Article
Materials Science, Multidisciplinary
Sanjay Sharma, Abhishek Kanugo, Juilee Gaikwad
Summary: Tazarotene's poor solubility and bioavailability have limited its applications for the treatment of psoriasis and acne. A study was conducted to develop solid lipid nanoparticles (SLN) of Tazarotene for effective topical delivery, with glyceryl monostearate identified as the best lipid and a combination of tween-span as a surfactant for SLNs. The optimized batch showed a zeta potential of -10.3 Mv and a drug release of 59% to 77% after 6 hours.
MATERIALS TECHNOLOGY
(2022)
Review
Chemistry, Medicinal
Maria Apostolou, Sulaf Assi, Amos A. Fatokun, Iftikhar Khan
Summary: This study aimed to identify the effects of lipids on the physicochemical properties of Nanostructured Lipid Carriers (NLCs) through literature review. The size of solid lipid and its complexity tend to affect the particle size of the final formulation, while the ratio of solid to liquid lipid can influence the particle size and stability of NLCs. Entrapment efficiency is highly dependent on drug-lipid interaction and solubility, with no direct correlation found between lipids used and zeta potential.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Cheng Wang
Summary: Nanomedicine represents a promising approach for improving drug delivery systems (DDSs), and the development of cell/tissue-based lipid carriers is a promising strategy.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Analytical
Tienan Gao, Cong Xu, Ming-Li Chen, Jian-Hua Wang, Lanqun Mao, Ping Yu
Summary: This study focuses on the relationship between surface charge and dynamic behaviors of particles at the orifice of a nanopipette. It discovers a parameter, angle theta, that can quantify the surface charge of single particles and distinguish gold and silica nanoparticles with different surface charges.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Chemical
Samah Benamer Oudih, Djamel Tahtat, Assia Nacer Khodja, Mohamed Mahlous, Yasmina Hammache, Abd-Errahim Guittoum, Salima Kebbouche Gana
Summary: A fractional factorial design was employed to optimize the production process of chitosan nanoparticles (ChNs) and analyze their size and zeta potential. The size of ChNs was influenced by the initial concentration and molecular weight of chitosan, TPP concentration, and stirring speed. The zeta potential was significantly affected by the chitosan molecular weight, chitosan concentration, and stirring speed. Analysis techniques such as FTIR, XRD, and DSC were used to characterize the ChNs and evaluate the crosslinking effect on their crystal structure.
POLYMER ENGINEERING AND SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Lili Cui, Morag R. Hunter, Silvia Sonzini, Sara Pereira, Steven M. Romanelli, Kai Liu, Weimin Li, Lihuan Liang, Bin Yang, Najet Mahmoudi, Arpan S. Desai
Summary: Researchers observed a significant improvement in mRNA functional delivery in vivo by automated LNPs compared to LNPs prepared using traditional microfluidics techniques. The data suggest that the mRNA loading per particle is a critical factor in enhancing mRNA functional delivery of automated LNPs.
Article
Pharmacology & Pharmacy
Hamdan N. Alajami, Ehab A. Fouad, Abdelkader E. Ashour, Ashok Kumar, Alaa Eldeen B. Yassin
Summary: This work optimized a colon delivery system using solid lipid nanoparticles (SLN) loaded with celecoxib (CXB) to enhance its anticancer activity. The prepared SLN exhibited nanoscale particle sizes, high zeta-potential values, and high entrapment efficiency. One formulation showed significant anticancer activity in all tested cancer cell lines.
Article
Environmental Sciences
Jianguo Liu, Xuezheng Yu, Ying Wang, Yunping Han, Yingnan Cao, Zixuan Wang, Jinxin Lyu, Ziyu Zhou, Ying Yan, Tianlong Zheng
Summary: The release of bioaerosols from solid waste dumps in rural China poses a potential health risk to the local population. This study investigated the emission and dispersion characteristics of bioaerosols from rural solid waste-treatment facilities in northwest China. The concentrations and size distributions of airborne bioaerosols were measured, and the microbial composition was analyzed using high-throughput sequencing. The study found that bioaerosols near the solid waste contained high concentrations of bacteria and fungi, and winter-indicator species with potential pathogenicity were detected. Inhalation was identified as the main exposure route for local residents, particularly children. The results highlight the health risk posed by bioaerosols in rural solid waste dumps and the need for appropriate risk assessment criteria and control measures.
