Integration of dissolution into physiologically-based pharmacokinetic models III: PK-Sim®

Simulated Biological Fluids with Possible Application in Dissolution Testing

(2015) Margareth R. C. Marques et al.   DISSOLUTION TECHNOLOGIES

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

(2011) Malcolm Rowland et al.   Annual Review of Pharmacology and Toxicology

An update on computational oral absorption simulation

(2011) Jennifer B Dressman et al.   Expert Opinion on Drug Metabolism & Toxicology

Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1: Oral solutions

(2011) Kirstin Thelen et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Evolution of a Detailed Physiological Model to Simulate the Gastrointestinal Transit and Absorption Process in Humans, Part II: Extension to Describe Performance of Solid Dosage Forms

(2011) Kirstin Thelen et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A Computational Systems Biology Software Platform for Multiscale Modeling and Simulation: Integrating Whole-Body Physiology, Disease Biology, and Molecular Reaction Networks

(2011) Thomas Eissing   Frontiers in Physiology

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

(2010) P Zhao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mechanism-based prediction of particle size-dependent dissolution and absorption: Cilostazol pharmacokinetics in dogs

(2010) Stefan Willmann et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Whole-body physiologically based pharmacokinetic population modelling of oral drug administration: inter-individual variability of cimetidine absorption

(2010) Stefan Willmann et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Population-Based Mechanistic Prediction of Oral Drug Absorption

(2009) Masoud Jamei et al.   AAPS Journal

Analysis of Nifedipine Absorption from Soft Gelatin Capsules Using PBPK Modeling and Biorelevant Dissolution Testing

(2009) Kirstin Thelen et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Towards Quantitative Prediction of Oral Drug Absorption

(2008) Jennifer B Dressman et al.   CLINICAL PHARMACOKINETICS

Modelling iterative compound optimisation using a self-avoiding walk

(2008) John Delaney   DRUG DISCOVERY TODAY

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

(2008) Andrea N Edginton et al.   Expert Opinion on Drug Metabolism & Toxicology