Review
Cell Biology
Atef Badji, Jessica Youwakim, Alexandra Cooper, Eric Westman, Anna Marseglia
Summary: This narrative review provides an evidence-based summary of the link between individual vascular risk/disorders and cognitive dysfunction, as well as the potential structural and biochemical pathophysiological processes. It highlights the need for future research to focus on comorbid vascular burden, integrate imaging and fluid biomarkers, implement a life-course approach, consider neuroprotective influences of positive life exposures, and address biological sex at birth and gender differences.
AGEING RESEARCH REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Ludan Yue, Xueyang Zhang, Chenchen Zhao, Rongchang Chen, Xiaoyuan Chen, Lang Rao
Summary: Inhaled drug delivery is an emerging route for the treatment of lung diseases, with advantages over oral and intravenous routes. However, there are physiological barriers that affect delivery efficacy in the respiratory tract. This review provides an overview of inhaled drug delivery methods, highlighting non-invasive strategies for treating lung diseases.
Article
Nutrition & Dietetics
Markku Laakso, Lilian Fernandes Silva
Summary: Diabetes, especially type 2 diabetes, is a global epidemic. Genetic and environment/lifestyle factors play a role in the risk of developing type 2 diabetes. Genetic studies of diabetes focus on different subgroups to provide personalized treatment options for patients.
Review
Forestry
Janet R. Backs, Mary Ashley
Summary: Quercus species, as integral components of the landscape in the northern hemisphere, have been threatened by human activities, highlighting the need to address their genetic variability and structure for conservation management strategies. The lack of sufficient genetic data for the protected oak species underscores critical research gaps that exist in this field.
Article
Materials Science, Multidisciplinary
Reham Fathi, Hongyu Wei, Bassiouny Saleh, N. Radhika, Jinghua Jiang, Aibin Ma, Mahmoud H. Ahmed, Qin Li, Kostya Ken Ostrikov
Summary: This review paper provides a detailed analysis of production techniques, microstructure features, mechanical properties, wear resistance, and corrosion behavior of functionally graded coatings (FGCs). It also explores FGC classifications and applications, as well as future directions for research in this field.
APPLIED MATERIALS TODAY
(2022)
Article
Engineering, Aerospace
Fabiola Colone, Francesca Filippini, Debora Pastina
Summary: From the Daventry Experiment in 1935 to the present day, passive radar technology has undergone significant development and expanded its range of applications to advanced and complex scenarios. This article explores the relevant applications and strategies for addressing challenges, demonstrating the feasibility through real-world data. Finally, it discusses the current trends and outlooks for this technology based on the open issues and challenges.
IEEE AEROSPACE AND ELECTRONIC SYSTEMS MAGAZINE
(2023)
Review
Cell Biology
Michael A. Cook, Gerard D. Wright
Summary: Antibiotics have played a crucial role in modern medicine, but they are facing challenges of microbial resistance and traditional reimbursement models. Therefore, innovation is needed in policy, quantitative understanding of societal value, and investment in alternatives. Significant investment in research and development is also necessary to address the antibiotic crisis.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Ke Li, Craig M. Crews
Summary: PROTACs are a type of molecules with novel event-driven mechanism, offering multiple advantages over traditional inhibitors, such as catalytic nature and targeted protein degradation, which may lead to improved therapeutic outcomes with reduced toxicity. However, further research and development efforts are needed to fully explore their potential.
CHEMICAL SOCIETY REVIEWS
(2022)
Review
Clinical Neurology
Hulya Ulugut, Yolande A. L. Pijnenburg
Summary: This study explores the historical roots of frontotemporal dementia (FTD), dating back to the 19th century, and recognizes it as a distinct neurological entity only a few decades ago. The methods include qualitative study and literature review, providing an overview of FTD's historical background, birth, evolution, and future directions. The results indicate that recognition of FTD was hindered by various factors such as rigid perceptions of dementia, division between neurology and psychiatry, limited neuroimaging capabilities, and lack of pathological proof.