ENVIRONMENTAL POLLUTION
(2023)
Article
Chemistry, Multidisciplinary
Jean-Baptiste Fleury, Vladimir A. Baulin, Xavier Le Guevel
Summary: Lateral diffusion of nano-objects on lipid membranes is a crucial process in cell biology. Recent studies indicate that nanoparticle diffusion is affected by membrane proteins and deviates from Brownian motion. The presence of a protein corona on protein-coated nanoparticles leads to anomalous superdiffusion.
Article
Engineering, Aerospace
Junlong Wang, Ningfei Wang, Xiangrui Zou, Wei Dong, Chao Wang, Lei Han, Baolu Shi
Summary: The accumulation of slag in solid rocket motors has a significant impact on engine safety. This study investigates the characteristics and influencing factors of slag deposition through experiments and numerical simulation. A deposition prediction model is developed to explore the effects of burning surface regression, particle size, detaching position, and nozzle structure. The results indicate that these parameters play a crucial role in slag accumulation.
AEROSPACE SCIENCE AND TECHNOLOGY
(2022)
Review
Engineering, Chemical
Claure N. Lunardi, Anderson J. Gomes, Fellipy S. Rocha, Jacopo De Tommaso, Gregory S. Patience
Summary: Zeta potential is a parameter expressing electrochemical equilibrium between particles and liquids, with applications in various fields. Proper characterization of nanoparticles, including information on size, surface charge, stability, and agglomeration behavior, is essential for developing therapeutic nanoformulations. Challenges in this approach include inadequate knowledge of standards, data interpretation, and laboratory practices.
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
(2021)
Article
Pharmacology & Pharmacy
Taha Umair Wani, Altaf Hussain Pandith, Faheem A. Sheikh
Summary: The review highlights the importance of chitosan in biomedical applications, discussing its physicochemical properties and their impact on formulation development. The charge density and physicochemical properties of chitosan play a crucial role in determining the effectiveness of its applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Kakon Nag, Md Enamul Haq Sarker, Samir Kumar, Habiba Khan, Sourav Chakraborty, Md Jikrul Islam, Juwel Chandra Baray, Maksudur Rahman Khan, Asif Mahmud, Uttam Barman, Eleus Hussain Bhuiya, Mohammad Mohiuddin, Naznin Sultana
Summary: We have developed a unique platform to continuously manufacture lipid nanoparticles (LNPs) with specific sizes that meet pharmaceutical regulatory requirements. Through the use of design of experiment methodology, we have identified critical process parameters and confirmed the robustness of the platform in producing LNPs with specific sizes within the design range. This technology has been successfully scaled up and validated, showing equivalent biological responses in R&D, pilot, and production batches of a candidate SARS-CoV-2 mRNA vaccine.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Mikolaj Dembek, Szymon Bocian, Boguslaw Buszewski
Summary: Zeta potential is a surface characteristic formed on the solid surface and liquid interface, which can be used to describe the surface properties of materials. In this study, four homemade stationary phases containing phosphate groups were investigated based on their surface zeta potential. The majority of cases showed negative zeta potential values, but positive zeta potential was observed in some solvents. It was also found that the type of silica gel used for the stationary phase synthesis did not affect the zeta potential.
Article
Chemistry, Multidisciplinary
Afang Ji, Minghao Xu, Yunzhi Pan, Lu Diao, Lin Ma, Li Qian, Junping Cheng, Mi Liu
Summary: This study compares the impact of different particle sizes of lipid particles on delivering mRNA vaccines and inducing immune responses. The results show that lipid microparticles (LMPs) have similar efficacy with lipid nanoparticles (LNPs) in delivering mRNA and preventing cancer. Immune adjuvants can improve the efficacy of mRNA vaccines. Considering the delivery efficiency and endocytosis, lipid microparticles have the potential to be an alternative delivery system for mRNA vaccines.
PHARMACEUTICAL RESEARCH
(2023)
