The Tumor Suppressor Kinase LKB1 Activates the Downstream Kinases SIK2 and SIK3 to Stimulate Nuclear Export of Class IIa Histone Deacetylases

Dephosphorylation at a Conserved SP Motif Governs cAMP Sensitivity and Nuclear Localization of Class IIa Histone Deacetylases

(2013) Donald R. Walkinshaw et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice

(2012) S. Sasagawa et al.   DEVELOPMENT

Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance

(2012) Herbert G Kasler et al.   EMBO JOURNAL

A Hormone-Dependent Module Regulating Energy Balance

(2011) Biao Wang et al.   CELL

Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

(2011) Maria M. Mihaylova et al.   CELL

Haploinsufficiency of HDAC4 Causes Brachydactyly Mental Retardation Syndrome, with Brachydactyly Type E, Developmental Delays, and Behavioral Problems

(2010) Stephen R. Williams et al.   AMERICAN JOURNAL OF HUMAN GENETICS

SIK2 Is a Centrosome Kinase Required for Bipolar Mitotic Spindle Formation that Provides a Potential Target for Therapy in Ovarian Cancer

(2010) Ahmed Ashour Ahmed et al.   CANCER CELL

Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice

(2010) Julien Bricambert et al.   JOURNAL OF CLINICAL INVESTIGATION

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

(2010) Daisuke Nakada et al.   NATURE

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

(2010) Sushma Gurumurthy et al.   NATURE

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

(2010) Boyi Gan et al.   NATURE

Lack of Sik1 in Mouse Embryonic Stem Cells Impairs Cardiomyogenesis by Down-Regulating the Cyclin-Dependent Kinase Inhibitor p57kip2

(2010) Antonio Romito et al.   PLoS One

PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy

(2010) C. H. Ha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation

(2010) D. Bungard et al.   SCIENCE

PiggyBac Transposon Mutagenesis: A Tool for Cancer Gene Discovery in Mice

(2010) R. Rad et al.   SCIENCE

New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion

(2010) A. Zagorska et al.   Science Signaling

The regulation and function of mammalian AMPK-related kinases

(2009) N. J. Bright et al.   Acta Physiologica

TORC2 Regulates Hepatic Insulin Signaling via a Mammalian Phosphatidic Acid Phosphatase, LIPIN1

(2009) Dongryeol Ryu et al.   Cell Metabolism

Regulation of ploidy and senescence by the AMPK-related kinase NUAK1

(2009) Nicolas Humbert et al.   EMBO JOURNAL

Inactivation of HDAC5 by SIK1 in AICAR-treated C2C12 Myoblasts

(2009) Hiroshi TAKEMORI et al.   ENDOCRINE JOURNAL

Inhibition of HDAC9 Increases T Regulatory Cell Function and Prevents Colitis in Mice

(2009) Edwin F. de Zoeten et al.   GASTROENTEROLOGY

14-3-3 regulates the nuclear import of class IIa histone deacetylases

(2008) Tomonori G. Nishino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of LKB1 in lung cancer development

(2008) L Makowski et al.   BRITISH JOURNAL OF CANCER

AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5

(2008) S. L. McGee et al.   DIABETES

Protein Kinase D-dependent Phosphorylation and Nuclear Export of Histone Deacetylase 5 Mediates Vascular Endothelial Growth Factor-induced Gene Expression and Angiogenesis

(2008) Chang Hoon Ha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase A Represses Skeletal Myogenesis by Targeting Myocyte Enhancer Factor 2D

(2008) M. Du et al.   MOLECULAR AND CELLULAR BIOLOGY

AKAP-Lbc Mobilizes a Cardiac Hypertrophy Signaling Pathway

(2008) Graeme K. Carnegie et al.   MOLECULAR CELL

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7

(2008) S. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA