Article
Multidisciplinary Sciences
K. G. Aghila Rani, Nelson C. Soares, Betul Rahman, Hamza M. Al-Hroub, Mohammad H. Semreen, Sausan Al Kawas
Summary: The study investigates the biochemical and pathophysiological changes caused by medwakh smoking and examines the salivary metabolomics profile of medwakh smokers. Analysis of saliva samples reveals 37 uniquely and differentially abundant metabolites and 20 differentially altered metabolic pathways in medwakh smokers. The study highlights the association of altered redox homeostasis, metabolic pathways, antioxidant system, and CRP levels with the distinctive saliva metabolomics profile in medwakh smokers. Further research is needed to explore the diagnostic utility of these altered metabolites in larger cohorts.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Ray-Yu Yang, Abel Wend-Soo Zongo, Yu-Chen Chen, Meng-Tsan Chiang, Daniel Zogona, Chun-Yin Huang, Hsien-Tsung Yao
Summary: This study investigates the effects of green and purple sweet potato leaves on hepatic xenobiotic-metabolizing enzymes, membrane transporters, and benzo[a]pyrene metabolism and accumulation in rats. The results indicate that sweet potato leaves can increase hepatic antioxidant activity, facilitate xenobiotic detoxification, and reduce benzo[a]pyrene accumulation.
Article
Medicine, Research & Experimental
Ahmed Abdeen, Amira Samir, Ashraf Elkomy, Mohamed Aboubaker, Ola A. Habotta, Ahmed Gaber, Walaa F. Alsanie, Omnia Abdullah, Heba A. Elnoury, Bodour Baioumy, Samah F. Ibrahim, Afaf Abdelkader
Summary: The study aimed to evaluate the therapeutic effect of date palm extract against gentamicin-induced hepato-renal injury. It was found that date palm extract could alleviate the damage caused by gentamicin to the liver and kidneys, possibly due to its high content of antioxidant and anti-inflammatory components.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemical Research Methods
Alexander Bollenbach, Dimitrios Tsikas
Summary: This study reports a novel two-step derivatization procedure for the specific quantitative measurement of GSH by GC-MS, demonstrating the linearity of the method and minimal interference from other substances.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Ting-Li Tang, Yan Yang, Lin Guo, Shuang Xia, Bikui Zhang, Miao Yan
Summary: Experimental findings indicate that Sunitinib induces hepatocellular death primarily by inducing apoptosis and autophagy, with the ROS/MAPKs signaling pathway playing a crucial role. Glycyrrhetinic acid can mitigate Sunitinib-induced cell damage by inhibiting apoptosis and autophagy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Francesca Provenza, Paolo Pastorino, Serena Anselmi, Marco Leporatti Persiano, Tommaso Scirocco, Gianluca De Rinaldis, Maria Cristina Fossi, Cristina Panti, Monia Renzi, Antonietta Specchiulli
Summary: This study assessed microplastics, trace elements, polycyclic aromatic hydrocarbon (PHA) levels, and the oxidative stress response in Mytilus galloprovincialis from two Italian lagoon ecosystems. They also determined the ecotoxicological effects of high-density polyethylene (HDPE) microplastics on the mussels. Trace element levels were comparable among sites, while microplastics were only found in mussels from one site. Polycyclic aromatic hydrocarbon levels were always below the limit of quantification. The mussels from a different site had higher levels of oxidative stress biomarkers. The exposure test showed significant effects on mortality and biochemical biomarkers, and similar effects were observed based on color and nourishment conditions.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Cell Biology
Zhitong Ge, Penghui Feng, Zijuan Zhang, Jianchu Li, Qi Yu
Summary: This study identified differential metabolites between IVL patients and healthy controls, with hypoxanthine and glycerophosphocholine potentially serving as protective factors, while acetylcarnitine and hydrocortisone as risk indicators for IVL development. These findings suggest a potential role of these hub metabolites as novel biomarkers for predicting the prognosis or progression of IVL.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ying Chen, Katherine D. Holland, Howard G. Shertzer, Daniel W. Nebert, Timothy P. Dalton
Summary: Reduced glutathione (GSH) and ascorbic acid (AA) are important antioxidants in mammalian tissues. Knockout mice lacking GSH biosynthesis genes or functional AA synthesis genes exhibited neurological abnormalities and seizures. A study found that the absence of both GSH and AA in mice led to spontaneous seizures and brain damage, but the addition of AA to the diet prevented these symptoms. The interaction between GSH and AA is crucial for normal brain function and neuronal health.
