Article
Chemistry, Multidisciplinary
Tae Heon Lee, Hye Jeong Kim, Bo-Ra Lee, Sang Bong Lee, Da-Sol Lee, Ye Ri Han, Kil Soo Kim, Young Kyu Song, Young Key Shim, Su-Jin Park, Dong-Won Kim, Yong Hyun Jeon
Summary: The unique ability of chlorophyll derivatives to accumulate in tumor tissues and cause a photodynamic effect under laser radiation has been successfully used in photodynamic therapy. Previous research on modified peripheral substituents in chlorophyll has shown that the presence and position of substituents in chlorin derivatives significantly affect biological activities. The synthesized MPPa derivatives with heterocyclic aromatic substituents or pyrazole moieties on the peripheral positions demonstrated photodynamic therapy effects in both in vitro and in vivo studies.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Chemistry, Applied
Laura Boetje, Xiaohong Lan, Fitrilia Silvianti, Jur van Dijken, Michael Polhuis, Katja Loos
Summary: This study presents a series of starch esters synthesized through transesterification reactions catalyzed by TBD in DMSO. By purging the reaction flask with nitrogen, the degree of substitution was increased. Long-chain fatty acids exhibited the most significant increase in DS, while starch esters from unsaturated fatty acids showed lower Tg and higher hydrophobicity compared to pristine starch.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Physical
Fei Huang, Guiyan Han, Xingjie Zhang, Yu Li, Zhenyuan Miao, Jianzhong Yao
Summary: In this study, a novel chlorin-based photosensitizer was designed and synthesized for tumor photodynamic therapy. The photosensitizer showed high phototoxicity, high dark toxicity/phototoxicity ratio, and excellent PDT antitumor efficacy in vitro and in vivo.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Spectroscopy
A. Yu Belik, A. Yu Rybkin, N. S. Goryachev, A. P. Sadkov, N. Filatova, A. G. Buyanovskaya, V. N. Talanova, Z. S. Klemenkova, V. S. Romanova, M. O. Koifman, A. A. Terentiev, A. Kotelnikov
Summary: The study focused on the synthesis and photodynamic activity of water-soluble amino acid fullerene C-60 derivatives (AFD) and their covalent addition of dye pyropheophorbide (PPa) in aqueous solution. The dyads formed nanoassociates through self-assembly, exhibiting a switch in photodynamic mechanism from type II to I and significant phototoxicity in Hela cells, suggesting potential against hypoxic tumors.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Spectroscopy
Xiaorong Wang, Hui Lv, Yingkai Sun, Guoping Zu, Xiaozhen Zhang, Yufang Song, Fengyang Zhao, Jingang Wang
Summary: Research on porphyrin-based photosensitizer system is of great theoretical and practical significance in photodynamic therapy (PDT) for cancer treatment. In this article, a series of porphyrin derivatives were designed and synthesized, leading to the construction of a push-pull porphyrin photosensitizer with two symmetrical ethanethioate groups. Through characterization and theoretical analysis, the relationship between porphyrin structure and properties was revealed. The synthesized porphyrin compounds demonstrated high singlet oxygen generation and low dark toxicity under long-wavelength light.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Medicinal
Ravindra R. Cheruku, Joseph Cacaccio, Farukh A. Durrani, Walter A. Tabaczynski, Ramona Watson, Kevin Siters, Joseph R. Missert, Erin C. Tracy, Mykhaylo Dukh, Khurshid Guru, Richard C. Koya, Pawel Kalinski, Heinz Baumann, Ravindra K. Pandey
Summary: Among the modified erlotinib conjugates investigated, PS 10 was identified as the most effective candidate for achieving tumor cell-specific accumulation and yielding improved long-term tumor control.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Joshua G. Hughes, David R. Chisholm, Andrew Whiting, John M. Girkin, Carrie A. Ambler
Summary: Reactive oxygen species (ROS) have dual effects in cells, playing important roles in cell signaling and defense, but also causing cell death and oxidative damage. Developing a method to image ROS has been a challenge for many years. In this study, a new fluorescence microscopy-based technique called Bullseye Analysis is reported, which allows visualization of the production and effects of ROS at a subcellular level. The technique was validated using ROS-reporter dyes and a ROS-inducing photosensitizer.
