Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: a PEARRL Review

Virtual bioequivalence for achlorhydric subjects: The use of PBPK modelling to assess the formulation-dependent effect of achlorhydria

(2017) Kosuke Doki et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The impact of reduced gastric acid secretion on dissolution of salts of weak bases in the fasted upper gastrointestinal lumen: Data in biorelevant media and in human aspirates

(2017) Chara Litou et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Influence of different proton pump inhibitors on the pharmacokinetics of voriconazole

(2017) Fang Qi et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Assessment of Bioequivalence of Weak Base Formulations Under Various Dosing Conditions Using Physiologically Based Pharmacokinetic Simulations in Virtual Populations. Case Examples: Ketoconazole and Posaconazole

(2017) Rodrigo Cristofoletti et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Functional dyspepsia

(2017) Paul Enck et al.   Nature Reviews Disease Primers

Absorption of Bupivacaine after Administration of a Lozenge as Topical Treatment for Pain from Oral Mucositis

(2016) Stine Mogensen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Assessment of Drug–Drug Interaction between Warfarin and Aprepitant and Its Effects on PT-INR of Patients Receiving Anticancer Chemotherapy

(2016) Junpei Takaki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication

(2016) Esther E. Fröhlich et al.   BRAIN BEHAVIOR AND IMMUNITY

Role of enterohepatic recirculation in drug disposition: cooperation and complications

(2016) Mohd Yaseen Malik et al.   DRUG METABOLISM REVIEWS

Physiologically Based Pharmacokinetic (PBPK) Modeling of Pitavastatin and Atorvastatin to Predict Drug-Drug Interactions (DDIs)

(2016) Peng Duan et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Physiologically Based Absorption Modeling to Impact Biopharmaceutics and Formulation Strategies in Drug Development—Industry Case Studies

(2016) Filippos Kesisoglou et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Characteristics of the Human Upper Gastrointestinal Contents in the Fasted State Under Hypo- and A-chlorhydric Gastric Conditions Under Conditions of Typical Drug – Drug Interaction Studies

(2016) Chara Litou et al.   PHARMACEUTICAL RESEARCH

Application of physiologically based pharmacokinetic modeling in predicting drug–drug interactions for sarpogrelate hydrochloride in humans

(2016) Soo Kyung Bae et al.   Drug Design Development and Therapy

P-glycoprotein and its role in drug-drug interactions

(2016) Andrew Finch et al.   Australian Prescriber

2014 Global Prescription Medication Statistics: Strong Growth and CNS Well Represented

(2015) Craig W. Lindsley   ACS Chemical Neuroscience

Effect of the Gastrointestinal Prokinetic Agent Erythromycin on the Pharmacokinetics of Pregabalin Controlled-Release in Healthy Individuals: A Phase I, Randomized Crossover Trial

(2015) Marci L. Chew et al.   CLINICAL DRUG INVESTIGATION

Development of a Physiologically Based Pharmacokinetic Model for Itraconazole Pharmacokinetics and Drug–Drug Interaction Prediction

(2015) Yuan Chen et al.   CLINICAL PHARMACOKINETICS

Sirolimus and everolimus in kidney transplantation

(2015) Dirk Jan A.R. Moes et al.   DRUG DISCOVERY TODAY

A novel dissolution method for evaluation of polysaccharide based colon specific delivery systems: A suitable alternative to animal sacrifice

(2015) Sachin Kumar Singh et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Physiologically Based Pharmacokinetic Modeling: From Regulatory Science to Regulatory Policy

(2014) V Sinha et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Lack of effect of colesevelam HCl on the single-dose pharmacokinetics of aspirin, atenolol, enalapril, phenytoin, rosiglitazone, and sitagliptin

(2014) Ling He et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Influence of Post-Transplant Immunosuppressive Therapy on Gastrointestinal Transit Using Biomagnetic Method: A Pilot Study

