Article
Clinical Neurology
Marie-Christine Reinert, Brenda Huppke, Hannah Hummel-Abmeier, Wiebke Stark, Jutta Gaertner, Peter Huppke
Summary: The results of this study have important implications: pretreatment sNfL levels are a valuable biomarker for underlying disease activity in pediatric patients with MS; pretreatment sNfL levels in pediatric patients with MS have a predictive value for the response to first-line therapy and the necessity of future therapy escalation; high sNfL levels during a relapse are associated with poor recovery in this age group.
Article
Multidisciplinary Sciences
Varangkana Wairachpanich, Vorapong Phupong
Summary: This study found that serum HMGB1 at 16-20(+6) weeks of gestation were effective in predicting preeclampsia, while the addition of uterine artery Doppler did not improve the prediction performance.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Physical
Federica Sebastiani, Marianna Yanez Arteta, Lennart Lindfors, Marite Cardenas
Summary: A time and cost-effective method was proposed to screen LNP formulations and select the most promising candidates for in vitro and in vivo studies. Two different approaches were explored to investigate the binding affinity between LNPs and serum proteins using sensor functionalisation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Margret Paar, Katharina Seifried, Gerhard Cvirn, Arabella Buchmann, Michael Khalil, Karl Oettl
Summary: This study aimed to evaluate the redox state of human serum albumin (HSA) in patients with multiple sclerosis in serum and CSF and its possible correlations with disease activity and severity. The results showed significant differences in the redox state of albumin in CSF compared to controls, while there was no difference in serum. The redox state of albumin in serum was associated with physical disability in remission, while the redox state in CSF was related to disease activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Rui Wang, Qin-Hui Wen, Xin-An Zeng, Jia-Wei Lin, Jian Li, Fei-Yue Xu
Summary: This study found that pulsed electric field pretreatment can increase the binding affinity between curcumin and bovine serum albumin, and improve the loading capacity and storage stability of curcumin. PEF pretreatment makes the protein structure more disordered and increases the binding affinity to curcumin.
Article
Engineering, Chemical
Wenning Chu, Sobhana A. Sripada, Hannah R. Reese, Dipendra Bhandari, Augustus Adams, Jae Sly, Michael Crapanzano, Stefano Menegatti
Summary: This study successfully purified IgG from human plasma using a two-column process integrating LigaGuard (TM) and LigaTrap (TM) adsorbents, demonstrating the potential of a fully chromatographic process in this area.
Article
Multidisciplinary Sciences
Alba Rudolf Vegas, Meriem Hamdi, Giorgia Podico, Heinrich Bollwein, Thomas Froehlich, Igor F. Canisso, Stefan Bauersachs, Carmen Alminana
Summary: This study identified specific molecules packed in uterine extracellular vesicles (uEVs) associated with maternal recognition of pregnancy (MRP) in mares, providing additional knowledge in this area. Further analysis is needed to confirm the role of these molecules in MRP in mares.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Environmental
Binbin Ouyang, Wei Xu, Wenli Zhang, Cuie Guang, Wanmeng Mu
Summary: A novel laccase Lyfu-Lac combined with ABTS and SA showed efficient removal of sulfonamides and tetracyclines residues. The removal efficiency varied for different residues in the two systems, and the mechanisms for removal of sulfonamides and tetracyclines were proposed.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Chemistry, Analytical
Haifa M. Almughamsi, Makella K. Howell, Samuel R. Parry, Joule E. Esene, Jacob B. Nielsen, Gregory P. Nordin, Adam T. Woolley
Summary: Researchers have developed a biomarker-based diagnostic technique for preterm birth risk using 3D printed microfluidic devices, which can selectively extract and detect multiple biomarkers associated with preterm birth.
