Article
Medicine, General & Internal
Stephen M. Goldman, Susan L. Eskridge, Sarah R. Franco, Jason M. Souza, Scott M. Tintle, Thomas C. Dowd, Joseph Alderete, Benjamin K. Potter, Christopher L. Dearth
Summary: The aim of this study was to develop a data-driven approach for identifying limb salvage cases and studying their clinical outcomes. With the use of medical code data, a population of 2018 US Service members who underwent limb salvage was identified, representing 59.5% of the combat-related lower extremity trauma population. Comparison with expert opinion showed moderate agreement, and the approach demonstrated potential for future retrospective analyses of short- and long-term outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Stephen M. Goldman, Susan L. Eskridge, Sarah R. Franco, Christopher L. Dearth
Summary: This retrospective study provides insights into the demographics and injury characteristics of a group of US Service members with combat-related lower extremity limb salvage. The LS cohort exhibited more blast injuries and greater injury burden compared to their peers with non-threatened limb trauma. However, limb retention outcomes were not significantly affected by demographic factors or total injury burden.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Jordan G. Tropf, Benjamin W. Hoyt, Sarah A. Walsh, Jeffery A. Gibson, Elizabeth M. Polfer, Jason M. Souza, Benjamin K. Potter
Summary: This study compared long-term health outcomes after high-energy lower-extremity trauma between patients who underwent flap-based limb salvage or amputation. The results showed that there were no significant differences in terms of body mass index (BMI) and development of metabolic disease between the two treatment cohorts.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Biochemistry & Molecular Biology
Rui D. Alvites, Mariana V. Branquinho, Ana C. Sousa, Federica Zen, Monica Maurina, Stefania Raimondo, Carla Mendonca, Luis Atayde, Stefano Geuna, Artur S. P. Varejao, Ana C. Mauricio
Summary: This study established a sheep model for common peroneal nerve injuries, describing nerve anatomy, functional consequences, surgical protocol, and therapeutic options. Through morphological and stereological studies, optimal access methods and study periods were determined, providing foundational data for future research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Zane B. Perkins, Alexander J. Kersey, Joseph M. White, Alexis L. Lauria, Brandon W. Propper, Nigel R. M. Tai, Todd E. Rasmussen
Summary: The study found that successful limb salvage is closely related to the duration of ischemia, with a 10% reduction in the probability of successful limb salvage for every hour delay to revascularization. Military trauma systems should prioritize rapid hemorrhage control and early limb revascularization.
Article
Orthopedics
Timothy Bage, Dominic M. Power
Summary: Nerves may be inadvertently injured during orthopaedic surgery, with the importance of diagnosis and treatment being emphasized. Timely clinical examination and interventions can prevent deterioration of the condition.
EFORT OPEN REVIEWS
(2021)
Review
Clinical Neurology
Ralph N. A. Murphy, Heba Elsayed, Sahiba Singh, Jo Dumville, Jason K. F. Wong, Adam J. Reid
Summary: The systematic review identified 56 individual outcome measures used in the management of PNI across 28 different countries, with a total of 7097 patients. Ten core domains were defined to standardize outcome reporting and facilitate development of novel treatments in the field of peripheral nerve injury.