ALZHEIMERS & DEMENTIA
(2023)
Review
Pharmacology & Pharmacy
Jun Wang, Yanmei Hu, Madeleine Zheng
Summary: Enterovirus A71 (EV-A71) is a significant human pathogen that particularly affects children. Existing vaccines for EV-A71 have limited protection and reduced efficacy against emerging strains. No approved antiviral for EV-A71 is currently available. Researchers have made progress in developing antivirals by targeting viral proteins and host factors, although some approaches have shown limited efficacy or side effects.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Materials Science, Multidisciplinary
Joseph Rich, Zhenhua Tian, Tony Jun Huang
Summary: The research in intracellular delivery technologies has surged with the advancement in cell-based therapies and reprogramming. Physical cell membrane permeabilization techniques, especially sonoporation, show promise in delivering functional cargos to various cells, but bubble-based methods may have limitations such as requiring contrast agents and potential damage to cell components. Development of non-bubble-based sonoporation mechanisms aims to overcome these limitations and improve intracellular delivery efficiency.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Review
Urology & Nephrology
Simit M. Doshi, Jay B. Wish
Summary: Cardiovascular disease is a leading cause of death in dialysis patients, with elevated serum phosphorus levels being an important risk factor. Traditional phosphate binders have limitations and new therapies targeting intestinal phosphate absorption pathways have been developed to improve phosphorus management and cardiovascular health.
KIDNEY INTERNATIONAL REPORTS
(2022)
Review
Chemistry, Multidisciplinary
Wentao Jiang, Ziyu Wu, Zheng Gao, Mimi Wan, Min Zhou, Chun Mao, Jian Shen
Summary: Artificial cells are constructed to imitate natural cells and can be used for studying biological processes and the origin of life. They can be endowed with various functions through the incorporation of proteins and genes, and have great potential in therapeutic applications.
Article
Biochemistry & Molecular Biology
Gelina S. Kopeina, Boris Zhivotovsky
Summary: This passage introduces that all living organisms have a limited lifespan, and research has mainly focused on the investigation of cellular processes such as proliferation and differentiation, neglecting the understanding of mechanisms of cell elimination. Since the 60s-70s, there has been a systematic study of cell death, which is currently one of the most rapidly developing areas in biomedicine. Due to the wide scope of this research field, the passage attempts to discuss some of the hottest topics that are of interest to many researchers, but not all of them.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Chemistry, Medicinal
Yasuhiro Nishida, Pernilla Christina Berg, Behnaz Shakersain, Karen Hecht, Akiko Takikawa, Ruohan Tao, Yumeka Kakuta, Chiasa Uragami, Hideki Hashimoto, Norihiko Misawa, Takashi Maoka
Summary: This review article provides a comprehensive exploration of the history, chemical and physical attributes, distribution, and biosynthesis of astaxanthin (AX). It also delves into the health benefits, biofunctional characteristics, and market status of AX, aiming to provide a robust foundation for future scientific endeavors addressing societal needs for sustainable nutritional and medicinal solutions.
Letter
Gastroenterology & Hepatology
M. F. Brandao Gois, Trishla Sinha, Johanne E. Spreckels, Arnau Vich Vila, Laura A. Bolte, Rinse K. Weersma, Cisca Wijmenga, Jingyuan Fu, Alexandra Zhernakova, Alexander Kurilshikov
Article
Immunology
Simone J. C. F. M. Moorlag, Vasiliki Matzaraki, Jelmer H. van Puffelen, Charlotte van der Heijden, Sam Keating, Laszlo Groh, Rutger Jan Roring, Olivier B. Bakker, Valerie A. C. M. Koeken, L. Charlotte J. de Bree, Sanne P. Smeekens, Marije Oosting, Raul Aguirre Gamboa, Niels P. Riksen, Ramnik J. Xavier, Cisca Wijmenga, Vinod Kumar, Reinout van Crevel, Boris Novakovic, Leo A. B. Joosten, Yang Li, Mihai G. Netea
Summary: Innate immune cells can develop memory characteristics through trained immunity. Host factors that affect the intensity of individual trained immunity responses are still largely unknown. This study identified key genes that influence trained immunity responses and highlighted the important roles of metabolic and epigenetic processes in regulating these responses.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Esteban A. Lopera-Maya, Alexander Kurilshikov, Adriaan van der Graaf, Shixian Hu, Sergio Andreu-Sanchez, Lianmin Chen, Arnau Vich Vila, Ranko Gacesa, Trishla Sinha, Valerie Collij, Marjiolein A. Y. Klaassen, Laura A. Bolte, Milla F. Brandao Gois, Pieter B. T. Neerincx, Morris A. Swertz, Hermie J. M. Harmsen, Cisca Wijmenga, Jingyuan Fu, Rinse K. Weersma, Alexandra Zhernakova, Serena Sanna
Summary: Host genetics influence the gut microbiome, with the LCT and ABO genes showing significant associations with microbial composition and function. The associations at the LCT locus are modulated by lactose intake, while those at ABO can be explained by participant secretor status determined by their FUT2 genotype. Further loci also show potential associations with microbial taxa and pathways. Larger sample sizes are needed to fully understand the effects of host genetics on the gut microbiome.
