Article
Biochemistry & Molecular Biology
Norikazu Koyasu, Fuminori Hyodo, Ryota Iwasaki, Hinako Eto, Abdelazim Elsayed Elhelaly, Hiroyuki Tomita, Shinichi Shoda, Masaki Takasu, Takashi Mori, Masaharu Murata, Akira Hara, Yoshifumi Noda, Hiroki Kato, Masayuki Matsuo
Summary: In this study, the usefulness of spatiotemporal redox status as an early imaging biomarker of tumor response after irradiation using in vivo DNP-MRI was demonstrated. The results showed that in vivo DNP-MRI/CmP allowed faster and earlier visualization of tumor redox status responses compared to the verification of morphological changes observed with 1.5 T MRI and cancer metabolism obtained by hyperpolarized C-13 pyruvate MRS. The early assessment of redox status alterations with in vivo DNP-MRI/CmP probe may provide efficient information regarding the effectiveness of subsequent radiation treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Jinlan Li, Xin Yu, Jianing Zhang, Nan Yan, Jing Jin, Wei Jiang
Summary: This paper studied the entropy-driven formation of binary superlattices assembled from polymer-tethered nanorods and nanospheres. The results indicated that the conformational entropy of the polymer chains and the mixing entropy of the nanorods and nanospheres are two parameters that determine the formation of binary superlattices.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Xuan Yue, Jinlan Li, Nan Yan, Wei Jiang
Summary: Recently, the spontaneous organization of two types of nanoparticles into binary nanoparticle superlattices has been widely studied. The distributions and arrangements of the nanoparticles can be precisely controlled by adjusting the gap size between neighboring nanoparticles, allowing for the design of new functional materials and devices.
Article
Chemistry, Multidisciplinary
Hao Fan, Wenda Wu, Mahalingam Ravivarma, Hongbin Li, Bo Hu, Jiafeng Lei, Yangyang Feng, Xiaohua Sun, Jiangxuan Song, Tianbiao Leo Liu
Summary: In this study, a stable organic catholyte was developed for aqueous organic redox flow batteries (AORFBs) through rational molecular engineering. The organic catholyte exhibited a long cycle-life and a low capacity fade rate, indicating excellent stability.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yutong Gao, Youshuang Zhou, Xiangyun Xu, Chungui Chen, Bijin Xiong, Jintao Zhu
Summary: A facile method is demonstrated to fabricate oriented colloidal crystals from polymer-tethered gold nanoparticles through capillary assembly. The orientation structure of the crystals is mainly determined by the chain length of polymer ligands and size of gold nanoparticles.
Article
Polymer Science
Xiaoxue Shen, Yan Zhang, Huibin He, Chenglin Yi, Wenhao Dong, Shunsheng Ye, Di Zheng, Jing Tao, Qi Wu, Xiaozheng Duan, Zhihong Nie
Summary: This article investigates the adsorption behaviors of charged polymer-grafted hairy nanoparticles (HNPs) on oppositely charged substrates in different solvent media through a combination of experiments and simulations. The results show that the adsorption process of HNPs is influenced by the release of counterions around charged polymers, leading to a higher energy barrier compared to bare NPs. This energy barrier can be reduced by changing the dielectricity of solvents, the ionization degree of grafted polymers, or the ionic strength of the solution.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Tomasz Staszewski, Malgorzata Borowko, Patrycja Boguta
Summary: In this study, we use coarse-grained molecular dynamics simulations to investigate the behavior of polymer-tethered particles on solid surfaces. We analyze changes in the internal structure of single particles with increasing strength of the particle-substrate interactions and find that the adsorbed particles are symmetric in a plane parallel to the substrate but asymmetric in the vertical direction. We further examine the adsorption of hairy nanoparticles dispersed in systems of different initial particle densities and show how the strength of the particle-substrate interactions affects the structure of the adsorbed phase, particle-wall potential, excess adsorption isotherms, and real adsorption isotherms.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Andrea Silva, Erio Tosatti, Andrea Vanossi
Summary: This study investigates the peeling process of graphene nanoribbons (GNRs) on a metal substrate at the nanoscale. Analytical modeling and numerical simulations reveal a novel setup where the GNRs have an elastically tethered tail end. Surprisingly, nontrivial scaling exponents are found to regulate the peeling evolution, affecting the adhered length, peeling force, and peeling angle. These findings are supported by realistic MD simulations.
