Article
Polymer Science
Svetlana Kurmaz, Natalia Fadeeva, Adelina Komendant, Vladislav M. Ignatiev, Nina S. Emelyanova, Gennady Shilov, Tatyana S. Stupina, Natalia Filatova, Maria A. Lapshina, Alexei A. Terentyev
Summary: New amphiphilic terpolymers were synthesized and studied for their aggregation behavior in polar media, showing that the addition of hydrophobic groups can stabilize ZnTPP and have no significant impact on cell viability, while also able to efficiently penetrate cells.
Article
Polymer Science
Shihai Wang, Yu Zhou, Wangwang Tao, Jingyi Liu, Hongxiang Chen, Zuyi Zhao
Summary: In this study, Fe3O4-modified magnetic amphiphilic polyurethane (MAPU) was successfully synthesized and proved to be suitable for targeted drug delivery systems. MAPU micelles showed excellent stability, biocompatibility, superparamagnetic properties, and potential clinical applications.
Article
Polymer Science
Yu-Zhuang Gao, Jun-Cai Chen, Zhe Cui, Cong-Lei Zhao, Yi-Xian Wu
Summary: APGA-g-PTHF amphiphilic graft copolymers with nanophase separation, hydrophobicity, and increased surface roughness were successfully synthesized. These copolymers exhibited good anti-protein performance and could form homogeneous nanospheres for drug delivery with high drug loading efficiency and fast release behavior.
Article
Engineering, Electrical & Electronic
Tao Xu, Huiping Liu, Rongjun Zhao, Linjie Yuan, Zewei Zhu, Xi Chen, Haoqin Hou, Xinwen Peng
Summary: Polymer film capacitors cannot meet the increasing demand for high-temperature (> 125 degrees C) applications in the rapid development of new energy. In order to develop high-temperature-resistant polymer dielectrics, a novel polyimide containing porphyrin units (PI-a) was prepared. High-performance polyimide dielectrics were developed by mixing PI-a and PI-b, resulting in a polyimide blend with excellent properties and high energy storage density. These polyimide blends can extend the applications of film capacitors at high temperature.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Review
Chemistry, Multidisciplinary
Jaskiran Kaur, Vijay Mishra, Sachin Kumar Singh, Monica Gulati, Bhupinder Kapoor, Dinesh Kumar Chellappan, Gaurav Gupta, Harish Dureja, Krishnan Anand, Kamal Dua, Gopal L. Khatik, Kuppusamy Gowthamarajan
Summary: Amphiphilic block copolymers are widely used in drug delivery for enhancing bioavailability, molecular targeting, and sustained release. However, challenges such as premature drug release, low drug loading capacity, and poor stability need to be addressed for wider clinical utility. Future studies should focus on exploring their full potential in the treatment and diagnosis of diseases.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Polymer Science
Chih-Hao Chang, Chih-Hung Chang, Ya-Wen Yang, Hsuan-Yu Chen, Shu-Jyuan Yang, Wei-Cheng Yao, Chi-Yang Chao
Summary: This study successfully synthesized a novel polystyrene-block-quaternized polyisoprene amphipathic block copolymer and controlled the antibacterial activity by regulating the block composition, side chain length, and polymer morphology. The polymers with N,N-dimethyldodecylamine side chains formed polymersome structures in aqueous solutions, exhibiting the best inhibiting bacterial growth efficiency.
