Article
Multidisciplinary Sciences
Muhammad Ishaque, Yamin Bibi, Abdul Qayyum, Marcello Iriti
Summary: The study focused on the medicinal plant Dryopteris ramosa as a potential source of bioactive phytochemicals, isolating two xanthonoid compounds with strong antioxidant potential. The investigation revealed that the isolated compounds, mangiferin and isomangiferin, showed comparable antioxidant effects to ascorbic acid, suggesting their promising role in combating oxidative stress. Further studies are needed to explore the pharmacological properties and potential new bioactive compounds in Dryopteris ramosa.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2021)
Article
Biology
Muhammad Ishaque, Yamin Bibi, Saadia Masood, Samha Al Ayoubi, Abdul Qayyum, Sobia Nisa, Waqas Ahmed
Summary: This study isolated mangiferin (MF) and isomangiferin (IsoMF) from Dryopteris ramosa and evaluated their antibacterial potential and cytotoxicity. The results showed that MF and IsoMF exhibited different antibacterial activities against various strains and low cytotoxicity towards brine shrimp. These findings suggest that MF and IsoMF may be potential candidates for the treatment of bacterial infections and other human ailments.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Haojue Wang, Wanfei Shao, Xianyi Lu, Chunxia Gao, Ling Fang, Xiaojun Yang, Peizhi Zhu
Summary: A novel nano-drug delivery system, HA-MA-MTX, was developed in this study to enhance the accumulation of MTX in tumors and minimize toxicity to normal tissues. The system combines MTX as a tumor-targeting ligand, HA as another tumor-targeting ligand, and MA as an anti-inflammatory agent. In vitro experiments showed that HA-MA-MTX nanoparticles effectively inhibited K7 cancer cells while exhibiting lower toxicity to normal MC3T3-E1 cells compared to MTX.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Food Science & Technology
Lisi Li, Yujia Dong, Xifu Liu, Meng Wang
Summary: Mangiferin, a natural polyphenolic compound found in many plants, has shown remarkable pharmacological activities such as anti-inflammatory, anti-tumor, antioxidative stress, and antiviral effects. Evidence suggests that it has therapeutic benefits in treating various liver diseases, including liver injury, nonalcoholic fatty liver disease, alcoholic liver disease, liver fibrosis, and hepatocellular carcinoma. This review aims to summarize the potential signaling pathways and findings of mangiferin in liver disease treatment, highlighting its potential as a therapeutic agent for liver disease in humans.
Article
Chemistry, Applied
Qi Wang, Weiwei Cheng, Yifeng Zhang, Qingzheng Kang, Vemana Gowd, Yuanyuan Ren, Feng Chen, Ka-Wing Cheng
Summary: Differential solvent extraction and phytochemical profiling were used to identify potent inhibitors of PhIP formation in Chinese chive. The inhibitory mechanism was found to be related to phenylacetaldehyde scavenging rather than antioxidant activities. Organic synthesis and structural elucidation confirmed the proposed mode of action for the novel inhibitor.
Article
Chemistry, Multidisciplinary
Alberto J. Nunez-Selles, Lauro Nuevas-Paz, Gregorio Martinez-Sanchez
Summary: This study found that metal-mangiferin complexes have good antioxidant and protection against protein oxidative damage effects in the adjuvant therapies of neurodegenerative diseases, cancer, diabetes, and cardiovascular disorders. The coordination complexes of Se (IV) and Zn (II) with mangiferin showed significantly improved antioxidant/protective effects compared to isolated mangiferin.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Hongyan Zhou, Shuyi Song, Xianming Lan, Yanan Li, Xiaoqing Yuan, Jingyi Yang, Min Li, Ting Cao, Jiayu Zhang
Summary: In this study, the metabolic processing of mangiferin was investigated using an analytical strategy named Drug Metabolite Clusters. A total of 67 mangiferin metabolites were detected in rat plasma, urine, feces samples, and liver microsomes. The study provided essential insight into the metabolites and metabolic pathways of mangiferin, which is important for further pharmacological studies and drug metabolite identification.
