Selective modulation through the glucocorticoid receptor ameliorates muscle pathology inmdxmice

Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle

(2014) Cristina Mammucari et al.   Autophagy

A Plant-Derived Ligand Favoring Monomeric Glucocorticoid Receptor Conformation with Impaired Transactivation Potential Attenuates Collagen-Induced Arthritis

(2014) P. Dewint et al.   JOURNAL OF IMMUNOLOGY

Identification of Disease Specific Pathways Usingin VivoSILAC Proteomics in Dystrophin DeficientmdxMouse

(2013) Sree Rayavarapu et al.   MOLECULAR & CELLULAR PROTEOMICS

Interference with Myostatin/ActRIIB Signaling as a Therapeutic Strategy for Duchenne Muscular Dystrophy

(2012) Helge Amthor et al.   CURRENT GENE THERAPY

Osteopontin deficiency delays inflammatory infiltration and the onset of muscle regeneration in a mouse model of muscle injury

(2012) K. Uaesoontrachoon et al.   Disease Models & Mechanisms

A Dissociated Glucocorticoid Receptor Modulator Reduces Airway Hyperresponsiveness and Inflammation in a Mouse Model of Asthma

(2012) L. L. Reber et al.   JOURNAL OF IMMUNOLOGY

Compound A, a Dissociated Glucocorticoid Receptor Modulator, Inhibits T-bet (Th1) and Induces GATA-3 (Th2) Activity in Immune Cells

(2012) Ana C. Liberman et al.   PLoS One

Glucocorticoid-Treated Mice Are an Inappropriate Positive Control for Long-Term Preclinical Studies in the mdx Mouse

(2012) Arpana Sali et al.   PLoS One

Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF-κB

(2011) Sandhya Sriram et al.   AGING CELL

Opposite effects of serum- and glucocorticoid-regulated kinase-1 and glucocorticoids on POMC transcription and ACTH release

(2011) Marie Helene Reiter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Molecular Mechanisms of Glucocorticoids-Mediated Neutrophil Survival

(2011) Arash S. Saffar et al.   CURRENT DRUG TARGETS

An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation

(2011) Alexander Rauch et al.   FASEB JOURNAL

Osteopontin is highly expressed in severely dystrophic muscle and seems to play a role in muscle regeneration and fibrosis

(2011) Simona Zanotti et al.   HISTOPATHOLOGY

The Dystrophin-Glycoprotein Complex in the Prevention of Muscle Damage

(2011) Jessica D. Gumerson et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

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(2011) Jennifer Peterson et al.   MOLECULAR MEDICINE

Systemic delivery of NEMO binding domain/IKKγ inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology

(2011) Daniel P. Reay et al.   NEUROBIOLOGY OF DISEASE

The soy isoflavone genistein blunts nuclear factor kappa-B, MAPKs and TNF-α activation and ameliorates muscle function and morphology in mdx mice

(2011) Sonia Messina et al.   NEUROMUSCULAR DISORDERS

Enhancing translation: Guidelines for standard pre-clinical experiments in mdx mice

(2011) Raffaella Willmann et al.   NEUROMUSCULAR DISORDERS

Aberrant repair and fibrosis development in skeletal muscle

(2011) Christopher J Mann et al.   Skeletal Muscle

Dissociation of Osteogenic and Immunological Effects by the Selective Glucocorticoid Receptor Agonist, Compound A, in Human Bone Marrow Stromal Cells

(2010) Martina Rauner et al.   ENDOCRINOLOGY

Inhibition of the IKK/NF-κB pathway by AAV gene transfer improves muscle regeneration in older mdx mice

(2010) Y Tang et al.   GENE THERAPY

A growth stimulus is needed for IGF-1 to induce skeletal muscle hypertrophy in vivo

(2010) Thea Shavlakadze et al.   JOURNAL OF CELL SCIENCE

Non-invasive Optical Imaging of Muscle Pathology in mdx Mice Using Cathepsin Caged Near-Infrared Imaging

(2010) Andreas R. Baudy et al.   MOLECULAR IMAGING AND BIOLOGY

A plant-derived glucocorticoid receptor modulator attenuates inflammation without provoking ligand-induced resistance

(2009) V Gossye et al.   ANNALS OF THE RHEUMATIC DISEASES

Differential mechanism of NF-κB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts

(2009) Valerie Gossye et al.   ARTHRITIS AND RHEUMATISM

Green tea extract decreases muscle pathology and NF-κB immunostaining in regenerating muscle fibers of mdx mice

(2009) Nicholas P. Evans et al.   CLINICAL NUTRITION

Glucocorticoids inhibit GATA-3 phosphorylation and activity in T cells

(2009) Ana C. Liberman et al.   FASEB JOURNAL

Mechanisms of Muscle Atrophy Induced by Glucocorticoids

(2009) O. Schakman et al.   HORMONE RESEARCH

Abrogation of Glucocorticoid Receptor Dimerization Correlates with Dissociated Glucocorticoid Behavior of Compound A

(2009) Steven Robertson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-β

(2009) Sylvia A. Vetrone et al.   JOURNAL OF CLINICAL INVESTIGATION

Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management

(2009) Katharine Bushby et al.   LANCET NEUROLOGY

Diagnosis and management of Duchenne muscular dystrophy, part 2: implementation of multidisciplinary care

(2009) Katharine Bushby et al.   LANCET NEUROLOGY

Antiinflammatory Properties of a Plant-Derived Nonsteroidal, Dissociated Glucocorticoid Receptor Modulator in Experimental Autoimmune Encephalomyelitis

(2009) Geert van Loo et al.   MOLECULAR ENDOCRINOLOGY

Preclinical drug trials in themdxmouse: Assessment of reliable and sensitive outcome measures

(2009) Christopher F. Spurney et al.   MUSCLE & NERVE

Role of IGF-I in skeletal muscle mass maintenance

(2009) David R. Clemmons   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Cushing's Syndrome

(2008) Rosario Pivonello et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Minireview: Latest Perspectives on Antiinflammatory Actions of Glucocorticoids

(2008) Karolien De Bosscher et al.   MOLECULAR ENDOCRINOLOGY

Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy

(2008) Miranda D. Grounds et al.   NEUROBIOLOGY OF DISEASE

Treatment with inhibitors of the NF-κB pathway improves whole body tension development in the mdx mouse

(2008) Ashley L. Siegel et al.   NEUROMUSCULAR DISORDERS

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL

Disodium cromoglycate protects dystrophin-deficient muscle fibers from leakiness

(2007) Maria Julia Marques et al.   MUSCLE & NERVE