Review
Biochemistry & Molecular Biology
Mariyam Khalid, Georg Petroianu, Abdu Adem
Summary: Persistent hyperglycemia in type 2 diabetes mellitus triggers a glycation reaction, resulting in the formation of AGEs. Binding of AGEs with its receptor RAGE activates various signaling pathways, leading to oxidative stress, inflammation, compromised insulin signaling, metabolic disturbances, pancreatic beta cell toxicity, and epigenetic modifications. This review summarizes the sources of AGEs, their role in metabolic dysfunction, and the AGEs/RAGE signaling cascade in type 2 diabetes mellitus and its associated complications.
Review
Nutrition & Dietetics
Julia S. Oliveira, Carolina de Almeida, Angela M. N. de Souza, Luciana D. da Cruz, Rita C. G. Alfenas
Summary: Critically analyzing studies on the effects of restricting dietary advanced glycation end-products (AGEs) on patients with type 2 diabetes, it was found that such restriction may help lower insulin resistance and blood sugar levels, but there is some controversy regarding its impact on inflammation and oxidative stress.
Review
Nutrition & Dietetics
Jeongmin Lee, Jae-Seung Yun, Seung-Hyun Ko
Summary: Diabetes is a chronic disease with a high health burden primarily caused by mortality or morbidity from vascular complications. Prolonged hyperglycemia leads to abnormal metabolism and the formation of advanced glycation end products (AGEs). The interaction between AGEs and their receptors promotes oxidative stress and inflammation through multiple pathways.
Article
Endocrinology & Metabolism
Tian Jiang, Yi Zhang, Fang Dai, Chao Liu, Honglin Hu, Qiu Zhang
Summary: This study aimed to explore the role of non-invasive detection of advanced glycation end products (AGEs) in the early screening of diabetes mellitus (DM) in the Chinese community and investigate the moderating effect of body mass index (BMI) and metabolic indexes. The results indicate that in Chinese participants with high AGE accumulation, priority should be given to the quality of metabolic-related indicators such as BMI, TG, and TC to effectively reduce fasting blood glucose levels.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Biochemistry & Molecular Biology
Raphael S. Pinto, Carlos A. Minanni, Aecio Lopes de Araujo Lira, Marisa Passarelli
Summary: This review focuses on the role of advanced glycation end products (AGEs) in cardiovascular disease (CVD). Clinical trials and experimental evidence are used to revisit the mechanisms by which AGEs contribute to CVD, including enhanced oxidative stress, inflammation, endoplasmic reticulum stress, and impairment in reverse cholesterol transport (RCT). AGEs promote cholesterol accumulation in the arterial wall through these pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Tomoka Nakamura, Tetsuro Tsujimoto, Kazuki Yasuda, Kohjiro Ueki, Hiroshi Kajio
Summary: This study aimed to determine whether a long-time shift in the levels of serum AGEs is associated with cardiovascular events in patients with poorly controlled type 2 diabetes. The study found that continuous low serum AGEs levels are associated with a low frequency of cardiovascular events in patients with poorly controlled type 2 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Karolina Kazmierczak, Pawel Zuchowski, Katarzyna Lapinska-Duczmal, Katarzyna Zabel, Zofia Sikorska, Magdalena Pol, Malgorzata Seredyka-Burduk, Bartosz L. Sikorski, Grazyna Malukiewicz
Summary: This study evaluated the correlation between diabetes mellitus and retinal vein occlusion using skin autofluorescence measurement of advanced glycation end products, especially in central retinal vein occlusion. The results showed a significant association between retinal vein occlusion and diabetes mellitus, particularly in the central form. Further studies with a larger sample size are recommended for future research.
