Article
Nutrition & Dietetics
Erin E. Morris, Neely C. Miller, Nicholas A. Marka, Jennifer L. Super, Emily M. Nagel, Juan David Gonzalez, Ellen W. Demerath, Sara E. Ramel
Summary: Retrospective studies show that parenteral nutrition during the first week after birth, providing calories, proteins, and lipids, is associated with improved neurodevelopment. However, an enhanced parenteral nutrition protocol in the early stage did not lead to improved neurodevelopmental outcomes. Instead, higher enteral caloric and protein intake in the first week after birth were associated with improved processing speed.
Review
Nutrition & Dietetics
Walter Mihatsch, Miguel Angel Jimenez Varas, Lucia Lorenzino Diehl, Virgilio Carnielli, Rahel Schuler, Corinna Gebauer, Miguel Saenz de Pipaon Marcos
Summary: The present systematic review aims to update the available evidence and examine the impact of standardized PN vs. individualized PN on protein intake, immediate morbidities, growth, and long-term outcome in preterm infants. Recent studies suggest that standardized PN may improve growth through higher nutrient intake, particularly protein, and reduce the incidence of sepsis. However, there is no significant effect on mortality, NEC incidence, or days of PN.
Article
Pediatrics
Mohammad Y. Bader, Melanie A. Lam, Fernando Munoz, Leslie Thompson, Ranjit I. Kylat
Summary: The study shows that there is no difference in the management of intravenous lipid emulsions when obtaining triglyceride levels randomly or as fasting samples. Obtaining triglyceride levels during routine lab draws is appropriate. This implies that 24-hour administration of intravenous lipid emulsions will not interfere with triglyceride levels.
FRONTIERS IN PEDIATRICS
(2021)
Article
Pediatrics
Meiying Quan, Zhenghong Li, Danhua Wang, Kurt Schibler, Li Yang, Jie Liu, Xuanguang Qin, Xin Zhang, Tongyan Han, Ying Li
Summary: This study examined the parental nutrition practice and clinical prescription factors for hospitalized late preterm infants. The results showed that over half of the infants were supported by parenteral nutrition and factors such as gestational age, birth weight, hypoglycemia, small for gestational age, feeding intolerance, neonatal respiratory distress syndrome, neonatal infection, and slow enteral nutrition advancement rate influenced the administration of parenteral nutrition.
FRONTIERS IN PEDIATRICS
(2022)
Article
Nutrition & Dietetics
Chiara Biagetti, Alessio Correani, Rita D'Ascenzo, Enrica Ferretti, Cecilia Proietti, Luca Antognoli, Ilaria Giretti, Adriana Pompilio, Paola Cogo, Virgilio P. Carnielli
Summary: In a large cohort of preterm infants receiving routine PN, the use of fish oil containing LE did not lead to better neurodevelopment outcomes compared to standard LE, despite some infants already receiving fish oil-enriched lipid emulsions. Large randomized controlled trials are needed to clarify the impact of fish oil containing LE on neurodevelopment in preterm infants.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
I-Lun Chen, Chih-Hsing Hung, Hsin-Chun Huang
Summary: This study found that lipid emulsions containing fish oil can improve the neurodevelopmental outcomes of premature infants, especially at ages two and five, with significant reductions in the prevalence of diseases such as ADHD and ASD.
