Review
Biochemistry & Molecular Biology
Pooja Mittal, Sujata Singh, Rajesh Sinha, Anju Shrivastava, Archana Singh, Indrakant Kumar Singh
Summary: MCL-1 plays a crucial role in cancer cells and its overexpression is associated with drug resistance. Advancements in selective MCL-1 inhibitors offer new therapeutic strategies for cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Medicine, Research & Experimental
Hyun-Ju Yu, Ji-Ae Shin, Su-Jung Choi, Sung-Dae Cho
Summary: Podophyllotoxin (PPT) inhibits the growth of human oral squamous cell carcinoma (OSCC) cells and induces apoptosis by lowering mitochondrial membrane potential and reducing Mcl-1 protein expression.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Manabu Yoshikawa, Yong-Woon Han, Hirofumi Fujii, Shu Aizawa, Tatsuya Nishino, Masayuki Ishikawa
Summary: In plants, siRNAs are amplified through cleavage by RISCs and play a crucial role in target repression. RDR6, SGS3, and SDE5 work together to ensure the specificity and efficiency of siRNA amplification and target inhibition in plants.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Medicine, Research & Experimental
Xing Lu, Hong Liang, Chris Orvig, Zhen-Feng Chen
Summary: Mcl-1, a member of the Bcl-2 family of proteins, plays a key role in regulating the intrinsic pathway of apoptosis and is correlated with cancer progression and drug resistance. Developing inhibitors of Mcl-1 is essential for effective cancer therapy.
CURRENT MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Malgorzata Opydo, Anna Mlyczynska, Ewa Mlyczynska, Agnieszka Rak, Elzbieta Kolaczkowska
Summary: Acute myeloid leukemia (AML) is a blood cancer characterized by abnormal cell proliferation and inhibition of apoptosis. The MCL-1 protein plays a critical role in the survival of AML cells. This study investigated the effects of a specific MCL-1 inhibitor, S63845, alone and in combination with other inhibitors, on AML cell lines. The results showed that S63845 decreased cell viability and induced apoptosis, and combined treatment enhanced apoptosis and induced cell differentiation. These findings suggest the potential use of MCL-1 inhibitors in combination with other pro-survival protein inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Shady I. Tantawy, Aloke Sarkar, Stefan Hubner, Zhi Tan, William G. Wierda, Abdelraouf Eldeib, Shuxing Zhang, Steven Kornblau, Varsha Gandhi
Summary: This study aims to investigate the mechanism of MCL-1i-induced Mcl-1 protein stability. Both in vivo and in vitro experiments demonstrate that MCL-1i-induced Mcl-1 protein stability is mainly associated with defective Mcl-1 ubiquitination and concurrent apoptosis induction. Additionally, MCL-1i also enhances Mcl-1Thr163 phosphorylation via ERK pathway, contributing to Mcl-1 stability.
CLINICAL CANCER RESEARCH
(2023)
Article
Cell Biology
Albert Manzano-Munoz, Clara Alcon, Pablo Menendez, Manuel Ramirez, Felix Seyfried, Klaus-Michael Debatin, Luder H. Meyer, Josep Samitier, Joan Montero
Summary: Multiple targeted therapies are being explored for improving clinical outcome in pediatric and young adult BCP-ALL, especially for relapsed patients. Using DBP evaluation, MEK inhibitor trametinib and multi-target tyrosine kinase inhibitor sunitinib were found to enhance apoptotic priming in NRAS-mutant and KMT2A-rearranged cell lines with high FLT3 expression, respectively.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yuqing Duan, Yunlong Jia, Jiali Wang, Tianxu Liu, Zishuo Cheng, Meixiang Sang, Wei Lv, Jing Qin, Lihua Liu
Summary: The study reveals that upregulated lncRNA DGCR5 promotes proliferation, migration, and invasion of ESCC cells while inhibiting apoptosis. DGCR5 directly binds to SRSF1, increasing its stability and initiating important isoform switch of Mcl-1. Cell-derived xenograft model confirms DGCR5's role in facilitating ESCC tumorigenesis.
