Leukocyte Homing, Fate, and Function Are Controlled by Retinoic Acid

Imprinting of CCR9 on CD4 T Cells Requires IL-4 Signaling on Mesenteric Lymph Node Dendritic Cells

(2014) R. Elgueta et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Instructive Role of Peripheral Tissue Cells in the Imprinting of T Cell Homing Receptor Patterns

(2014) F. Edele et al.   JOURNAL OF IMMUNOLOGY

Vitamin A Deficiency Decreases and High Dietary Vitamin A Increases Disease Severity in the Mouse Model of Asthma

(2014) G. U. Schuster et al.   JOURNAL OF IMMUNOLOGY

Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF- -Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression

(2014) S. Xiao et al.   JOURNAL OF IMMUNOLOGY

Stromal Cells Confer Lymph Node-Specific Properties by Shaping a Unique Microenvironment Influencing Local Immune Responses

(2014) M. Ahrendt et al.   JOURNAL OF IMMUNOLOGY

Dissecting the Role of Retinoic Acid Receptor Isoforms in the CD8 Response to Infection

(2014) Y. Guo et al.   JOURNAL OF IMMUNOLOGY

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

(2014) Serge A. van de Pavert et al.   NATURE

A general approach to site-specific antibody drug conjugates

(2014) Feng Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis

(2014) A. Mortha et al.   SCIENCE

Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration

(2013) K. Aoyama et al.   BLOOD

Dhrs3 Protein Attenuates Retinoic Acid Signaling and Is Required for Early Embryonic Patterning

(2013) Richard Kin Ting Kam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The STRA6 Receptor Is Essential for Retinol-binding Protein-induced Insulin Resistance but Not for Maintaining Vitamin A Homeostasis in Tissues Other Than the Eye

(2013) Daniel C. Berry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract

(2013) Darren Ruane et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Critical Role for All-trans Retinoic Acid for Optimal Effector and Effector Memory CD8 T Cell Differentiation

(2013) S. R. Allie et al.   JOURNAL OF IMMUNOLOGY

β-Carotene in Golden Rice is as good as β-carotene in oil at providing vitamin A to children

(2012) Guangwen Tang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Donor-Specific CD8+Foxp3+ T Cells Protect Skin Allografts and Facilitate Induction of Conventional CD4+Foxp3+ Regulatory T Cells

(2012) N. M Lerret et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A Retinoic Acid--Rich Tumor Microenvironment Provides Clonal Survival Cues for Tumor-Specific CD8+ T Cells

(2012) Y. Guo et al.   CANCER RESEARCH

Reduced Frequencies and Heightened CD103 Expression among Virus-Induced CD8+T Cells in the Respiratory Tract Airways of Vitamin A-Deficient Mice

(2012) Rajeev Rudraraju et al.   Clinical and Vaccine Immunology

Retinal attenuates inflammatory arthritis by reciprocal regulation of IL-17-producing T cells and Foxp3+ regulatory T cells and the inhibition of osteoclastogenesis

(2012) Mi-Kyung Park et al.   IMMUNOLOGY LETTERS

Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut

(2012) Susan M. Schlenner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: 4-1BB Controls Regulatory Activity in Dendritic Cells through Promoting Optimal Expression of Retinal Dehydrogenase

(2012) S.-W. Lee et al.   JOURNAL OF IMMUNOLOGY

Retinoic Acid Attenuates Rheumatoid Inflammation in Mice

(2012) S.-K. Kwok et al.   JOURNAL OF IMMUNOLOGY

The Living Eye "Disarms" Uncommitted Autoreactive T Cells by Converting Them to Foxp3+ Regulatory Cells following Local Antigen Recognition

(2012) R. Zhou et al.   JOURNAL OF IMMUNOLOGY

Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling

(2012) J Zhao et al.   Mucosal Immunology

CD8α+β− and CD8α+β+ plasmacytoid dendritic cells induce Foxp3+ regulatory T cells and prevent the induction of airway hyper-reactivity