Article
Nutrition & Dietetics
Ilaria Giretti, Alessio Correani, Luca Antognoli, Chiara Monachesi, Paolo Marchionni, Chiara Biagetti, Maria Paola Bellagamba, Paola Cogo, Rita D'Ascenzo, Ilaria Burattini, Virgilio P. Carnielli
Summary: The study showed that in preterm infants, blood urea concentration was positively correlated with intravenous amino acid intake and negatively correlated with intravenous non-protein energy intake. This suggests that adjusting intravenous amino acid intake based on blood urea concentrations is justified.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Anders K. Nilsson, Anders Pedersen, Daniel Malmodin, Anna-My Lund, Gunnel Hellgren, Chatarina Lofqvist, Ingrid Hansen Pupp, Ann Hellstrom
Summary: The serum concentration of free choline in extremely preterm infants decreases in the first week after birth, then gradually increases over the next 90 days without reaching the initial levels. There is a negative correlation between a high intake of parenteral fluids and serum-free choline levels.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Christoph Binder, Hannah Schned, Nicholas Longford, Eva Schwindt, Margarita Thanhaeuser, Alexandra Thajer, Katharina Goeral, Matteo Tardelli, David Berry, Lukas Wisgrill, David Seki, Angelika Berger, Katrin Klebermass-Schrehof, Andreas Repa, Vito Giordano
Summary: The study compared the impact of using S-LE and SMOF-LE on neuronal conduction in preterm infants, finding no significant difference in N2 and P2 values between the two groups, but a possible better treatment effect in the SMOF-LE group with a trend towards shorter latency.
Article
Nutrition & Dietetics
Ola Abd El-Aziz Sayed, Sahar B. Hassan, Ayat Abdelkader, Mahmoud Elsabahy, Nafisa H. R. Abdelaziz, Ahmed M. El-Sayed
Summary: The study evaluated the stability, safety, and efficacy of PN admixtures containing 4-oil ILE in preterm neonates for the first time. The results showed that the PN admixtures were stable at 25 degrees Celsius and were safe and well tolerated over an 8-day period, with the need for close monitoring of serum triglyceride levels.
NUTRITION IN CLINICAL PRACTICE
(2021)
Article
Nutrition & Dietetics
Giovanni Boscarino, Maria Giulia Conti, Maria Di Chiara, Marco Bianchi, Elisa Onesta, Francesca Faccioli, Giorgia Deli, Paola Repole, Salvatore Oliva, Francesco Cresi, Gianluca Terrin
Summary: Early minimal enteral feeding is associated with fewer PN-related metabolic complications and a higher rate of survival in critically ill newborns.
Article
Nutrition & Dietetics
Colin Morgan, Samantha Parry, Julie Park, Maw Tan
Summary: This study investigated the effects of a SCAMP nutrition regimen on neurodevelopmental outcomes in very-preterm infants. Although the regimen improved head growth failure, it did not show statistically significant improvement in neurodevelopmental outcomes.
Article
Nutrition & Dietetics
Karla Paulina Luna-Castillo, Xochitl Citlalli Olivares-Ochoa, Rocio Guadalupe Hernandez-Ruiz, Iris Monserrat Llamas-Covarrubias, Sarai Citlalic Rodriguez-Reyes, Alejandra Betancourt-Nunez, Barbara Vizmanos, Erika Martinez-Lopez, Jose Francisco Munoz-Valle, Fabiola Marquez-Sandoval, Andres Lopez-Quintero
Summary: Approximately 25-50% of the global population has elevated serum triglyceride levels, which are associated with increased risks of atherogenic particles, non-alcoholic fatty liver disease, and pancreatitis. High serum triglyceride levels are also linked to cardiovascular disease, the leading cause of death in Western countries. The causes of hypertriglyceridemia are multifactorial, with primary causes including genetic disorders, and secondary causes including lifestyle factors, medical conditions, and medication. Dietary intervention is recommended as the initial step in treating and preventing lipid alterations, with macronutrient distribution changes such as fat or protein, low-carbohydrate diets, and caloric restriction proving to be effective strategies in reducing triglyceride levels. The Mediterranean diet has shown consistent evidence of efficacy in treating hypertriglyceridemia, while omega-3 supplements have been extensively studied and shown effective results in reducing triglyceride levels.