Article
Orthopedics
John C. Dunn, Michael D. Eckhoff, Tyler C. Nicholson, William Campbell, Kimbra Kenney, Jonathan Smith, Mark Landau, Matthew Miller, Jason Souza, Leon J. Nesti
Summary: This study described combat-sustained peripheral nerve injuries and outcomes after evaluation in a military multidisciplinary peripheral nerve clinic. Service members with more severe initial injuries had worse final outcomes and timely evaluation was associated with improved sensory recovery.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2021)
Article
Biochemistry & Molecular Biology
Jingyi Du, Nan Cheng, Yifan Deng, Ping Xiang, Jianfen Liang, Zhenye Zhang, Ziqing Hei, Xiang Li
Summary: This study reveals the potential role of astrocyte senescence in neuroinflammation following peripheral nerve injury. Treatment with senolytic drug combination can effectively attenuate inflammation and alleviate pain sensitivity, providing a novel therapeutic strategy for neuropathic pain.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Dermatology
Guohua Wang, Huipeng Li, Baoxing Chen, Pengwei Guo, Hua Zhang
Summary: A meta-analysis was conducted to compare the outcomes of endovascular surgery (ES) and open surgery (OS) in managing peripheral artery diseases (PADs) with regards to amputation and limb salvage (LS). The analysis included 31 studies with a total of 19,948 individuals with PADs, of which 8,861 underwent ES and 11,087 underwent OS. The findings showed that ES significantly reduced the risk of amputation compared to OS in PADs patients. However, there was no significant difference between ES and OS in terms of limb salvage at 30 days, 1 year, and 3 years in PADs patients. These results highlight the potential benefits of ES in reducing amputation risk in PADs patients, although caution should be exercised due to the small sample size of some included studies.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kanav Goyal, Purnima Aggarwal, Monica Gupta
Summary: This study compared the CSA of the sural and tibial nerves in diabetic peripheral neuropathy patients, finding that the CSA of the tibial nerve had higher sensitivity in the DPN group for screening purposes. Ultrasound can be used as the initial diagnostic tool for detecting DPN, especially in cases where nerve conduction studies are negative.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Paramita Basu, Dayna L. Averitt, Camelia Maier, Arpita Basu
Summary: Oxidative stress is associated with peripheral neuropathic pain, and the Nrf2 signaling pathway can alleviate the pain. Nrf2 binds with protein 1 in normal conditions but translocates to the nucleus and binds with other proteins during neuropathy, thus reducing pathology and pain.
Article
Critical Care Medicine
Patricia Rodarte, Jamieson O'Marr, Billy Haonga, Deogratias Patrick, Kian Niknam, Mayur Urva, Abigail Cortez, Willem-Jan Metsemakers, David Shearer, Saam Morshed
Summary: This study evaluates the diagnostic performance of telephone questionnaires in identifying patients with fracture-related infections (FRIs) after open tibia fracture fixation in Tanzania. The study shows that telephone questionnaires have adequate diagnostic performance, with drainage being the main indicator for FRIs.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Orthopedics
Changhoon Jeong, Sang Uk Lee, Hyun Gyun Kim, Sun Young Joo
Summary: Trampoline-related fractures of the proximal tibial metaphysis in young children are often caused by using a trampoline with a heavier person. However, there were no significant changes in limb alignment observed during at least one year of follow-up.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Trevor Poitras, Douglas W. Zochodne
Summary: Common mechanisms of peripheral axon regeneration are recruited following diverse forms of damage to peripheral nerve axons. Supporting peripheral axon regrowth could be achieved through direct axon support or manipulation of the inflammatory milieu. Understanding the molecular barriers to regrowth and exploiting the downstream signaling pathways that impact neuron growth are promising approaches for promoting adult peripheral axon regeneration. This review emphasizes intrinsic aspects of adult peripheral axon regeneration and highlights several molecular barriers to regrowth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Peter R. Wasky, Michael J. Beltran
Summary: Intramedullary nailing for periarticular lower extremity fractures is difficult, especially as the fracture extends closer to the joint surface. Factors such as bone condition, soft tissue injury, and fracture pattern need to be considered when deciding between using a nail or a plate.
ORTHOPEDIC CLINICS OF NORTH AMERICA
(2021)
Article
Orthopedics
Phillip M. Mitchell, Joseph T. Labrum, Michael J. Beltran, Cory A. Collinge
Summary: The Gibson approach did not reliably provide increased anterior exposure compared with a K-L approach in a cadaver model. A trochanteric osteotomy can be expected to add 1-2 cm of increased anterior exposure in both approaches.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2021)
Article
Education, Scientific Disciplines
Sophia A. Traven, Kathy M. McGurk, Alyssa D. Althoff, Zeke J. Walton, Lee R. Leddy, Benjamin K. Potter, Harris S. Slone
Summary: Operative times for lower extremity orthopedic trauma increased as resident seniority increased. Senior resident participation was associated with increased wound dehiscence, whereas junior resident participation was associated with an increased risk of deep surgical site infections. Academic quarter within the academic year did not correlate with any of the surgical complications.
