Review
Biochemistry & Molecular Biology
Yan He, Miao Miao Sun, Guo Geng Zhang, Jing Yang, Kui Sheng Chen, Wen Wen Xu, Bin Li
Summary: The PI3K/Akt signaling pathway plays a crucial role in cancer, and targeting inhibitors against it may aid in drug discovery. Additionally, combining pathway inhibitors with other cancer treatment strategies could be an effective approach to solving therapeutic dilemmas.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Cell Biology
Wenke Wang, Bei Shi, Ruiting Cong, Mingjun Hao, Yuanyuan Peng, Hongyue Yang, Jiahui Song, Di Feng, Naijin Zhang, Da Li
Summary: The PI3K/AKT signaling pathway plays a crucial role in glucose metabolism. It directly affects glucose metabolism by phosphorylating enzymes and regulators, and indirectly promotes aerobic glycolysis by increasing glucose transporters and glycolytic enzymes. The RING-finger adaptor has been found to have an important role in PI3K/AKT signaling, but there is currently no comprehensive review on its role in glucose metabolism.
CELL DEATH DISCOVERY
(2022)
Article
Neurosciences
Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Zikang Yang, John Bosco Ruganzu, Zhuoyuan Yang, Xiangyuan Wu, Wei Bi, Shengfeng Ji, Weina Yang
Summary: This study found that TREM2 can inhibit tau hyperphosphorylation and neuronal apoptosis through the activation of the PI3K/Akt/GSK-3β signaling pathway, thereby improving Alzheimer's disease. This finding helps us better understand the protective role of TREM2 in tau pathology and provides new ideas and targets for the treatment of Alzheimer's disease.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Fisheries
Xiaotong Sun, Hongtao Nie, Xiwu Yan
Summary: This study identified and investigated three novel glycogen metabolism-related proteins in Manila clam, suggesting their potential involvement in innate immunity and important role in immune defense.
Article
Pharmacology & Pharmacy
Sally A. Abuelezz, Nevien Hendawy
Summary: This study investigates the protective effects of CoQ10 against cognitive impairment induced by Scop and reveals its ability to inhibit oxidative stress, amyloid deposition, and modulate the PI3K/Akt/GSK-3 beta/CREB/BDNF/TrKB pathway.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Biology
Dalia O. Saleh, Sawsan S. Mahmoud, Azza Hassan, Eman F. Sanad
Summary: This study aimed to investigate the protective effect of omega-3 fatty acids (co-3FA) against DOX-induced acute liver damage and the underlying mechanism. The results showed that pre-administration of co-3FA can alleviate DOX-induced liver injury and affect multiple indicators and signaling pathways related to liver damage.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Cell Biology
Liping Wang, Zhangui Tang
Summary: Oral submucous fibrosis (OSF) is a chronic, progressive, scarring, premalignant disease of the oral mucosa, with complex pathogenic factors including areca nut chewing, nutrition, genetics, and immune factors. Immune factors have recently become the focus of medical research on OSF, with attention on how they play a role in the disease's pathogenesis and treatment. OSF is characterized by significant changes in the immune microenvironment, prompting studies on the role of immune cells and substances in the disease.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Long He, Jennifer Endress, Sungyun Cho, Zhongchi Li, Yuxiang Zheng, John M. Asara, John Blenis
Summary: Serine/one-carbon metabolism plays a critical role in cancer cell growth, but the regulatory mechanisms are not well understood. This study reveals that glycogen synthase kinase 3 (GSK3) plays a key role in regulating the expression of serine/one-carbon metabolic enzymes. Inhibition of nuclear GSK3 signaling enhances the efficacy of serine/one-carbon metabolism inhibitors in suppressing cancer cell proliferation.
Article
Chemistry, Multidisciplinary
Mingyuan Chen, Tengqian Sun, Yanghao Zhong, Xin Zhou, Jin Zhang
Summary: This study investigates Akt activity and regulation on lysosomes, showing that 3-phosphoinositides accumulate on lysosomal surface and play a crucial role in Akt and mTORC1 activation.
ACS CENTRAL SCIENCE
(2021)
Article
Medicine, Research & Experimental
Xiao-Fei Ding, Jie Chen, Huai-Lu Ma, Yong Liang, Yun-Fei Wang, Hai-Tao Zhang, Xin Li, Guang Chen
Summary: In this study, it was found that KIR2DL4 is overexpressed in renal cell carcinoma (RCC) cells and promotes RCC progression through the activation of the PI3K/AKT signaling pathway.
