Article
Clinical Neurology
Ya-Mei Tzeng, I-Hsun Li, Hui-Han Kao, Jui-Hu Shih, Chin-Bin Yeh, Yi-Hsien Chen, Li-Ting Kao
Summary: This study found that antidepressants can reduce the subsequent risk of psoriasis in patients with major depressive disorder, particularly selective serotonin reuptake inhibitors and low-dose antidepressants have significant protective effects.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Cell Biology
Colby E. Witt, Sergio Mena, Lauren E. Honan, Lauren Batey, Victoria Salem, Yangguang Ou, Parastoo Hashemi
Summary: This study used fast-scan controlled-adsorption voltammetry (FSCAV) to measure low-periodicity fluctuations in serotonin levels in mouse hippocampi. Correlation analyses revealed that these oscillations were present in vivo but not in vitro, and were not significantly different under different conditions (sex and stress paradigm). The administration of a selective serotonin reuptake inhibitor resulted in a shift in the frequency of the oscillations, suggesting regulation by transporter proteins. Additionally, the experimental parameters of FSCAV were optimized for higher temporal resolution, leading to more pronounced shifts in oscillation frequency and decreased amplitude.
Article
Pharmacology & Pharmacy
Juhee Lim, Yeojin Bang, Kyeong-Man Kim, Hyun Jin Choi
Summary: This study investigated the effects of differentiation on the serotonergic neuronal phenotype of the mouse hippocampal neuronal cell line HT22. The results showed that differentiation promoted neurite outgrowth and upregulation of N-methyl-D-aspartate receptor and choline acetyltransferase in HT22 cells. Furthermore, proteins required for serotonergic neurotransmission were significantly upregulated in differentiated HT22 cells. These findings suggest that differentiated HT22 cells have enhanced functional serotonergic properties and could be used for assessing the efficacy of antidepressant 5-HT reuptake inhibitors.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Psychiatry
Yukitoshi Izumi, Angela M. Reiersen, Eric J. Lenze, Steven J. Mennerick, Charles F. Zorumski
Summary: By studying rat hippocampal slices, it was found that fluvoxamine and other selective serotonin reuptake inhibitors (SSRIs) can overcome the inhibition of long-term potentiation (LTP) caused by acute inflammatory stimulus, possibly through activation of Sigma 1 receptors (S1Rs) and synthesis of neurosteroids. These SSRIs may be beneficial in diseases involving inflammatory stress.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Raymond W. Lam, Hee-Kit Wong, Ramruttun A. Kumarsing, Anna N. Chua, Roger C. Ho, Roger S. McIntyre, Cyrus S. Ho
Summary: This study aimed to investigate the effect of fluoxetine on bone microarchitecture and mechanical properties in a rodent model of depression. The results showed that fluoxetine did not significantly affect trabecular number compared to the control group, but had a significant reduction when compared to the group with depression induced by chronic mild stress (CMS). Fluoxetine also significantly increased the cross-sectional area, trabecular bone area, structural strength, and osteoblasts/bone area.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Nam-Ju Ji, Seung-Yeon Jeon, Kyung-Joon Min, Myung Ki, Weon-Young Lee
Summary: This study investigated the relationship between the type of initial antidepressants and treatment adherence in outpatients with new onset depression. The results showed a significant association between initial antidepressant type and treatment adherence during the first three- and six-month treatment periods for employed and self-employed patients newly diagnosed with major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Abeer Essam Hakam, Gabriela Vila, Poliana Mendes Duarte, Marcia Phemba Mbadu, Dannia Sulaiman Ai Angary, Ikramuddin Aukhil, Rodrigo Neiva, Helio Doyle Pereira da Silva, Jia Chang
Summary: This study found that patients taking antidepressants are at higher risk of dental implant failure, with users of SNRI and TCA having the highest risk of implant loss. However, conclusions about TCA are based on a limited number of cases.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Multidisciplinary Sciences
Yun Han Kwon, Suhrid Banskota, Huaqing Wang, Laura Rossi, Jensine A. Grondin, Saad A. Syed, Yeganeh Yousefi, Jonathan D. Schertzer, Katherine M. Morrison, Michael G. Wade, Alison C. Holloway, Michael G. Surette, Gregory R. Steinberg, Waliul I. Khan
Summary: Chronic exposure to Allura Red AC increases susceptibility to colitis in mice dependent on the serotonin biosynthetic enzyme TPH1. Intermittent exposure, more typical for humans, does not increase susceptibility. The impact of chronic exposure to this common synthetic colorant on colitis is mediated through colonic 5-HT levels and is microbiota-dependent and -independent.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Mu Li, Qingyang Chen, Yuan-Wei Zhang
Summary: Conformational changes in the serotonin transporter (SERT) play a critical role in its transport mechanism. This study presents a cell-based method for studying conformational changes in SERT using fluorescent substrates and fluorescence imaging analysis. The results provide insights into the conformational mechanism of SERT and demonstrate the efficacy of the cell-based fluorometric method in studying monoamine transporters and therapeutic agents for psychiatric disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
George M. Anderson, Isabella Bruno-Pacella
Summary: This article assesses the bioeffect of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) and compares them using neuroimaging and in vitro measurements. The study finds that these drugs typically result in a 70-90% reduction in platelet serotonin (5-HT) content. The bioeffect is similar among different types of SSRIs and SNRIs and is consistent with other assessment methods.
PSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Brian P. Brennan, Jiana Schnabel, Harrison G. Pope, James I. Hudson
Summary: The use of serotonergic antidepressants in hospitalized COVID-19 patients did not show a significant difference in outcomes compared to those not using antidepressants, based on the results of a study that aimed to replicate previous findings.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Abeer Essam Hakam, Poliana Mendes Duarte, Marcia Phemba Mbadu, Ikramuddin Aukhil, Helio Doyle Pereira da Silva, Jia Chang
Summary: This study found that the use of antidepressant medications was associated with higher alveolar bone levels and less clinical attachment loss in patients with periodontitis. Specifically, only SSRI class users and multiple-class users showed significantly less periodontal breakdown.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Mu Li, Xintong Zhang, Sixiang Chen, Hanhe Liu, Yuan-Wei Zhang
Summary: This study reveals a novel structural characteristic of the neurotransmitter sodium symporter (NSS) family, specifically in TuriSERT, and demonstrates the unique substrate binding site and 1:1 stoichiometry of sodium-substrate binding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rachel A. Davies, Vy T. Nguyen, Jose M. Eltit, Richard A. Glennon
Summary: a-Pyrrolidinohexiophenone (a-PHP) is a synthetic cathinone central stimulant that is structurally similar to a-PVP. It is a potent dopamine transporter (DAT) reuptake inhibitor. In this study, a series of 4-substituted a-PHP analogues were examined, and most showed selective DAT reuptake inhibition with a narrow range of potency. The 4-CF3 analogue was an outlier with reduced potency and selectivity. QSAR study was not possible due to limited empirical results.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Michal Wicinski, Bartlomiej J. Kaluzny, Slawomir Liberski, Daria Marczak, Jakub J. Kaluzny
Summary: Acute angle closure (AAC) is a rare but serious ophthalmological condition, often associated with the use of selective serotonin reuptake inhibitors (SSRIs). AAC in individuals receiving SSRIs is mainly caused by pupillary block mechanism, but may also result from other mechanisms such as uveal effusion.
APPLIED SCIENCES-BASEL
(2021)