Article
Chemistry, Multidisciplinary
Kazi Nadim Hossain, Md. Shafiqul Islam, Sheikh Hasibur Rahman, Subroto Sarker, Milon Mondal, Mohammad Asikur Rahman, Sadeq K. Alhag, Laila A. Al-Shuraym, Othman A. Alghamdi, Muhammad Torequl Islam, Ammar AL-Farga, Mohamed El-Shazly, Md. Jahir Alam, Heba A. S. El-Nashar
Summary: This study investigated the antioxidant, anti-inflammatory, and hepatoprotective activities of Wissadula periplocifolia. The results showed that it has strong antioxidant, anti-inflammatory, and hepatoprotective effects.
Article
Medicine, Research & Experimental
W. A. Saka, R. E. Akhigbe, A. O. Abidoye, O. S. Dare, A. O. Adekunle
Summary: The study showed that Dichlorvos induced hepatic and renal damage, accompanied by redox dyshomeostasis. L-arginine was found to reverse the damage and improve organ structure, suggesting a potential therapeutic role against Dichlorvos-induced toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Environmental Sciences
Hu Zhang, Lu Lu, Chao Zhao, Qiwei Liu, Qian Zhou, Ying Zhang, Yuepu Pu, Shizhi Wang, Ran Liu, Lihong Yin
Summary: This study comprehensively investigated the disturbance of hepatic lipid homeostasis induced by nitrosamines in mice and found that nitrosamines exposure caused liver injury, inflammatory infiltrates, and hepatic edema. Lipidomic profiling analysis revealed alterations in various lipid levels, along with increased fatty acid oxidation and activation of inflammatory responses. These findings provide new insights into the early toxic effects of nitrosamines exposure.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Plant Sciences
Simeng Chu, Yujie Lu, Wenjuan Liu, Xiaoyao Ma, Jiamin Peng, Xiaoying Wang, Min Jiang, Gang Bai
Summary: This study investigates the mechanism of TET-induced hepatotoxicity and reveals that TET covalently binds to GST, leading to liver injury, while UA competitively binds to GST to protect the liver from TET-induced damage.
Article
Anatomy & Morphology
Omer Faruk Koroglu, Mehmet Gunata, Nigar Vardi, Azibe Yildiz, Burhan Ates, Cemil Colak, Lokman Hekim Tanriverdi, Hakan Parlakpinar
Summary: Despite the multiple beneficial biological activities of NRG in protecting the liver, the study found that NRG could not effectively prevent histopathological changes in the VPA-induced hepatotoxicity model.
Article
Food Science & Technology
Dongyi Wu, Chenglin Yang, Mengran Yang, You Wu, Yan Mao, Xinyan Zhou, Ji Wang, Zhihang Yuan, Jing Wu
Summary: This study investigates the hepatotoxicity of CIT, a mycotoxin found in crops, in mice. The results suggest that CIT induces liver damage and apoptosis in mice through the regulation of the Ca2+/ER stress signaling pathway.
Article
Chemistry, Analytical
Ryu Mochizuki, Akane Kobayashi, Hiromitsu Takayama, Toshihiko Toida, Yasumitsu Ogra
Summary: The Konig reaction is a useful method for detecting cyanide and its derivatives. In this study, we found that it can also be used to quantify glutathione and applied it to determine the levels of reduced and oxidized glutathiones. The method showed good sensitivity and was successfully applied to measure GSH and GSSG levels in cells exposed to oxidative stress.
ANALYTICAL METHODS
(2023)
Article
Mathematical & Computational Biology
Hans Westerhoff, Alexey N. Kolodkin
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Ewelina Weglarz-Tomczak, Thierry D. G. A. Mondeel, Diewertje G. E. Piebes, Hans V. Westerhoff
Summary: Research has shown that the dependency of hepatocellular carcinoma on glucose/glutamine is associated with proliferation and lactate production, but does not necessarily increase with higher glucose concentration. Conversely, there is no such association with glutamine. The integration of gene expression and nutrient availability data into genome-wide models has been found to improve the prediction of metabolic phenotypes.