Article
Nutrition & Dietetics
Ulrika Sjoebom, Mats X. Andersson, Aldina Pivodic, Anna -My Lund, Mireille Vanpee, Ingrid Hansen-Pupp, David Ley, Dirk Wackernagel, Karin Savman, Lois E. H. Smith, Chatarina Lofqvist, Ann Hellstrom, Anders K. Nilsson
Summary: This study focused on the risk of deficits in long-chain polyunsaturated fatty acids (LCPUFAs) in preterm infants, which may lead to morbidities and hinder neurodevelopment. By analyzing the serum fatty acid profiles of preterm infants and the impact of enteral and parenteral lipid sources, the study found that enteral supplementation of fatty acids can increase the target fatty acids without significant impact on other fatty acids, while parenteral lipid administration can result in decreased levels of AA and DHA relative to other fatty acids. The study also observed differences in fatty acid patterns when expressed in relative or absolute units.
CLINICAL NUTRITION
(2023)
Article
Pediatrics
Wissam Alburaki, Kamran Yusuf, Jenna Dobry, Rachel Sheinfeld, Belal Alshaikh
Summary: Providing high early dose of parenteral lipid in the first week of age in very low birth weight (VLBW) infants resulted in less weight loss and lower incidence of extrauterine growth restriction (EUGR).
JOURNAL OF PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Ilaria Giretti, Alessio Correani, Luca Antognoli, Chiara Monachesi, Paolo Marchionni, Chiara Biagetti, Maria Paola Bellagamba, Paola Cogo, Rita D'Ascenzo, Ilaria Burattini, Virgilio P. Carnielli
Summary: The study showed that in preterm infants, blood urea concentration was positively correlated with intravenous amino acid intake and negatively correlated with intravenous non-protein energy intake. This suggests that adjusting intravenous amino acid intake based on blood urea concentrations is justified.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Chiara Monachesi, Anil K. Verma, Giulia N. Catassi, Tiziana Galeazzi, Elisa Franceschini, Valentina Perticaroli, Elena Lionetti, Carlo Catassi
Summary: This study investigated the level of gluten contamination in the daily diet of celiac children on a gluten-free diet. Results showed that in a country with high celiac disease awareness, the daily unintended exposure to gluten of treated celiac children on regular follow-up is very low, and did not exceed the tolerable threshold of gluten intake in the gluten-free diet.
Article
Nutrition & Dietetics
Chiara Biagetti, Alessio Correani, Rita D'Ascenzo, Enrica Ferretti, Cecilia Proietti, Luca Antognoli, Ilaria Giretti, Adriana Pompilio, Paola Cogo, Virgilio P. Carnielli
Summary: In a large cohort of preterm infants receiving routine PN, the use of fish oil containing LE did not lead to better neurodevelopment outcomes compared to standard LE, despite some infants already receiving fish oil-enriched lipid emulsions. Large randomized controlled trials are needed to clarify the impact of fish oil containing LE on neurodevelopment in preterm infants.
CLINICAL NUTRITION
(2021)
Article
Engineering, Biomedical
Duy-Anh Nguyen, Aurelie De Mul, Aparna U. Hoskote, Paola Cogo, Eduardo M. da Cruz, Simon Erickson, Javier J. Lasa, Ravi R. Thiagarajan, Melania M. Bembea, Oliver Karam
Summary: This study aims to explore the practice and indications for pediatric ECPR. The survey results reveal significant differences in ECPR candidacy based on patient category, location of arrest, duration of CPR, witness status, and last blood pH. Further research should help define the optimal ECPR initiation strategy.
Article
Biochemical Research Methods
Manuela Simonato, Francesca Ricci, Chiara Catozzi, Matteo Storti, Sonia Giambelluca, Alessio Correani, Fabrizio Salomone, Paola Cogo, Virgilio Carnielli
Summary: Stable isotope tracing is a safe method for metabolic studies, and this study demonstrates the feasibility of using deuterium-depleted water (DDW) as a metabolic precursor for lipid synthesis. The results suggest that DDW can be used to label pulmonary surfactant lipids in animals and humans.
JOURNAL OF MASS SPECTROMETRY
(2022)
Article
Nutrition & Dietetics
Giulia N. Catassi, Alfredo Pulvirenti, Chiara Monachesi, Carlo Catassi, Elena Lionetti
Summary: The combination of DGP IgG and TTG IgA antibodies can improve the diagnostic sensitivity of celiac disease in children under 2 years of age, although TTG IgA has higher specificity.
