PI3Kγ deletion reduces variability in the in vivo osteolytic response induced by orthopaedic wear particles

Epigenetic Silencing Mediated through Activated PI3K/AKT Signaling in Breast Cancer

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Inferring the functional effects of mutation through clusters of mutations in homologous proteins

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Bacterial Pathogen-associated Molecular Patterns Stimulate Biological Activity of Orthopaedic Wear Particles by Activating Cognate Toll-like Receptors

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Genome-scale techniques highlight the epigenome and redefine fundamental principles of gene regulation

(2010) J Wesley Pike   JOURNAL OF BONE AND MINERAL RESEARCH

Individual susceptibility to periprosthetic osteolysis is associated with altered patterns of innate immune gene expression in response to pro-inflammatory stimuli

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Important roles of PI3K  in osteoclastogenesis and bone homeostasis

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Variation in cytokine genes can contribute to severity of acetabular osteolysis and risk for revision in patients with ABG 1 total hip arthroplasty: a genetic association study

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Review of recent genome-wide association scans in lupus

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Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty

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Stimulation of macrophage TNFα production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-κB pathways but is independent of p38 and JNK

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