Review
Biochemistry & Molecular Biology
Lijun Zhang, Cheng Huang, Shengjie Fan
Summary: Mangiferin, a major constituent in mango and other plants, has shown potential therapeutic effects on organ fibrosis by improving renal, pulmonary, cardiac, and hepatic fibrosis through the inhibition of inflammation, oxidative stress, and fibrogenesis.
Article
Biochemistry & Molecular Biology
Maddalena Sguizzato, Francesca Ferrara, Supandeep Singh Hallan, Anna Baldisserotto, Markus Drechsler, Manuela Malatesta, Manuela Costanzo, Rita Cortesi, Carmelo Puglia, Giuseppe Valacchi, Elisabetta Esposito
Summary: This study designed ethosomes and transethosomes as topical delivery systems for mangiferin, demonstrating faster diffusion kinetics of mangiferin from transethosomes. In vitro experiments showed that both ethosomes and transethosomes had antioxidant and anti-inflammatory effects on human keratinocytes exposed to cigarette smoke. Mangiferin entrapment capacity was evaluated through ultracentrifugation and HPLC.
Article
Biochemistry & Molecular Biology
Min Feng, Shaoqiang Wei, Shidong Zhang, Ying Yang
Summary: The study found that mangiferin can regulate inflammation and cell pyroptosis through inhibiting the NF-κ B pathway, suppressing inflammatory caspase-mediated pyroptosis cascades, and reducing GSDMD cleavage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Karim Naraki, Ramin Rezaee, Habibeh Mashayekhi-Sardoo, A. Wallace Hayes, Gholamreza Karimi
Summary: Mangiferin (MGF) is a polyphenolic compound extracted from mango trees, which has diverse effects such as antioxidant, antiapoptotic properties, and has been shown to modulate inflammatory pathways. MGF exerts protective effects against the toxic effects of pharmaceuticals, heavy metals, and environmental chemicals by suppressing lipid peroxidation, oxidative stress, inflammatory factors, and activating survival signaling pathways.
PHYTOTHERAPY RESEARCH
(2021)
Article
Plant Sciences
Ramy S. Yehia, Sarah A. Altwaim
Summary: Due to their low cost, toxicity, and health risks, medicinal plants are considered useful sources of biologically active compounds. Mangifera indica L., a medicinal plant with high bioactive metabolite content, was investigated for its antimicrobial and antioxidant properties. Mangiferin, isolated from M. indica leaves using ethanol as the extraction solvent, demonstrated promising antimicrobial efficacy against fungal and bacterial pathogens. It also exhibited strong radical scavenging activity and potential as an antioxidant. In addition, mangiferin showed antitumor effects and induced apoptosis in MCF-7 cells. These findings suggest that mangiferin has potential applications in the medical industry.
Review
Oncology
Muhammad Sarfraz, Abida Khan, Gaber El-Saber Batiha, Muhammad Furqan Akhtar, Ammara Saleem, Basiru Olaitan Ajiboye, Mehnaz Kamal, Abuzer Ali, Nawaf M. Alotaibi, Shams Aaghaz, Muhammad Irfan Siddique, Mohd Imran
Summary: Mangiferin, derived from Mangifera indica L., has shown potential as an anticancer agent. Researchers have explored its effects on breast cancer cells through in vitro and in vivo models. However, its low solubility and bioavailability have posed challenges, prompting the use of nanotechnology-based drug delivery systems to enhance its efficacy and safety.
Article
Biochemistry & Molecular Biology
Abdur Rehman Sarwar, Furqan Muhammad Iqbal, Muhammad Anjum Jamil, Khizar Abbas
Summary: Making nanoscale drug carriers can improve the bioavailability of slightly water-soluble medications. This study aimed to prepare nanocrystals of mangiferin for sustained drug delivery and enhance its pharmacokinetic profile.
Article
Pharmacology & Pharmacy
Maddalena Sguizzato, Francesca Ferrara, Paolo Mariani, Alessia Pepe, Rita Cortesi, Nicolas Huang, Fanny Simeliere, Paola Boldrini, Anna Baldisserotto, Giuseppe Valacchi, Elisabetta Esposito
Summary: This study described a formulative research for the development of vesicular systems for mangiferin based on phosphatidylcholine and the block copolymer pluronic, and compared their effect on mangiferin transdermal administration. The results showed that multilamellar vesicles retain mangiferin drugs more effectively than unilamellar ones, and the protective effect exerted by Plurethosomes and transethosomes suggests their possible application in enhancing cutaneous antioxidant defense.