Article
Biochemistry & Molecular Biology
Yansen Wang, Chenyang Li, Yudong Zheng, Yajie Xie, Kun Qiao, Wei He, Siming Yang
Summary: In this study, BC/SPI composite membranes were prepared and demonstrated high efficiency in removing bilirubin and excellent blood compatibility. These membranes showed high adsorption efficiency, fast adsorption rate, and maintained high adsorption rate even in the presence of albumin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Organic
Yirui Cao, Congzhi Zhu, Maciej Barlog, Kayla P. Barker, Xiaozhou Ji, Alexander J. Kalin, Mohammed Al-Hashimi, Lei Fang
Summary: An extensive polycyclic pi-system with 23 fused rings was synthesized via a highly efficient borylation reaction, forming four B-N covalent bonds and four B <- N coordinate bonds. The B <- N coordinate bonds not only lock the backbone into a near-coplanar conformation but also decrease the LUMO energy level, demonstrating the dual utility of this strategy for the synthesis of rigid polycyclic molecules and the development of n-type conjugated materials for organic electronics and photovoltaics.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Dmitry V. Zaretsky, Maria V. Zaretskaia, Yaroslav I. Molkov
Summary: Senile plaques, composed mainly of beta-amyloid peptide, are the main characteristic of Alzheimer's disease. The concentration of soluble beta-amyloid-42 in cerebrospinal fluid and the density of amyloid deposits are strongly negatively correlated. However, Alzheimer's disease patients have lower levels of soluble beta-amyloid-42 in cerebrospinal fluid compared to individuals with normal cognition. The goal of this study was to infer deviations of beta-amyloid-42 metabolism parameters that underlie this difference using data from the Alzheimer's Disease Neuroimaging Initiative cohort.
Article
Chemistry, Multidisciplinary
Chan Wang, Mengdie Xue, Xiao Liu, Jingjing Chen, Mengdie Jiang, Liuting Zheng, Ruxuan Ma, Chengjin Ding, Yaping Tao, Hao Zhang, Qin Liu, Da Huo
Summary: This study challenges the traditional view of protein corona effect as a hindrance to drug delivery efficacy, showing that it can actually enhance delivery and reduce toxicity when used strategically. By utilizing depleted serum to create functional protein coronas on nanomaterials, it was found that the passivation process could improve therapeutic effects and decrease adverse reactions. Moreover, this approach showed promising results in cancer treatment, offering a potential strategy for precision nanomedicine development.
Article
Engineering, Chemical
Wei Shi, Shun-Nan Zhu, Hong Xu, Kai-Bin Li, Si-Qi Zhang, Tian-Yi Zhang, Chao-Ying Fang, Xiao-Bin Zhang, De-Man Han
Summary: This study explored the potential of dual-ligand hydrophobic charge induction chromatography for simultaneous recovery of bovine serum albumin and bovine immunoglobulin G. Results showed that dual-ligand mode had stable coupling efficiency ratio and broke through the adsorption capacity limit of single-ligand mode. It exhibited good adsorption performance for both components, confirming its effectiveness as a strategy for biological separation.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Vida Dehghan Niestanak, Larry D. Unsworth
Summary: Chronic kidney disease is a major cause of mortality, characterized by the gradual progression of kidney dysfunction and accumulation of protein-bound uremic toxins (PBUTs) in the bloodstream. The inadequate effectiveness of conventional treatments, such as hemodialysis, in clearing PBUTs highlights the importance of studying how these toxins bind to blood proteins. This study gathered data on the binding of various PBUTs to human serum albumin and reviewed common techniques used to investigate the thermodynamics and structure of the PBUT-albumin interaction, providing valuable insights for improving toxin clearance through dialysis or designing better adsorbents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jemma Evans, Giuseppe Infusini, Jacqui McGovern, Leila Cuttle, Andrew Webb, Thomas Nebl, Liz Milla, Roy Kimble, Margit Kempf, Christine J. Andrews, David Leavesley, Lois A. Salamonsen
Letter
Obstetrics & Gynecology
Catherine Cluver, Natalie Hannan, Stephen Tong
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2019)
Review
Developmental Biology
Carole-Anne Whigham, Teresa M. MacDonald, Susan P. Walker, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Article
Developmental Biology