MICROSCOPY AND MICROANALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Nuo Yu, Pu Qiu, Qian Ren, Mei Wen, Peng Geng, Daniel K. Macharia, Meifang Zhu, Zhigang Chen
Summary: The study introduces a strategy to convert double-edged sword PSs into single-edged knife ones, achieving efficient inhibition of tumors, as well as persistent and high phototoxicity inhibition.
Article
Pharmacology & Pharmacy
Vladimir Makarov, Daria Pominova, Anastasiya Ryabova, Igor D. Romanishkin, Arina V. Voitova, Rudolf W. Steiner, Victor B. Loschenov
Summary: The study focuses on the biomedical applications of phthalocyanine nanoparticles (AlPc NPs) as nanophotosensitizers. The research discovers that AlPc NPs can enter cells, localize in lysosomes, exhibit fluorescence, and achieve photodynamic therapy.
Article
Chemistry, Applied
Bingjie Hou, Wenyuan Zhang, Cuili Li, Xueqin Sun, Xiaoxia Feng, Jiacheng Liu
Summary: This study reports the synthesis and evaluation of four cationic porphyrins as potential photodynamic therapeutic agents. The results show that ZnP2 exhibits high phototoxicity towards cancer cells and low toxicity towards normal cells, making it a promising candidate for photodynamic therapy.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jaydeepsinh Chavda, Anjali Rajwar, Dhiraj Bhatia, Iti Gupta
Summary: Novel zinc porphyrins containing pharmacophoric groups derived from Sorafenib were found to have excellent PDT based autophagy inhibition of cancer cells. Molecular docking studies showed strong binding with mTOR protein kinase. These findings suggest that these zinc porphyrins have potential as theranostic agents for anti-cancer applications.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Applied
Loveleen Kaur Gulati, Gurleen Kaur Gulati, Satish Kumar
Summary: This article discusses the use of photochromism in photodynamic therapy, highlighting the potential of photochromic substances in three different roles to enhance efficacy: as photosensitizers, switches to conventional photosensitizers, and reserves of singlet oxygen.
Article
Chemistry, Medicinal
Fei Huang, Yu Li, Xing-Jie Zhang, Mei-Yu Lin, Gui-Yan Han, Hui-Ying Lin, Hui-Yun Lin, Zhenyuan Miao, Bu-Hong Li, Chun-Quan Sheng, Jian-Zhong Yao
Summary: Novel chlorin e6-based conjugate 10b, designed and synthesized as photosensitizer, showed strong phototoxicity against cancer cells by reducing efflux of intracellular photosensitizer and localizing in various organelles. It induced cell apoptosis, ROS production, autophagy, and cell cycle arrest. In vivo experiments demonstrated that 10b significantly inhibited tumor growth and prolonged survival time. Therefore, 10b has great potential as a promising photosensitizer.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Huijuan Dong, John E. Cronan
Summary: The Enterococcus faecalis genome contains two genes, fabK and fabI, which encode enoyl-ACP reductases with different structures. Previous research showed that FabK, due to weak expression, is not the major contributor to cellular enoyl ACP reductase activity. However, overproduction of FabK is lethal, whereas overproduction of FabI only slows down growth. This is because enoyl ACP reductase overproduction disrupts unsaturated fatty acid synthesis by competing with FabO, a putative 3-ketoacyl-ACP synthase I, via FabN. This study provides evidence that enoyl-ACP reductase must be matched to the genes involved in unsaturated fatty acid synthesis.
MOLECULAR MICROBIOLOGY
(2022)
Review
Anatomy & Morphology
Fadya Adnane, Emad El-Zayat, Heba Mohamed Fahmy
Summary: This review discusses the therapeutic efficacy of photodynamic therapy and nanotechnology as combinational approaches in treating different types of skin cancer. It covers the mechanism and cell destruction capability of photodynamic therapy, different types of photosensitizers, and the ideal characteristics of nanoparticles used as drug delivery systems. The review also highlights the recent preclinical studies and clinical trials using nanoparticles loaded with different drugs and triggered with photodynamic therapy for skin cancer treatment.