Article
Chemistry, Multidisciplinary
Lei Zhang, Yawen Deng, Congxia Xie, Zhongtao Wu
Summary: The functions of materials are highly dependent on their ordered molecular arrangements. Researchers have discovered a low molecular weight spiropyran that exhibits photochromism and powerful adhesion in a disordered solid state. The adhesion strength can be regulated by light, and the specific color state corresponds to different levels of adhesion strength. The isomer ratio and molecular packing density of the spiropyran are the key factors determining the adhesion ability. This discovery provides a new strategy for developing functional materials using low molecular weight compounds.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Oncology
Ahmed Elgehama, Yixuan Wang, Ying Yu, Lin Zhou, Zhixiu Chen, Liwei Wang, Lijun Sun, Jian Gao, Biao Yu, Yan Shen, Qiang Xu
Summary: This study unravels the action mechanism of PTP1B in stabilizing Bcr-Abl1 protein and indicates that the PTP1B-Bcr-Abl1 interaction might be one of druggable targets for TKI-resistant CML with point mutations.
Article
Chemistry, Multidisciplinary
Youxi Chen, Guozhi Xiao, Dapeng Zhu, Biao Yu
Summary: Sepositoside A is a prototypical cyclic steroid glycoside with a hybrid 16-membered ring composed of the steroid skeleton and a 1,2-trans-linked trisaccharide. We report a convenient method to construct the strained 16-membered ring via Au(I)-catalyzed intramolecular addition of alcohol to epoxide, leading to two simplified analogues. Although a similar macroetherification in relevant steroid trisaccharides has been extensively studied, it has failed to provide the macrocyclic skeleton of Sepositoside A.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Bingfeng Shi, Youxi Chen, Mingyu Geng, Dapeng Zhu, Biao Yu
Summary: Sepositoside A is a major cyclic steroid glycoside found in starfishes, featuring a strained 16-membered ring formed by a linear trisaccharide tethered to C3 and C6 of the steroid aglycone. Attempts to synthesize the desired steroid-pyranose etherate linkage and assemble the glycans stepwise have been unsuccessful. Alternative approaches to construct the steroid-pyranose etherate linkage will be explored in future articles.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Lei Zhang, Han Liu, Qianyao Du, Guoqiang Zhang, Shanhui Zhu, Zhongtao Wu, Xiliang Luo
Summary: Photoresponsive phase change materials have the ability to store and release both photon and heat energy. By designing azobenzene surfactants at the molecular level, it is possible to achieve high gravimetric energy density and enhance molar isomerization enthalpy.
Article
Engineering, Biomedical
Lei Zhang, Yun Liu, Kang Wang, Guoqiang Zhang, Qianyao Du, Qikai Liang, Zhongtao Wu
Summary: Compared to classical block copolymers, self-assembly of small molecules is advantageous in addressing small features. Azobenzene-containing DNA thermotropic liquid crystals (TLCs) without solvents form assembly as block copolymers. However, their self-assembly behavior has not been fully investigated.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Dapeng Zhu, Mingyu Geng, Dacheng Shen, Biao Yu
Summary: This article presents a formal total synthesis study of starfish cyclic steroid glycosides 1 and 2 isolated from the Pacific starfish Echinaster Luzonicus. The synthetic route is highly modular and versatile, involving Au(I)-catalyzed intramolecular glycosylation for constructing the 16-membered macrocycles, efficient installation of unsaturated sugar moieties using ortho-hexynylbenzoates, post-oxidation elaboration of the glucuronic acid unit, and de novo synthesis of the ether-linked pyranose unit.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xiaojuan Zhang, Peng Xu, Zhengbing Zhou, Yazhou Zhang, Biao Yu, Yugen Zhu
Summary: Due to the complexity and diversity of carbohydrates, efficient methods for homogeneous oligosaccharides are limited. Chemical synthesis is a reliable approach for accessing homogeneous samples, relying on glycosylation reactions. This study presents a novel leaving group, 8-phenylethynyl-1-naphthoate, which enables efficient glycosylation reactions under mild gold(I)-catalysis. The unique base-stability of the anomeric naphthoate group allows compatibility with various chemical transformations, and the protocol allows for minimally protected glycosylation processes. Mechanistic studies explain the characteristics of 8-phenylethynyl-1-naphthoate.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Organic
Bei-Bei Zhan, Kai-Sheng Xie, Qian Zhu, Weiping Zhou, Dapeng Zhu, Biao Yu
Summary: A Cu-(OTf)(2)-catalyzed glycosylation protocol using glycosyl ortho-N-phthalimidoylpropynyl benzoates(NPPBs) as donors was developed, which exhibits an inexpensive catalyst, convenient conditions, high to excellent yields, and a broad substrate scope. Mechanistic studies showed the formation of an isochromen-4-ylcopper-(II) intermediate upon leaving group departure.
