期刊
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
卷 21, 期 1, 页码 30-33出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/poc.1273
关键词
metformin; glitazones; tautomerism; mechanism of action; PPAR gamma; AMPK
This theoretical study attempts to find out similarity between metformin and glitazone class of antidiabetic drugs. It was found that some tautomeric forms of both metformin and thiazolidinedione ring of glitazones have similar molecular electrostatic potential (MESP) surface and may bind to a common complementary surface. Complexation and docking studies were also carried out in order to support this hypothesis. Copyright (C) 2007 John Wiley & Sons, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据