Article
Pharmacology & Pharmacy
Carine Marmentini, Dimitrius Santiago P. S. F. Guimaraes, Tanes de Lima, Francisco Breno S. Teofilo, Natalia S. da Silva, Gabriela M. Soares, Antonio C. Boschero, Mirian A. Kurauti
Summary: The study demonstrates that rosiglitazone can improve the viability of INS-1E cells exposed to hIAPP, independent of insulin-degrading enzyme (IDE) modulation. Rosiglitazone inhibited hIAPP fibrillation and reduced hIAPP-induced expression of CHOP, ATF4, and p-eIF2a, suggesting that TZDs treatment may be a promising approach to preserve β-cell mass and function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Decio L. Eizirik, Florian Szymczak, Maria Ines Alvelos, Frank Martin
Summary: This article discusses the importance of focusing on beta-cells in type 1 diabetes, proposing the design of therapies by defining regulatory networks rather than solely targeting the immune system.
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Article
Immunology
Soraya Sajadimajd, Niloofar Deravi, Kimia Forouhar, Roja Rahimi, Ali Kheirandish, Roodabeh Bahramsoltani
Summary: Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and beta-cell dysfunction, and its incidence is increasing worldwide. Research has shown that long-term high blood sugar leads to beta-cell failure and death through endoplasmic reticulum (ER) stress. Herbal compounds such as ginsenoside compound K, baicalein, quercetin, and resveratrol have demonstrated significant improvement of T2DM through modulation of ER stress. These findings suggest that herbal constituents have the potential to prevent and treat various complications of T2DM.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Xiangqian Li, Lina Wang, Gang Meng, Xiaoling Chen, Shushu Yang, Mengjun Zhang, Zhengni Zheng, Jie Zhou, Zhu Lan, Yuzhang Wu, Li Wang
Summary: This study provides evidence for the negative impact of high glucose intake as a dietary factor on the pathogenesis of type 1 diabetes. Therefore, avoiding high sugar intake may be an effective disease prevention strategy for children or adults susceptible to type 1 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Saurabh Vig, Joost M. Lambooij, Arnaud Zaldumbide, Bruno Guigas
Summary: In type 1 diabetes, beta-cell destruction is caused by inflammation and autoimmunity, with the interaction between the endoplasmic reticulum (ER) and mitochondria playing a crucial role in beta-cell dysfunction and immune activation. The crosstalk between these organelles regulates calcium homeostasis, oxidative stress, and the generation of mitochondrial-derived factors, impacting the pathogenesis of the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Abubakar Ibrahim Jatau, Aishatu Shehu, Lukman Mustapha, Ibrahim Muazzamu Aliyu, Rabi'u Nuhu Danraka, Abdulbasit Amin, Auwal Adam Bala, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Mohd Rais Mustafa, Siti Safiah Mokhtar
Summary: The endoplasmic reticulum (ER) is vital for cellular functions, but disruptions in its homeostasis can lead to ER stress, linked to diseases like cancer, obesity, and diabetes. The mechanisms of ER stress related to chronic hyperglycemia and hyperlipidemia in type II diabetes remain unclear.
Review
Endocrinology & Metabolism
Hiroshi Ikegami, Naru Babaya, Shinsuke Noso
Summary: Although diabetes mellitus is classified into different types based on etiology, there are shared susceptibilities and mechanisms in beta-cell failure among these subtypes. Understanding these common features can aid in the development of therapeutic strategies regardless of the type of diabetes. Future prospects in this area are also highlighted in the review.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Helmut Hiller, Dawn E. Beachy, Joseph J. Lebowitz, Stefanie Engler, Justin R. Mason, Douglas R. Miller, Irina Kusmarteva, Laura M. Jacobsen, Amanda L. Posgai, Habibeh Khoshbouei, Richard A. Oram, Desmond A. Schatz, Andrew T. Hattersley, Bernd Bodenmiller, Mark A. Atkinson, Harry S. Nick, Clive H. Wasserfall
Summary: This study found dysregulated expression of monogenic diabetes genes in the pancreas of individuals with T1D and at risk for T1D, with some genes related to cellular stress responses. Three arms of the ISR were significantly repressed in the pancreas of autoantibody+ individuals.