Article
Cell Biology
Anastasia Gulyaeva, Sanzhima Garmaeva, Renate A. A. A. Ruigrok, Daoming Wang, Niels P. Riksen, Mihai G. Netea, Cisca Wijmenga, Rinse K. Weersma, Jingyuan Fu, Arnau Vich Vila, Alexander Kurilshikov, Alexandra Zhernakova
Summary: In this study, gut metagenomic data from 1,950 individuals in the Netherlands were analyzed to explore the diversity and functional role of crAss-like phages in human populations. The researchers identified 1,556 crAss-like phage genomes and predicted their hosts to be bacteria of the phylum Bacteroidetes. The study also discovered striking divergent regions in the transcriptional regions of closely related crAss-like phages and explored the temporal stability of these phages over a 4-year period, finding associations between their abundance and several human phenotypes.
Article
Multidisciplinary Sciences
R. Gacesa, A. Kurilshikov, A. Vich Vila, T. Sinha, M. A. Y. Klaassen, L. A. Bolte, S. Andreu-Sanchez, L. Chen, V. Collij, S. Hu, J. A. M. Dekens, V. C. Lenters, J. R. Bjork, J. C. Swarte, M. A. Swertz, B. H. Jansen, J. Gelderloos-Arends, S. Jankipersadsing, M. Hofker, R. C. H. Vermeulen, S. Sanna, H. J. M. Harmsen, C. Wijmenga, J. Fu, A. Zhernakova, R. K. Weersma
Summary: This study analyzed the gut microbiome of 8,208 individuals from the Netherlands and found that the microbiome is primarily shaped by the environment and cohabitation. Only about 6.6% of microbial taxa are heritable, while around 48.6% of taxa are significantly influenced by cohabitation. Additionally, the study identified numerous associations between the microbiome and health, diet, socioeconomic factors, and early-life and current exposome.
Article
Biology
Xiaojing Chu, Anna W. M. Janssen, Hans Koenen, Linzhung Chang, Xuehui He, Irma Joosten, Rinke Stienstra, Yunus Kuijpers, Cisca Wijmenga, Cheng-Jian Xu, Mihai G. Netea, Cees J. Tack, Yang Li, Christoph Buettner
Summary: This study reveals that genetic variants significantly affect T cell composition and susceptibility to type 1 diabetes (T1D). Specifically, the CCR5+ regulatory T cells are associated with T1D through the CCR region, suggesting a shared genetic regulation. In addition, 15 genetic loci that influence immune responses in T1D were identified, including 12 loci that have never been reported in healthy population studies, implying a disease-specific genetic regulation.
Article
Immunology
Aaron D. Ramirez-Sanchez, Xiaojing Chu, Rutger Modderman, Yvonne Kooy-Winkelaar, Sibylle Koletzko, Ilma R. Korponay-Szabo, Riccardo Troncone, Cisca Wijmenga, Luisa Mearin, Sebo Withoff, Iris H. Jonkers, Yang Li
Summary: This study used single-cell RNA sequencing to analyze blood samples from children and identify biomarkers for celiac disease. Differential gene expression profiles were observed in specific cell types before and after disease development. The study also identified genes and pathways associated with CD4+ T cells and NK cells, which could potentially serve as biomarkers for early diagnosis of celiac disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Zlatan Mujagic, Melpomeni Kasapi, Daisy M. A. E. Jonkers, Isabel Garcia-Perez, Lisa Vork, Zsa Zsa R. M. Weerts, Jose Ivan Serrano-Contreras, Alexandra Zhernakova, Alexander Kurilshikov, Jamie Scotcher, Elaine Holmes, Cisca Wijmenga, Daniel Keszthelyi, Jeremy K. Nicholson, Joram M. Posma, Ad A. M. Masclee
Summary: Combining microbiome and metabolome data can distinguish between irritable bowel syndrome (IBS) patients and healthy controls. Unsupervised clustering based on fecal microbiome-metabolome data revealed distinct subsets of IBS patients. The study also found associations between altered serotonin metabolism, unfavorable stress response related to gastrointestinal symptoms, and IBS, supporting the importance of the microbiome-gut-brain axis in the pathogenesis of IBS.
