Article
Nutrition & Dietetics
Ilaria Giretti, Rita D'Ascenzo, Alessio Correani, Luca Antognoli, Chiara Monachesi, Chiara Biagetti, Adriana Pompilio, Luisita Marinelli, Ilaria Burattini, Paola Cogo, Virgilio P. Carnielli
Summary: This study found that hypertriglyceridemia and lipid tolerance are common in preterm infants, particularly in infants with lower gestational age. Lipid tolerance is negatively associated with complications of prematurity.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Karla Paulina Luna-Castillo, Xochitl Citlalli Olivares-Ochoa, Rocio Guadalupe Hernandez-Ruiz, Iris Monserrat Llamas-Covarrubias, Sarai Citlalic Rodriguez-Reyes, Alejandra Betancourt-Nunez, Barbara Vizmanos, Erika Martinez-Lopez, Jose Francisco Munoz-Valle, Fabiola Marquez-Sandoval, Andres Lopez-Quintero
Summary: Approximately 25-50% of the global population has elevated serum triglyceride levels, which are associated with increased risks of atherogenic particles, non-alcoholic fatty liver disease, and pancreatitis. High serum triglyceride levels are also linked to cardiovascular disease, the leading cause of death in Western countries. The causes of hypertriglyceridemia are multifactorial, with primary causes including genetic disorders, and secondary causes including lifestyle factors, medical conditions, and medication. Dietary intervention is recommended as the initial step in treating and preventing lipid alterations, with macronutrient distribution changes such as fat or protein, low-carbohydrate diets, and caloric restriction proving to be effective strategies in reducing triglyceride levels. The Mediterranean diet has shown consistent evidence of efficacy in treating hypertriglyceridemia, while omega-3 supplements have been extensively studied and shown effective results in reducing triglyceride levels.
Article
Pediatrics
Mohammad Y. Bader, Melanie A. Lam, Fernando Munoz, Leslie Thompson, Ranjit I. Kylat
Summary: The study shows that there is no difference in the management of intravenous lipid emulsions when obtaining triglyceride levels randomly or as fasting samples. Obtaining triglyceride levels during routine lab draws is appropriate. This implies that 24-hour administration of intravenous lipid emulsions will not interfere with triglyceride levels.
FRONTIERS IN PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Gema Villa Lopez, Maria Angeles Valero Zanuy, Ivan Gonzalez Barrios, Maria Maiz Jimenez, Pilar Gomis Munoz, Miguel Leon Sanz
Summary: The incidence of hypertriglyceridemia in critically ill patients with ARDS-COVID-19 receiving PN was 37 cases per 100 patient-days. Risk factors for this complication included obesity and the use of lopinavir/ritonavir or Propofol. Patients with hypertriglyceridemia required longer duration of PN support, but it did not affect mortality rates.
Article
Endocrinology & Metabolism
Shu Ye, Hui Ran, Hongmei Zhang, Hui Wu, Wen Li, Shichun Du, Qing Su
Summary: KPT2D is a subtype of T2D with characteristics of overweight or obesity, more severe hyperglycemia, and impaired beta-cell functions. Patients with KPT2D have significantly higher serum triglyceride levels, with a higher proportion of very high levels compared to T2D patients.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Review
Nutrition & Dietetics
John K. DiBaise, James S. Scolapio
Summary: This article highlights the importance of home parenteral and enteral nutrition in clinical nutrition and the development of these therapies to support patients. It emphasizes the need for healthcare providers to understand all aspects of HPEN in order to provide safe, effective, and cost-effective support to patients.
