Article
Pharmacology & Pharmacy
Nina Dragicevic, Bojan Nikolic, Volker Albrecht, Alfred Fahr
Summary: Invasomes can enhance the skin penetration of mTHPC and deliver it to tumors, making them a potential option for topical PDT. The study also confirmed transdermal mTHPC delivery and suggested the possibility of using invasomes for diseases requiring systemic drug absorption.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Ilya Yakavets, Aurelie Francois, Laureline Lamy, Max Piffoux, Florence Gazeau, Claire Wilhelm, Vladimir Zorin, Amanda K. A. Silva, Lina Bezdetnaya
Summary: The presence of stromal components significantly influences the uptake of nanoparticles, while the penetration and photodynamic therapy efficacy are less affected. Among the three lipid-based nanoformulations, mTHPC-EVs showed superior cellular uptake and photodynamic efficiency due to their high loading capacity. The results of this study enhance our understanding of how stromal components impact the delivery of nanoparticles to tumors.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biology
Abdullah A. Alkahtane, Hamzah A. Alghamdi, Alanoud T. Aljasham, Saad Alkahtani
Summary: This study aimed to enhance the pharmacological value of Fe3O4 for colorectal cancer diagnosis by developing chitosan-coated Fe3O4. The results demonstrated that the nanohybrid exhibited enhanced ROS activity and effective cell death in colorectal carcinoma cell lines, offering a promising MRI contrasting agent for colorectal cancer diagnosis.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Lorena Rodriguez, Gabriela Di Venosa, Martin A. Rivas, Angeles Juarranz, Francisco Sanz-Rodriguez, Adriana Casas
Summary: The study found that Ras transfection affects cell morphology, extracellular matrix, and cell-cell adhesion, resulting in increased resistance to photodynamic therapy (PDT).
Article
Chemistry, Multidisciplinary
Nazli Farajzadeh, Nilgun Guler Kusculu, H. Yasemin Yenilmez, Dilek Bahar, Zehra Altuntas Bayir
Summary: In this study, the DNA cleavage activities of new silicon phthalocyanines were investigated for their potential in cancer treatment. The results showed that these compounds exhibited significant cleavage activities on plasmid DNA, higher inhibition activity against human topoisomerase I, and cytotoxicity against colorectal cancer cells.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Oncology
Fabian Lang, Maria F. Contreras-Gerenas, Marton Gelleri, Jan Neumann, Ole Kroeger, Filip Sadlo, Krzysztof Berniak, Alexander Marx, Christoph Cremer, Hans-Achim Wagenknecht, Heike Allgayer
Summary: Tumour cell heterogeneity and its early individual diagnosis present a fundamental challenge in cancer diagnosis and therapy. Single molecule localisation microscopy (SMLM) has been used to analyze subcellular features, although primarily limited to cultured cell lines. A new approach using SMLM allows for quantitative analysis of chromatin nanostructure in individual cells from resected colorectal carcinoma patient tissue, providing insights into differences in chromatin architecture between normal and carcinoma tissues.
Article
Biotechnology & Applied Microbiology
Yongtai Zhang, Qing Xia, Tong Wu, Zehui He, Yanyan Li, Zhe Li, Xuefeng Hou, Yuanzhi He, Shuyao Ruan, Zhi Wang, Jia Sun, Nianping Feng
Summary: The designed HA&RBCm-LCNPs with a honeycomb structure efficiently encapsulated paclitaxel and IR780 for enhanced antitumor effects, overcoming barriers and enhancing specificity to target cells, resulting in a safe and efficient treatment vehicle.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biophysics
Paulo Emilio Feuser, Arthur Poester Cordeiro, Gustavo de Bem Silveira, Maria Eduarda Anastacio Borges Correa, Paulo Cesar Lock Silveira, Claudia Sayer, Pedro Henrique Hermes de Araujo, Ricardo Andrez Machado-de-Avila, Alexandre Goncalves Dal Bo
Summary: The study evaluated the synergistic effect of DETC and ZnPc co-encapsulated in liposomes, showing reduced cytotoxic effects and inhibited damage to cells compared to free DETC + ZnPc. Additionally, both the free drugs and co-encapsulated ones demonstrated enhanced phototoxic effects on human breast cancer cells, attributed to DETC-induced decreases in antioxidant enzyme activity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Toxicology
Sonam Chandra, Saba Qureshi, Deepti Chopra, Saumya Shukla, Sunil Kumar Patel, Jyoti Singh, Ratan Singh Ray
Summary: This study reveals that DMA undergoes photodegradation under UVA and sunlight exposure, leading to phototoxic and photogenotoxic effects on human skin cells. The activation of DMA results in the generation of intracellular ROS, destabilization of lysosomes, mitochondrial membrane depolarization, DNA fragmentation, and apoptosis.