Review
Oncology
Jia Xiang, Rui Zhao, Bo Wang, Xinran Sun, Xu Guo, Songwen Tan, Wenjie Liu
Summary: Nanotechnology plays an important role in the research of anti-tumor drugs, providing a way to improve drug efficacy and bioavailability by selecting appropriate nanocarriers.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yunfeng Yan, Fangtao Zhu, Huahui Su, Xiaomin Liu, Qidi Ren, Fangqian Huang, Wenbo Ye, Mengdan Zhao, Yunchun Zhao, Junpeng Zhao, Qi Shuai
Summary: This study constructed a library of 144 functional triblock polymers and discovered three effective carriers for siRNA delivery through high-throughput screening. In vitro evaluation showed that the siRNA-loaded nanoparticles fabricated with these polymers effectively silenced luciferase genes with low cytotoxicity. The chemical structure of the polymers significantly affected the physicochemical properties and in vitro delivery efficacy of the siRNA-loaded nanoparticles. In vivo experiments demonstrated that siRNA nanoparticles based on a specific polymer accumulated at tumor sites, suggesting the potential of this polymer in improving blood circulation and biodistribution of siRNA nanoparticles. This functional triblock polymer platform holds great potential in siRNA-based cancer therapies.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Engineering, Multidisciplinary
ChiXu Zhao, XiaoYan Yuan, Shan Bai, PingChuan Sun, YunHui Zhao, KongYing Zhu, LiXia Ren, XiaoHui Li
Summary: Highly transparent antifogging and antibacterial coatings were developed through thermal curing of zwitterionic copolymers, showing excellent antifogging and antibacterial properties with amphiphilicity, providing promising potential for biomedical device applications.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2021)
Article
Polymer Science
Chie Kojima, Tomoka Hirose, Risa Katayama, Akikazu Matsumoto
Summary: 2-Methacryloyloxyethyl phosphorylcholine (MPC) polymers have been used as coating agents and drug delivery carriers in medical devices. In this study, amphiphilic MPC polymers were used, and their self-assembling properties and PTX solubilization were examined. The results suggest that the hydrophobicity and self-assembling properties of amphiphilic MPC polymers play a crucial role in PTX solubilization and drug action, which need to be controlled by the polymer sequence and composition of the hydrophobic monomer.
Article
Biotechnology & Applied Microbiology
Marion Le Gal, Estelle Renard, Christelle Simon-Colin, Benoit Larrat, Valerie Langlois
Summary: Nanoparticles based on PEGylated and fluorinated nanocapsules containing a liquid core of perfluorooctyl bromide (PFOB) were successfully formulated for potential F-19 MRI imaging agents. By utilizing marine bacteria to produce unsaturated poly(hydroxyalkanoate) (PHAU) and conducting controlled thiol-ene reactions, PHA-g-(F; PEG)-based PFOB nanocapsules were developed with a diameter of 250-300 nm, showing promise as novel contrast agents for F-19 MRI due to their visibility and acquisition time.
BIOENGINEERING-BASEL
(2021)
Article
Green & Sustainable Science & Technology
Jianlong Wang, Chao Li, Kai Han, Jinfeng Yuan, Zhicheng Pan, Mingwang Pan
Summary: Researchers synthesized amphiphilic functional terpolymers through in-situ copolymerization and prepared terpolymer ultrafiltration membranes. These membranes showed advantages over blend membranes with stable covalent bonding and excellent antifouling and permeable properties. This research provides a new strategy for facile preparation of amphiphilic functional ultrafiltration membranes and effective removal of micropollutants.
JOURNAL OF CLEANER PRODUCTION
(2023)
Review
Engineering, Chemical
Paolo Trucillo
Summary: This study provides a critical review of mathematical models for drug carriers, discussing their dependencies on physical, chemical, empirical, or semi-empirical variables. The release profiles of the most representative models are quantitatively represented. The study serves as a helpful resource for students and researchers in understanding the existing models and developing new ones.
Article
Pharmacology & Pharmacy
Andrey Kuskov, Dragana Nikitovic, Aikaterini Berdiaki, Mikhail Shtilman, Aristidis Tsatsakis
Summary: This study assessed the pharmacokinetics, anti-inflammatory profile, and ulcerogenic potential of indomethacin-loaded PVP nanoparticles. The results showed that the loaded nanoparticles exhibited superior anti-inflammatory activity and a safer gastrointestinal profile compared to the free drug.
Article
Nanoscience & Nanotechnology
Takashi Miyata, Yasuaki Inoue, Kazuhito Takada, Akifumi Kawamura
Summary: Liquid crystalline polymers (LCPs) have unique structures and properties that make them useful for fabricating optical devices and high-performance fibers. In this study, LCP-g-OEG micelles were synthesized for medical applications, exhibiting temperature-responsive drug release behavior.
ACS APPLIED MATERIALS & INTERFACES
(2022)