Article
Biochemistry & Molecular Biology
Amanda J. Berberich, Alexandra M. Ouedraogo, Salimah Z. Shariff, Robert A. Hegele, Kristin K. Clemens
Summary: The incidence of severe and very severe hypertriglyceridemia in Canadian adults is 1 in 400 and 1 in 2500, respectively. Males, individuals with diabetes, obesity, and alcohol abuse are at highest risk for very severe hypertriglyceridemia. Increased surveillance is recommended for these high-risk groups.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Medicine, General & Internal
Xin Yan, Sanyuan Zhang, Junmei Jia, Jiaolin Yang, Yilai Song, Haoran Duan
Summary: Malnutrition is common in gynecological cancer patients, and the efficacy of total parenteral nutrition (TPN) treatment is controversial. This study found that endometrial and cervical cancer, pre-intervention body weight, and serum albumin level were significant predictors of malnutrition in gynecological cancer patients. TPN treatment improved serum albumin levels and reduced hospitalization duration.
FRONTIERS IN MEDICINE
(2022)
Review
Nutrition & Dietetics
David Berlana
Summary: Parenteral nutrition is a life-saving intervention for patients who cannot receive oral or enteral nutrition. It consists of essential components such as carbohydrates, lipids, amino acids, vitamins, and electrolytes. Parenteral nutrition should be provided through a central line to prevent complications. However, peripheral administration is possible in some cases. Monitoring and early management are crucial to prevent complications associated with parenteral nutrition therapy.
Article
Public, Environmental & Occupational Health
Hye Rin Choi, Hyeon Chang Kim
Summary: The study aimed to investigate the association between age at first childbirth and the risk of hypertriglyceridemia among Korean women. The results showed that giving birth to one's first child before the age of 20 years was associated with an increased risk of hypertriglyceridemia.
EPIDEMIOLOGY AND HEALTH
(2022)
Article
Nutrition & Dietetics
Traci Grucz, Jessica Crow, Stephanie Davis, Erin Gager, Jessica Beattie, Kenneth Shermock, David Sugrue, Andrew Jarrell
Summary: The addition of levocarnitine in parenteral nutrition did not lead to a significant difference in triglyceride levels at 30 days for hospitalized adults with hypertriglyceridemia. However, there was a greater rate of improvement in triglyceride levels pre-intervention to post-intervention with the addition of levocarnitine.
NUTRITION IN CLINICAL PRACTICE
(2022)
Review
Nutrition & Dietetics
Maria Elena Capra, Giacomo Biasucci, Giuseppe Banderali, Cristina Pederiva
Summary: Hypertriglyceridemia is a lipid disorder that can range in prevalence, being very common when considering slightly elevated triglyceride plasma values and extremely rare when only severely elevated levels are considered. The severe forms are often caused by genetic mutations, while secondary forms are usually less severe and can be linked to various diseases or drugs. Nutritional intervention plays a crucial role in treating hypertriglyceridemia, with different approaches for different forms.
Article
Nutrition & Dietetics
Giovanni Boscarino, Maria Giulia Conti, Maria Di Chiara, Marco Bianchi, Elisa Onesta, Francesca Faccioli, Giorgia Deli, Paola Repole, Salvatore Oliva, Francesco Cresi, Gianluca Terrin
Summary: Early minimal enteral feeding is associated with fewer PN-related metabolic complications and a higher rate of survival in critically ill newborns.
Article
Nutrition & Dietetics
Alexander Folwaczny, Elisa Waldmann, Julia Altenhofer, Kerstin Henze, Klaus G. Parhofer
Summary: Fasting and postprandial hypertriglyceridemia are risk factors for atherosclerosis. Dietary interventions may impact postprandial triglyceride metabolism in mildly to moderately hypertriglyceridemic patients. Replacing saturated fatty acids with medium-chain fatty acids could be a treatment option for preventing postprandial hypertriglyceridemia in these patients.
Review
Nutrition & Dietetics
Gregory Guthrie, Douglas Burrin
Summary: Total parenteral nutrition (TPN) is a critical intervention for infants unable to feed orally, but prolonged reliance on TPN poses a risk of liver injury, particularly through parenteral nutrition associated cholestasis (PNAC) driven by lipid emulsions. Studies suggest that new emulsions containing fish oil and medium chain triglycerides show promise in reducing the incidence of PNAC.