(2014) Maria do Carmo B. Teixeira et al.   DIGESTIVE DISEASES AND SCIENCES

Pharmacokinetic Drug Interaction Profiles of Proton Pump Inhibitors: An Update

(2014) Ralph-Steven Wedemeyer et al.   DRUG SAFETY

Hospital admissions/visits associated with drug-drug interactions: a systematic review and meta-analysis

(2014) Supinya Dechanont et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Administration of a Probiotic Can Change Drug Pharmacokinetics: Effect of E. coli Nissle 1917 on Amidarone Absorption in Rats

(2014) Zuzana Matuskova et al.   PLoS One

Immunosuppressive therapies for inflammatory bowel disease

(2014) Talia Zenlea   WORLD JOURNAL OF GASTROENTEROLOGY

Corticosteroids and risk of gastrointestinal bleeding: a systematic review and meta-analysis

(2014) Sigrid Narum et al.   BMJ Open

Migraine and Gastroparesis From a Gastroenterologist's Perspective

(2013) Henry P. Parkman   HEADACHE

Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity

(2013) Anne Vrieze et al.   JOURNAL OF HEPATOLOGY

A single-dose pharmacokinetic study of fentanyl sublingual spray in cancer patients with and without oral mucositis

(2013) N. Parikh et al.   JOURNAL OF PAIN

Impaired Drug Absorption Due to High Stomach pH: A Review of Strategies for Mitigation of Such Effect To Enable Pharmaceutical Product Development

(2013) Amitava Mitra et al.   MOLECULAR PHARMACEUTICS

Commensal bacteria at the interface of host metabolism and the immune system

(2013) Jonathan R Brestoff et al.   NATURE IMMUNOLOGY

Gut Pharmacomicrobiomics: the tip of an iceberg of complex interactions between drugs and gut-associated microbes

(2013) Rama Saad et al.   Gut Pathogens

Oral mucositis in patients receiving low-dose methotrexate therapy for rheumatoid arthritis: report of 2 cases and literature review

(2013) Matthias Troeltzsch et al.   Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Prevention of infection caused by immunosuppressive drugs in gastroenterology

(2013) Katarzyna Orlicka et al.   Therapeutic Advances in Chronic Disease

The possible effects of mesalazine on the intestinal microbiota

(2012) L. Xue et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Utility of a physiologically-based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug-drug-disease interaction scenario for rivaroxaban during the drug review process: implications for clinical practice

(2012) Joseph A. Grillo et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Reduced absorption of long-chain fatty acids during methotrexate-induced gastrointestinal mucositis in the rat

(2012) Margot Fijlstra et al.   CLINICAL NUTRITION

Drug Absorption Interactions Between Oral Targeted Anticancer Agents and PPIs: Is pH-Dependent Solubility the Achilles Heel of Targeted Therapy?

(2012) N R Budha et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Burden of Gastrointestinal Disease in the United States: 2012 Update

(2012) Anne F. Peery et al.   GASTROENTEROLOGY

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(2012) Valentina Tremaroli et al.   NATURE

The influence of probiotic treatment on sulfasalazine metabolism in rat

(2012) Hee Ji Lee et al.   XENOBIOTICA

Mesalazine (5-aminosalicylic acid) alters faecal bacterial profiles, but not mucosal proteolytic activity in diarrhoea-predominant irritable bowel syndrome

(2011) C. N. Andrews et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Efficacy of 5-Aminosalicylates in Crohn's Disease: Systematic Review and Meta-Analysis

(2011) Alexander C Ford et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Upregulation of P-glycoprotein by probiotics in intestinal epithelial cells and in the dextran sulfate sodium model of colitis in mice

(2011) Seema Saksena et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Clinically Significant Drug Interactions with Antacids

(2011) Ryuichi Ogawa et al.   DRUGS

Use and indications of cholestyramine and bile acid sequestrants

(2011) Franco Scaldaferri et al.   Internal and Emergency Medicine

Effect of Cyclosporine on the Pharmacokinetics of Aliskiren in Healthy Subjects

(2011) Sam Rebello et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Using Absorption Simulation and Gastric pH Modulated Dog Model for Formulation Development To Overcome Achlorhydria Effect