APPLIED SCIENCES-BASEL
(2021)
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Review
Endocrinology & Metabolism
Lin Mao, Ruili Yin, Longyan Yang, Dong Zhao
Summary: Atherosclerosis is a chronic inflammatory disease caused by factors like hyperglycemia, dyslipidemia, AGEs, inflammation, and insulin resistance. AGEs play a significant role in the pathogenesis of AS by affecting the function of VSMCs, contributing to the development and progression of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemical Research Methods
Akinobu Suzuki, Akito Yabu, Hiroaki Nakamura
Summary: The global aging population and the increase in diabetes cases have led to a high prevalence of musculoskeletal disorders in elderly and diabetic patients, which are associated with advanced glycation end products (AGEs). AGEs accumulate in tissues and contribute to various aging and diabetes-related conditions such as osteoporosis, osteoarthritis, and neuropathy. Understanding the mechanisms of AGEs can potentially lead to the development of novel prevention and therapy methods for these disorders, improving patients' quality of life.
Review
Endocrinology & Metabolism
Armando Rojas, Cristian Lindner, Ileana Gonzalez, Miguel Angel Morales
Summary: Evidence has shown the crucial role of the receptor for advanced-glycation end-products (RAGE) in causing inflammatory cellular responses and organ damage in diabetes patients. COVID-19 pandemic has highlighted the increased risks of complications and death in diabetic patients, which may be associated with the activated state of the RAGE axis and its impact on lung inflammation.
WORLD JOURNAL OF DIABETES
(2021)
Review
Biochemistry & Molecular Biology
Aditi Chopra, Thilini N. Jayasinghe, Joerg Eberhard
Summary: Periodontitis can increase the levels of AGEs, even in the absence of hyperglycemia. This explains the relationship between periodontitis and related diseases such as diabetes.
Review
Endocrinology & Metabolism
Savita Bansal, Archana Burman, Asok Kumar Tripathi
Summary: The incidence of type 2 diabetes mellitus is increasing rapidly, with cardiovascular complications being the leading cause of mortality. Advanced glycation end products (AGEs) play a crucial role in the pathophysiology of diabetes.
WORLD JOURNAL OF DIABETES
(2023)
Review
Nutrition & Dietetics
Melpomeni Peppa, Ioanna Mavroeidi
Summary: Research indicates that dietary advanced glycation end products play a significant role in health and disease, contributing to the pathogenesis of various diseases and their complications in animal models. They are also involved in changes related to the aging process.
Article
Biochemistry & Molecular Biology
Linzehao Li, Qinghe Song, Xiandang Zhang, Yan Yan, Xiaolei Wang
Summary: The study aimed to investigate the association between allicin treatment of diabetes and Advanced Glycation End products (AGEs). The results showed that allicin can alleviate diabetes by inhibiting AGE formation, reducing RAGE levels, relieving oxidative stress, and promoting insulin secretion.
Article
Clinical Neurology
Ming-Kai Hsieh, Mu-Yi Liu, Tsung-Ting Tsai, Po-Liang Lai, Ching-Lung Tai
Summary: Through an in vitro biomechanical study on porcine spines, it was found that placing two cross-links individually at the proximal and distal ends of the center of the construct is the optimal and efficient configuration for long-segment spinal fixation, providing biomechanical stability.