Article
Ophthalmology
Suryan Dunker, Bjorn Winkens, Frank van den Biggelaar, Rudy Nuijts, Pieter Jan Kruit, Mor Dickman
Summary: This Dutch registry study identified risk factors for rebubbling and early graft failure in DMEK. Rebubbling was associated with higher graft failure, while older recipient age and surgical complications were risk factors for rebubbling. Early graft failure risk factors included transplantation before 2016 and surgical complications. Rebubbling was also associated with significantly lower endothelial cell densities.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
M. M. Suverein, T. S. R. Delnoij, R. Lorusso, G. J. Brandon Bravo Bruinsma, L. Otterspoor, C. V. Elzo Kraemer, A. P. J. Vlaar, J. J. van der Heijden, E. Scholten, C. den Uil, T. Jansen, B. van den Bogaard, M. Kuijpers, K. Y. Lam, J. M. Montero Cabezas, A. H. G. Driessen, S. Z. H. Rittersma, B. G. Heijnen, D. Dos Reis Miranda, G. Bleeker, J. de Metz, R. S. Hermanides, J. Lopez Matta, S. Eberl, D. W. Donker, R. J. van Thiel, S. Akin, O. van Meer, J. Henriques, K. C. Bokhoven, L. Mandigers, J. J. H. Bunge, M. E. Bol, B. Winkens, B. Essers, P. W. Weerwind, J. G. Maessen, M. C. G. van de Poll
Summary: Extracorporeal cardiopulmonary resuscitation (CPR) and conventional CPR have similar effects on survival with a favorable neurologic outcome in patients with refractory out-of-hospital cardiac arrest.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Neurosciences
Elske Gravesteijn, Jos J. Adam, Ronald P. Mensink, Bjorn Winkens, Jogchum Plat
Summary: This study found that NWT-03 egg protein hydrolysate can improve cognitive function in patients with metabolic syndrome, especially in the executive function domain. The specific mechanism of action needs further research.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Sport Sciences
Yingyi Wu, Pascal W. M. Van Gerven, Renate H. M. de Groot, Bert O. O. Eijnde, Bjorn Winkens, Hans H. C. M. Savelberg
Summary: University students often engage in prolonged sitting, which negatively affects their cognition and mood. Light-intensity physical activity (LIPA) breaks may improve attention and executive functioning. However, interrupting sitting with LIPA did not have significant acute effects on attention, response inhibition, working memory updating, or mood.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Oncology
Lennart Huizing, Lin Chen, Anjali A. A. Roeth, Lara R. R. Heij, Bryn Flinders, Stefan A. W. Bouwense, Benjamin Balluff, Ulf P. P. Neumann, Ron M. A. Heeren, Steven W. M. Olde Damink, Rob J. J. Vreeken, Frank G. G. Schaap
Summary: Sulfatides were found in tumor tissue of patients with intrahepatic cholangiocarcinoma (iCCA), and the abundance and ratio of unsaturated to saturated sulfatides were associated with tumor recurrence in iCCA patients.