Article
Chemistry, Multidisciplinary
Yuchen Fu, Sai Zhao, Yulong Fan, Yannis Yan Lum Ho, Yufeng Wang, Dangyuan Lei, Peiyang Gu, Thomas P. Russell, Yu Chai
Summary: Nanoparticles can undergo phase transfer from the aqueous phase to the organic phase via a single-aggregation-single pathway, challenging the conventional idea that aggregation inhibits NP transfer. Charged amphiphilic polymers effectively act as chaperons for the NP transfer and offer a unique way to manipulate the dispersion and distribution of NPs in two immiscible liquids. In addition, intentionally jamming the NP-polymer assembly at the liquid/liquid interface can inhibit the transfer process.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Malgorzata Borowko, Tomasz Staszewski, Joanna Tomasik
Summary: In this study, we investigate the structural properties of Janus ligand-tethered nanoparticles at liquid-liquid interfaces using coarse-grained molecular dynamics simulations. The interactions between different chains and liquids are considered. The simulation results show that the trapped Janus hairy particles at the interface exhibit different configurations characterized by vertical displacement distance, orientation of the Janus line relative to the interface, and particle shape. Various morphologies, such as dumbbell-like and core-shell, are observed for the Janus hairy particles at the interface. The shape of the adsorbed particles is analyzed in detail and compared with predictions from a simple phenomenological approach. This work can contribute to the applications of Janus hairy particles in nanotechnology.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Eva Vargas, Fangyu Zhang, Amira Ben Hassine, Victor Ruiz-Valdepenas Montiel, Rodolfo Mundaca-Uribe, Ponnusamy Nandhakumar, Putian He, Zhongyuan Guo, Zhidong Zhou, Ronnie H. Fang, Weiwei Gao, Liangfang Zhang, Joseph Wang
Summary: This study presents a unique design of bioelectronic affinity sensors using natural cell membranes as recognition layers for protein detection and prevention of biofouling. By coating electrochemical transducers with human macrophage membrane as the capture layer and human red blood cell membrane as the nonspecific binding prevention layer, the sensor demonstrates a remarkable limit of detection for tumor necrosis factor alpha (TNF-alpha) cytokine. The integration of natural cell membranes and electronic transduction offers synergistic functionalities for a broad range of biosensing applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Nanoscience & Nanotechnology
Nayeong Jeon, Ilhyung Choi, Peter C. W. Lee, Eunji Lee
Summary: This study successfully monitored ice recrystallization inhibition (IRI) activity by designing peptide nanoscaffolds with gold nanoparticles, providing a promising strategy for the design of new cryopreservatives.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Analytical
Nathaniel L. Dominique, Shelby L. Strausser, Jacob E. Olson, William C. Boggess, David M. Jenkins, Jon P. Camden
Summary: This study investigates the stability and potential biological applications of N-heterocyclic carbene (NHC) self-assembled monolayers (SAMs) on gold surfaces, while utilizing laser desorption ionization mass spectrometry (LDI-MS) to explore the surface chemistry of NHC. By studying NHC-functionalized gold nanoparticles using LDI-MS, insights into the packing of NHC monolayers on gold surfaces and the stability of NHC ligands post-ligation were gained. The ability of LDI-MS to probe postsynthetic modifications of anchored NHCs, such as the reduction of nitro-NHC-AuNPs to amine-NHC-AuNPs, highlights its importance for current and future applications of NHC surfaces.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Malgorzata Borowko, Tomasz Staszewski
Summary: Coarse-grained molecular dynamics simulations were used to study adsorption on ligand-tethered particles. The study found that the number of ligands, their length, the size of the core, and the interaction parameters all affect the excess adsorption isotherm, the thickness of the polymer corona, and its morphology. The research also revealed the adsorption-induced structural transitions of polymer coatings and compared the behavior of systems involving curved and flat brushes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Lin Liu, Yong Chang, Xingyue Ji, Jiayu Chen, Mengyu Zhang, Suling Yang
Summary: A sensitive electrochemical biosensor for telomerase detection was developed by integrating homogeneous extension and hybridization reactions and surface-tethered detection. The biosensor exhibited strong electrochemical signals from the oxidation of Fc tags when the bio-DNA/DNA/Fc-AuNP hybrids were tethered to streptavidin-modified electrodes through specific avidin-biotin interactions. This method has great potential in clinical diagnosis and anti-cancer drug development.