GLOBAL SPINE JOURNAL
(2023)
Article
Chemistry, Analytical
Chung-An Chen, Ping-Yeh Chiu, Tse-Hao Huang, Natalie Yi-Ju Ho, Fu-Cheng Kao, Tsung-Ting Tsai
Summary: Appropriate follow-up after treatment initiation in patients with osteoporosis is challenging. Serum biomarkers, such as procollagen type I propeptide (PINP), can provide clinically useful information for disease management. However, rapid and cost-effective methods for detecting serum PINP are lacking. In this study, we developed a high-sensitivity lateral flow immunoassay with a stacking pad (sLFIA) for quantitative detection of PINP and found that it can serve as a point-of-care test (POCT) for monitoring medication response and managing osteoporosis.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Chi-Jen Tai, Chih-Hua Chao, Atallah F. Ahmed, Chia-Hung Yen, Tsong-Long Hwang, Fang-Rong Chang, Yusheng M. Huang, Jyh-Horng Sheu
Summary: Chemical investigation of the Red Sea sponge Spongia sp. resulted in the discovery of four new compounds, secodinorspongins A-D (1-4), as well as a known compound sponginolide (5). The structures of these compounds and their absolute configurations were elucidated using spectroscopic methods and a comparison of calculated and experimental CD spectra. A possible biosynthetic pathway for compounds 1-4 was proposed. The cytotoxic, antibacterial, and anti-inflammatory activities of compounds 1-5 were also evaluated, with compound 1 showing inhibitory activity against Staphylococcus aureus growth, and compounds 4 and 5 suppressing superoxide-anion generation and elastase release in human neutrophils.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
I-Ting Wu, Yu-Chen Fan, Guan-Zhou Lin, Yi-Lin Wang, Tsong-Long Hwang, Kuei-Hung Lai, Hsu -Ming Chung
Summary: Chemical investigations on the ethyl acetate extract of the octocoral Capnella imbricata collected from the waters of Taiwan led to the isolation of three capnellenes, including one new metabolite. The structures and relative stereochemistry of the isolated metabolites were determined through extensive spectroscopic analyses and X-ray diffraction analysis. The anti-inflammatory activity of compounds 1-3 was evaluated by examining their inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Lina Ammar, Hung-Yu Lin, Shou-Ping Shih, Tsen-Ni Tsai, Yu-Ting Syu, Mohammad Abdel-Halim, Tsong-Long Hwang, Ashraf H. Abadi
Summary: PDE5 inhibitors have anticancer effects and cGMP elevation plays a role in CRC. We synthesized 31 derivatives of 9-benzylaminoacridine and found 22 of them showed micromolar or sub-micromolar inhibition against PDE5. Compounds 11, 12, and 28 exhibited significant growth inhibition, superior Topo II inhibitory activity, low micromolar PDE5 inhibition, and affected cell cycle progression in HCT-116 CRC cells. These compounds have potential as effective therapeutic agents against cancer.
Article
Food Science & Technology
Yu-Li Chen, Chun-Yu Chen, Kuei-Hung Lai, Yu-Chia Chang, Tsong-Long Hwang
Summary: This study found that flavone C-glycosides in Lophatherum gracile are the main active components with anti-inflammatory and antiviral effects. They developed a simple chromatography-based method to extract flavone C-glycoside-enriched extract and demonstrated its ability to inhibit respiratory bursts and neutrophil extracellular trap formation. Additionally, the extract was shown to inhibit SARS-CoV-2 pseudovirus infection by interfering with the binding of the spike protein to ACE2.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Materials Science, Biomaterials
Cheng-Yu Lin, Huang-Ping Yu, Yen-Tzu Chang, Zih-Chan Lin, Ahmed Alalaiwe, Tsong-Long Hwang, Jia-You Fang
Summary: This study developed NIMP-R14-conjugated immunonanoparticles for specific targeting of neutrophils associated with psoriasiform dermatitis. The immunonanoparticles accurately recognized and uptake neutrophils, exhibited anti-inflammatory capability, and showed potential as a delivery system for treating psoriasis.
