Article
Chemistry, Multidisciplinary
Woo Jin Lee, Wan Yi Li, Sang Woo Lee, Sung Keun Jung
Summary: The extract of Soroseris hirsuta demonstrates anti-inflammatory and antioxidant effects on LPS-activated murine macrophages, inhibiting nitric oxide expression and key signaling pathways related to inflammation and oxidative stress.
APPLIED SCIENCES-BASEL
(2021)
Article
Immunology
Chathuri Kaushalya Marasinghe, Won-Kyo Jung, Jae-Young Je
Summary: This study found that phloroglucinol, a secondary metabolite of marine seaweeds, has potential anti-inflammatory effects by inhibiting oxidative stress, reducing pro-inflammatory cytokine secretion and prostaglandin production in LPS-stimulated RAW264.7 macrophages. These effects may be mediated through the activation of the AMPK/Nrf2/HO-1 pathway.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Maria G. Detsika, Elias A. Lianos
Summary: Heme oxygenase-1 has a new cytoprotective role by regulating the complement control protein, which helps prevent kidney injury. Targeting HO-1 induction in specific cells could be a novel approach to attenuate complement-dependent kidney diseases.
Article
Medicine, General & Internal
Hui-Wen Lin, Yi-Ju Lee, Deng-Jye Yang, Ming-Chang Hsieh, Ching-Chung Chen, Wei-Li Hsu, Yuan-Yen Chang, Cheng-Wei Liu
Summary: The study showed that the Flos Lonicerae Japonicae water extract (FLJWE) and luteolin effectively reduced inflammation in PRV-infected cells by inhibiting NF-kappa B pathway and inducing HO-1 expression, making them potential antiviral agents.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Zhen Liang, Zhaoshi Zheng, Qi Guo, Meng Tian, Jing Yang, Xiu Liu, Xiaojuan Zhu, Songyan Liu
Summary: This study investigates the role of hypoxia-inducible factor (HIF)-1 alpha/heme oxygenase (HO)-1 in hippocampal neuron ferroptosis during epilepsy. The results suggest that there are metabolic differences between epilepsy patients and healthy individuals, with increased oxidative stress, heightened bilirubin, and augmented iron metabolism in epileptic blood. The active HIF-1 pathway in epileptic pathogenesis and perturbations in HIF-1 alpha signaling are reinforced by the analysis. The study implicates that HIF-1 alpha/HO-1 potentially regulates hippocampal neuronal ferroptosis, iron metabolism, and oxidative stress, thereby promoting the propagation of epilepsy.
Article
Oncology
Rui Li, Xin Zeng, Meihua Yang, Xiaohui Xu, Jinmei Feng, Liming Bao, Bingqian Xue, Xin Wang, Yi Huang
Summary: The study found that DPP-4i may accelerate murine breast cancer metastasis by promoting an oncogenic ROS-NRF2-HO-1 axis, inducing aberrant oxidative stress through ROS overproduction. Therefore, this research not only reveals the oncogenic role of DPP-4i in breast cancer progression but also provides a new strategy to alleviate the adverse effects of DPP-4i by targeting HO-1.
FRONTIERS IN ONCOLOGY
(2021)
Article
Environmental Sciences
Jinlong Li, Yuanyuan Guo, Xiaoxu Duan, Bing Li
Summary: Inorganic arsenic induces immune tolerance in murine dendritic cells by down-regulating the expression of phenotypic molecules, pro-inflammatory factors, and T-lymphocyte cytokines. The immunosuppressive property of arsenic may be partially mediated by the HO-1 pathway, contributing to the development of infections and malignant diseases.