CELL DEATH & DISEASE
(2021)
Article
Genetics & Heredity
Beatrice Tolksdorf, Sina Zarif, Juergen Eberle, Ahmet Hazini, Babette Dieringer, Franziska Jonsson, Florian Kreppel, Jens Kurreck, Henry Fechner
Summary: Silencing of Mcl-1 can overcome TRAIL resistance in melanoma cells and enhance the cytotoxicity of TRAIL-expressing adenovirus. The increase of apoptosis induced by Mcl-1 silencing is the main mechanism for this effect, which occurs in both TRAIL-sensitive and TRAIL-resistant melanoma cells.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Oncology
Yue Wang, Deying Wang, Yao Wang, Haotian Yang, Guan Wang, Shuangshuang Wu
Summary: The treatment of acute myeloid leukemia (AML) remains a clinical challenge, however, research shows that inhibiting the anti-apoptotic protein MCL-1 can increase apoptosis in AML cells induced by the chemotherapeutic drug Ara-C, providing a new approach for the clinical treatment of AML.
Article
Oncology
Wei Wu, Xiaonian Cao, Luxia Mo
Summary: The study demonstrates that KDM4D is overexpressed in AML and can promote AML progression by regulating the expression of MCL-1, correlating with poor overall survival in AML patients. This suggests that KDM4D may serve as a novel target for the treatment of AML.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Muhammad R. Suleiman, Hanxun Wang, Danxia Huang, Huibin Wang, Johnson Joseph, Tianci Huang, Fengjiao Zhang, Jian Wang, Maosheng Cheng
Summary: Mcl-1 protein is a significant target for cancer therapeutics, with two potential inhibitors identified in this study through screening and evaluation of drug-like compounds. These compounds showed a tendency to inhibit leukemia cell viability with Mcl-1 expressions, suggesting their potential as effective anticancer agents.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Review
Biochemistry & Molecular Biology
Jelena Rakocevic, Milan Dobric, Rada Vucic, Matija Furtula, Ivan Zaletel, Katarina Milutinovic, Ana Ilijevski, Milica Labudovic Borovic, Miloje Tomasevic, Milos Bajcetic
Summary: The PCSK9 enzyme interferes with LDL cholesterol metabolism. Inhibiting PCSK9 lowers LDL cholesterol levels. Monoclonal antibodies targeting PCSK9 have shown strong and persistent effects, but require frequent subcutaneous injections. Inclisiran, a synthesized siRNA, inhibits PCSK9 synthesis and provides sustained LDL cholesterol lowering with twice-yearly applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Vijendra Singh, Mohammed Hafiz Uddin, Jeffrey A. Zonder, Asfar S. Azmi, Suresh Kumar Balasubramanian
Summary: While mechanistic studies have shed light on the molecular mechanisms of AML and led to the development of new targeted therapies, resistance remains a significant issue in AML treatment. The exploration of circRNA in AML biology and therapy resistance shows promise in providing new insights and potential solutions to managing this disease.
Review
Chemistry, Multidisciplinary
Kun Li, Mei Lu, Xinhua Xia, Yuanyu Huang
Summary: Photothermal therapy (PTT) is a new treatment technique that has attracted worldwide attention in cancer treatment due to its excellent absorption ability, easy regulation, and biodegradability. The synergistic therapy of photothermal and RNA interfering (RNAi) has recently become a hot research topic, showing potential in enhancing the therapeutic effect against tumors.