Article
Oncology
Ju Hee Kim, Jae Myung Park, Yoon Jin Roh, In-Wook Kim, Tayyaba Hasan, Myung-Gyu Choi
Article
Biochemistry & Molecular Biology
In-Wook Kim, Jae Myung Park, Yoon Jin Roh, Ju Hee Kim, Myung-Gyu Choi, Tayyaba Hasan
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2016)
Article
Oncology
Yoon Jin Roh, Ju Hee Kim, In-Wook Kim, Kun Na, Jae Myung Park, Myung-Gyu Choi
MOLECULAR CANCER THERAPEUTICS
(2017)
Meeting Abstract
Oncology
In-Wook Kim, Ju Hee Kim, Jae Myung Park, Myung-Gyu Choi
Article
Oncology
Ju Hee Kim, Yong-Wan Kim, In-Wook Kim, Dong Chun Park, Yong Wook Kim, Keun-Ho Lee, Chun Keun Jang, Woong Shick Ahn
INTERNATIONAL JOURNAL OF ONCOLOGY
(2013)
Article
Oncology
Yong-Wan Kim, Su Mi Bae, Yong Wook Kim, Dong Choon Park, Keun-Ho Lee, Hai-Bo Liu, In-Wook Kim, Chun Keun Jang, Woong Shick Ahn
INTERNATIONAL JOURNAL OF ONCOLOGY
(2013)
Article
Oncology
Ju Hee Kim, In-Wook Kim
Meeting Abstract
Biotechnology & Applied Microbiology
In-Wook Kim, Khaphetsi J. Mahasa, Lisette de Pillis, Rachid Ouifki, Amina Eladdadi, Philip Maini, A-Rum Yoon, Chae-Ok Yun
Meeting Abstract
Biotechnology & Applied Microbiology
In-Wook Kim, Bok Ki Jung, Won Jai Lee, Eunhye Kang, Yong Oock Kim, Dong Kyun Rah, In Sik Yun, Chae-Ok Yun
Meeting Abstract
Biotechnology & Applied Microbiology
In-Wook Kim, Yan Li, JinWoo Hong, Joung-Eun Oh, A-Rum Yoon, Chae-Ok Yun
Article
Multidisciplinary Sciences
Youngjae Won, Byungjun Park, Inwook Kim, Seungrag Lee
Meeting Abstract
Gastroenterology & Hepatology
Myung-Gyu Choi, Yoon Jin Roh, In-Wook Kim, Ju Hee Kim, Jae Myung Park, Tayyaba Hasan
Meeting Abstract
Gastroenterology & Hepatology
Myung Gyu Choi, Yoon Jin Roh, In Wook Kim, Ju Hee Kim, Jae Myung Park, Tayyaba Hasan
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2014)
Meeting Abstract
Gastroenterology & Hepatology
Myung-Gyu Choi, In-Wook Kim, Ju Hee Kim, Jae Myung Park
Meeting Abstract
Gastroenterology & Hepatology
Jae Myung Park, Ju Hee Kim, In-Wook Kim, Myung-Gyu Choi
Article
Biochemistry & Molecular Biology
Girgis Obaid, Menitte Eroy, Jie Zhao, Shazia Bano, Mari Mino-Kenudson, Tayyaba Hasan
Summary: The presence of desmoplasia in pancreatic ductal adenocarcinoma (PDAC) is associated with poor treatment outcomes and reduced drug delivery. By analyzing collagen subtypes in PDAC tumors following different treatment regimens, immunofluorescence profiling can predict long-term survival and tumor growth inhibition. This information can aid in personalized treatment and improve patient survival.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Fatemeh Malekpour, Rashin Bahrami, Mahshid Hodjat, Neda Hakimiha, Behnam Bolhari, Aidin Sooratgar, Soheil Niavarzi
Summary: This study investigated the effect of photobiomodulation (PBM) therapy using an 808 nm diode laser on cellular modulation mechanisms in regenerative endodontic procedures (REPs). The results showed that PBM treatment significantly increased cell viability and migration, and enhanced the release of TGF-131 from dentin.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Pranathi Tata, Ramakrishnan Ganesan, Jayati Ray Dutta
Summary: Thin film coatings with potent antibacterial properties are widely used in medical devices, frequently touched surfaces, and food packaging. However, achieving antibacterial performance under both light and dark conditions remains a challenge. In this study, we successfully prepared AgBr-coated ZnO nanorod thin film architecture using a unique surfactant-mediated solution-phase spin-coating approach. The resulting structures showed dual functionality as antimicrobial agents and photosensitizers, effectively enhancing the visible-light photodisinfection efficacy of ZnO nanorods. The concentration of the surfactant-based precursor solution could be modulated to control the AgBr content. Additionally, components like urea and lactic acid were found to enhance the photocatalytic efficiency of the structures.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