(2012) V Lombardi et al.   Mucosal Immunology

Retinoic acid regulates the development of a gut-homing precursor for intestinal dendritic cells

(2012) R Zeng et al.   Mucosal Immunology

TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells

(2012) Hayato Takahashi et al.   NATURE IMMUNOLOGY

MicroRNA 10a Marks Regulatory T Cells

(2012) Lukas T. Jeker et al.   PLoS One

In situ differentiation of CD8αα Τ cells from CD4 T cells in peripheral lymphoid tissues

(2012) Yukiko Nambu et al.   Scientific Reports

Upregulation of Retinal Dehydrogenase 2 in Alternatively Activated Macrophages during Retinoid-dependent Type-2 Immunity to Helminth Infection in Mice

(2012) Mara J. Broadhurst et al.   PLoS Pathogens

The S. mansoni glycoprotein ω-1 induces Foxp3 expression in NOD mouse CD4+ T cells

(2011) Paola Zaccone et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Retinoic acid from retinal pigment epithelium induces T regulatory cells

(2011) Yuko Kawazoe et al.   EXPERIMENTAL EYE RESEARCH

MyD88 and Retinoic Acid Signaling Pathways Interact to Modulate Gastrointestinal Activities of Dendritic Cells

(2011) Eduardo J. Villablanca et al.   GASTROENTEROLOGY

Essential Role for Retinoic Acid in the Promotion of CD4+ T Cell Effector Responses via Retinoic Acid Receptor Alpha

(2011) Jason A. Hall et al.   IMMUNITY

CD4+Foxp3+regulatory T cells induced by TGF-β, IL-2 and all-trans retinoic acid attenuate obliterative bronchiolitis in rat trachea transplantation

(2011) Qian Shi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mechanism of All-trans-retinal Toxicity with Implications for Stargardt Disease and Age-related Macular Degeneration

(2011) Yu Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice

(2011) Swantje I. Hammerschmidt et al.   JOURNAL OF CLINICAL INVESTIGATION

Prostaglandin E2 suppresses the differentiation of retinoic acid–producing dendritic cells in mice and humans

(2011) Angus Stock et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A retinoic acid–dependent checkpoint in the development of CD4+T cell–mediated immunity

(2011) Karina Pino-Lagos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A New Look at Immune Privilege of the Eye: Dual Role for the Vision-Related Molecule Retinoic Acid

(2011) Ru Zhou et al.   JOURNAL OF IMMUNOLOGY

Chronic Helminth Infection Promotes Immune Regulation In Vivo through Dominance of CD11cloCD103- Dendritic Cells

(2011) K. A. Smith et al.   JOURNAL OF IMMUNOLOGY

Expression of Retinaldehyde Dehydrogenase Enzymes in Mucosal Dendritic Cells and Gut-Draining Lymph Node Stromal Cells Is Controlled by Dietary Vitamin A

(2011) R. Molenaar et al.   JOURNAL OF IMMUNOLOGY

Vitamin A Deficiency Impairs Vaccine-Elicited Gastrointestinal Immunity

(2011) D. R. Kaufman et al.   JOURNAL OF IMMUNOLOGY

MyD88-Dependent TLR1/2 Signals Educate Dendritic Cells with Gut-Specific Imprinting Properties

(2011) S. Wang et al.   JOURNAL OF IMMUNOLOGY

Small Molecule Inhibitors of Retinoic Acid 4-Hydroxylase (CYP26): Synthesis and Biological Evaluation of Imidazole Methyl 3-(4-(aryl-2-ylamino)phenyl)propanoates

(2011) Mohamed S. Gomaa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Retinoic Acid as a Vaccine Adjuvant Enhances CD8+ T Cell Response and Mucosal Protection from Viral Challenge

(2011) X. Tan et al.   JOURNAL OF VIROLOGY

Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cells

(2011) E Jaensson-Gyllenbäck et al.   Mucosal Immunology

Mucosal memory CD8+ T cells are selected in the periphery by an MHC class I molecule