Review
Biochemistry & Molecular Biology
Agnieszka Walewska, Milena Krajewska, Aleksandra Stefanowska, Aleksandra Buta, Renata Bilewicz, Pawel Krysinski, Piotr Bednarczyk, Piotr Koprowski, Adam Szewczyk
Summary: This paper critically reviews the techniques used in studying the function of mitochondrial potassium channels. The evaluation focuses on the advantages and limitations of these techniques. The functional analysis of mitochondrial potassium channels presents additional challenges compared to plasma membrane channels. The paper critically evaluates three types of techniques and presents new possible approaches for studying mitochondrial potassium channels. It aims to assist researchers in selecting reliable methods and in evaluating the reported results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Przemyslaw Miszta, Ewa Nazaruk, Dorota Nieciecka, Mariusz Mozajew, Pawel Krysinski, Renata Bilewicz, Slawomir Filipek
Summary: Lipidic cubic phases were used as a convenient environment to study the transport properties of the membrane antiporter EcCLC, showing more efficient chloride ion transport at acidic pH and decreased film resistance at lower pH. The inhibitor DIDS decreased transport efficiency upon hydrolysis to DADS at both pH values. Molecular dynamics simulations in lipidic cubic phases allowed for studying collective movements of chloride ions to elucidate the mechanism of ion transport by the EcCLC antiporter. These findings suggest that the protein-modified lipidic cubic phase film is a simple system for screening potential inhibitors of integral membrane proteins, and lipidic cubic phases may be important for developing new electrochemical sensors for membrane proteins and enzyme electrodes.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Electrochemistry
Agnieszka Wieckowska, Elzbieta Jablonowska, Maciej Dzwonek, Marcin Jaskolowski, Renata Bilewicz
Summary: This study investigated the assembly of Au nanoclusters with lipids and the formation of hybrid monolayers on electrodes. The Langmuir-Blodgett technique was used to control the composition and organization of the mixed monolayer at the air-water interface. The electrochemical properties of the modified electrode were studied and the Au nanoclusters were found to act as electron transfer mediators.
Article
Chemistry, Physical
Margot Jacquet, Silvio Osella, Ersan Harputlu, Barbara Palys, Monika Kaczmarek, Ewa K. Nawrocka, Adam A. Rajkiewicz, Marcin Kalek, Pawel P. Michalowski, Bartosz Trzaskowski, C. Gokhan Unlu, Wojciech Lisowski, Marcin Pisarek, Krzysztof Kazimierczuk, Kasim Ocakoglu, Agnieszka Wieckowska, Joanna Kargul
Summary: The covalent attachment of metalorganic wires on electron-rich surfaces, fluorine-doped tin oxide and single-layer graphene, leads to the promotion of p-doping of the graphene and significantly enhanced photocurrent, demonstrating potential applications in various fields.
CHEMISTRY OF MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Olga Swiech, Maciej Majdecki, Renata Bilewicz
Summary: This study presents a multicomponent polymer material for electrochemical sensing, consisting of polyethylene glycol, nanoparticles modified with a lipoic acid derivative of cyclodextrin, and a biocompatible cross linker. The material enhances the sensor's selectivity and detection limit through improved analyte binding and conductivity. It was successfully used for the detection of ferrocene derivative and ibuprofen at low concentrations.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Analytical
Agnieszka Wieckowska, Elzbieta Jablonowska, Marcin Jaskolowski, Renata Bilewicz
Summary: Metal nanostructures are commonly used in thin films to enhance the conductivity of electrodes. In this study, we show that even at very low surface concentrations, gold clusters act as remote electrodes, facilitating electron transfer to solution species when embedded in a lipid film. The presence of gold clusters enables efficient electron transfer through the lipid barrier, as demonstrated by the electrode processes of hexaammineruthenium(III). Reversibility of the electrochemical probe is restored with the addition of as low as 0.01 mol% of Au clusters dispersed in the outer leaflet of the lipid bilayer.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Michalina Zaborowska, Aleksandra Bartkowiak, Ewa Nazaruk, Dorota Matyszewska, Renata Bilewicz
Summary: The Langmuir technique was used to compare the layers obtained by spreading lipid liquid-crystalline nanoparticles with the monolayers obtained by mixing the same components in chloroform at the air-water interface. The isotherms obtained for the mixed components system and the cubosome-derived layer showed similarity, indicating the disintegration of cubosomes into a single monolayer upon contact with the air-water interface. AFM imaging confirmed the presence of intact cubosomes on the surface of mica when performed in water. This study provides insights into the behavior of lipid nanoparticles at interfaces.