Article
Immunology
Niels J. M. Verstegen, Victor Ubels, Hans V. Westerhoff, S. Marieke van Ham, Matteo Barberis
Summary: Germinal center reactions are crucial for the correct functioning of the adaptive immune system, leading to the formation of high affinity, class switched antibodies. Through a dynamic process involving various cells and molecules, B cells undergo differentiation into memory B cells and plasma cells, ultimately enhancing the immune response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Legal
Nicola J. Hewitt, John Troutman, Julia Przibilla, Andreas Schepky, Gladys Ouedraogo, Catherine Mahony, Gerry Kenna, Mustafa Varcin, Mathew P. Dent, Cosmetics Europe
Summary: A novel approach was developed to characterize the biokinetics of phenoxyethanol, including the identification of its major metabolite, phenoxyacetic acid, and comparing intracellular concentrations with in vivo tissue levels to determine safety margin.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Medicine, Legal
Camilla Alexander-White, Dagmar Bury, Mark Cronin, Matthew Dent, Eric Hack, Nicola J. Hewitt, Gerry Kenna, Jorge Naciff, Gladys Ouedraogo, Andreas Schepky, Catherine Mahony, Cosmetics Europe
Summary: This paper presents a 10-step read-across framework for cosmetics safety assessment when the threshold of toxicological concern approach is not possible. The framework builds on established approaches and incorporates new methodologies, such as in vitro assays and physiologically-based kinetic modelling, to substantiate hypotheses on toxicological similarity. The data from these new methodologies can be used to perform a next generation risk assessment for data-poor target substances based on data-rich analogues.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Environmental Sciences
Zahid Hassan, Martin Braster, Wilfred F. M. Roling, Hans Westerhoff
Summary: Arsenate-reducing microorganisms can mobilize arsenic into groundwater. A cultivation-based metagenomic strategy was developed to infer actual activities and bridge the knowledge gap between cultivation-independent and cultivation-dependent analyses. This study clarifies the mechanism for arsenic mobilization and redistribution in rural drinking water wells and highlights the potential risks and the need for appropriate bioremediation strategies. Rating: 8/10.
GEOMICROBIOLOGY JOURNAL
(2023)
Article
Chemistry, Organic
Robert N. Goldberg, Robert T. Giessmann, Peter J. Halling, Carsten Kettner, Hans Westerhoff
Summary: The measurement of apparent equilibrium constants K ' for enzyme-catalyzed reactions involves critical details that cannot be neglected in order to avoid systematic errors. Interferences, impurities, and failure to achieve equilibrium are significant factors to consider. Careful reporting of results, including substance identification, reaction specification, reaction conditions, equilibrium constant definition, nomenclature, symbols, units, and uncertainties, is of great importance. This document provides a general discussion on various aspects of equilibrium measurements and STRENDA recommendations regarding the measurements and reporting of results.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Yanhua Liu, Hans V. Westerhoff
Summary: Inborn error of metabolism phenylketonuria (PKU) is typically caused by inactivation of phenylalanine hydroxylase (PAH). The reduced PAH activity results in elevated phenylalanine levels and phenylpyruvate in urine. Flux balance analysis (FBA) predicts reduced growth rate in PKU, unless tyrosine is supplemented. However, the PKU phenotype is brain-specific and can be treated by phenylalanine reduction instead of tyrosine supplementation. This study presents an extended FBA model that explains the brain specificity of the disease, the role of phenylpyruvate as a biomarker, the effect of excess phenylalanine on brain pathology, and the superiority of phenylalanine deprivation as therapy.
JOURNAL OF INHERITED METABOLIC DISEASE
(2023)
Article
Mathematics
Hans V. V. Westerhoff
Summary: Dynamic variables in non-equilibrium systems of life are determined by catalytic activities, which are related to genome expression. Modulating gene expression or enzyme function through medicinal drugs is becoming increasingly important. Despite the complexity of cellular systems biology, there are simple principles guiding the control of variables such as fluxes, concentrations, and half-times. By using time-unit invariance, a multitude of laws governing the control coefficients of multiple variables by all catalytic activities can be derived. The control of these variables is determined by time, resulting in simple integer sums when the variables are at maximum, minimum, or steady states.
Article
Biology
David D. van Niekerk, Erik Rust, Frank Bruggeman, Hans V. Westerhoff, Jacky L. Snoep
Summary: By analyzing models from the JWS Online and Biomodels databases, we investigated the use of the disequilibrium ratio as an estimator for the flux control of a reaction. While no functional relationship was found, the disequilibrium ratio can still be used as an estimator for the maximal flux control of a reaction step. We further expanded the analysis by incorporating the overall pathway disequilibrium ratio in the expression, leading to explicit expressions for flux control coefficients.
Article
Biology
Hans V. Westerhoff
Summary: This article resolves the paradoxes between microbial growth rate, enzyme activity, and flux control coefficients. The study found that under optimization conditions, enzyme control coefficients can equal zero, and flux balance analysis effectively maximizes growth yield, thereby resolving these contradictions.
Article
Physics, Multidisciplinary
Yanfei Zhang, Hans V. Westerhoff
Summary: Confronted with unfavorable output processes, free-energy transducers can shift to lower gears to reduce output per unit input. This option is well-known in machines but not appreciated in biology. This study extends thermodynamic principles to explain biological gear shifting and identifies mechanisms. It shows that gear shifting optimizes performance in living systems, allowing them to switch to catabolic pathways with lower ATP stoichiometry, thereby increasing ATP synthesis flux and ensuring continued growth even in challenging conditions.
Article
Mathematical & Computational Biology
Yanhua Liu, Hans V. Westerhoff
Summary: This study develops a method called 'dynamic competition Flux Balance Analysis' (dcFBA), which can accommodate changes in cell density caused by competition. The experiment shows that signal transduction between cells is crucial for the co-existence of diverse cell types in multicellular organisms. Moreover, mutants that lose social characteristics can outgrow other cells, suggesting that 'asocialness' rather than enhanced growth rates may characterize cancer cells and organisms causing ecological blooms.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2023)
Article
Biology
Joost W. Aerts, Serban M. Sarbu, Traian Brad, Pascale Ehrenfreund, Hans V. Westerhoff
Summary: Movile Cave is a unique and challenging ecosystem where specialized prokaryotic communities can adapt to different subenvironments and respond to environmental changes in a relatively short time.
Article
Biology
Frank J. Bruggeman, Maaike Remeijer, Maarten Droste, Luis Salinas, Meike Wortel, Robert Planque, Herbert M. Sauro, Bas Teusink, Hans Westerhoff
Summary: This paper extends the scope of metabolic control analysis (MCA) to a whole-cell context, considering metabolism in the evolutionary context of growth-rate maximisation. The study shows that elementary flux modes (EFMs) naturally emerge as optimal metabolic networks in this context, and their control properties can be derived. The paper also demonstrates the estimation of flux control coefficients from proteomics and ribosome-profiling data. The findings provide insights into the control of metabolic enzymes on growth rate and contribute to the understanding of general principles in cell biochemistry.
Article
Chemistry, Analytical
Bingbing Liu, Jie Cao, Lu Liu, Min Zeng, Hongli Yu, Hao Wu
Summary: This study investigated the effect of processing with Chebulae Fructus on the chemical composition of Euphorbia pekinensis (EP) and found that it could alter the composition and reduce toxicity, providing a scientific basis for optimizing processing technology and handling other ethnomedicines with toxic properties.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Renuka P. Rathnasekara, Abu M. Rustum
Summary: A simple and robust HPLC method was developed for simultaneous determination of four active pharmaceutical ingredients and their degradation products. The method successfully separated the peaks of interest and demonstrated stability-indicating capability by separating the degradation products in stressed samples.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Bryan Lee, Gita Kharal, Benjamin Sreenan, Claire Lin, Ruosheng Zeng, Colin A. Fox, Patricia Ellison, Robert O. Ryan, Paul J. Brett, David Aucoin, Xiaoshan Zhu
Summary: In this study, a new type of Mn-doped nanocrystals was developed for detecting a biomarker of a fatal disease. The sensitivity of the detection was enhanced by surface treatment and time-resolved reading, achieving a detection limit comparable to enzyme-based immunoassay.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xiaoling Liu, Ting Yang, Lu Chen, Lili Lan, Guoxiang Sun, Ping Guo
Summary: In this study, the quality of Yiqing tablet was comprehensively evaluated using multi-component quantification, multi-dimensional fingerprint construction, and antioxidant activity analysis. The results showed that the sample had 25 components with antioxidant activity according to the HPLC fingerprint and most bands of FTIR also showed antioxidant activity. Based on the evaluation results of HPLC and FTIR fingerprint, all samples were classified as first level, demonstrating the consistency of sample quality. This study provides a new idea for achieving comprehensive quality evaluation of traditional Chinese medicines.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Siqi Li, Hao Guo, Yan Gao, Wen Tian, Shan Wang, Chen Shen, Lili Xu, Hailong Liu, Jinliang Zhang, Yingwu Wang
Summary: Using competitive ELISA to detect free cytokines is limited in accurately determining their real state and quantity. In this study, a novel cytokine immunoassay was developed using Rosetta molecular docking prediction technique to establish a method that can detect the true concentration of free cytokines without disrupting the dynamic equilibrium.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Changqing Yu, Tiantian Xie, Haiyan Liu, Ligai Bai
Summary: A phenyl-hybrid monolithic adsorbent with porous structure and multiple functional groups was prepared. It was used for the online extraction and quantification of coumarins in mouse plasma, showing good removal ability and selectivity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Joao B. Pereira Jr, Vanessa S. Carvalho, William Q. Ferreira, Rennan G. O. Araujo, Sergio L. C. Ferreira
Summary: This work presents a simple, cost-effective, and environmentally friendly method for determining the content of multiple elements in medicinal herbs using ICP OES. The optimized experimental parameters result in low dissolved organic carbon content and residual acidity concentration. The accuracy of the method is confirmed through the analysis of certified reference materials, and its environmental friendliness is validated using the AGREE metric. Principal component analysis is used to classify the medicinal herbs based on their inorganic constituent concentrations.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Orwa Siddig, Chenxi Liu, Mohamed Abdulbagi, Min Song, Yu-ting Lu, Tai-jun Hang
Summary: In this study, a reliable LC-QTOF-MS method was developed to separate and characterize process-related substances and degradation products of Lurasidone hydrochloride. The results showed that Lurasidone hydrochloride exhibited instability under certain stress conditions, and several previously unidentified compounds were discovered. The study emphasizes the importance of monitoring and controlling related substances in the manufacturing processes to optimize the process and ensure quality control.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Jiaxi Fang, Luping Wang, Di Zhang, Yan Liang, Shouxin Li, Jingkui Tian, Qiang He, Juan Jin, Wei Zhu
Summary: This study reports that a novel compound called CPS-A exhibits therapeutic effects on cisplatin-induced acute kidney injury (AKI) and explores its potential mechanisms through transcriptomics and metabolomics. CPS-A improves cell viability, reduces inflammatory markers, and attenuates cisplatin-induced kidney injury. The study also identifies potential targets related to amino acid metabolism.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ricardo Conde, Nadia Oliveira, Elisabete Morais, Ana Paula Amaral, Adriana Sousa, Goncalo Graca, Ignacio Verde
Summary: Decreased levels of tyrosine, glutamate, valine, leucine, and isoleucine are associated with worsening pathological cognitive decline. Decreased levels of isobutyrate, histidine, acetone, and unknown-1 metabolite are potential biomarkers with neuroprotective and antioxidant actions for cognitive decline.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
A. L. Santunione, F. Palazzoli, P. Verri, D. Vandelli, V. Castagnetti, C. Profeta, E. Silingardi
Summary: This study describes two fatal suicide cases involving four cardiovascular drugs, and presents the concentrations and distribution of these drugs in different post-mortem specimens. The study developed a fast, sensitive, and simple method for drug detection suitable for forensic purposes.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Meiyun Shi, Xinyue Zheng, Yuncheng Ge, Ning Zhang, Luyao Yu, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin
Summary: This study investigated the cellular uptake of low, medium and high molecular weight polyethylene glycol (PEG) in MCF-7 cells using UPLC-MS/MS and CID techniques. The results showed that PEG600, PEG2K, PEG4K and PEG10K exhibited low toxicity and had limited cellular entry at concentrations of 5-1200 μg/mL. Additionally, the environmental friendliness of the developed analytical methods was evaluated.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ruijin Geng, Mengjie Yu, Jinbiao Xu, Yuanwang Wei, Qiong Wang, Junguo Chen, Fei Sun, Kun Xu, Han Xu, Xiaohui Liu, Juhua Xiao, Xianchao Zhang, Baogang Xie
Summary: This study validated serum methionine as a potential biomarker for Kawasaki disease (KD), and found that its alteration is associated with the activation of DNMT1 in KD patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Eman Shawky, Rasha A. Nassra, Aliaa M. T. El-Alkamy, Shaimaa M. Sallam, Samah M. El Sohafy
Summary: This study employed network pharmacology-based analysis and reverse molecular docking to investigate the molecular targets and pathways associated with gynecological disorders and the potential therapeutic effects of fenugreek constituents. The results highlighted the potential of steroidal saponins, isoflavones, and flavones as active constituents of fenugreek with implications for lactation, reproductive processes, and estrogenic activity. Animal model study further supported the presence of these bioactive compounds and their effects on body weight, serum prolactin levels, serum estradiol levels, and ovarian histological structure.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xuelong Zhao, Ruixue Dai, Jing Wang, Liangliang Cao, Peidong Chen, Weifeng Yao, Fangfang Cheng, Beihua Bao, Li Zhang
Summary: This study identified the skin-permeable and skin-retainable components of Cayratia japonica ointment and found that flavonoids are the main active components that play a crucial role in the inflammatory and proliferative phases of wound healing.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)