TOXICOLOGY IN VITRO
(2022)
Article
Oncology
Pradeep Velusamy, Sridhar Muthusami, Ramakrishnan Arumugam
Summary: Skin cancer is a highly deadly form of cancer that affects one in three cancer patients worldwide. Researchers have found that a combination of p-coumaric acid and naringin can effectively treat skin cancer cells with fewer side effects.
Article
Chemistry, Multidisciplinary
Yu Zhao, Zihan Chen, Qiushi Li, Xianghui Cao, Qingqing Huang, Linqi Shi, Yang Liu
Summary: An immune-enhancing polymer-reinforced liposome (IERL) with a stable nanostructure and a bioactive surface is developed to enhance antigen cross-presentation and immune cell death-associated antitumor responses.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Oncology
Brennan J. Wadsworth, Che-Min Lee, Kevin L. Bennewith
Summary: Background solid tumour perfusion instability can lead to radiation resistance in transiently hypoxic cells. Transiently hypoxic tumour cells can survive up to 72 hours and are sensitive to vascular dysfunction induced by high-dose ionising radiation.
BRITISH JOURNAL OF CANCER
(2022)
Article
Chemistry, Multidisciplinary
Sara Abreu, Nuno Vale, Olivia Salome G. P. Soares
Summary: Due to the increase in new types of cancer cells and resistance to drugs, nanotechnology is being applied to biomedical areas as an alternative cancer treatment to minimize side effects and drug resistance and improve treatment efficacy. This study focused on finding a promising cancer treatment for colorectal adenocarcinoma cells using carbon nanotubes (CNTs) combined with different drugs (5-fluorouracil (5-FU) and repurposing drugs tacrine (TAC) and ethionamide (ETA)). CNT samples with different functional groups and textural properties were prepared and characterized, and the results showed that CNTs doped with nitrogen and sulfur groups (CNT-BM-N and CNT-H2SO4-BM) improved the activity of 5-FU and TAC.
Article
Gastroenterology & Hepatology
Feng Wang, You-Sheng Huang, Hao-Xiang Wu, Zi-Xian Wang, Ying Jin, Yi-Chen Yao, Yan-Xing Chen, Qi Zhao, Shifu Chen, Ming-Ming He, Hui-Yan Luo, Miao-Zhen Qiu, De-Shen Wang, Feng-Hua Wang, Mingyan Xu, Yu-Hong Li, Rui-Hua Xu
Summary: The study investigated the genomic heterogeneity of circulating tumor DNA in patients with metastatic colorectal cancer during different treatments, revealing the impact of RAS/BRAF mutations on patients' treatment outcomes. The findings suggest that changes in plasma RAS/BRAF mutational status can significantly affect survival outcomes in these patients.
Article
Oncology
Maria Teresa Rodrigo-Calvo, Karmele Saez de Gordoa, Sandra Lopez-Prades, Ivan Archilla, Alba Diaz, Mario Berrios, Jordi Camps, Eva Musulen, Miriam Cuatrecasas
Summary: The aim of this study was to identify lymphatic vessels (LVs) in the mucosa of in-situ colorectal cancer (CRC) and detect tumor burden in regional lymph nodes (LNs). LVs were found in the mucosa of all tumors (39/39; 100%) using D240 immunostains. LNs were analyzed by both H&E and a RT-PCR-based molecular method. Low amounts of tumor burden were detected in 11/39 (28%) cases using the molecular assay. The quantification of tumor burden in LNs can help with clinical management.