Editorial Material
Endocrinology & Metabolism
Barbara E. Corkey, Laurie E. Kilpatrick, Carmella Evans-Molina
Summary: This study suggests that individuals with susceptible HLA phenotypes and elevated sensitivity to cytokines and free fatty acids (FFA) are at a higher risk of developing autoimmune diseases as a result of a prior major inflammatory event. The enhanced responsiveness of pancreatic beta-cells to inflammatory cytokines and FFA may lead to abnormal presentation of granule proteins on the cell surface, triggering an autoimmune response.
Article
Agriculture, Multidisciplinary
Yujie Zhao, Yao Liu, Jianjun Deng, Chenhui Zhu, Xiaoxuan Ma, Min Jiang, Daidi Fan
Summary: This study found that ginsenoside F4 can inhibit skeletal muscle insulin resistance and improve the state of T2DM, and its mechanism is related to the inhibition of PTP1B activity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Yating Li, Siqian Gong, Meng Li, Xiaoling Cai, Wei Liu, Simin Zhang, Yumin Ma, Yingying Luo, Lingli Zhou, Xiuying Zhang, Xiuting Huang, Xueying Gao, Mengdie Hu, Yufeng Li, Qian Ren, Yanai Wang, Xianghai Zhou, Xueyao Han, Linong Ji
Summary: This study aimed to explore the prevalence and clinical characteristics of WFS1-related diabetes (WFS1-DM) in a Chinese population with early-onset type 2 diabetes (EOD). Through sequencing the exons of the WFS1 gene in 690 EOD patients, 33 rare variants were identified, and 6 patients were found to have pathogenic or likely pathogenic variants associated with WFS1-DM. These patients exhibited lower C-peptide levels and the need for insulin treatment. WFS1-DM is often misdiagnosed as type 2 diabetes, and genetic testing is helpful for personalized treatment.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Farsad Afshinnia, Thekkelnaycke M. Rajendiran, Chenchen He, Jaeman Byun, Daniel Montemayor, Manjula Darshi, Jana Tumova, Jiwan Kim, Christine P. Limonte, Rachel G. Miller, Tina Costacou, Trevor J. Orchard, Tarunveer S. Ahluwalia, Peter Rossing, Janet K. Snell-Bergeon, Ian H. de Boer, Loki Natarajan, George Michailidis, Kumar Sharma, Subramaniam Pennathur
Summary: Patients with type 1 diabetes (T1D) may experience rapid decline of kidney function due to specific lipidomic predictors, including unsaturated free fatty acids and phosphatidylcholine (PC), which were found to be independently associated with this decline.
Article
Multidisciplinary Sciences
Asli Okan, Necdet Demir, Berna Sozen
Summary: Diabetes mellitus has profound effects on the female mammalian reproductive system and early embryonic development, mainly by triggering ER-stress induced apoptotic cascade. This study provides new insights into understanding the pathological effects of diabetes on ovarian function and early embryo development.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Perrin Guyer, David Arribas-Layton, Anthony Manganaro, Cate Speake, Sandra Lord, Decio L. Eizirik, Sally C. Kent, Roberto Mallone, Eddie A. James
Summary: A recent study discovered novel splice variant and secretory granule antigens within the HLA class I peptidome of human islets, and found that CD8(+) T cells from peripheral blood and human islets recognize these antigens. Through a systematic discovery process, the study identified novel CD4(+) T cell epitopes derived from these antigens. The study further demonstrated the contribution of unconventional antigens to the loss of tolerance in autoimmune diabetes.
Article
Cardiac & Cardiovascular Systems
Pieter Martens, Chantal Mathieu, Thomas Vanassche
Summary: The presence of type 2 diabetes puts patients at a higher risk for cardiovascular disease, heart failure, and chronic kidney disease. Glucose control alone is not enough to prevent these complications, but new drugs like SGLT2-I and GLP-1RA show promise in reducing these risks. However, the uptake of these drugs in clinical practice, especially GLP-1RA, is low.