(2011) Amitava Mitra et al.   MOLECULAR PHARMACEUTICS

Diagnosis and treatment of chronic constipation - a European perspective

(2011) J. Tack et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Effects of therapeutic doses of lactulose vs. polyethylene glycol on isotopic colonic transit

(2010) P. JOUËT et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Relation of Proton Pump Inhibitor Use After Percutaneous Coronary Intervention With Drug-Eluting Stents to Outcomes

(2010) Michael A. Gaglia et al.   AMERICAN JOURNAL OF CARDIOLOGY

Bile Acids Improve the Antimicrobial Effect of Rifaximin

(2010) C. Darkoh et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Risk of Rehospitalization for Patients Using Clopidogrel With a Proton Pump Inhibitor

(2010) Karen M. Stockl   ARCHIVES OF INTERNAL MEDICINE

Recurrence of Acute Myocardial Infarction in Patients Discharged on Clopidogrel and a Proton Pump Inhibitor After Stent Placement for Acute Myocardial Infarction

(2010) Jason Evanchan et al.   CLINICAL CARDIOLOGY

Drug-Drug Interaction Profiles of Proton Pump Inhibitors

(2010) Ryuichi Ogawa et al.   CLINICAL PHARMACOKINETICS

Effectiveness and tolerability of colesevelam hydrochloride for bile-acid malabsorption in patients with cancer: A retrospective chart review and patient questionnaire

(2010) Linda Wedlake et al.   CLINICAL THERAPEUTICS

Probiotic treatment reduces blood glucose levels and increases systemic absorption of gliclazide in diabetic rats

(2010) Hani Al-Salami et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Simulating Fasted Human Intestinal Fluids: Understanding the Roles of Lecithin and Bile Acids

(2010) Erik Söderlind et al.   MOLECULAR PHARMACEUTICS

Probiotics and the gut microbiota in intestinal health and disease

(2010) Mélanie G. Gareau et al.   Nature Reviews Gastroenterology & Hepatology

Effects of bisacodyl on ascending colon emptying and overall colonic transit in healthy volunteers

(2009) N. MANABE et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Systematic review: impaired drug absorption related to the co-administration of antisecretory therapy

(2009) E. LAHNER et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Modulation of Intestinal Barrier Properties by Probiotics: Role in Reversing Colitis

(2009) Silvia C. Resta-Lenert et al.   Annals of the New York Academy of Sciences

Effects of Chenodeoxycholate and a Bile Acid Sequestrant, Colesevelam, on Intestinal Transit and Bowel Function

(2009) Suwebatu T. Odunsi–Shiyanbade et al.   Clinical Gastroenterology and Hepatology

Burden of Digestive Diseases in the United States Part I: Overall and Upper Gastrointestinal Diseases

(2009) James E. Everhart et al.   GASTROENTEROLOGY

Bioavailability of Mycophenolate Mofetil and Enteric-Coated Mycophenolate Sodium Is Differentially Affected by Pantoprazole in Healthy Volunteers

(2009) Korbinian Rupprecht et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Proton Pump Inhibitor Co-medication Reduces Mycophenolate Acid Drug Exposure in Heart Transplant Recipients

(2009) Sieglinde Kofler et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Effect of omeprazole on the plasma concentrations of indinavir when administered alone and in combination with ritonavir

(2008) H. L. Tappouni et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Azathioprine-Induced Warfarin Resistance

(2008) S. R Vazquez et al.   ANNALS OF PHARMACOTHERAPY

Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy

(2008) Kunihiro Suzuki et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics

(2008) A. F. Hofmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The gastrointestinal microbiota as a site for the biotransformation of drugs

(2008) Tiago Sousa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Effects of Acid-Reducing Agents on the Pharmacokinetics of Lopinavir/Ritonavir and Ritonavir-Boosted Atazanavir

(2008) Cheri E. Klein et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Significant Decrease in Nelfinavir Systemic Exposure After Omeprazole Coadministration in Healthy Subjects

(2007) Annie F Fang et al.   PHARMACOTHERAPY