Polycystins and partners: proposed role in mechanosensitivity

Phosphorylation of C-terminal polycystin-2 influences the interaction with PIGEA14: A QCM study based on solid supported membranes

(2013) Daniela Morick et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechano-Gated Ion Channels in Sensory Systems

(2013) Patrick Delmas et al.   CELL

Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli

(2013) Xingjian Jin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells

(2013) Rémi Peyronnet et al.   EMBO REPORTS

Smooth muscle cell transient receptor potential polycystin-2 (TRPP2) channels contribute to the myogenic response in cerebral arteries

(2013) Damodaran Narayanan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Direct recording and molecular identification of the calcium channel of primary cilia

(2013) Paul G. DeCaen et al.   NATURE

Primary cilia are specialized calcium signalling organelles

(2013) Markus Delling et al.   NATURE

The ciliary flow sensor and polycystic kidney disease

(2013) Fruzsina Kotsis et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis

(2013) B. Coste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinesin motors and primary cilia

(2012) Kristen J. Verhey et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mechanical cues in cellular signalling and communication

(2012) Nickolay V. Bukoreshtliev et al.   CELL AND TISSUE RESEARCH

Polycystin-1 and polycystin-2 are both required to amplify inositol-trisphosphate-induced Ca2+ release

(2012) D. Mekahli et al.   CELL CALCIUM

Gating the mechanical channel Piezo1

(2012) Philip A. Gottlieb et al.   Channels

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

Protein Phosphatase-1α Interacts with and Dephosphorylates Polycystin-1

(2012) Stephen C. Parnell et al.   PLoS One

Structural Interaction and Functional Regulation of Polycystin-2 by Filamin

(2012) Qian Wang et al.   PLoS One

Primary Cilia-Mediated Mechanotransduction in Human Mesenchymal Stem Cells

(2012) David A. Hoey et al.   STEM CELLS

Sensing pressure with ion channels

(2012) Bernd Nilius et al.   TRENDS IN NEUROSCIENCES

Mechanoprotection by Polycystins against Apoptosis Is Mediated through the Opening of Stretch-Activated K2P Channels

(2012) Rémi Peyronnet et al.   Cell Reports

A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells

(2011) David A. Hoey et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Polycystins, focal adhesions and extracellular matrix interactions

(2011) Iain A. Drummond   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Critical role of TRPP2 and TRPC1 channels in stretch-induced injury of blood–brain barrier endothelial cells

(2011) Jonathan Berrout et al.   BRAIN RESEARCH

Molecular regulations governing TREK and TRAAK channel functions

(2011) Jacques Noël et al.   Channels

The γ-Secretase Cleavage Product of Polycystin-1 Regulates TCF and CHOP-Mediated Transcriptional Activation through a p300-Dependent Mechanism

(2011) David Merrick et al.   DEVELOPMENTAL CELL

Why kidneys fail in autosomal dominant polycystic kidney disease

(2011) Jared J. Grantham et al.   Nature Reviews Nephrology

Electromechanical coupling in the cardiac myocyte; stretch-arrhythmia feedback

(2011) Henk E. D. J. ter Keurs   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases

(2011) Y.-H. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eukaryotic Mechanosensitive Channels

(2010) Jóhanna Árnadóttir et al.   Annual Review of Biophysics

Receptor protein tyrosine phosphatases are novel components of a polycystin complex

(2010) Catherine A. Boucher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Atomic Force Microscopy Reveals the Alternating Subunit Arrangement of the TRPP2-TRPV4 Heterotetramer

(2010) Andrew P. Stewart et al.   BIOPHYSICAL JOURNAL

The retinitis pigmentosa protein RP2 interacts with polycystin 2 and regulates cilia-mediated vertebrate development

(2010) Toby Hurd et al.   HUMAN MOLECULAR GENETICS

Naturally Occurring Osmolytes Modulate the Nanomechanical Properties of Polycystic Kidney Disease Domains