Review
Biochemistry & Molecular Biology
Ayleen Fernandez-Fierro, Samanta C. Funes, Mariana Rios, Camila Covian, Jorge Gonzalez, Alexis M. Kalergis
Summary: The heme oxygenase (HO) system involves three isoforms, with HO-1 being the most studied and overexpression of this enzyme promoting anti-inflammatory products. However, overexpression of HO leading to neonatal jaundice has prompted the development of inhibitors. Various types of inhibitors have been identified, including competitive and non-competitive ones, with potential medical implications in metabolic diseases and immune-mediated diseases such as cancer and Alzheimer's disease. Selective inhibition of HO isoforms may contribute to the treatment of these ailments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiangyun Li, Jianbo Yu, Lirong Gong, Yuan Zhang, Shuan Dong, Jia Shi, Cui Li, Yuting Li, Yanfang Zhang, Haibo Li
Summary: Sepsis-induced acute lung injury leads to oxidative stress, inflammation, apoptosis, and changes in Golgi morphology. Activating the HO-1 pathway can alleviate Golgi stress and oxidative stress, providing a therapeutic target for treating acute lung injury.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Medicinal
Wei Wang, Shou-Kai Wang, Qi Wang, Zhe Zhang, Bo Li, Zi-Dan Zhou, Jian-Feng Zhang, Chao Lin, Ting-Xiao Chen, Zhen Jin, You-Zhi Tang
Summary: A series of diclofenac hybrid molecules were synthesized and evaluated for their ability to inhibit NO in LPS-induced RAW 264.7 macrophage cells. Among them, compound 1 showed the highest NO-inhibitory ability (approximately 66%) with no significant cytotoxicity. Compound 1 also exhibited superior NF-KB-inhibitory ability compared to diclofenac by activating the Nrf2/HO-1 signaling pathway. Additionally, compound 1 demonstrated promising anti-inflammatory effects in a DSS-induced mice model of colitis and showed lower ulcerogenic potential compared to diclofenac in rats. The diclofenac-eugenol hybrid (compound 1) has the potential to serve as a novel anti-inflammatory agent due to its ability to inhibit the NF-KB signaling pathway and activate HO-1 expression, both in vitro and in vivo, without toxicity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Rheumatology
Chhanda Biswas, Niansheng Chu, Thomas N. Burn, Portia A. Kreiger, Edward M. Behrens
Summary: Activation of the HO-1/IL-10 axis can significantly ameliorate MAS disease activity. Treatment with MMF can increase HO-1 levels in a murine MAS model, leading to improvements in disease parameters.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hwan Lee, Zhiming Liu, Chi-Su Yoon, Linsha Dong, Wonmin Ko, Eun-Rhan Woo, Dong-Sung Lee
Summary: The study identified phenylheptatriyne from Coreopsis lanceolata as an anti-neuroinflammatory and anti-inflammatory compound, showing inhibition of inflammatory cytokine secretion and nitric oxide production. This compound may have therapeutic potential for neuroinflammation-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yingjie Zhu, Chunyan Wang, Jingjing Luo, Shucheng Hua, Dan Li, Liping Peng, Hongmei Liu, Lei Song
Summary: Zingerone treatment alleviated oxidative stress and inflammation in asthma models by upregulating the AMPK/Nrf2/HO-1 signaling pathway.
Article
Multidisciplinary Sciences
Johannes J. Kovarik, Andrea Bileck, Gerhard Hagn, Samuel M. Meier-Menches, Tobias Frey, Anna Kaempf, Marlene Hollenstein, Tarik Shoumariyeh, Lukas Skos, Birgit Reiter, Marlene C. Gerner, Andreas Spannbauer, Ena Hasimbegovic, Doreen Schmidl, Gerhard Garhofer, Mariann Gyongyosi, Klaus G. Schmetterer, Christopher Gerner
Summary: In order to understand the pathophysiology of long COVID-19 syndrome (LCS), an exploratory study was conducted using blood plasma samples from three groups: healthy vaccinated individuals without SARS-CoV-2 exposure, asymptomatic recovered patients at least three months after SARS-CoV-2 infection, and symptomatic patients at least three months after SARS-CoV-2 infection with LCS. The study found that recovered individuals had slightly elevated pro-inflammatory cytokine levels compared to patients with LCS. Additionally, LCS patients showed low levels of acute phase proteins and macrophage-derived secreted proteins, but high levels of anti-inflammatory oxylipins and osmolytes. The study proposes that alternatively polarized macrophages may be a major contributor to these molecular alterations.
Article
Pharmacology & Pharmacy
Hye-Eun Choi, Eun Jeong Jeon, Dong Young Kim, Mi Jin Choi, Hana Yu, Jea Il Kim, Hyae Gyeong Cheon
Summary: This study investigated the effects of sodium salicylate on adipocyte browning and found that it can induce browning by up-regulating HO-1 and promoting M2 polarization.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)