Review
Pharmacology & Pharmacy
Nina Dragicevic, Howard Maibach
ADVANCED DRUG DELIVERY REVIEWS
(2018)
Article
Biophysics
Nina Dragicevic-Curic, Dietrich Scheglmann, Volker Albrecht, Alfred Fahr
COLLOIDS AND SURFACES B-BIOINTERFACES
(2009)
Article
Biophysics
Nina Dragicevic-Curic, Dietrich Scheglmann, Volker Albrecht, Alfred Fahr
COLLOIDS AND SURFACES B-BIOINTERFACES
(2009)
Article
Chemistry, Medicinal
Nina Dragicevic, Danina Krajisnik, Jela Milic, Alfred Fahr, Howard Maibach
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2019)
Review
Pharmacology & Pharmacy
Nina Dragicevic-Curic, Alfred Fahr
EXPERT OPINION ON DRUG DELIVERY
(2012)
Article
Pharmacology & Pharmacy
Nina Dragicevic-Curic, Sven Winter, Mirjana Stupar, Jela Milic, Danina Krajisnik, Burkhard Gitter, Alfred Fahr
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2009)
Article
Pharmacology & Pharmacy
Nina Dragicevic-Curic, Susanna Graefe, Burkhard Gitter, Sven Winter, Alfred Fahr
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2010)
Article
Pharmacology & Pharmacy
Nina Dragicevic-Curic, Manfred Friedrich, Silvia Petersen, Dietrich Scheglmann, Dennis Douroumis, Winfried Plass, Alfred Fahr
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2011)
Article
Chemistry, Multidisciplinary
Nina Dragicevic-Curic, Dietrich Scheglmann, Volker Albrecht, Alfred Fahr
JOURNAL OF CONTROLLED RELEASE
(2008)
Article
Biochemistry & Molecular Biology
Nina Dragicevic-Curic, Sven Winter, Danina Krajisnik, Mirjana Stupar, Jela Milic, Susanna Graefe, Alfred Fahr
JOURNAL OF LIPOSOME RESEARCH
(2010)
Article
Biochemistry & Molecular Biology
Nina Dragicevic-Curic, Susanna Graefe, Volker Albrecht, Alfred Fahr
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2008)
Article
Pharmacology & Pharmacy
Luca Casula, Rosa Pireddu, Maria Cristina Cardia, Elena Pini, Donatella Valenti, Michele Schlich, Chiara Sinico, Salvatore Marceddu, Nina Dragicevic, Anna Maria Fadda, Francesco Lai
Summary: Combining microneedle arrays with nanosuspensions can enhance the skin delivery of water insoluble drugs by temporarily disrupting the stratum corneum.
Article
Chemistry, Medicinal
N Dragicevic-Curic, M Stupar, J Milic, T Zoric, D Krajisnik, D Vasiljevic
Article
Biochemistry & Molecular Biology
Girgis Obaid, Menitte Eroy, Jie Zhao, Shazia Bano, Mari Mino-Kenudson, Tayyaba Hasan
Summary: The presence of desmoplasia in pancreatic ductal adenocarcinoma (PDAC) is associated with poor treatment outcomes and reduced drug delivery. By analyzing collagen subtypes in PDAC tumors following different treatment regimens, immunofluorescence profiling can predict long-term survival and tumor growth inhibition. This information can aid in personalized treatment and improve patient survival.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Fatemeh Malekpour, Rashin Bahrami, Mahshid Hodjat, Neda Hakimiha, Behnam Bolhari, Aidin Sooratgar, Soheil Niavarzi
Summary: This study investigated the effect of photobiomodulation (PBM) therapy using an 808 nm diode laser on cellular modulation mechanisms in regenerative endodontic procedures (REPs). The results showed that PBM treatment significantly increased cell viability and migration, and enhanced the release of TGF-131 from dentin.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Pranathi Tata, Ramakrishnan Ganesan, Jayati Ray Dutta
Summary: Thin film coatings with potent antibacterial properties are widely used in medical devices, frequently touched surfaces, and food packaging. However, achieving antibacterial performance under both light and dark conditions remains a challenge. In this study, we successfully prepared AgBr-coated ZnO nanorod thin film architecture using a unique surfactant-mediated solution-phase spin-coating approach. The resulting structures showed dual functionality as antimicrobial agents and photosensitizers, effectively enhancing the visible-light photodisinfection efficacy of ZnO nanorods. The concentration of the surfactant-based precursor solution could be modulated to control the AgBr content. Additionally, components like urea and lactic acid were found to enhance the photocatalytic efficiency of the structures.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
