Article
Chemistry, Organic
Zhiliang Chu, Huijuan Chen, Shuai Shan, Xiaona Wang, Chunfang Gao, Guirong Qu, Zhongyu Liu, Haiming Guo
Summary: A new one-step method for the synthesis of 1,2,4-triazolo[3,4-i]purine derivatives has been reported, with good yield and easy operation. Factors affecting the reaction were discussed, laying a foundation for further study of these compounds.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Satheesh Borra, Hun Young Kim, Kyungsoo Oh
Summary: A one-pot tandem approach to [1,2,3]triazolo[1,5-a]quinolines was developed from (E)-s-chlorovinyl ketones and 2-azidoaryl carbonyls using a sequence of alpha-vinyl aldol and azide- alkyne cycloaddition reactions. The intramolecular azide-alkyne cycloaddition of allenol intermediates was promoted by NEt3 and nickel catalysts. The [1,2,3]triazolo[1,5-a]quinolines are important precursors to alpha-diazoimines and can provide valuable heterocyclic compounds through denitrogenative transformations.
Article
Chemistry, Medicinal
Maria Chiara Pismataro, Tommaso Felicetti, Chiara Bertagnin, Maria Giulia Nizi, Anna Bonomini, Maria Letizia Barreca, Violetta Cecchetti, Dirk Jochmans, Steven De Jonghe, Johan Neyts, Arianna Loregian, Oriana Tabarrini, Serena Massari
Summary: The study identified 1,2,4-triazolo[1,5-a] pyrimidine (TZP) as a suitable scaffold for developing anti-influenza virus compounds, with compound 22 showing high activity. Furthermore, the research highlighted the potential of TPZ scaffold in the search for anti-coronavirus agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Organic
Felien Reniers, Stijn Anthonissen, Luc Van Meervelt, Wim Dehaen
Summary: This study presents a three-step synthetic pathway for the synthesis of fully decorated 8-azapurines, with a special focus on 6-alkyl derivatives. A diverse library of 8-azapurines was successfully obtained through interrupted CuAAC, oxidation, and cyclization reactions using various alkynes, azides, and amidines. Additionally, postfunctionalization reactions were demonstrated for selected substrates.
Article
Chemistry, Organic
Zi-Qi Geng, Chunhui Zhao, Hao-Dong Qian, Si-Jia Li, Hao Peng, Hao Xu
Summary: A Cu/Ag relay catalyzed cascade reaction was used to synthesize chiral triazole-fused pyrazine scaffolds. This method utilized a novel N,N,P-ligand and showed high efficiency, functional group tolerance, excellent enantioselectivities, and a broad substrate scope using readily available starting materials.
Article
Chemistry, Organic
Joomyung Jun, Ronald T. Raines
Summary: The synthesis of alpha-aryl-alpha-diazoamides was achieved through a two-step process involving Pd-catalyzed C-H arylation and aminolysis, enabling the esterification of carboxyl groups in aqueous solution to become substrates for an esterase. This broad synthetic route paves the way for further development of diazo compounds in chemical biology.
Editorial Material
Cell & Tissue Engineering
Joseph R. Herdy, Lukas Karbacher, Jerome Mertens
Summary: Researchers dissect the process of converting human somatic cells into iNs into two largely independent steps and identify key players in each stage.
Article
Biochemistry & Molecular Biology
Manel Ben Hassen, Dhouha Msalbi, Badr Jismy, Fares Elghali, Sami Aifa, Hassan Allouchi, Mohamed Abarbri, Fakher Chabchoub
Summary: A series of new [1,2,4]triazolo[4,3-a]pyrimidine derivatives were synthesized using a one-pot three-component synthesis. The structures of the compounds were confirmed by various analyses. The compounds were evaluated for their antitumor activity and displayed promising results against cancer cell lines.
Article
Spectroscopy
Lucyna Dyminska, Jerzy Hanuza, Jan Janczak, Maciej Ptak, Rados law Lisiecki
Summary: In this study, the herbicides azafenidin and flumetsulam were characterized using IR, Raman, UV-Vis, and emission spectroscopy. The triazolopyridine component, which is the most prominent and active ingredient in these herbicides, was characterized using XRD, FTIR, Raman, UV-Vis, and emission spectra. Comparison was made between the experimental data and the results of DFT quantum chemical calculations to analyze the characteristics of the triazolopyridine component in the studied herbicides.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Engineering, Environmental
Guo-Xi Yang, Hong-Ji Tan, Jue-Wen Zhao, Jie-Ji Zhu, Xin He, Jing-Xin Jian, Mu-Han Zhou, Si-Lu Tao, Qing-Xiao Tong
Summary: In this study, three donor-acceptor emitters were designed and synthesized, and their thermal stability and high photoluminescence quantum yields were demonstrated. The structure-property relationships between different substituted sites were also revealed. The fabricated organic light-emitting diodes exhibited high external quantum efficiency.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Eduardo Rodrigo, Rainer Wiechert, Magnus W. Walter, Wilfried Braje, Herve Geneste
Summary: By using KOH, the direct F to OH exchange of aromatic and heteroaromatic substrates can be achieved under mechanochemical conditions, making the process more atom economical and environmentally friendly compared to other methods.
Article
Chemistry, Medicinal
Qianqian Feng, Jinfeng Zhang, Shuang Luo, Yong Huang, Zhiyun Peng, Guangcheng Wang
Summary: In this study, a series of compounds with alpha-glucosidase inhibitory activity were synthesized, and compound 5o showed potential as an antidiabetic drug.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Sijie Xie, Xuan Zhang, Xiaoyu Tan, Wei Zhang, Wei Guo, Ning Han, Zhenyu Zhou, Yinzhu Jiang, Ivo F. J. Vankelecom, Jan Fransaer
Summary: This study reports a simple and inexpensive method to achieve impurity-free MOF film deposition on nonconductive poly(ether sulfone) (PES) membranes. The proposed strategy allows the generation of MOF units on the membrane-electrolyte interface through the counter-diffusion of ions, resulting in the deposition of a pure MOF film on untreated polymer membranes.
ACS MATERIALS LETTERS
(2022)
Article
Chemistry, Organic
Timothy J. Paris, Chris Schwartz, Eric Sundall, Rachel Willand-Charnley
Summary: A rapid one-step synthesis of alpha-ketoacetals was achieved via electrophilic etherification, obtaining different yields of products using specific substrates and peroxyacetals. The method is applicable for C-O bond formation at tertiary carbons, with the alpha-OCH3 group playing a critical role in ensuring product formation.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Ting Zhou, Yuqi Zhu, Hong Zhang, Jieyin He, Hongguang Li, Ming Lang, Jian Wang, Shiyong Peng
Summary: A one-pot tandem annulation of 1,6-allenynes with organic azides was reported using copper catalysis and TsOH promotion, providing N-allyl 1,2,3-triazole-fused structures in moderate to excellent yields under mild reaction conditions. Additionally, the N-allyl products can be further diversified by selectively reducing them to the N-alkyl counterparts.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