Review
Oncology
Anouk A. S. van den Bosch, Johanna M. A. Pijnenborg, Andrea Romano, Bjorn Winkens, Louis J. M. van der Putten, Roy F. P. M. Kruitwagen, Henrica M. J. Werner
Summary: This systematic review found that adipose tissue (AT) distribution plays a significant role in the development and prognosis of endometrial cancer (EC), correlating with obesity measures, histological subtypes, lymph node metastasis, and sex steroid levels. Further well-designed prospective studies are needed to explore these differences more specifically and understand how it can contribute to the prediction and therapy of EC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Nicole Hildebrand, Allard G. Wijma, Bart C. Bongers, Sander S. Rensen, Marcel den Dulk, Joost M. Klaase, Steven W. M. Olde Damink
Summary: The study aims to assess the feasibility of a home-based exercise prehabilitation program in unfit patients scheduled for pancreatic surgery. The program includes high-intensity interval training and functional task exercises to improve patients' aerobic capacity and muscle function, leading to better treatment outcomes and quality of life. The results of this study may have important implications for implementing prehabilitation programs in complex abdominal surgeries such as pancreatic surgery.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Gastroenterology & Hepatology
L. M. Janssen, A. Rezazadeh Ardabili, M. J. L. Romberg-Camps, B. Winkens, R. J. van den Broek, J. Hulst, H. J. A. Verwijs, D. Keszthelyi, D. M. A. E. Jonkers, A. A. van Bodegraven, M. J. Pierik, Z. Mujagic
Summary: Abdominal pain is common in patients with IBD in remission and is associated with psychosocial factors. A more holistic treatment approach for patients with IBD suffering from abdominal pain may improve quality of care and subjective wellbeing.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Nutrition & Dietetics
Marla T. H. Hahnraths, Bjorn Winkens, Onno C. P. van Schayck
Summary: Understanding the health effects of scaled-up school-based interventions is crucial for integrating health in schools. This study examined the effectiveness of the Healthy Primary School of the Future (HPSF) initiative in real-world settings. Due to COVID-19 limitations, implementation of HPSF activities was restricted. Results showed that waist circumference in the medium implementer group significantly increased at one-year and two-year follow-up compared to the low implementer group. No significant effects were observed for other outcomes.
Article
Oncology
Monse W. M. Wieland, Walmari Pilz, Bjorn Winkens, Ann Hoeben, Anna C. H. Willemsen, Bernd Kremer, Laura W. J. Baijens
Summary: Oropharyngeal dysphagia, malnutrition, sarcopenia, and frailty are common risks in newly diagnosed head-and-neck cancer patients. Early identification through multi-domain screening can help prevent complications and improve treatment outcomes.
Article
Oncology
Gregory van der Kroft, Leonard Wee, Sander S. Rensen, Ralph Brecheisen, David P. J. van Dijk, Roman Eickhoff, Anjali A. Roeth, Florian T. Ulmer, Andre Dekker, Ulf P. Neumann, Steven W. M. Olde Damink
Summary: The study aimed to investigate whether body composition-associated radiomics features hold additional value over conventional body composition analysis and clinical patient characteristics used to predict survival of pancreatic ductal adenocarcinoma (PDAC) patients. The results showed that radiomics features provided improved predictive performance compared to conventional body composition variables for the prediction of overall survival of PDAC patients undergoing primary resection.
FRONTIERS IN ONCOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
N. Bevers, A. Aliu, D. Wong, L. Derijks, B. Winkens, A. Vreugdenhil, M. Pierik, P. Van Rheenen
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Endocrinology & Metabolism
Kelly G. H. van de Pas, Maartje A. P. de Krom, Bjorn Winkens, Francois M. H. van Dielen, Anita C. E. Vreugdenhil
Summary: This study aimed to evaluate the health-related quality of life (HRQoL) in treatment-seeking children and adolescents with overweight, obesity, and severe obesity. The results showed that individuals with severe obesity had significantly lower physical and psychological wellbeing compared to those with overweight and obesity. It is important for lifestyle intervention programs to consider the specific needs of this vulnerable group.
Meeting Abstract
Gastroenterology & Hepatology
J. Snijkers, B. Winkens, L. Vork, Z. Z. Weerts, Z. Mujagic, C. Leue, J. Kruimel, D. Jonkers, A. Masclee, D. Keszthelyi
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Geriatrics & Gerontology
Anne G. R. Visser, Bjorn Winkens, Jos M. G. A. Schols, Rob Janknegt, Bartholomeus Spaetgens
Summary: This study assessed the impact of polypharmacy on 30-day COVID-related mortality in nursing home residents. The results showed that nursing home residents with a higher number of medications and who were not vaccinated had a higher 30-day COVID-related mortality. These findings have important implications for managing COVID-19 in the frail nursing home population.
EUROPEAN GERIATRIC MEDICINE
(2023)