Roles and post-translational regulation of cardiac class IIa histone deacetylase isoforms

HDAC6 contributes to pathological responses of heart and skeletal muscle to chronic angiotensin-II signaling

(2014) Kimberly M. Demos-Davies et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy

(2014) Min Xie et al.   CIRCULATION

Regulation of Acetylation of Histone Deacetylase 2 by p300/CBP-Associated Factor/Histone Deacetylase 5 in the Development of Cardiac Hypertrophy

(2014) Gwang Hyeon Eom et al.   CIRCULATION RESEARCH

Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling

(2014) Lorenz H. Lehmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure

(2013) Priti Anand et al.   CELL

Detrimental Effect of Class-selective Histone Deacetylase Inhibitors during Tissue Regeneration following Hindlimb Ischemia

(2013) Francesco Spallotta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Tumor Suppressor Kinase LKB1 Activates the Downstream Kinases SIK2 and SIK3 to Stimulate Nuclear Export of Class IIa Histone Deacetylases

(2013) Donald R. Walkinshaw et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dephosphorylation at a Conserved SP Motif Governs cAMP Sensitivity and Nuclear Localization of Class IIa Histone Deacetylases

(2013) Donald R. Walkinshaw et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC4 controls histone methylation in response to elevated cardiac load

(2013) Mathias Hohl et al.   JOURNAL OF CLINICAL INVESTIGATION

BET acetyl-lysine binding proteins control pathological cardiac hypertrophy

(2013) Jessica I. Spiltoir et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

HDAC Inhibition Suppresses Cardiac Hypertrophy and Fibrosis in DOCA-Salt Hypertensive Rats via Regulation of HDAC6/HDAC8 Enzyme Activity

(2013) Hae Jin Kee et al.   KIDNEY & BLOOD PRESSURE RESEARCH

HDAC-dependent ventricular remodeling

(2013) Min Xie et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Neurohormonal Regulation of Cardiac Histone Deacetylase 5 Nuclear Localization by Phosphorylation-Dependent and Phosphorylation-Independent Mechanisms

(2012) Robert S. Haworth et al.   CIRCULATION RESEARCH

Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy

(2012) Shouji Matsushima et al.   CIRCULATION RESEARCH

Acute β-Adrenergic Activation Triggers Nuclear Import of Histone Deacetylase 5 and Delays Gq-induced Transcriptional Activation

(2012) Chia-Wei Jenny Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic Potential for HDAC Inhibitors in the Heart

(2011) Timothy A. McKinsey   Annual Review of Pharmacology and Toxicology

Defective sumoylation pathway directs congenital heart disease

(2011) Jun Wang et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Treatment of Chronic Heart Failure With β-Adrenergic Receptor Antagonists

(2011) Michael R. Bristow   CIRCULATION RESEARCH

Nuclear Effects of G-Protein Receptor Kinase 5 on Histone Deacetylase 5–Regulated Gene Transcription in Heart Failure

(2011) Yan Zhang et al.   Circulation-Heart Failure

Spatiotemporally Distinct Protein Kinase D Activation in Adult Cardiomyocytes in Response to Phenylephrine and Endothelin

(2011) Julie Bossuyt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4

(2011) Johannes Backs et al.   JOURNAL OF CELL BIOLOGY

Back to your heart: Ubiquitin proteasome system-regulated signal transduction

(2011) Andrea L. Portbury et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

SUMO1-dependent modulation of SERCA2a in heart failure

(2011) Changwon Kho et al.   NATURE

Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly

(2011) Ju He et al.   NUCLEIC ACIDS RESEARCH

Targeted deletion of NF-κB p50 diminishes the cardioprotection of histone deacetylase inhibition

(2010) L. X. Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats

(2010) Abishek Iyer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inside HDAC with HDAC inhibitors

(2010) Philippe Bertrand   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

HDAC Inhibition Attenuates Inflammatory, Hypertrophic, and Hypertensive Responses in Spontaneously Hypertensive Rats

(2010) Jeffrey P. Cardinale et al.   HYPERTENSION

Isoform-selective HDAC inhibitors: Closing in on translational medicine for the heart

(2010) Timothy A. McKinsey   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Nuclear Import of Histone Deacetylase 5 by Requisite Nuclear Localization Signal Phosphorylation

(2010) Todd M. Greco et al.   MOLECULAR & CELLULAR PROTEOMICS

Chemical phylogenetics of histone deacetylases

(2010) James E Bradner et al.   Nature Chemical Biology

Valproate attenuates the risk of myocardial infarction in patients with epilepsy: a nationwide cohort study

(2010) Jonas Bjerring Olesen et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy

(2010) C. H. Ha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of HDAC nuclear export and cardiomyocyte hypertrophy by novel irreversible inhibitors of CRM1

(2009) Lauren Monovich et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Epigenetic control of skull morphogenesis by histone deacetylase 8

(2009) M. Haberland et al.   GENES & DEVELOPMENT

The   isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload

(2009) J. Backs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Agonist-induced nuclear export of GFP-HDAC5 in isolated adult rat ventricular myocytes

(2009) Yanyu Peng et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

VEGF Stimulates HDAC7 Phosphorylation and Cytoplasmic Accumulation Modulating Matrix Metalloproteinase Expression and Angiogenesis

(2008) Chang Hoon Ha et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure

(2008) Pasquale Gallo et al.   CARDIOVASCULAR RESEARCH

A Redox-Dependent Pathway for Regulating Class II HDACs and Cardiac Hypertrophy

(2008) Tetsuro Ago et al.   CELL

Quantitative Control of Adaptive Cardiac Hypertrophy by Acetyltransferase p300

(2008) Jian Qin Wei et al.   CIRCULATION

Ca 2+ /Calmodulin-Dependent Protein Kinase IIδ and Protein Kinase D Overexpression Reinforce the Histone Deacetylase 5 Redistribution in Heart Failure

(2008) Julie Bossuyt et al.   CIRCULATION RESEARCH

AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5

(2008) S. L. McGee et al.   DIABETES

Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice

(2008) Anne Granger et al.   FASEB JOURNAL

Protein Kinase D-dependent Phosphorylation and Nuclear Export of Histone Deacetylase 5 Mediates Vascular Endothelial Growth Factor-induced Gene Expression and Angiogenesis

(2008) Chang Hoon Ha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transgenic Overexpression of Hdac3 in the Heart Produces Increased Postnatal Cardiac Myocyte Proliferation but Does Not Induce Hypertrophy

(2008) Chinmay M. Trivedi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

(2008) Rusty L. Montgomery et al.   JOURNAL OF CLINICAL INVESTIGATION

Histone Deacetylase 5 Acquires Calcium/Calmodulin-Dependent Kinase II Responsiveness by Oligomerization with Histone Deacetylase 4

(2008) J. Backs et al.   MOLECULAR AND CELLULAR BIOLOGY

Requirement of protein kinase D1 for pathological cardiac remodeling

(2008) J. Fielitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PP2A Regulates HDAC4 Nuclear Import

(2007) Gabriela Paroni et al.   MOLECULAR BIOLOGY OF THE CELL