(2011) Yujun Huang et al.   NATURE IMMUNOLOGY

Cyp26b1 Regulates Retinoic Acid-Dependent Signals in T Cells and Its Expression Is Inhibited by Transforming Growth Factor-β

(2011) Hajime Takeuchi et al.   PLoS One

Retinoic Acid and Rapamycin Differentially Affect and Synergistically Promote the Ex Vivo Expansion of Natural Human T Regulatory Cells

(2011) Tatiana N. Golovina et al.   PLoS One

All-Trans Retinoic Acid Promotes TGF-β-Induced Tregs via Histone Modification but Not DNA Demethylation on Foxp3 Gene Locus

(2011) Ling Lu et al.   PLoS One

Retinyl palmitate does not have an adjuvant effect on the antibody response of chicks to keyhole limpet hemocyanin regardless of vitamin A status

(2011) K. A. Livingston et al.   POULTRY SCIENCE

Retinoic Acid Generates Regulatory T Cells in Experimental Transplantation

(2011) C. Moore et al.   TRANSPLANTATION PROCEEDINGS

Defective response of CD4+ T cells to retinoic acid and TGFβ in systemic lupus erythematosus

(2011) Eric S Sobel et al.   ARTHRITIS RESEARCH & THERAPY

Vitamin A Metabolism: An Update

(2011) Diana N. D’Ambrosio et al.   Nutrients

Ex Vivo-Expanded Natural CD4+CD25+ Regulatory T Cells Synergize With Host T-Cell Depletion to Promote Long-Term Survival of Allografts

(2010) G. Xia et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Regulatory CD8+ T cells induced by exposure to all-trans retinoic acid and TGF-β suppress autoimmune diabetes

(2010) Minoru Kishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Skin-draining lymph nodes contain dermis-derived CD103- dendritic cells that constitutively produce retinoic acid and induce Foxp3+ regulatory T cells

(2010) M. Guilliams et al.   BLOOD

Retinoic acid-induced gut tropism improves the protective capacity of Treg in acute but not in chronic gut inflammation

(2010) Astrid Menning et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Positive and Negative Transcriptional Regulation of the Foxp3 Gene is Mediated by Access and Binding of the Smad3 Protein to Enhancer I

(2010) Lili Xu et al.   IMMUNITY

Effectiveness of measles vaccination and vitamin A treatment

(2010) C. R. Sudfeld et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Retinoic Acid-Induced CCR9 Expression Requires Transient TCR Stimulation and Cooperativity between NFATc2 and the Retinoic Acid Receptor/Retinoid X Receptor Complex

(2010) Y. Ohoka et al.   JOURNAL OF IMMUNOLOGY

Retinoic Acid Determines the Precise Tissue Tropism of Inflammatory Th17 Cells in the Intestine

(2010) C. Wang et al.   JOURNAL OF IMMUNOLOGY

Downregulation of Th17 Cells in the Small Intestine by Disruption of Gut Flora in the Absence of Retinoic Acid

(2010) H.-R. Cha et al.   JOURNAL OF IMMUNOLOGY

Control of α4β7 Integrin Expression and CD4 T Cell Homing by the β1 Integrin Subunit

(2010) Christopher C. DeNucci et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: All-Trans Retinoic Acid Sustains the Stability and Function of Natural Regulatory T Cells in an Inflammatory Milieu

(2010) X. Zhou et al.   JOURNAL OF IMMUNOLOGY

Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells

(2010) S G Kang et al.   Mucosal Immunology

Local Induction of Immunosuppressive CD8+ T Cells in the Gut-Associated Lymphoid Tissues

(2010) Diana Fleissner et al.   PLoS One

Characterization of Protective Human CD4+CD25+ FOXP3+ Regulatory T Cells Generated with IL-2, TGF-β and Retinoic Acid

(2010) Ling Lu et al.   PLoS One

Conversion of Th2 memory cells into Foxp3+ regulatory T cells suppressing Th2-mediated allergic asthma

(2010) B.-S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of  -Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