Article
Multidisciplinary Sciences
Emily Golden, Rabab Rashwan, Eleanor A. Woodward, Agustin Sgro, Edina Wang, Anabel Sorolla, Charlene Waryah, Wan Jun Tie, Elisabet Cuyas, Magdalena Ratajska, Iwona Kardas, Piotr Kozlowski, Elizabeth K. M. Johnstone, Heng B. See, Ciara Duffy, Jeremy Parry, Kim A. Lagerborg, Piotr Czapiewski, Javier A. Menendez, Adam Gorczynski, Bartosz Wasag, Kevin D. G. Pfleger, Christina Curtis, Bum-Kyu Lee, Jonghwan Kim, Joseph Cursons, Nathan J. Pavlos, Wojciech Biernat, Mohit Jain, Andrew J. Woo, Andrew Redfern, Pilar Blancafort
Summary: AAMDC, a frequently amplified gene in ER+ breast cancer, regulates metabolic enzymes, controls PI3K-AKT-mTOR signaling, and shows sensitivity to combination therapy with anti-estrogens, potentially serving as a target for selective blockers in malignancies.
NATURE COMMUNICATIONS
(2021)
Article
Physiology
Gautam Bandyopadhyay, Kechun Tang, Nicholas J. G. Webster, Geert van den Bogaart, Sushil K. Mahata
Summary: Catestatin (CST), a peptide derived from Chromogranin A, promotes hepatic glycogen synthesis by reducing glucose production, increasing glycogen synthesis, inhibiting glycogenolysis, and enhancing downstream insulin signaling.
Review
Biochemistry & Molecular Biology
Divya M. Teli, Anuradha K. Gajjar
Summary: Elevated glucose level due to β-cell dysfunction is a key marker of Type-II diabetes. GSK-3, an enzyme involved in glycogen metabolism control, has been explored for its potential as a target for diabetes treatment. This review article examines the structural analysis and molecular modeling of GSK-3, as well as advancements in the development of GSK-3 inhibitors as potential therapeutics for Type II diabetes.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Monal Yuwanati, Ramya Ramadoss, Yasusei Kudo, Pratibha Ramani, Mullainathan Senthil Murugan
Summary: This study reveals a low prevalence of oral submucous fibrosis (OSMF) among areca nut chewers (ANC) through a pooled analysis of multiple studies. However, further large-scale studies are recommended to validate this finding.
Article
Oncology
Yuming Xu, Erhui Jiang, Zhe Shao, Zhengjun Shang
Summary: In this study, it was found that CAFs regulate tumor angiogenesis in oral squamous cell carcinoma by downregulating FENDRR, possibly through the PI3K/AKT pathway. The results indicate that the expression of FENDRR is downregulated in OSCC patients, and the lower expression of FENDRR in CAFs can influence gene expression and activation of the PI3K/AKT pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Pei-Chin Lin, Chao-Neng Cheng, Hsi-Yuan Huang, Yu-Hsin Tseng, Ya-Sian Chang, Chien-Yu Lin, Jan-Gowth Chang
MOLECULAR GENETICS & GENOMIC MEDICINE
(2020)
Article
Medicine, Research & Experimental
Pei-Chin Lin, Shyh-Shin Chiou, Wan-Yi Hsu, Yu-Mei Liao, Shih-Pien Tsai, Hsiu-Lan Su, Ping-Tao Lu, Yu-Hsin Tseng
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2020)
Review
Medicine, Research & Experimental
Yu-Hsin Tseng, Rei-Cheng Yang, Tzong-Shi Lu
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Tzu-Ying Lee, Yu-Hsin Tseng
Article
Plant Sciences
Michele Rodda, Yu-Hsin Tseng, Alexandre K. Monro
Article
Cell Biology
Yoshiko Kono, Ching- Peng, Kazuo Oginuma, Rosario R. Rubite, Yu-Hsin Tseng, Hsun-An Yang, Kuo-Fang Chung
Summary: This study reports cytological investigations of 26 species of Begonia sect. Baryandra, including five karyotype analyses that are the first report in the group, 24 species reported cytologically for the first time, and two species re-examined. Incorporating previous and present studies, chromosome numbers of 40 out of 78 species in sect. Baryandra are now available. The ancestral chromosome number of 2n=30 is suggested as the most likely in the group, with 2n=28 considered a derived number.
Article
Dentistry, Oral Surgery & Medicine
Nan-Chin Lin, Shih-Min Hsia, Tong-Hong Wang, Po-Jung Li, Yu-Hsin Tseng, Kuo-Chou Chiu, Hsi-Feng Tu, Yin-Hwa Shih, Tzong-Ming Shieh
Summary: NEAT1, a lncRNA, is involved in the progression and chemotherapy resistance of oral cancer, and its expression level is related to the survival rate of patients with oral squamous cell carcinoma.
