Article
Instruments & Instrumentation
Michele Schlich, Umberto M. Musazzi, Virginia Campani, Marco Biondi, Silvia Franze, Francesco Lai, Giuseppe De Rosa, Chiara Sinico, Francesco Cilurzo
Summary: The skin is an important site for drug absorption, and recent research has supported the design of innovative nanosystems to improve the absorption of poorly skin-permeable drugs. However, topically applied liposomal systems face several challenges, making their clinical application difficult.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biophysics
Saeid Moghassemi, Arezoo Dadashzadeh, Hafez Jafari, Pejman Ghaffari-Bohlouli, Amin Shavandi, Christiani A. Amorim
Summary: This study developed a liposomal oxygen-releasing scaffold to address the inadequate oxygen supply in tissue engineering. The results showed that this method can improve cell viability under hypoxic conditions, providing a simple and effective solution for cellular oxygenation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Agnieszka Kostrzebska, Karolina Paczek, Angelika Weselak, Witold Musial
Summary: Due to its high instability and rapid degradation under adverse conditions, tetracycline hydrochloride (TC) poses challenges in developing a stable formulation for acne treatment. The aim of the study was to propose a hydrogel formulation that ensures TC stability and activities against the components of sebum. Formulations with varying proportions of anionic polymer and alcoholamine, containing different polymers, were developed and evaluated for TC stability and activity against sebum components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Chemical
Changsheng Gan, Rong Cheng, Kun Xu, Jingwen Zhang, Honglei Wang, Tiantian Xu, Huiya Li, Liu Yang
Summary: Blank hydrogels and niosomal hydrogels loading CoQ10 were prepared using CBM and SCL as materials. The addition of SCL increased the viscosity and modulus of the hydrogels, showing better shear thinning behavior. A dense network structure was formed in CBM-SCL-Gel, especially for CBM/SCL at 5/4 and 5/5, due to hydrogen bonding between CBM and SCL. The swelling behaviors of the composite gels followed pseudo-second-order kinetics, with CBM/SCL at 5/1 exhibiting the highest swelling capability. The addition of SCL also changed the water absorption mechanism to a non-Fickian diffusion mode. The gel properties were not significantly affected by the CoQ10 niosomes, and the niosomal gel showed high stability of CoQ10 after 30 days of storage.
POLYMER ENGINEERING AND SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Kenan Aloss, Peter Hamar
Summary: Doxorubicin (DOX) is a potent anti-cancer agent that has attracted significant research interest for its high efficacy but dose-limiting toxicities. Various strategies, including liposomes, targeted liposomes, and pH-sensitive or thermo-sensitive liposomes combined with local heating, have been explored to enhance DOX delivery to tumors. Clinical trials have shown promising results for lyso-thermosensitive liposomal DOX (LTLD), MM-302, and C225-immunoliposomal (IL)-DOX. Additionally, preclinical models have demonstrated improved anti-tumor activity with functionalized PEGylated liposomal DOX (PLD), TSLs, and PSLs. However, further investigations are needed to address issues such as fast clearance, ligand density optimization, stability, and release rate.
Article
Pharmacology & Pharmacy
Zhe Lv, Han Bao, Ming Zhu, Yizhuo Xie, Huan Tang, Dongfanghui Miao, Xin Guo, Xinhui Zhai, Shanshan Wang, Hongli Chen, Dengli Cong, Xin Liu, Jin Pei
Summary: Excessive sebum is the main cause of seborrheic diseases. Chemical medicines often have side effects, so polypeptides with fewer side effects are considered ideal for reducing sebum production. An inhibiting polypeptide (SREi) was developed to suppress the activation of sterol regulatory element-binding proteins-1 (SREBP-1). Anionic deformable liposomes containing SREi were prepared and showed high entrapment efficiency, small particle size, and negative surface charge. When formulated into a hydrogel, the SREi liposomes exhibited sustained release and improved cellular uptake and transdermal absorption. In vivo studies confirmed that the SREi hydrogel had the strongest inhibitory effect on sebum synthesis and gland growth. Histological analysis showed reduced sebaceous gland lobes in the SREi hydrogel group. Overall, this study suggests that the SREi hydrogel has potential applications in diseases related to excessive sebum production.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Materials Science, Biomaterials
Min Xu, Shaozhen Wu, Li Ding, Caijiao Lu, Huangjing Qian, Jinmiao Qu, Yu Chen
Summary: This study innovatively prepared adhesive piezoelectric antibacterial hydrogels with carboxymethyl chitosan (CMCS), tannic acid (TA), carbomer (CBM), and piezoelectric FeWO4 nanorods. The hydrogels exhibited high expansibility, degradability, and adjustable rheological properties. The piezoelectric effect of FeWO4 was triggered by ultrasound, effectively generating reactive oxygen species and preventing wound infection, thus promoting skin wound healing in bacteria-infected mice.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Pharmacology & Pharmacy
Agnieszka Kostrzebska, Adrianna Zlocinska, Witold Musial
Summary: The study found that the TC concentration decreased from 9.37 µg/mL to 4.41 µg/mL within approximately two months when stored at 23 degrees C under photoprotection. However, lowering the storage temperature did not improve the final level of TC. Additionally, the TC level in aqueous solution decreased drastically to approximately 1 µg/mL in the presence of AMPD.
Article
Engineering, Biomedical
Deepika Malhotra, Sharadwata Pan, Lars Ruether, Gerrit Schlippe, Werner Voss, Natalie Germann
Summary: A custom-made technique was reported to synthesize process-convenient skin scaffolds by tuning the mechanical properties of hydrogels based on naturally occurring polysaccharides to match rheological properties of native human skins. Mechanical parameters were studied using oscillatory shear rheology, showing significant findings on the influence of kappa-carrageenan concentration on the elastic modulus and intercycle strain-softening behavior of the hydrogels. Diffusion experiments on caffeine permeation attributes demonstrated improved barrier features with increasing kappa-carrageenan concentration, achieving comparable penetration features with commercial 3D skin models.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Anfal M. M. Alkandari, Yasser M. M. Alsayed, Atallah M. M. El-Hanbaly
Summary: The aim of this study was to develop a suitable method for encapsulating a tracer in liposomes to enhance the stability and efficacy of radiopharmaceuticals. The results showed that liposomal encapsulation reduced uptake and retention of the drug in unintended organs, and also reduced its cytotoxic effect. Adding cholesterol during the formulation process enhanced the stability and specificity of the targeted organs.
Article
Pharmacology & Pharmacy
Nina Dragicevic, Bojan Nikolic, Volker Albrecht, Alfred Fahr
Summary: Invasomes can enhance the skin penetration of mTHPC and deliver it to tumors, making them a potential option for topical PDT. The study also confirmed transdermal mTHPC delivery and suggested the possibility of using invasomes for diseases requiring systemic drug absorption.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Nanoscience & Nanotechnology
Mingyuan Li, Meng Li, Xinyi Li, Wanhui Shao, Xiujuan Pei, Ruyue Dong, Hongmeng Ren, Lin Jia, Shiqin Li, Wenlin Ma, Yi Zeng, Yun Liu, Hua Sun, Peng Yu
Summary: In this study, collagen liposomes were prepared with the addition of polyol, which not only increased the solubility of collagen but also improved its skin penetration. The results showed that the collagen liposomes had good stability and were more easily absorbed by the skin. This study provides a new method for improving the bioavailability and permeability of collagen in biomedical, cosmeceutical, and pharmaceutical industries.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Oncology
Giulia Ferrari, Lisa Y. Pang, Fabio De Moliner, Marc Vendrell, Richard J. M. Reardon, Andrew J. Higgins, Sunil Chopra, David J. Argyle
Summary: Bleomycin, a chemotherapy agent, can cause severe pulmonary toxicity when administered systemically. Bleosome, a novel formulation of bleomycin encapsulated in ultra-deformable (UD) liposomes, may be a potential topical chemotherapy for non-melanoma skin cancer. The study found that Bleosome can effectively penetrate through the skin, releasing bleomycin to deeper layers and suggesting its efficacy as a topical treatment warrants further investigation.
Article
Chemistry, Physical
Xiaoling Huang, Mingmin Zhang, Xin Su
Summary: Environmentally responsive intelligent viscoelastic fluids have been widely used in various fields, and their rheological behavior can be altered by different stimulation methods. Among these methods, CO2 has attracted significant attention due to its non-toxic and abundant nature. In this study, carbomer (CBM), a pH-responsive polymer with potential CO2-responsiveness, was employed in CO2-responsive viscosity decreasing viscoelastic fluids. The effects of arginine (Arg) on the rheological behavior of CBM solution and the CO2-responsive viscosity of CBM/Arg viscoelastic fluid were investigated. The results demonstrated the potential of CBM/Arg viscoelastic fluid in achieving significant viscosity decrease after CO2 response.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Livia Budai, Marianna Budai, Zsofia Edit Fuelopne Papay, Petra Szalkai, Noemi Anna Niczinger, Shosho Kijima, Kenji Sugibayashi, Istvan Antal, Nikolett Kallai-Szabo
Summary: Janus-faced viscoelastic gelling agents, possessing both elastic and viscous characteristics, provide materials with unique features. The viscoelasticity of various liposomal dispersions was investigated in this study, focusing on the impact of lipid concentration, the presence of cholesterol or DSPC, and the gelling agents PVA and HEC. The composition and lamellarity/size of lipid vesicles were found to influence the oscillation rheological properties of the liposomal formulations.
Review
Pharmacology & Pharmacy
Nina Dragicevic, Howard Maibach
ADVANCED DRUG DELIVERY REVIEWS
(2018)
Article
Chemistry, Medicinal
Nina Dragicevic, Danina Krajisnik, Jela Milic, Alfred Fahr, Howard Maibach
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2019)
Article
Materials Science, Biomaterials
Jelena Janicijevic, Jela Milic, Bojan Calija, Ana Micov, Radica Stepanovic-Petrovic, Maja Tomic, Aleksandra Dakovic, Vladimir Dobricic, Bojana Nedic Vasiljevic, Danina Krajisnik
JOURNAL OF MATERIALS CHEMISTRY B
(2018)
Article
Pharmacology & Pharmacy
Andjelka Racic, Bojan Calija, Jela Milic, Nikola Milasinvic, Danina Krajisnik
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2019)
Article
Polymer Science
Bojan Calija, Jela Milic, Nikola Milasinovic, Aleksandra Dakovic, Kata Trifkovic, Jovica Stojanovic, Danina Krajisnik
JOURNAL OF APPLIED POLYMER SCIENCE
(2020)
Article
Chemistry, Applied
Anka Jevremovic, Patrycja Bober, Matej Micusik, Jaroslav Kulicek, Udit Acharya, Jiri Pfleger, Maja Milojevic-Rakic, Danina Krajisnik, Miroslava Trchova, Jaroslav Stejskal, Gordana Ciric-Marjanovic
MICROPOROUS AND MESOPOROUS MATERIALS
(2019)
Review
Immunology
Celine Lemoine, Aneesh Thakur, Danina Krajisnik, Romain Guyon, Stephanie Longet, Agnieszka Razim, Sabina Gorska, Ivana Pantelic, Tanja Ilic, Ines Nikolic, Ed C. Lavelle, Andrzej Gamian, Snezana Savic, Anita Milicic
Article
Materials Science, Biomaterials
Valentina Jaukovic, Danina Krajisnik, Aleksandra Dakovic, Ana Damjanovic, Jugoslav Krstic, Jovica Stojanovic, Bojan Calija
Summary: Selective lumen etching combined with polycation modification is a promising approach for improving the functionality of Halloysite nanotubes as drug carriers. This method can increase payload, polymer binding capacity, and sustained release properties without significant effects on cytocompatibility.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Chemistry, Physical
Milica Spasojevic, Aleksandra Dakovic, George E. Rottinghaus, Milena Obradovic, Danina Krajisnik, Marija Markovic, Jugoslav Krstic
Summary: The natural kaolin was modified with different amounts of ODMBA to create organokaolinites, and their adsorption of mycotoxins OCHRA and ZEN was studied at varying pH levels. The adsorption capacities of both mycotoxins increased with higher levels of surfactant on the kaolin surface, but varied at different pH values.
APPLIED CLAY SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Zeljko Janicijevic, Ana Stankovic, Bojana Zegura, Dorde Veljovic, Ljiljana Djekic, Danina Krajisnik, Metka Filipic, Magdalena M. Stevanovic
Summary: An innovative low-cost wet precipitation synthesis method was reported for gelatin-modified zinc oxide nanoparticles. The nanoparticles showed slight reduction in cell viability and low genotoxic potential at very high doses in human hepatocellular carcinoma cell line HepG2. Further studies are warranted for their potential applications in antibacterial agents or dietary supplements with low overall toxicity.
JOURNAL OF NANOPARTICLE RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Andjelka Racic, Bojan Calija, Jela Milic, Bisera Jurisic Dukovski, Jasmina Lovric, Vladimir Dobricic, Ana Micov, Milja Vukovic, Radica Stepanovic-Petrovic, Danina Krajisnik
Summary: This work formulated viscous eye drops using medium chain chitosan and hydroxypropyl guar gum as carriers for olopatadine. Physicochemical properties of the formulations were satisfactory, with in vitro studies showing non-toxicity and good anti-pruritic effects on eye cells. The viscous ophthalmic vehicle may be a feasible strategy to enhance the efficacy of olopatadine.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Luca Casula, Rosa Pireddu, Maria Cristina Cardia, Elena Pini, Donatella Valenti, Michele Schlich, Chiara Sinico, Salvatore Marceddu, Nina Dragicevic, Anna Maria Fadda, Francesco Lai
Summary: Combining microneedle arrays with nanosuspensions can enhance the skin delivery of water insoluble drugs by temporarily disrupting the stratum corneum.
Review
Immunology
Brankica Filipic, Ivana Pantelic, Ines Nikolic, Dragomira Majhen, Zorica Stojic-Vukanic, Snezana Savic, Danina Krajisnik
Summary: Since the development of the first vaccine, vaccination has had a significant impact on global health, reducing the burden of infectious diseases. Modern vaccines rely on nanotechnology platforms, which can induce a broader immune response and are easy to manufacture and use. This review provides an overview of promising nanoadjuvants and nanoparticulate delivery systems, discussing their technological and immunological advantages, drawbacks, and possible side effects.
Article
Chemistry, Physical
Bojan Calija, Jela Milic, Jelena Janicijevic, Aleksandra Dakovic, Danina Krajisnik
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