BIOMATERIALS SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Po-Jen Chen, Hsin-Hui Tseng, Yi-Hsuan Wang, Shu-Yen Fang, Shun-Hua Chen, Chun-Hong Chen, Sheng-Chieh Tsai, Yu-Chia Chang, Yung-Fong Tsai, Tsong-Long Hwang
Summary: This study found that palbociclib has therapeutic potential for neutrophil-associated psoriasiform dermatitis by inhibiting neutrophilic inflammation. The anti-inflammatory effects of palbociclib were mediated through the targeting of phosphatidylinositol 3-kinase (PI3K) rather than CDK4/6. Palbociclib significantly improved imiquimod-induced psoriasiform dermatitis in mice, including symptoms, neutrophil infiltration, Akt activation, and cytokine up-regulation.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shun-Chin Yang, Yi-Hsuan Wang, Chiu-Ming Ho, Yung-Fong Tsai, Ping-Jyun Sung, Tony Eight Lin, Tsong-Long Hwang
Summary: In this study, it was found that the cyclic lipopeptide IA-1 from marine Bacillus amyloliquefaciens can inhibit the inflammatory response of neutrophils and mitigate inflammatory damage in ARDS. IA-1 acts as a competitive antagonist for the damage-sensing receptor FPR1, reducing downstream signaling pathways and inflammatory injuries. This suggests that IA-1 could be a therapeutic option for ARDS.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Ching-Hui Tsai, Alan Chuan-Ying Lai, Yu-Cheng Lin, Po-Yu Chi, Yun-Chi Chen, Yao-Hsu Yang, Chien-Han Chen, Sheng-Yeh Shen, Tsong-Lon Hwang, Ming-Wei Su, I-Ling Hsu, Yu-Chi Huang, Anke H. Maitland-van der Zee, Michael J. McGeachie, Kelan G. Tantisira, Ya-Jen Chang, Yungling L. Lee
Summary: The association between neutrophil extracellular traps (NETs) and response to inhaled corticosteroids (ICS) in asthma was investigated. It was found that neutrophils play a potential role in uncontrolled asthma, and NET abundance is associated with nonresponse to ICS. Furthermore, CCL4L2 was identified as a potential therapeutic target for individuals with asthma refractory to ICS.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Plant Sciences
Chia-Jung Liu, Chien-Chiao Wang, Chun-Feng Chang, Mingzi M. Zhang, Lun Kelvin Tsou, Zhi-Hong Wen, Tsong-Long Hwang, You-Ying Chen, Ping-Jyun Sung
Summary: Two new 16-hydroxybriaranes were isolated from a coral identified as Briareum stechei, and their structures were confirmed through 2D-NMR studies and comparison with literature data. It was found that one of the compounds, briarane 2, could significantly reduce the release of inducible nitric oxide synthase (iNOS) by 87.92% at a concentration of 10 μM.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Plant Sciences
Ju-Hsin Cheng, Ho-Cheng Wu, Chia-Hung Yen, Tsong-Long Hwang, Horng-Huey Ko, Hsun-Shuo Chang
Summary: Non-alcoholic fatty liver disease (NAFLD) is a liver disease caused by the accumulation of excess lipids. The research aimed to investigate the bioactive components of Formosan plants that could reduce lipid droplet accumulation. The study found that the methanolic extract of Elaeagnus glabra Thunb. showed excellent anti-LD accumulation activity and isolated several compounds with potential therapeutic effects.
Article
Chemistry, Multidisciplinary
Hieu Tran Trung, Kartiko Arif Purnomo, Szu-Yin Yu, Zih-Jie Yang, Hao-Chun Hu, Tsong-Long Hwang, Nguyen Ngoc Tuan, Le Ngoc Tu, Dau Xuan Duc, Le Dang Quang, Anders Backlund, Tran Dinh Thang, Fang-Rong Chang
Summary: Two new rearranged 2,3-seco-tirucallane triterpenoids, meliadubins A and B, were isolated from the barks of Melia dubia Cav. These compounds exhibited significant anti-inflammatory and antifungal activities.
Article
Chemistry, Medicinal
Bo-Rong Peng, Li-Guo Zheng, Lo-Yun Chen, Mohamed El-Shazly, Tsong-Long Hwang, Jui-Hsin Su, Mei-Hsien Lee, Kuei-Hung Lai, Ping-Jyun Sung
Summary: Four new 24-homoscalarane compounds were isolated from a marine sponge collected in the Southern waters of Taiwan. These compounds showed antioxidant and anti-inflammatory activities, and they were able to inhibit neutrophilic inflammatory responses.
Article
Chemistry, Medicinal
Tsong-Long Hwang, Jing-Yi Lin, Liang-Mou Kuo, Ganesh Kumar Dhandabani, Pei-Wen Hsieh
Summary: The compound 29 showed high inhibitory potency against HNE and dual effects on O2·- generation and elastase release, making it a promising candidate for treating neutrophilic inflammatory diseases.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