JOURNAL OF DENTAL SCIENCES
(2022)
Article
Oncology
Yu-Hsin Tseng, Rei-Cheng Yang, Shyh-Shin Chiou, Tzong-Ming Shieh, Yin-Hwa Shih, Pei-Chin Lin
Summary: The study demonstrated that curcumin induces apoptosis in cytarabine-resistant myeloid leukemia cells by inhibiting BCAT1 and mTOR pathways. Understanding the mechanism behind curcumin-induced apoptosis in resistant cells may support the development of novel drugs for leukemia treatment.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Shuo-Yu Wang, Yin-Hwa Shih, Tzong-Ming Shieh, Yu-Hsin Tseng
Summary: This study investigated the mechanisms of cytarabine resistance in acute myeloid leukemia (AML) and suggested the potential application of proteasome inhibitors in relapsed or refractory leukemia patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
I-Chen Chen, Shu-Chi Wang, Yi-Ting Chen, Hsin-Han Tseng, Po-Len Liu, Tzu-Chieh Lin, Hsin-En Wu, Yuan-Ru Chen, Yu-Hsin Tseng, Jong-Hau Hsu, Zen-Kong Dai, Jau-Ling Suen, Chia-Yang Li
Summary: The research has shown that corylin can alleviate acute lung injury induced by LPS by protecting lung tissue through inhibiting inflammatory cell infiltration and reducing the secretion of inflammatory factors.
Article
Multidisciplinary Sciences
Chiun Huang, Fang-Hua Chu, Yi-Shiang Huang, Yu-Ching Tu, Yu-Mei Hung, Yu-Hsin Tseng, Chang-En Pu, Cheng Te Hsu, Chi-Hsiang Chao, Yu-Shyang Chou, Shau-Chian Liu, Ya Ting You, Shuo-Yu Hsu, Hsiang-Chih Hsieh, Chieh-Ting Wang, Chi-Tsong Chen
Summary: Chamaecyparis formosensis is an endemic species in Taiwan that is under threat from excessive use and illegal felling. This study developed an individual identification system for C. formosensis to provide scientific evidence for court use and deter illegal felling. Biogeographical analysis revealed that C. formosensis from different geographic areas belong to the same genetic population and can be further divided into three clusters.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
I-Chen Chen, Yi-Ching Liu, Yen-Hsien Wu, Shih-Hsing Lo, Zen-Kong Dai, Jong-Hau Hsu, Yu-Hsin Tseng
Summary: This review summarizes the current research on proteasome inhibitors for pulmonary fibrosis, discussing their mechanisms and potential.
Article
Biochemistry & Molecular Biology
I-Chen Chen, Yi-Ching Liu, Yen-Hsien Wu, Shih-Hsing Lo, Shu-Chi Wang, Chia-Yang Li, Zen-Kong Dai, Jong-Hau Hsu, Chung-Yu Yeh, Yu-Hsin Tseng
Summary: Pulmonary hypertension (PH) is a severe progressive disease caused by the uncontrolled proliferation of pulmonary artery smooth muscle cells (PASMCs). The down-regulation of Mitofusin-2 (MFN2) is known to contribute to PH. In this study, it was found that hypoxia increases the viability and reduces the expression of MFN2 in PASMCs. However, MFN2 overexpression and the use of proteasome inhibitors restored MFN2 expression, inhibited hypoxia-induced proliferation, and induced the expression of cleaved-PARP1, suggesting their potential in improving the hypoxia-induced proliferation of PASMCs.
Article
Chemistry, Medicinal
Yin-Hwa Shih, Cheng-Chia Yu, Kai-Chi Chang, Yu-Hsin Tseng, Po-Jung Li, Shih-Min Hsia, Kuo-Chou Chiu, Tzong-Ming Shieh
Summary: The study found that the combination of temoporfin and KI significantly reduced the MICs and MBCs of Lactobacillus acidophilus and Lactobacillus paracasei under normal and hypoxic conditions, while increasing H2O2 production. Temoporfin improved biofilm removal of Aggregatibacter actinomycetemcomitans, Enterococcus faecalis, and Staphylococcus aureus under normal oxygen conditions and reduced the expression of antibiotic resistance-related genes in MRSA. Combining temoporfin with ampicillin or chlorhexidine significantly enhanced the bactericidal effect on MRSA.
Article
Chemistry, Analytical
Tzong-Ming Shieh, Yu-Hsin Tseng, Shih-Min Hsia, Tong-Hong Wang, Wan-Chen Lan, Yin-Hwa Shih
Summary: The exosome precipitation method affects the purity and downstream applications of exosomes. This study optimized the protocol of the PEG-based approach for extracting OSCC-derived exosomes and found that 8% PEG is the ideal choice for higher purity and better transfection efficiency.