CHINESE CHEMICAL LETTERS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Shin-ichi Yamada, Takumi Hasegawa, Kohei Okuyama, Nobuhiro Yamakawa, Masaya Okura, Masao Hashidume, Souichi Yanamoto, Masaya Akashi, Tadaaki Kirita, Masahiro Umeda, Hiroshi Kurita
CLINICAL ORAL INVESTIGATIONS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Kazuaki Miyagawa, Susumu Tanaka, Sachie Hiroishi, Yutaka Matsushita, Shumei Murakami, Mikihiko Kogo
CLINICAL ORAL INVESTIGATIONS
(2020)
Article
Dentistry, Oral Surgery & Medicine
S. Yanamoto, Y. Denda, Y. Ota, T. Hasegawa, M. Akashi, M. Okura, S. -I. Yamada, H. Kurita, N. Yamakawa, T. Kirita, M. Ueda, M. Umeda
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2020)
Article
Neurosciences
Soju Seki, Susumu Tanaka, Saori Yamada, Tadataka Tsuji, Akifumi Enomoto, Yudai Ono, Scott H. Chandler, Mikihiko Kogo
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Katsuhiko Amano, Daisuke Okuzaki, Tomonao Aikawa, Mikihiko Kogo
Article
Nursing
Eriko Matsunaka, Yukari Kumagai, Miho Ike, Sachiko Takano, Mikihiko Kogo
JAPAN JOURNAL OF NURSING SCIENCE
(2020)
Article
Multidisciplinary Sciences
Emiko Tanaka Isomura, Makoto Matsukawa, Kiyoko Nakagawa, Ryo Mitsui, Mikihiko Kogo
Article
Medicine, General & Internal
Atsushi-Doksa Lee, Kazuma Harada, Susumu Tanaka, Yusuke Yokota, Takashi Mima, Akifumi Enomoto, Mikihiko Kogo
WORLD JOURNAL OF CLINICAL CASES
(2020)
Article
Oncology
Yoshihide Ota, Tadahide Noguchi, Eiichiro Ariji, Chihiro Fushimi, Nobukazu Fuwa, Hiroyuki Harada, Takafumi Hayashi, Ryuichi Hayashi, Yoshitaka Honma, Masahiko Miura, Taisuke Mori, Hitoshi Nagatsuka, Masaya Okura, Michihiro Ueda, Narikazu Uzawa, Kazuhiro Yagihara, Hisao Yagishita, Masashi Yamashiro, Souichi Yanamoto, Tadaaki Kirita
Summary: This article emphasizes the importance of standardizing basic concepts and rules for the treatment of oral cancer. It highlights the need for detailed rules specific to oral cancer characteristics to contribute to its diagnosis, treatment, and research progress. The article also mentions the revision of general rules for oral cancer as per the UICC 8th edition.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Tomofumi Naruse, Souichi Yanamoto, Mitsunobu Otsuru, Nobuhiro Yamakawa, Tadaaki Kirita, Yukari Shintani, Tatsushi Matsumura, Masaya Okura, Masashi Sasaki, Yoshihide Ota, Shin-ichi Yamada, Hiroshi Kurita, Masahiro Umeda
Summary: The study suggests that the weekly cetuximab plus paclitaxel regimen may be a treatment option for patients with recurrent or metastatic oral squamous cell carcinoma that is refractory to platinum-based chemotherapy or progressive disease after chemotherapy. Adverse events were tolerable and manageable, with overall efficacy being relatively promising.
ANTICANCER RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Kyoko Kurioka, Katsuhiko Amano, Kazuma Harada, Masaya Okura, Mikihiko Kogo, Susumu Tanaka
Summary: Melanotic neuroectodermal tumor of infancy (MNTI) is a rare head and neck tumor that is typically diagnosed within the first year of age. Although classified as a benign tumor, some reports suggest local relapse or distant metastasis similar to a malignant tumor. This case report presents the secondary case of a 3-month-old boy with maxillary MNTI and a good prognosis after 10 years of follow-up.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ryuichi Itoh, Shin-ichi Yamada, Takumi Hasegawa, Nobuhiro Yamakawa, Yuya Denda, Hiroki Otagiri, Masaya Okura, Souichi Yanamoto, Masaya Akashi, Tadaaki Kirita, Yoshihide Ota, Masahiro Umeda, Hiroshi Kurita
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Susumu Tanaka, Masataka Higuchi, Soju Seki, Akifumi Enomoto, Mikihiko Kogo
JOURNAL OF ORAL SCIENCE
(2020)
Article
Surgery
Emiko Tanaka Isomura, Kiyoko Nakagawa, Ryo Mitsui, Yosuke Shogen, Takeshi Fujita, Mikihiko Kogo
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2020)
Article
Dentistry, Oral Surgery & Medicine
Yuko Kondo, Kaori Oya, Manabu Sakai, Chisato Fujiwara, Fumiaki Tojo, Yu Usami, Yasuo Fukuda, Mikihiko Kogo, Mitsunobu Kishino
ORAL SCIENCE INTERNATIONAL
(2020)