Review
Endocrinology & Metabolism
Athena Philis-Tsimikas, Harpreet S. Bajaj, Kamilla Begtrup, Roman Cailleteau, Amoolya Gowda, Ildiko Lingvay, Chantal Mathieu, David Russell-Jones, Julio Rosenstock
Summary: This article describes the clinical development program ONWARDS phase 3a, which investigates the use of once-weekly basal insulin icodec in the treatment of type 2 and type 1 diabetes. Six trials are being conducted to evaluate the efficacy and safety of icodec, with consideration of different clinical scenarios and comparator treatments.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Caro Minschart, Astrid Lammertyn, Paul Van Crombrugge, Carolien Moyson, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Toon Maes, Els Dufraimont, Nele Roggen, Christophe De Block, Yves Jacquemyn, Farah Mekahli, Katrien De Clippel, Annick Van Den Bruel, Anne Loccufier, Annouschka Laenen, Roland Devlieger, Chantal Mathieu, Katrien Benhalima
Summary: The level of gestational weight gain (GWG) during pregnancy is associated with adverse pregnancy outcomes in women with gestational diabetes (GDM) compared to women with normal glucose tolerance (NGT). Low GWG below recommended levels frequently occurs in GDM women without increased risk for adverse outcomes. Excessive GWG is associated with increased risk for neonatal hypoglycemia and worse metabolic profile postpartum in GDM women, and with higher rates of instrumental delivery and larger infants in NGT women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Alexandra Coomans de Brachene, Corentin Scoubeau, Anyishai E. Musuaya, Jose Maria Costa-Junior, Angela Castela, Julie Carpentier, Vitalie Faoro, Malgorzata Klass, Miriam Cnop, Decio L. Eizirik
Summary: This study reveals the unexpected potential of exercise training to preserve the health of beta cells, opening up a new avenue for preventing or slowing down the progression of diabetes through muscle-beta cell communication.
Letter
Endocrinology & Metabolism
Chantal Mathieu, Stefano Del Prato
Editorial Material
Endocrinology & Metabolism
Chantal Mathieu, Eleanor Kennedy, Patrick Schrauwen, Hindrik Mulder
Editorial Material
Endocrinology & Metabolism
Chantal Mathieu, Jeannette Soderberg, Stefano Del Prato, Anne-Marie Felton, Xavier Cos, Carine de Beaufort, Jean-Francois Gautier, Bastian Hauck, Angus Forbes, Robert Heine, Peter Schwarz, Bart Torbeyns
Article
Cell Biology
Kerstin Griess, Michael Rieck, Nadine Muller, Gergely Karsai, Sonja Hartwig, Angela Pelligra, Robert Hardt, Caroline Schlegel, Jennifer Kuboth, Celina Uhlemeyer, Sandra Trenkamp, Kay Jeruschke, Jurgen Weiss, Leon Peifer-Weiss, Weiwei Xu, Sandra Cames, Xiaoyan Yi, Miriam Cnop, Mathias Beller, Holger Stark, Arun Kumar Kondadi, Andreas S. Reichert, Daniel Markgraf, Marianne Wammers, Dieter Haeussinger, Oliver Kuss, Stefan Lehr, Decio Eizirik, Heiko Lickert, Eckhard Lammert, Michael Roden, Dominic Winter, Hadi Al-Hasani, Doris Hoeglinger, Thorsten Hornemann, Jens C. Bruning, Bengt-Frederik Belgardt
Summary: Impaired proinsulin-to-insulin processing in pancreatic beta-cells is a key defective step in both type 1 diabetes and type 2 diabetes. This study reveals the roles of specific sphingolipid species and sphingolipid-binding proteins in beta-cell function and T2D-associated beta-cell failure.
NATURE CELL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Decio L. Eizirik, Florian Szymczak, Roberto Mallone
Summary: In type 1 diabetes, pancreatic beta-cells are destroyed by the immune system, while neighboring alpha-cells are spared. The key differences between these cells, including the expression of antiapoptotic genes, ER stress-related genes, viral recognition and innate immune response genes, and immune-inhibitory molecules, contribute to the different vulnerabilities to autoimmune destruction and the preferential survival of alpha-cells.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Immunology
Daniel Andersen, Janne Marie Moll, Pankaj Arora, Niels Banhos Danneskiold-Samsoe, Si Brask Sonne, Christopher Thomas Workman, Andrew Richard Williams, Karsten Kristiansen, Susanne Brix
Summary: Intestinal tuft cells and immune responses were examined in mice fed a high-fat diet and gavaged with helminth PCF. Helminth PCF upregulated gene expression in tuft cells and increased levels of innate lymphoid cells and eosinophils. Network analyses revealed immunometabolic cues linking tuft cell response to fat mass ratio and eosinophils in eWAT to body fat mass regulation.
