Journal
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
Volume 21, Issue 1, Pages 30-33Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/poc.1273
Keywords
metformin; glitazones; tautomerism; mechanism of action; PPAR gamma; AMPK
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This theoretical study attempts to find out similarity between metformin and glitazone class of antidiabetic drugs. It was found that some tautomeric forms of both metformin and thiazolidinedione ring of glitazones have similar molecular electrostatic potential (MESP) surface and may bind to a common complementary surface. Complexation and docking studies were also carried out in order to support this hypothesis. Copyright (C) 2007 John Wiley & Sons, Ltd.
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