(2010) S. Manicassamy et al.   SCIENCE

Retinoic acid attenuates acute heart rejection by increasing regulatory T cell and repressing differentiation of Th17 cell in the presence of TGF-β

(2010) Guohua Wang et al.   TRANSPLANT INTERNATIONAL

Synthetic Retinoid AM80 Inhibits Th17 Cells and Ameliorates Experimental Autoimmune Encephalomyelitis

(2009) Christian Klemann et al.   AMERICAN JOURNAL OF PATHOLOGY

Retinoid ameliorates experimental autoimmune myositis, with modulation of Th cell differentiation and antibody production in vivo

(2009) Naho Ohyanagi et al.   ARTHRITIS AND RHEUMATISM

DNA vaccination with all-trans retinoic acid treatment induces long-term survival and elicits specific immune responses requiring CD4+ and CD8+ T-cell activation in an acute promyelocytic leukemia mouse model

(2009) K. Furugaki et al.   BLOOD

Anti-inflammatory effect of retinoic acid on experimental autoimmune uveoretinitis

(2009) H. Keino et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells

(2009) I D Iliev et al.   GUT

Retinoic Acid Can Directly Promote TGF-β-Mediated Foxp3+ Treg Cell Conversion of Naive T Cells

(2009) Daniel Mucida et al.   IMMUNITY

Localized Th1-, Th2-, T Regulatory Cell-, and Inflammation-Associated Hepatic and Pulmonary Immune Responses in Ascaris suum-Infected Swine Are Increased by Retinoic Acid

(2009) H. Dawson et al.   INFECTION AND IMMUNITY

GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity

(2009) Aya Yokota et al.   INTERNATIONAL IMMUNOLOGY

Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines

(2009) Jens Nolting et al.   JOURNAL OF EXPERIMENTAL MEDICINE

De Novo Generation and Enhanced Suppression of Human CD4+CD25+ Regulatory T Cells by Retinoic Acid

(2009) J. Wang et al.   JOURNAL OF IMMUNOLOGY

Lymph Node Stromal Cells Support Dendritic Cell-Induced Gut-Homing of T Cells

(2009) R. Molenaar et al.   JOURNAL OF IMMUNOLOGY

All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis

(2009) Aiping Bai et al.   JOURNAL OF LEUKOCYTE BIOLOGY

All-trans-Retinoic Acid Represses Obesity and Insulin Resistance by Activating both Peroxisome Proliferation-Activated Receptor  /  and Retinoic Acid Receptor

(2009) D. C. Berry et al.   MOLECULAR AND CELLULAR BIOLOGY

Retinoids differentially regulate the progression of autoimmune diabetes in three preclinical models in mice

(2009) Stanislava Stošić-Grujičić et al.   MOLECULAR IMMUNOLOGY

Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning

(2009) I D Iliev et al.   Mucosal Immunology

Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma

(2009) Sangeeta Goswami et al.   NATURE IMMUNOLOGY

Toll-like receptor 2–dependent induction of vitamin A–metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity

(2009) Santhakumar Manicassamy et al.   NATURE MEDICINE

Impact on allergic immune response after treatment with vitamin A

(2009) Victor Matheu et al.   Nutrition & Metabolism

Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid

(2008) N. Spiegl et al.   BLOOD

The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production

(2008) Harry D Dawson et al.   BMC IMMUNOLOGY

All-trans Retinoic Acid Inhibits Type 1 Diabetes by T Regulatory (Treg)-Dependent Suppression of Interferon- -Producing T-cells Without Affecting Th17 Cells

(2008) Y.-H. Van et al.   DIABETES

Retinoic Acid Enhances Foxp3 Induction Indirectly by Relieving Inhibition from CD4+CD44hi Cells

(2008) Jonathan A. Hill et al.   IMMUNITY

Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo

(2008) Swantje I. Hammerschmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

(2008) Satoshi Uematsu et al.   NATURE IMMUNOLOGY

Role of retinoic acid in the imprinting of gut-homing IgA-secreting cells

(2008) J. Rodrigo Mora et al.   SEMINARS IN IMMUNOLOGY