Christiane Albrecht, Larry Chamley, D. Stephen Charnock-Jones, Sally Collins, Hiroshi Fujiwara, Thaddeus Golos, Solene Grayo, Natalie Hannan, Lynda Harris, Kiyotake Ichizuka, Nicholas P. Illsley, Mitsutoshi Iwashita, Sampada Kallol, Abdulla Al-Khan, Gendie Lash, Takeshi Nagamatsu, Akitoshi Nakashima, Kaoru Niimi, Masataka Nomoto, Christopher Redman, Shigeru Saito, Kenji Tanimura, Masatoshi Tomi, Hirokazu Usui, Manu Vatish, Bryce Wolfe, Eiko Yamamoto, Perrie O'Tierney-Ginn
Article
Medicine, General & Internal
Fiona C. Brownfoot, Natalie J. Hannan, Ping Cannon, Vi Nguyen, Roxanne Hastie, Laura J. Parry, Sevvandi Senadheera, Laura Tuohey, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Article
Genetics & Heredity
Jemma Evans, Kathryn J. Walker, Maree Bilandzic, Sophie Kinnear, Lois A. Salamonsen
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Article
Developmental Biology
Teresa M. MacDonald, Susan P. Walker, Richard Hiscock, Ping Cannon, Alesia Harper, Elizabeth Murray, Lisa Hui, Kirsten Dane, Anna Middleton, Valerie Kyritsis, Natasha de Alwis, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Article
Biochemical Research Methods
Jemma Evans, Jennifer Hutchison, Lois A. Salamonsen, David W. Greening
Article
Obstetrics & Gynecology
Natasha Pritchard, Tu'uhevaha Kaitu'u-Lino, Lynda Harris, Stephen Tong, Natalie Hannan
Summary: Nanomedicine technology in reproductive medicine and obstetrics holds promise for targeted therapeutic strategies that enhance efficacy and minimize off-target effects. Through nanoparticle delivery systems, interventions can effectively address various issues in reproductive medicine, providing new treatment options for women's health and reproductive capacity.
HUMAN REPRODUCTION UPDATE
(2021)
Review
Virology
Krishneel Singh, Stuart T. Hamilton, Antonia W. Shand, Natalie J. Hannan, William D. Rawlinson
Summary: Cellular receptors in human cytomegalovirus (HCMV) transmission play a crucial role in congenital infection, with placental trophoblast cells expressing various receptors for HCMV entry. This review summarizes the different HCMV receptors expressed in placental cells and their role in viral entry and tropism.
REVIEWS IN MEDICAL VIROLOGY
(2021)
Article
Developmental Biology
Faith Andres, Georgia P. Wong, Susan P. Walker, Teresa M. MacDonald, Emerson Keenan, Ping Cannon, Tuong-Vi Nguyen, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: The circulating ADAM12 levels in the first trimester are reduced in fetal growth restriction and preeclampsia. This study validates ADAM12 as a biomarker for small for gestational age infants near term, but its predictive value for preeclampsia is inconsistent.
Article
Developmental Biology
Yann W. Yap, Natalie J. Hannan, Euan M. Wallace, Sarah A. Marshall
Summary: Nrf proteins have been found to play a crucial role in placental-derived oxidative stress-induced pregnancy disorders. Successful silencing of Nrf proteins in human cells has been achieved for further research.
Article
Developmental Biology
Lucy A. Bartho, Daniel R. McKeating, Natalie J. Hannan, Tu'uhevaha J. Kaitu'u-Lino, Anthony Perkins
Summary: This study aimed to investigate the correlation between genes related to mitochondria, endoplasmic reticulum (ER), and cellular senescence in placentae affected by pregnancy complications. The findings suggest that genes associated with mitochondrial dynamics and aging undergo changes in placentae affected by pregnancy pathologies. The TOMM20/PARK2 ratio may be a promising marker for distinguishing between healthy and unhealthy placental tissue.
MOLECULAR HUMAN REPRODUCTION
(2022)
Review
Developmental Biology
Bridget M. Arman, Natalie K. Binder, Natasha de Alwis, Tu'uhevaha J. Kaitu'u-Lino, Natalie J. Hannan
Summary: Preterm birth is a major cause of neonatal morbidity and mortality worldwide. Current therapies for preterm birth have limited effectiveness. This review explores the potential of repurposing drugs with known safety profiles to prevent or treat preterm birth.
Article
Developmental Biology
Natalie K. Binder, Natasha de Alwis, Sally Beard, Elif Kadife, Alesia Harper, Tuuhevaha J. Kaitu'u-Lino, Fiona C. Brownfoot, Natalie J. Hannan
Summary: The anti-inflammatory drug sulfasalazine has been identified as a potential therapeutic for the treatment of preeclampsia, as it effectively mitigates endothelial dysfunction and promotes vasodilation. However, in a mouse model, sulfasalazine had limited effects on blood pressure and fetal growth.