PARASITE IMMUNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Andrea M. Yeung, Jingtong Huang, Ambarish Pandey, Ibrahim A. Hashim, David Kerr, Rodica Pop-Busui, Connie M. Rhee, Viral N. Shah, Lia Bally, Antoni Bayes-Genis, Yong Mong Bee, Richard Bergenstal, Javed Butler, G. Alexander Fleming, Gregory Gilbert, Stephen J. Greene, Mikhail N. Kosiborod, Lawrence A. Leiter, Boris Mankovsky, Thomas W. Martens, Chantal Mathieu, Viswanathan Mohan, Kershaw Patel, Anne Peters, Eun-Jung Rhee, Giuseppe M. C. Rosano, David B. Sacks, Yader Sandoval, Jane Jeffrie Seley, Oliver Schnell, Guillermo Umpierrez, Kayo Waki, Eugene E. Wright Jr, Alan H. B. Wu, David C. Klonoff
Summary: The Diabetes Technology Society assembled a panel of clinician experts to review the current evidence on biomarker screening of people with diabetes for heart failure and provide recommendations for diagnosis and management to prevent disease progression.
PROGRESS IN CARDIOVASCULAR DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Matthias Weith, Jan Grossbach, Mathieu Clement-Ziza, Ludovic Gillet, Maria Rodriguez-Lopez, Samuel Marguerat, Christopher T. Workman, Paola Picotti, Jurg Baehler, Ruedi Aebersold, Andreas Beyer
Summary: The complexity of cellular and organismal traits is a result of the integration of genetic and environmental factors through molecular networks. While the structure and propagation of effects in networks are best understood at the level of functional modules, there is currently no established concept to include the global network state.
MOLECULAR SYSTEMS BIOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
J. De Meulemeester, M. M. Visser, B. Keymeulen, C. Vercammen, M. Strivay, G. Vanhaverbeke, C. De Block, L. Van Huffel, L. Winne, I. Lowyck, K. Spincemaille, R. Radermecker, D. Ballaux, C. Mathieu, P. Gillard
Article
Mathematics, Applied
Susan Ghaderi, Masoud Ahookhosh, Adam Arany, Alexander Skupin, Panagiotis Patrinos, Yves Moreau
Summary: This paper proposes a gradient-based Markov Chain Monte Carlo (MCMC) method for sampling from the posterior distribution of problems with nonsmooth potential functions. By using smoothing techniques, the original potential function is approximated by a smooth function with the same critical points, leading to a smoothing ULA method called SULA. Non-asymptotic convergence results of SULA are established under mild assumptions on the original potential function. Numerical results demonstrate the promising performance of SULA on both synthetic and real chemoinformatics data.
APPLIED MATHEMATICS AND COMPUTATION
(2024)
Review
Medicine, Research & Experimental
Laura M. Jacobsen, Jennifer L. Sherr, Elizabeth Considine, Angela Chen, Sarah M. Peeling, Margo Hulsmans, Sara Charleer, Marzhan Urazbayeva, Mustafa Tosur, Selma Alamarie, Maria J. Redondo, Korey K. Hood, Peter A. Gottlieb, Pieter Gillard, Jessie J. Wong, Irl B. Hirsch, Richard E. Pratley, Lori M. Laffel, Chantal Mathieu, I ADA EASD PMD
Summary: Jacobsen, Sherr et al. evaluate the utility of novel technologies in the treatment of type 1 diabetes. Their systematic review finds technologies such as continuous glucose monitoring, insulin pumps, and decision support tools improve important measures (e.g., HbA1c, time in range, quality of life) allowing precision-directed uptake of technology.
COMMUNICATIONS MEDICINE
(2023)