Article
Nutrition & Dietetics
Natascha Stroebinger, Shane M. Rutherfurd, Sharon J. Henare, Jose F. Perez Hernandez, Paul J. Moughan
Summary: The study found that dietary calcium can lead to the formation of calcium-fatty acid soaps, decreasing fat absorption in the gastrointestinal tract. Different fat sources have varying effects on this process.
JOURNAL OF NUTRITION
(2021)
Article
Food Science & Technology
Jian-Feng Zhou, Wen-Jun Wang, Zhong-Ping Yin, Guo-Dong Zheng, Ji-Guang Chen, Jing-En Li, Ling-Li Chen, Qing-Feng Zhang
Summary: Quercetin was found to inhibit pancreatic lipase and interact with it in both in vitro and in vivo studies. In vivo experiments showed that pre-administration of quercetin could significantly reduce fat absorption in rats for at least 2 hours, while increasing fat excretion in feces. The trends of fat and quercetin content in rat feces were similar.
Article
Agriculture, Multidisciplinary
Lisha Wang, Zhi Wang, Tianji Xia, Fangrui Cao, Linhu Ye, Ruile Pan, Suwei Jin, Mingzhu Yan, Qi Chang
Summary: This study found that Cajaninstilbene acid (CSA) is primarily absorbed through passive transport and that metabolism is the major barrier limiting its oral bioavailability. Four new CSA metabolites were discovered in rats, mainly excreted through bile.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
J. E. Rico, W. A. Myers, A. Javaid, R. Gervais, J. W. McFadden
Summary: The digestibility and content of 16C and 22C fatty acids in milk fat are influenced by different treatments, with 1-carbon donors having no effect on the digestibility of 22C fatty acids. The content and yield of 16:0 and 22:6 in milk fat show significant differences between different treatments.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Kellie L. May, Anna C. Pham, Gisela Ramirez, Carmen Herrera-Hidalgo, Muhammad Naeem Iqbal, Ghislaine Robert-Nicoud, Andrew J. Clulow, Tore Bengtsson, Ben J. Boyd
Summary: This study investigates the interaction of mesoporous silica particles (MSPs) with lipid digestion process and highlights their potential in reducing lipid absorption and calorific intake through interactions with lipase enzymes and lipid digestion products.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Peter Gajdos, Veronika Urbanikova, Maria Vicenova, Milan Certik
Summary: Yarrowia lipolytica has been genetically modified to enhance the production of very long chain fatty acids (VLCFA), such as behenic acid and erucic acid, which are industrially valuable compounds. By overexpressing specific enzymes and blocking fatty acid degradation pathways, the production of VLCFA in Y. lipolytica has been significantly improved.
MICROBIAL CELL FACTORIES
(2022)
Article
Nutrition & Dietetics
Michael McBurney, Nathan L. Tintle, Ramachandran S. Vasan, Aleix Sala-Vila, William S. Harris
Summary: The study compared a combination of red blood cell FA levels with standard risk factors for CVD and found that red blood cell FA patterns were as predictive of risk for death during the next 11 years as standard risk factors. This suggests that the FA fingerprint may serve as a potential predictor of all-cause mortality.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Review
Nutrition & Dietetics
Kira Zhi Hua Lai, Nagam A. Yehia, Zhila Semnani-Azad, Sonia Blanco Mejia, Beatrice A. Boucher, Vasanti Malik, Richard P. Bazinet, Anthony J. Hanley
Summary: Recent observational studies suggest that circulating very long-chain saturated fatty acids (VLCSFAs) are inversely associated with cardiometabolic outcomes. This review aimed to assess the effects of diet, physical activity, and smoking on circulating VLCSFAs; however, the limited evidence and methodological limitations of the included studies make it unclear.
ADVANCES IN NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Chunlin Li, Siyu Yu, Xiaoxiao Li, Ying Cao, Meng Li, Guang Ji, Li Zhang
Summary: The HZRG formula has been shown to alleviate non-alcoholic steatohepatitis (NASH) by improving hepatic steatosis, reducing inflammation, and modulating the bile acid profile and gut dysbiosis. It enhances fecal bile acid excretion by inhibiting bile acid transporters, and improves the intestinal environment through the modulation of tight junction proteins.
FRONTIERS IN PHARMACOLOGY
(2022)
Letter
Immunology
Anselme Millogo, Ahmed Loukil, Coralie L'Ollivier, Diakourga Arthur Djibougou, Sylvain Godreuil, Michel Drancourt
Summary: Detection of Mycobacterium leprae in the feces of a leprosy patient in Burkina Faso using various methods raises questions about the role of fecal excretion of M. leprae in the natural history and diagnosis of leprosy.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Immunology
Wiwat Chancharoenthana, Supitcha Kamolratanakul, Peerapat Visitchanakun, Supistha Sontidejkul, Thanya Cheibchalard, Naraporn Somboonna, Sarn Settachaimongkon, Asada Leelahavanichkul
Summary: The impacts of metabolomic changes in uremic condition are not fully understood. In a mouse experiment, Candida administration worsened the condition of uremic mice and induced leaky gut, while the administration of SCFA-producing probiotics attenuated these effects. Overall, the use of probiotics in uremia is supported.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Fabian A. Vogelpohl, Antonio W. Gomes-Neto, Ingrid A. Martini, Camilo G. Sotomayor, Dion Groothof, Maryse C. J. Oste, Margaretha Rebecca Heiner-Fokkema, Frits A. J. Muskiet, Stefan P. Berger, Gerjan Navis, Ido P. Kema, Stephan J. L. Bakker
Summary: In kidney transplant recipients (KTR), very long chain saturated fatty acids (VLSFA) are inversely associated with infectious disease mortality, especially behenic acid (C22:0) showing a reverse correlation with all-cause mortality risk.
Article
Food Science & Technology
Charlotte Dorothea Stemler, Katharina Anne Scherf
Summary: In cake production, lipases with appropriate substrate specificity are required to minimize the release of short-chain fatty acids that cause undesirable off-flavors. However, the release of free fatty acids in lipase reactions did not correspond to the substrate specificities observed in the p-nitro-phenyl assay. Thus, the prediction of lipase reactions using the PNP assay should be reevaluated for real food systems such as cakes.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Farzad Mohammadi, Miranda Green, Emma Tolsdorf, Karine Greffard, Mickael Leclercq, Jean-Francois Bilodeau, Arnaud Droit, Jane Foster, Nicolas Bertrand, Iwona Rudkowska
Summary: This study compared the effects of consuming 2-3% industrially originated trans-fatty acids (I-tFAs) and ruminant trans-fatty acids (R-tFAs) on gut microbiome and fecal metabolite profiles in mice. Results showed that TPA intake decreased the abundance of Staphylococcus sp55 but increased Staphylococcus sp119. EA intake also increased the abundance of Staphylococcus sp119 but decreased Ruminococcaceae UCG-014, Lachnospiraceae, and Clostridium sensu stricto 1. Fecal short-chain fatty acids were increased after TPA while decreased after EA after 7 and 28 days. This study highlights the distinct effects of TPA and EA on specific microbial taxa and fecal metabolite profiles.
Article
Energy & Fuels
Mun Yuen Chang, Eng-Seng Chan, Cher Pin Song
Summary: A low-cost liquid lipase from genetically modified Aspergillus oryzae was used for biodiesel production, showing high tolerance and reaction efficiency in feedstocks with high FFA content, leading to a high conversion rate.