syndrome shares many common features with early onset Alzheimer's disease, including defects in brain insulin resistance, oxidative stress, and protein activation status in synaptic plasticity mechanisms. These abnormalities appear early in DS model mice, which may contribute to the development of AD in DS.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Chiara Lanzillotta, Fabio Di Domenico
Summary: Down syndrome is characterized by early onset Alzheimer's disease due to triplication of genes on chromosome 21, leading to oxidative stress and protein oxidation. Therapeutic approaches targeting antioxidant response and protein stability have shown efficacy in murine models, but further studies are needed for clinical translation.
Article
Biochemistry & Molecular Biology
Ilaria Zuliani, Chiara Lanzillotta, Antonella Tramutola, Eugenio Barone, Marzia Perluigi, Serena Rinaldo, Alessio Paone, Francesca Cutruzzola, Francesco Bellanti, Matteo Spinelli, Francesca Natale, Salvatore Fusco, Claudio Grassi, Fabio Di Domenico
Summary: This study reveals that aberrant protein O-GlcNAcylation plays a significant role in the neurodegenerative process induced by a high-fat diet, potentially promoting the development of Alzheimer's disease and mitochondrial impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Marzia Perluigi, Anna Picca, Elita Montanari, Riccardo Calvani, Federico Marini, Roberto Matassa, Antonella Tramutola, Alberto Villani, Giuseppe Familiari, Fabio Di Domenico, D. Allan Butterfield, Kenneth J. Oh, Emanuele Marzetti, Diletta Valentini, Eugenio Barone
Summary: The study found that nEVs isolated from DS children showed a significant increase in insulin resistance marker pIRS1(Ser636) and hyperactivation of the Akt/mTOR/p70S6K pathway downstream from IRS1, possibly driven by higher inhibition of PTEN. Additionally, high levels of pGSK3 beta(Ser9) were also observed. These alterations in the insulin-signaling/mTOR pathways are believed to be early events in the DS brain, contributing to the cognitive dysfunction and intellectual disability seen in this unique population.
ALZHEIMERS & DEMENTIA
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
D. Allan Butterfield, Eugenio Barone, Fabio Di Domenico, Marzia Perluigi
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sara Pagnotta, Antonella Tramutola, Eugenio Barone, Fabio Di Domenico, Valeria Pittala, Loredana Salerno, Valentina Folgiero, Matteo Caforio, Franco Locatelli, Stefania Petrini, D. Allan Butterfield, Marzia Perluigi
Summary: This study focuses on the role of BACH1/NRF2 ratio in the regulation of antioxidant response and its impact on patients with Down syndrome. The results show that overexpression of BACH1 disrupts the induction of antioxidant response genes, leading to oxidative damage accumulation. Additionally, administration of CAPE and VP961 promotes NRF2 nuclear translocation in cells from Down syndrome patients, improving antioxidant response.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Chiara Lanzillotta, Antonella Tramutola, Fabio Di Domenico, Bindu Paul, Solomon Snyder, D. Allan Butterfield, Marzia Perluigi, Joao Duarte, Eugenio Barone
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Fabio Di Domenico, Chiara Lanzillotta, Eugenio Barone, Antonella Tramutola, Marzia Perluigi
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Antonella Tramutola, Sara Pagnotta, Fabio Di Domenico, Marzia Perluigi, Eugenio Barone
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Neurosciences
Chiara Urbinati, Chiara Lanzillotta, Livia Cosentino, Daniela Valenti, Maria Cristina Quattrini, Livia Di Crescenzo, Francesca Prestia, Donatella Pietraforte, Marzia Perluigi, Fabio Di Domenico, Rosa Anna Vacca, Bianca De Filippis
Summary: Metformin treatment can selectively correct cognitive flexibility defects, improve mitochondrial function, and inhibit oxidative stress in female mice with Rett syndrome (RTT). However, it does not affect the general health and motor skills of RTT mice.
Article
Biochemistry & Molecular Biology
Antonella Tramutola, Simona Lanzillotta, Giuseppe Aceto, Sara Pagnotta, Gabriele Ruffolo, Pierangelo Cifelli, Federico Marini, Cristian Ripoli, Eleonora Palma, Claudio Grassi, Fabio Di Domenico, Marzia Perluigi, Eugenio Barone
Summary: Down syndrome (DS) is associated with Alzheimer's disease (AD) and brain insulin resistance. The KYCCSRK peptide has shown potential for improving insulin signaling in DS and reducing AD-like neuropathology in mice.
Meeting Abstract
Biochemistry & Molecular Biology
Fabio Di Domenico
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
