Tubers from patients with tuberous sclerosis complex are characterized by changes in microtubule biology through ROCK2 signalling

Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition.

(2015) Pooja Mohan et al.   Oncotarget

Tubulin Polymerization Promoting Protein 1 (Tppp1) Phosphorylation by Rho-associated Coiled-coil Kinase (Rock) and Cyclin-dependent Kinase 1 (Cdk1) Inhibits Microtubule Dynamics to Increase Cell Proliferation

(2013) Alice V. Schofield et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis

(2012) Pradeep S. Tanwar et al.   HUMAN MOLECULAR GENETICS

Rho-associated Coiled-coil Kinase (ROCK) Protein Controls Microtubule Dynamics in a Novel Signaling Pathway That Regulates Cell Migration

(2012) Alice V. Schofield et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sustained Activation of mTOR Pathway in Embryonic Neural Stem Cells Leads to Development of Tuberous Sclerosis Complex-Associated Lesions

(2011) Laura Magri et al.   Cell Stem Cell

Centrosomes, microtubules and neuronal development

(2011) Marijn Kuijpers et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex

(2011) J. Goto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP

(2011) Jawdat Al-Bassam et al.   TRENDS IN CELL BIOLOGY

Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer

(2011) Christopher A. Maxwell et al.   PLOS BIOLOGY

TACC3-TSC2 maintains nuclear envelope structure and controls cell division

(2010) Laia Gómez-Baldó et al.   CELL CYCLE

The pathophysiology of tuberous sclerosis complex

(2010) Peter B. Crino   EPILEPSIA

Cytokinesis and cancer: Polo loves ROCK‘n’ Rho(A)

(2010) Jing Li et al.   Journal of Genetics and Genomics

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The tuberous sclerosis complex

(2009) Ksenia A. Orlova et al.   Annals of the New York Academy of Sciences

Gene Expression Analysis of Tuberous Sclerosis Complex Cortical Tubers Reveals Increased Expression of Adhesion and Inflammatory Factors

(2009) Karin Boer et al.   BRAIN PATHOLOGY

Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse

(2009) S. W. Way et al.   HUMAN MOLECULAR GENETICS

Defects in cell polarity underlie TSC and ADPKD-associated cystogenesis

(2009) Cleo S. Bonnet et al.   HUMAN MOLECULAR GENETICS

Biological Convergence of Cancer Signatures

(2009) Xavier Solé et al.   PLoS One

Distinct Roles for ROCK1 and ROCK2 in the Regulation of Keratinocyte Differentiation

(2009) Frances E. Lock et al.   PLoS One

Tuberous sclerosis complex proteins control axon formation

(2008) Y.-J. Choi et al.   GENES & DEVELOPMENT

Zebrafish Tsc1 reveals functional interactions between the cilium and the TOR pathway

(2008) Linda M. DiBella et al.   HUMAN MOLECULAR GENETICS

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway

(2008) Tiffiney R. Hartman et al.   HUMAN MOLECULAR GENETICS

CentrosomeDB: a human centrosomal proteins database

(2008) R. Nogales-Cadenas et al.   NUCLEIC ACIDS RESEARCH