(2010) Liang Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SYMPOSIUM REVIEW: Gating of two pore domain potassium channels

(2010) Alistair Mathie et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mechanosensitivity of ion channels based on protein-lipid interactions

(2010) K. Yoshimura et al.   Journal of the Royal Society Interface

Carboxy Terminal Tail of Polycystin-1 Regulates Localization of TSC2 to Repress mTOR

(2010) Ruhee Dere et al.   PLoS One

Identification of a Polycystin-1 Cleavage Product, P100, That Regulates Store Operated Ca2+ Entry through Interactions with STIM1

(2010) Owen M. Woodward et al.   PLoS One

Nephrocystin-1 Forms a Complex with Polycystin-1 via a Polyproline Motif/SH3 Domain Interaction and Regulates the Apoptotic Response in Mammals

(2010) Claas Wodarczyk et al.   PLoS One

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Molecular basis of mechanosensitivity

(2009) Stuart M. Brierley   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Polycystin-1 and -2 Dosage Regulates Pressure Sensing

(2009) Reza Sharif-Naeini et al.   CELL

Mechanotransduction by TRP Channels: General Concepts and Specific Role in the Vasculature

(2009) Jun Yin et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Ciliary Polycystin-2 Is a Mechanosensitive Calcium Channel Involved in Nitric Oxide Signaling Cascades

(2009) Wissam A. AbouAlaiwi et al.   CIRCULATION RESEARCH

A Pathogenic C Terminus-truncated Polycystin-2 Mutant Enhances Receptor-activated Ca2+Entry via Association with TRPC3 and TRPC7

(2009) Kyoko Miyagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polycystin-1 Interacts with Inositol 1,4,5-Trisphosphate Receptor to Modulate Intracellular Ca2+Signaling with Implications for Polycystic Kidney Disease

(2009) Yun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transient Receptor Potential Channels TRPP2 and TRPC1 Form a Heterotetramer with a 2:2 Stoichiometry and an Alternating Subunit Arrangement

(2009) Toshiro Kobori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homophilic and heterophilic polycystin 1 interactions regulate E-cadherin recruitment and junction assembly in MDCK cells

(2009) A. J. Streets et al.   JOURNAL OF CELL SCIENCE

Sensing pressure in the cardiovascular system: Gq-coupled mechanoreceptors and TRP channels

(2009) Reza Sharif-Naeini et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Polycystic Kidney Disease

(2008) Peter C. Harris et al.   Annual Review of Medicine

Molecular components of the adherens junction

(2008) Carien M. Niessen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Endothelial Cilia Are Fluid Shear Sensors That Regulate Calcium Signaling and Nitric Oxide Production Through Polycystin-1

(2008) Surya M. Nauli et al.   CIRCULATION

Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits

(2008) Chang-Xi Bai et al.   EMBO REPORTS

The mechano-gated K2P channel TREK-1

(2008) Alexandra Dedman et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Polycystin-2 is regulated by endoplasmic reticulum-associated degradation

(2008) G. Liang et al.   HUMAN MOLECULAR GENETICS

Polycystin-1 C-terminal tail associates with β-catenin and inhibits canonical Wnt signaling

(2008) Mark Lal et al.   HUMAN MOLECULAR GENETICS

Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2α

(2008) Genqing Liang et al.   HUMAN MOLECULAR GENETICS

Sensing Tension

(2008) Heather A. Drummond et al.   HYPERTENSION

TRPP2 and TRPV4 form a polymodal sensory channel complex

(2008) Michael Köttgen et al.   JOURNAL OF CELL BIOLOGY

Nek8 Regulates the Expression and Localization of Polycystin-1 and Polycystin-2

(2008) E. Sohara et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TRP channels and mechanosensory transduction: insights into the arterial myogenic response

(2008) Reza Sharif-Naeini et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2

(2008) L. Geng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA