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Which comes first? The obesity or the insulin? The behavior or the biochemistry?

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JOURNAL OF PEDIATRICS
Volume 152, Issue 5, Pages 601-602

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MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2008.01.021

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Zebrowski, L. Kuechenmeister, M. Thevarayapillai, M. Daniels, H. Speer, N. Forghani, R. Quintana, C. Reh, A. Bhangoo, P. Desrosiers, L. Ireland, T. Misla, C. Torres, S. Wells, J. Villar, M. Yu, D. Berry, D. Cook, J. Soder, A. Powell, M. Ng, M. Morrison, Z. Haslam, M. Lawson, B. Bradley, J. Courtney, C. Richardson, C. Watson, E. Keely, D. DeCurtis, M. Vaccarcello-Cruz, Z. Torres, K. Sandberg, H. Hsiang, B. Joy, D. McCormick, H. Jones, J. Bell, S. Hargadon, S. Hudson, M. Kummer, S. Sauder, E. Sutton, K. Gensel, R. Aguirre-Castaneda, V. Benavides Lopez, D. Hemp, S. Allen, J. Stear, E. Davis, T. Jones, A. Roberts, J. A. Dart, N. Paramalingam, L. E. Levitt Katz, N. Chaudhary, K. M. Murphy, S. M. Willi, B. Schwartzman, C. Kapadia, D. Larson, D. McClellan, G. Shaibai, L. A. Kelley, G. Villa, C. Kelley, R. Diamond, M. Kabbani, T. Dajani, F. Hoekstra, M. Magorno, J. Holst, V Chauhan, N. Wilson, P. Bononi, M. Sperl, A. Millward, M. Eaton, L. Dean, J. Olshan, H. Renna, C. Milliard, D. Snyder, S. Beaman, K. Burch, J. Chester, A. Ahmann, B. Wollam, D. DeFrang, R. Fitch, K. Jahnke, K. Hanavan, B. Klopfenstein, L. Nicol, R. W. Bergstrom, T. Noland, J. Brodksy, L. Bacon, J. B. Quintos, L. S. Topor, S. Bialo, B. Bancroft, A. G. Soto, W. Lagarde, H. Lockemer, T. Vanderploeg, M. A. Ibrahim, M. Huie, V Sanchez, R. Edelen, R. Marchiando, T. Repas, M. Wasson, P. Auker, J. Culbertson, T. Kieffer, D. Voorhees, T. Borgwardt, L. DeRaad, K. Eckert, E. Isaacson, H. Kuhn, A. Carroll, M. Schubert, G. Francis, S. Hagan, T. Le, M. Penn, E. Wickham, C. Leyva, K. Rivera, J. Padilla, I Rodriguez, N. Jospe, J. Czyzyk, B. Johnson, U. Nadgir, N. Marlen, G. Prakasam, C. Rieger, N. Glaser, E. C. Heiser, B. Harris, C. Foster, H. Slater, K. Wheeler, D. L. Donaldson, D. E. Hale, R. Tragus, D. R. Word, J. Lynch, L. Pankratz, W. Rogers, R. Newfield, S. Holland, M. Hashiguchi, M. Gottschalk, A. Philis-Tsimikas, R. Rosal, S. Franklin, S. M. Guardado, N. Bohannon, M. Garcia, T. Aguinaldo, J. Phan, V Barraza, D. Cohen, J. Pinsker, U. Khan, J. Wiley, L. Jovanovic, P. Misra, M. Wright, K. Huang, M. Skiles, S. Maxcy, C. Pihoker, K. Cochrane, J. Fosse, S. Kearns, M. Klingsheim, N. Wright, L. Viles, H. Smith, S. Heller, M. Cunningham, A. Daniels, L. Zeiden, J. Field, R. Walker, K. J. Griffin, L. Bartholow, C. Erickson, B. Krabbenhoft, C. Sandman, A. Vanveldhuizen, J. Wurlger, A. Zimmerman, K. Hanisch, L. Davis-Keppen, A. Cotterill, J. Kirby, M. Harris, A. Schmidt, C. Kishiyama, C. Flores, J. Milton, W. Martin, C. Whysham, A. Yerka, T. Freels, J. M. Hassing, J. Webster, R. Green, P. Carter, J. Galloway, D. Hoelzer, S. Roberts, S. Said, P. Sullivan, H. F. Allen, E. Reiter, E. Feinberg, C. Johnson, L. A. Newhook, D. Hagerty, N. H. White, L. Levandoski, J. Kyllo, C. Benoit, P. Iyer, F. Diamond, H. Hosono, S. Jackman, L. Barette, P. Jones, I Sills, S. Bzdick, J. Bulger, R. Weinstock, I Douek, R. Andrews, G. Modgill, G. Gyorffy, L. Robin, N. Vaidya, S. Crouch, K. O'Brien, C. Thompson, N. Thorne, J. Blumer, J. Kalic, L. Klepek, J. Paulett, B. Rosolowski, J. Horner, M. Watkins, J. L. Casey, K. Carpenter, C. Burns, J. Horton, C. Pritchard, D. Soetaert, A. G. Wynne, K. Kaiserman, M. Halvorson, C. Chin, O. Y. Molina, C. Patel, R. Senguttuvan, M. Wheeler, O. Furet, C. Steuhm, D. H. Jelley, S. Goudeau, L. Chalmers, D. Greer, C. Panagiotopoulos, D. L. Metzger, D. Nguyen, M. Horowitz, M. P. Christiansen, E. Glades, C. Morimoto, M. Macarewich, R. Norman, K. Patin, C. Vargas, A. Barbanica, A. Yu, P. Vaidyanathan, W. Osborne, R. Mehra, S. Kaster, S. Neace, G. Reeves, C. Cordrey, L. Marrs, T. Miller, S. Dowshen, D. Doyle, S. Walker, D. Catte, H. Dean, M. Drury-Brown, B. Hackman, M. M. C. Lee, S. Malkani, K. Cullen, K. Johnson, P. Hampton, M. McCarrell, C. Curtis, E. Paul, Y. Zambrano

DIABETES CARE (2019)

Article Environmental Sciences

Association of Prenatal Urinary Concentrations of Phthalates and Bisphenol A and Pubertal Timing in Boys and Girls

Kimberly Berger, Brenda Eskenazi, Katherine Kogut, Kimberly Parra, Robert H. Lustig, Louise C. Greenspan, Nina Holland, Antonia M. Calafat, Xiaoyun Ye, Kim G. Harley

ENVIRONMENTAL HEALTH PERSPECTIVES (2018)

Article Gastroenterology & Hepatology

Diet and Exercise in Pediatric Liver Transplant Recipients: Behaviors and Association With Metabolic Syndrome

Julia H. Chambers, Melissa Zerofsky, Robert H. Lustig, Philip Rosenthal, Emily R. Perito

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2019)

Article Obstetrics & Gynecology

Association of phthalates, parabens and phenols found in personal care products with pubertal timing in girls and boys

Kim G. Harley, Kimberly P. Berger, Katherine Kogut, Kimberly Parra, Robert H. Lustig, Louise C. Greenspan, Antonia M. Calafat, Xiaoyun Ye, Brenda Eskenazi

HUMAN REPRODUCTION (2019)

Article Endocrinology & Metabolism

Isocaloric Fructose Restriction Reduces Serum D-Lactate Concentration in Children With Obesity and Metabolic Syndrome

Ayca Erkin-Cakmak, Yasmin Bains, Russell Caccavello, Susan M. Noworolski, Jean-Marc Schwarz, Kathleen Mulligan, Robert H. Lustig, Alejandro Gugliucci

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2019)

Article Oncology

Conformal Radiation Therapy for Pediatric Ependymoma, Chemotherapy for Incompletely Resected Ependymoma, and Observation for Completely Resected, Supratentorial Ependymoma

Thomas E. Merchant, Anne E. Bendel, Noah D. Sabin, Peter C. Burger, Dennis W. Shaw, Eric Chang, Shengjie Wu, Tianni Zhou, David D. Eisenstat, Nicholas K. Foreman, Christine E. Fuller, Edwina Templeton Anderson, Juliette Hukin, Ching C. Lau, Ian F. Pollack, Fred H. Laningham, Robert H. Lustig, Floyd D. Armstrong, Michael H. Handler, Chris Williams-Hughes, Sandra Kessel, Mehmet Kocak, David W. Ellison, Vijay Ramaswamy

JOURNAL OF CLINICAL ONCOLOGY (2019)

Article Medicine, General & Internal

Association of a Workplace Sales Ban on Sugar-Sweetened Beverages With Employee Consumption of Sugar-Sweetened Beverages and Health

Elissa S. Epel, Alison Hartman, Laurie M. Jacobs, Cindy Leung, Michael A. Cohn, Leeane Jensen, Laura Ishkanian, Janet Wojcicki, Ashley E. Mason, Robert H. Lustig, Kimber L. Stanhope, Laura A. Schmidt

JAMA INTERNAL MEDICINE (2020)

Article Nutrition & Dietetics

Effects of Isocaloric Fructose Restriction on Ceramide Levels in Children with Obesity and Cardiometabolic Risk: Relation to Hepatic De Novo Lipogenesis and Insulin Sensitivity

Emily Olson, Jung H. Suh, Jean-Marc Schwarz, Susan M. Noworolski, Grace M. Jones, John R. Barber, Ayca Erkin-Cakmak, Kathleen Mulligan, Robert H. Lustig, Michele Mietus-Snyder

Summary: The study found that reducing fructose intake led to a decrease in ceramide levels, which negatively correlated with insulin sensitivity and potentially served as an intermediary link between hepatic DNL, insulin resistance, and CMR.

NUTRIENTS (2022)

Article Psychology, Clinical

Effects of a Mindfulness-Based Intervention on Distress, Weight Gain, and Glucose Control for Pregnant Low-Income Women: A Quasi-Experimental Trial Using the ORBIT Model

E. Epel, B. Laraia, K. Coleman-Phox, C. Leung, C. Vieten, L. Mellin, J. L. Kristeller, M. Thomas, N. Stotland, N. Bush, R. H. Lustig, M. Dallman, F. M. Hecht, N. Adler

INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE (2019)

Meeting Abstract Psychology, Multidisciplinary

A BRIEF INTERVENTION REDUCES SUGAR-SWEETENED BEVERAGE (SSB) CONSUMPTION IN HIGH RISK PEOPLE DURING AN SSB WORKSITE SALES BAN

Ashley E. Mason, Laura Schmidt, Laura Ishkanian, Laurie M. Jacobs, Cindy Leung, Leeane M. Jensen, Michael A. Cohn, Samantha G. Schleicher, Alison Hartman, Janet Wojcicki, Robert H. Lustig, Elissa S. Epel

ANNALS OF BEHAVIORAL MEDICINE (2019)

Article Endocrinology & Metabolism

Treatment of Hypothalamic Obesity with Dextroamphetamine: A Case Series

Christian Denzer, Friederike Denzer, Belinda S. Lennerz, Heike Vollbach, Robert H. Lustig, Martin Wabitsch

OBESITY FACTS (2019)

Meeting Abstract Nursing

The Usability and Acceptability of a Patient-Centered Mobile Health Tracking App among a Sample of Adult Radiation Oncology Patients

Susan Birkhoff, Mary Ann Cantrell, Helene Moriarty, Robert Lustig

NURSING RESEARCH (2018)

Article Pediatrics

Multicomponent Strategy Improves Human Papillomavirus Vaccination Rates Among Adolescents with Sickle Cell Disease

Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins

Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.

JOURNAL OF PEDIATRICS (2024)

Article Pediatrics

Effect of Systemic Hydrocortisone on Brain Abnormalities and Regional Brain Volumes in Ventilator-dependent Infants Born Preterm: Substudy of the SToP-BPD Study

Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa

Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.

JOURNAL OF PEDIATRICS (2024)

Article Pediatrics

Predictors of Transition Outcomes in Cystic Fibrosis: Analysis of National Patient Registry and CF RISE (Responsibility. Independence. Self-care. Education) Data

Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone

Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.

JOURNAL OF PEDIATRICS (2024)

Article Pediatrics

Quantification of Enteric Dysfunction in Cystic Fibrosis: Inter- and Intraindividual Variability

Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein

Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.

JOURNAL OF PEDIATRICS (2024)

Article Pediatrics

Right Atrial Enlargement on Electrocardiogram in Previously Healthy Young

Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora

Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.

JOURNAL OF PEDIATRICS (2024)

Article Pediatrics

Spectrum of Disease in Hospitalized Newborns with Congenital Micrognathia: A Cohort of 3,236 Infants at North American Tertiary-Care Intensive Care Units

Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo

Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.

JOURNAL OF PEDIATRICS (2024)

Article Pediatrics

Opioid Utilization after Cardiac Surgery in the Pediatric Medicaid-Insured Population

Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban

Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.

JOURNAL OF PEDIATRICS (2024)

Article Pediatrics

Tracking of Cardiorespiratory Fitness from Childhood to Mid-adulthood

Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen

Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.

JOURNAL OF PEDIATRICS (2024)

Article Pediatrics

Blood Pressure Outcomes in NICU-Admitted Infants with Neonatal Hypertension: A Pediatric Nephrology Research Consortium Study

Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes

Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.

JOURNAL OF PEDIATRICS (2024)

Editorial Material Pediatrics

Real-World Evidence for Neonatal Drug Development: Challenges and Opportunities

Kanwaljit Singh, John Concato, Jonathan M. Davis

JOURNAL OF PEDIATRICS (2024)

Article Pediatrics

The Influence of Dietary Counseling Over 20 Years on Tracking of Non-High-Density Lipoprotein Cholesterol from Infancy to Young Adulthood

Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen

Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.

JOURNAL OF PEDIATRICS (2024)

Article Pediatrics

One Step Closer to Safer: Counseling Outcomes from American Academy of Pediatrics Firearm Safe Storage Education Training

Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin

Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.

JOURNAL OF PEDIATRICS (2024)

Article Pediatrics

Health-Related Quality of Life for Parents of Infants with Bronchopulmonary Dysplasia

Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta

Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.

JOURNAL OF PEDIATRICS (2024)

Article Pediatrics

Reference Values for Cardiorespiratory Fitness in Patients Aged 6 to 18 Years

Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward

Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.

JOURNAL OF PEDIATRICS (2024)

Article Pediatrics

Early Elbow Flexion Contracture Predicts Shoulder Contracture in Infants with Brachial Plexus Birth Injury

David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer

Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.

JOURNAL OF PEDIATRICS (2024)