JOURNAL OF SURGICAL EDUCATION
(2021)
Article
Orthopedics
Colonel B. K. Potter, Michael J. Bosse
Summary: The clinical practice guideline focuses on the treatment of severe lower limb trauma and provides evidence-based recommendations for key decisions on limb salvage versus early amputation. There are 11 recommendations in the guideline to evaluate important decision factors. The work group also emphasized the need for further research on the treatment of high-energy lower extremity trauma and the shared decision-making process.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2021)
Article
Orthopedics
Shumaila Sarfani, Michael J. Beltran, Michael Benvenuti, Cory A. Collinge
Summary: This retrospective study aimed to describe the pathoanatomy of femoral neck fractures in young patients, particularly focusing on Pauwels II and III fractures. The study identified common features such as wide-based caudal head-neck segment, presence of comminution, and various orientations and deformities of the fractures. The goal was to improve surgeons' decision-making for treatment.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2021)
Editorial Material
Orthopedics
Benjamin K. Potter
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2022)
Editorial Material
Orthopedics
Benjamin K. Potter
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2022)
Editorial Material
Orthopedics
Benjamin K. Potter
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2022)
Editorial Material
Orthopedics
Benjamin K. Potter
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Article
Critical Care Medicine
Cassie J. Rowe, Sarah A. Walsh, Andrea H. Dragon, Alisha M. Rhodes, Olivia L. Pak, Elsa Ronzier, Benjamin Levi, Benjamin K. Potter, Philip J. Spreadborough, Thomas A. Davis
Summary: Tourniquets are critically important for controlling traumatic extremity hemorrhage. This study investigated the effects of prolonged tourniquet application and delayed limb amputation on survival, systemic inflammation, and remote organ injury. The results showed that prolonged tourniquet application and delayed limb amputation increased the risk of complications, including systemic inflammation and dysfunction of remote organs. Improved strategies are needed to mitigate these systemic effects, especially in military settings. Additionally, further research is necessary to extend the time window for evaluating limb viability after tourniquet deflation and develop new point of care tests to assess the risks of tourniquet deflation for limb preservation and patient care optimization.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Orthopedics
Benjamin W. Hoyt, Alexander E. Lundy, Donald F. Colantonio, Henry Robertson, DesRaj M. Clark, Scott M. Tintle, Benjamin K. Potter
Summary: Patients with combat-related lower extremity amputations experience a rapid decline in bone mineral density in both amputated and intact limbs, stabilizing after approximately 3 years, with an average loss of 100 HU after 1,000 days. Other factors affecting bone mineral density include ambulatory status, age, surgical complications, level of amputation, and vitamin-D treatment.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Orthopedics
Jordan G. Tropf, Benjamin W. Hoyt, Sarah A. Walsh, Jeffery A. Gibson, Elizabeth M. Polfer, Jason M. Souza, Benjamin K. Potter
Summary: This study compared long-term health outcomes after high-energy lower-extremity trauma between patients who underwent flap-based limb salvage or amputation. The results showed that there were no significant differences in terms of body mass index (BMI) and development of metabolic disease between the two treatment cohorts.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Review
Orthopedics
Ashley B. Anderson, Conor F. McCarthy, Benjamin W. Hoyt, Jonathan A. Forsberg, Benjamin K. Potter
Summary: This review discusses the impact of common human systemic diseases on bone homeostasis and the molecular mechanisms involved. Understanding key pathways in bone biology can lead to improved treatment and recognition of bone homeostasis-related diseases by surgeons.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2023)
Article
Medicine, General & Internal
Stephen M. Goldman, Susan L. Eskridge, Sarah R. Franco, Jason M. Souza, Scott M. Tintle, Thomas C. Dowd, Joseph Alderete, Benjamin K. Potter, Christopher L. Dearth
Summary: The aim of this study was to develop a data-driven approach for identifying limb salvage cases and studying their clinical outcomes. With the use of medical code data, a population of 2018 US Service members who underwent limb salvage was identified, representing 59.5% of the combat-related lower extremity trauma population. Comparison with expert opinion showed moderate agreement, and the approach demonstrated potential for future retrospective analyses of short- and long-term outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Michael S. S. Valerio, William A. A. Pace, Connor P. P. Dolan, Jorge B. B. Edwards, Naveena B. B. Janakiram, Benjamin K. K. Potter, Christopher L. L. Dearth, Stephen M. M. Goldman
Summary: This study aimed to develop and characterize a closed intra-articular fracture (IAF) mediated post-traumatic osteoarthritis (PTOA) model in rats to serve as a testbed for putative disease modifying interventions. The results showed that a high-energy (5 J) blunt-force impact effectively induced intra-articular fractures in rats and resulted in typical osteoarthritic changes at 56 days, suggesting that this model can provide a reliable testbed for screening disease modifying interventions for high-energy joint injuries.
JOURNAL OF EXPERIMENTAL ORTHOPAEDICS
(2023)