Correction
Genetics & Heredity
Esteban A. Lopera-Maya, Alexander Kurilshikov, Adriaan van der Graaf, Shixian Hu, Sergio Andreu-Sanchez, Lianmin Chen, Arnau Vich Vila, Ranko Gacesa, Trishla Sinha, Valerie Collij, Marjiolein A. Y. Klaassen, Laura A. Bolte, Milla F. Brandao Gois, Pieter B. T. Neerincx, Morris A. Swertz, Hermie J. M. Harmsen, Cisca Wijmenga, Jingyuan Fu, Rinse K. Weersma, Alexandra Zhernakova, Serena Sanna
Article
Medicine, General & Internal
Marwah Doestzada, Daria V. Zhernakova, Inge C. L. van den Munckhof, Daoming Wang, Alexander Kurilshikov, Lianmin Chen, Vincent W. Bloks, Martijn van Faassen, Joost H. W. Rutten, Leo A. B. Joosten, Mihai G. Netea, Cisca Wijmenga, Niels P. Riksen, Alexandra Zhernakova, Folkert Kuipers, Jingyuan Fu
Summary: This study systematically investigated the associations between branched-chain amino acids (BCAAs) and cardiometabolic diseases (CMD), and found significant correlations but no causal relationships between BCAAs and CMD parameters. Specific associations were identified for isoleucine, and the association of valine was influenced by obesity status. These findings highlight the clinical importance of individual BCAAs in the diagnosis, prevention, and treatment of CMD.
Review
Genetics & Heredity
Victoria E. J. M. Palasantzas, Isabel Tamargo-Rubio, Kieu Le, Jelle Slager, Cisca Wijmenga, Iris H. Jonkers, Vinod Kumar, Jingyuan Fu, Sebo Withoff
Summary: Genome-wide association studies (GWAS) have identified numerous genetic variants associated with complex genetic diseases and drug efficacy. However, functional characterization of these variants is challenging due to the lack of human model systems. Organ-on-a-chip (OoC) platforms, enabled by advances in molecular and nanotechnology, provide personalized platforms for studying the impact of genetics and environment on organ physiology. This review highlights the technology and showcases the potential of OoCs in disease modeling and pharmacogenetic research.
TRENDS IN GENETICS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Shixian Hu, J. Casper Swarte, Yanni Li, Johannes Bjork, Ranko Gacesa, Arnau Vich Vila, Rianne Douwes, Valerie Collij, Alexander Kurilshikov, Aadrian Post, Marjolein A. Y. Klaassen, Michele F. Eisenga, Antonio W. Gomes-Neto, Daan Kremer, Bernadien H. Jansen, Tim J. Knobbe, Stefan P. Berger, Jan-Stephan F. Sanders, M. Rebecca Heiner-Fokkema, Robert J. Porte, Frans J. C. Cuperus, Vincent E. Demeijer, Cisca Wijmenga, Eleonora A. M. Festen, Alexandra Zhernakova, Jingyuan Fu, Hermie J. M. Harmsen, Hans Blokzijl, Stephan J. L. Bakker, Rinse Weersma
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Esteban A. Lopera-Maya, Alexander Kurilshikov, Adriaan van der Graaf, Shixian Hu, Sergio Andreu-Sanchez, Lianmin Chen, Arnau Vich-Vila, Ranko Gacesa, Trishla Sinha, Valerie Collij, Marjolein A. Y. Klassen, Laura A. Bolte, Milla F. Brandao-Gois, Pieter B. T. Neerincx, Morris A. Swertz, Hermie J. M. Harmsen, Cisca Wijmenga, Jingyuan Fu, Rinse K. Weersma, Alexandra Zhernakova, Serena Sanna
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Genetics & Heredity
Maarja Lepamets, Chiara Auwerx, Margit Noukas, Annique Claringbould, Eleonora Porcu, Mart Kals, Tuuli Jurgenson, Andrew Paul Morris, Urmo Vosa, Murielle Bochud, Silvia Stringhini, Cisca Wijmenga, Lude Franke, Hedi Peterson, Jaak Vilo, Kaido Lepik, Reedik Magi, Zoltan Kutalik
Summary: In this study, a CNV quality score was developed based on multi-omics evidence to improve CNV detection methods. The use of the score improved the statistical power for downstream association analyses.
HUMAN GENETICS AND GENOMICS ADVANCES
(2022)
Meeting Abstract
Gastroenterology & Hepatology
A. R. Bourgonje, S. Andreu-Sanchez, T. Vogl, S. Hu, A. Vich Vila, S. Leviatan, A. Kurilshikov, S. Klompus, I. N. Kalka, H. M. Van Dullemen, A. Weinberger, M. C. Visschedijk, E. A. M. Festen, K. N. Faber, C. Wijmenga, G. Dijkstra, E. Segal, J. Fu, A. Zhernakova, R. K. Weersma
JOURNAL OF CROHNS & COLITIS
(2022)