Review
Chemistry, Analytical
Martina Zatloukalova, Lukasz Poltorak, Renata Bilewicz, Jan Vacek
Summary: Some biologically active substances are unstable and poorly soluble in aqueous media, which limits their bioavailability. Incorporating these compounds into lipid-based liquid crystalline phases or nanoparticles can enhance their stability, transport properties, bioavailability, and applicability. This overview aims to explain the self-assembly principle of lipidic amphiphilic molecules in water and present the current biosensing and biomedical applications of lipidic bicontinuous cubic and hexagonal phases, with a focus on electrochemical protocols.
Article
Chemistry, Analytical
Katarzyna Szot-Karpinska, Patryk Kudla, Urszula Orzel, Magdalena Narajczyk, Martin Jonsson-Niedziolka, Barbara Palys, Slawomir Filipek, Andreas Ebner, Joanna Niedziolka-Jonsson
Summary: This study investigates the interactions between C-reactive protein (CRP) and CRP-binding peptide materials, identifying the best binder as the P3 peptide. The P3 peptide is used for CRP recognition on electrodes, demonstrating its potential as a receptor for CRP.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Michalina Zaborowska, Marcin Broniatowski, Philippe Fontaine, Renata Bilewicz, Dorota Matyszewska
Summary: In this study, the effect of statins on model lipid rafts and their components was investigated using a combined GIXD/PM-IRRAS/BAM approach for the first time. It was found that the hydrophobicity of the drugs and the organization of the lipid layer determined the drug-lipid interaction.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Chemistry, Physical
Mateusz Kasztelan, Sylwia Zoladek, Wladyslaw Wieczorek, Barbara Palys
Summary: Engineering of plasmonic properties of gold nanostructures expands their applications in various fields, such as photocatalysis, photothermal effects, and ultra-sensitive surface-enhanced Raman spectroscopy (SERS). In this study, we present a novel template-free synthesis method to obtain gold nanobowls (AuNBs) by depositing them on graphene oxide (GO) layers. Compared to gold nanospheres (AuNSs) and gold nanourchins (AuNUs), AuNBs exhibit significantly higher enhancement factors in SERS. Moreover, the GO materials can modify the SERS enhancement by enabling or disabling charge transfer, causing nanoparticle aggregation and hot spot formation, and contributing dipole effects through abundant polar groups on the surface.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Nanoscience & Nanotechnology
Kornelia Bobrowska, Kamila Sadowska, Krzysztof Stolarczyk, Marta Przesniak-Welenc, Piotr Golec, Renata Bilewicz
Summary: In this study, hybrid nanoflowers based on bovine serum albumin (BSA) and hydroxyapatite (HA) were successfully synthesized and characterized. The nanoflowers were able to embed ciprofloxacin and release it in a controlled manner. Additionally, the nanoflowers exhibited antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Analytical
Katarzyna Szot-Karpinska, Patryk Kudla, Urszula Orzel, Magdalena Narajczyk, Martin Jonsson-Niedziolka, Barbara Palys, Slawomir Filipek, Andreas Ebner, Joanna Niedziolka-Jonsson
Summary: This study investigates the interactions between C-reactive protein (CRP) and new CRP-binding peptide materials using experimental methods and theoretical simulations. Three specific CRP-binding peptides were identified and their binding efficiency towards CRP was demonstrated. The study consistently showed that the P3 peptide is the best CRP binder. The study also presents a potential candidate peptide, P3, as a receptor for CRP.
ANALYTICAL CHEMISTRY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
A. Buta, E. Nazaruk, B. Kulawiak, P. Koprowski, A. Szewczyk, R. Bilewicz