Article
Chemistry, Multidisciplinary
Wei Liu, Ziqiang Wang, Tayyab Gulzar, Xiaodong Zhang, Guoping Ding, Peng Xu, Biao Yu
Summary: We have revealed that EPP glycosides can be utilized as glycosylation donors through an unprecedented activation mechanism. We further report that EPP glycosides without the 3,5-dimethyl groups, previously installed to prevent side reactions, can also undergo effective glycosylation. By employing an EPP 2-azidoglucoside as a donor, we have successfully constructed the challenging alpha-GlcN-(1 -> 4)-GlcA linkage, leading to a heparin tri-saccharides precursor.
PURE AND APPLIED CHEMISTRY
(2023)
Article
Chemistry, Applied
Han Liu, Lei Zhang, Guoqiang Zhang, Qianyao Du, Kang Wang, Xiliang Luo, Zhongtao Wu
Summary: In this study, two azobenzene-containing ammonium surfactants with bulky head groups were designed and synthesized to reduce the molecular packing density, facilitating the solid-liquid phase change of photoresponsive phase change materials (PPCMs) under UV light. By further reducing the molecular packing density, the reported PPCMs achieved more complete and faster phase change, making them potential candidates for energy storage and photolithography materials. This study introduces a new molecular designing strategy for fabricating azobenzene-based PPCMs.
Article
Chemistry, Organic
Yan Xia, Yingjie Wang, Zhaolun Zhang, Tayyab Gulzar, Yuqi Lin, Jing Wang, Dapeng Zhu, Biao Yu
Summary: The synthesis of neopetrosins A and C, two 2-indolyl C-a-D- mannopyranosides, and their congeners has been achieved via a direct Ni/photoredox-catalyzed reductive coupling of 3-methoxycarbonyl-2-iodo-1H-indoles with pyranosyl bromides.
Article
Chemistry, Multidisciplinary
Kang Wang, Jing Zhao, Xu Zhang, Lijia Jiang, Xue Zhou, Congxia Xie, Xiaofei Jia, Lei Zhang, Zhongtao Wu
Summary: A porous noncovalent organic framework with AIE effect is designed and synthesized as a support for gold nanoparticles, which can be easily detected, separated, and recycled in the reduction of nitrobenzene and dye compounds in aqueous conditions, presenting the features of green chemistry.
Article
Chemistry, Organic
Wei Liu, Zhifei Hu, Peng Xu, Biao Yu
Summary: Here, we presented a convenient procedure to prepare EPP glycosides and their application in the synthesis of the clinically approved anticoagulant fondaparinux. Additionally, we successfully achieved the synthesis of heparin-like tetrasaccharides using EPP glycosides in a one-pot orthogonal glycosylation reaction.
Article
Chemistry, Multidisciplinary
Wu Hou, Xin Cao, Peng Xu, Biao Yu
Summary: In this study, the synthesis of two tetranorditerpenoid dilactones, Wentilactones A and B, with promising antitumor activities is reported for the first time. The synthesis involves the use of a common precursor, 3 beta-hydroxydilactone 6, derived from (S)-Wieland-Miescher ketone, and allows for easy modification on the A-ring, resulting in compounds such as CJ-1445, asperolide B, and an unnamed natural congener 4.
CHEMICAL COMMUNICATIONS
(2022)