Article
Gastroenterology & Hepatology
Chiara Monachesi, Anil K. Verma, Giulia N. Catassi, Elisa Franceschini, Simona Gatti, Rosaria Gesuita, Elena Lionetti, Carlo Catassi
Summary: The study found that even traces of gluten in a standard gluten-free diet may lead to positivity in urinary gluten immunogenic peptides (GIP) determination. However, false negativity is common after ingesting 10-1,000 mg of gluten. Therefore, urinary GIP determination may not be a reliable tool to assess compliance to a gluten-free diet for patients with celiac disease or other gluten-related disorders.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Review
Food Science & Technology
Anil K. Verma, Sayanti Mandal, Aadhya Tiwari, Chiara Monachesi, Giulia N. Catassi, Akash Srivastava, Simona Gatti, Elena Lionetti, Carlo Catassi
Summary: Wheat gluten triggers celiac disease, and a strict gluten-free diet is currently the only treatment. The use of CRISPR/Cas9 technology to develop wheat varieties with low immunogenicity shows promise, but further studies are needed for efficient application and exploration.
Article
Obstetrics & Gynecology
Stefano Tombolini, Flavia De Angelis, Alessio Correani, Paolo Marchionni, Chiara Monachesi, Enrica Ferretti, Francesca Staffolani, Rita D'Ascenzo, Virgilio Carnielli
Summary: This study aimed to evaluate the association between low regional cerebral oxygen saturation (rScO2) and neurodevelopment in preterm infants classified as no brain injury (NBI). The results showed that in NBI preterm infants, rScO2<55% for more than 10 hours in the first 3 days of life (NIRS10H) was negatively associated with neurodevelopment at 24 months. Furthermore, NBI infants with NIRS10H were found to have lower systemic saturation values.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Chiara Biagetti, Alessio Correani, Luca Antognoli, Ilaria Burattini, Rita D'Ascenzo, Maria Paola Bellagamba, Emanuela Andresciani, Angela Maria Felicita Garzone, Paola Cogo, Virgilio P. P. Carnielli
Summary: After analyzing the data of infants with a birth weight between 1250 and 1499 g, it was found that only 26% of them needed parenteral nutrition (PN). Among them, 19% needed PN for medical reasons, while 7% had no clear indication. Infants who received medically indicated PN were younger, smaller, sicker, and had lower weight gain. Infants managed with enteral nutrition showed no significant differences in body size, development, and neurodevelopment compared to reference values.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Genetics & Heredity
Lucia Santoro, Chiara Monachesi, Lucia Zampini, Lucia Padella, Tiziana Galeazzi, Elena Santori, Rosanna Cordiali, Andrea Dardis, Carlo Catassi, Emilia Boccieri, Federica Galaverna, Franco Locatelli
Summary: This article describes a case of alpha-mannosidosis (AM) in an infant who received enzyme replacement therapy (ERT) before and during hematopoietic stem cell transplantation (HSCT). Eight ERT infusions were given before HSCT, followed by an additional 90 days of treatment. After 3 years post-HSCT, the clinical and laboratory data show that early intervention may reduce disease progression and the levels of mannosyl-oligosaccharides (OS) in urine and plasma. This report emphasizes the importance of early diagnosis and prompt initiation of treatment in minimizing the progression of symptoms in AM.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Pediatrics
Tiziana Galeazzi, Sara Quattrini, Dorina Pjetraj, Simona Gatti, Chiara Monachesi, Elisa Franceschini, Luisita Marinelli, Giulia N. N. Catassi, Elena Lionetti, Carlo Catassi
Summary: The purpose of this cross-sectional study was to determine the distribution of 25(OH)D levels in healthy Italian school-age children and investigate its relationship with factors such as season, BMI, gender, age, and ethnicity. The results showed that healthy Italian schoolchildren have low 25(OH)D levels, especially during winter and spring. This indicates the need for effective initiatives to support adequate vitamin D levels in this population group.
ITALIAN JOURNAL OF PEDIATRICS
(2023)