Article
Parasitology
Necati Ozpinar, Gulnaz Culha, Tugba Kaya, Hasan Yucel
Summary: The study showed that benzothiazole derivatives have suppressive effects on the reproductive potential of Acanthamoeba parasites, with 2-Amino-6(trifluoromethoxy)-benzothiazole being the most effective. This substance may be a promising new therapeutic agent for diseases caused by Acanthamoeba parasites, as supported by potential animal experiments.
Article
Microbiology
Anna C. Randag, Lieke de Kroon, Henny Otten, Cindy Arias Claro-Handgraaf, Barbara Schimmer, Titia Kortbeek, Jeroen van Rooij, Foekje F. Stelma
Summary: This study investigates the effectiveness of contact lens solutions available on the Dutch market against Acanthamoeba castellanii and Acanthamoeba polyphaga. The results show that only a few solutions provide sufficient effectiveness against trophozoites, but none against cysts. These findings underline the importance of proper hygiene when handling contact lenses.
Article
Parasitology
M. Reyes-Batlle, I Rodriguez-Talavera, I Sifaoui, R. L. Rodriguez-Exposito, P. Rocha-Cabrera, J. E. Pinero, J. Lorenzo-Morales
Summary: Acanthamoeba keratitis (AK) is a corneal infection with symptoms like eye redness and pain, and there is currently no established treatment. Research has shown that Matrix Ocular (R) has high anti-Acanthamoeba activity without toxic effects on the eye, suggesting Arabinogalactan derivatives as a new source of anti-AK compounds.
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
(2021)
Article
Parasitology
Olfa Chiboub, Eulalia Capote-Yanes, Ines Sifaoui, Maria Reyes-Batlle, Ruben L. Rodriguez-Exposito, Jose E. Pinero, Jacob Lorenzo-Morales
Summary: Recent research has shown that some commercial eye drops have the potential to inhibit the activity of Acanthamoeba and induce programmed cell death in the pathogen, demonstrating promising pharmacological effects.
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
(2021)
Article
Parasitology
Ruben Martin-Escolano, Sonia Molero Romero, Jesus G. Diaz, Clotilde Marin, Manuel Sanchez-Moreno, Ma Jose Rosales
Summary: This study evaluated the activity of flavonoid glycosides isolated from medicinal plants against Acanthamoeba castellanii, with compounds 2 and 3 showing potential for the development of novel therapeutic approaches against Acanthamoeba infections.
Article
Ophthalmology
Kirti Megha, Megha Sharma, Chayan Sharma, Amit Gupta, Rakesh Sehgal, Sumeeta Khurana
Summary: Chlorhexidine and pentamidine isethionate were the most effective and safe agents against both trophozoites and cysts forms of our Acanthamoeba isolates. Fluconazole had higher MIC but was nontoxic. Polymyxin B was effective at high MIC but therapeutic dose was found toxic.
Article
Microbiology
Anas Abdullah Hamad
Summary: The study aimed to evaluate the efficacy of certain plant extracts and compare them with current biocides on the viability of Acanthamoeba castellanii cysts and trophozoites in vitro. The results showed that the biguanides PHMB, chlorhexidine, and octenidine had excellent effectiveness against A. castellanii trophozoites and cysts. The plant extracts also showed significant activity against A. castellanii at lower concentrations, with Proskia plant extract having the lowest cysticidal concentration value.
Article
Microbiology
Lidia Chomicz, Jacek P. Szaflik, Beata Szostakowska, Justyna Izdebska, Wanda Baltaza, Monika Lazicka-Galecka, Agnieszka Kuligowska, Anna Machalinska, Pawel J. Zawadzki, Jerzy Szaflik
Summary: This study presents the isolation and identification of Acanthamoeba strains causing serious keratitis. The strains were examined at the cellular and molecular levels and cultivated in vitro, showing variability in dynamics and high viability. The findings highlight the importance of in vitro monitoring for assessing the pathogenic potential of Acanthamoeba strains.
Article
Biochemistry & Molecular Biology
Balsam Qubais Saeed, Mutasem Rawas Qalaji, Noor Akbar, Ruqaiyyah Siddiqui, Cagliani Roberta, Shaista Manzoor, Jibran Sualeh Muhammad, Ahmed Omar Adrees, Rula Al-Shahrabi, Naveed Ahmed Khan
Summary: The study determined the benefits of using 5FU and CQ nanoparticles against A. castellanii, with 5FU showing stronger anti-Acanthamoeba activity and lower cytotoxicity, while CQ and CQ-NP had poorer effects and greater damage to human cells.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
(2022)
Article
Environmental Sciences
Mona Awad Alonazi, Ikram Jemel, Nadine Moubayed, Mona Alwhibi, Nahed Nasser E. El-Sayed, Abir Ben Bacha
Summary: The ethanolic extracts of Origanum syriacum and Salvia lanigera showed anti-inflammatory and membrane-stabilizing effects without cytotoxicity to colorectal cancer cell lines. The differences in their pharmacological efficiencies may be attributed to their chemical compositions, particularly the content of oxygenated monoterpenoids. These extracts are promising candidates for treating inflammatory diseases related to oxidative stress and microbial infections.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Analytical
Sebastian Schwaminger, Marina E. Rottmueller, Ramona Fischl, Behnam Kalali, Sonja Berensmeier
Summary: The newly developed point-of-care method allows for fast and efficient detection of bacteria in water by generating immunocomplexes and concentrating pathogens. Testing with fluorescent Escherichia coli and Legionella pneumophila cells showed accurate results within half an hour, marking a significant advancement in pathogen analysis.
Article
Biochemistry & Molecular Biology
Nidal Jaradat, Samer Abdallah, Nawaf Al-Maharik, Mohammad Altamimi, Mohammed Hawash, Mohammad Qneibi, Abeer Abu Khair, Anaal Zetawi, Leena Jabarin
Summary: This study found that the essential oils of Salvia fruticosa have antibacterial and cytotoxic effects, and can inhibit the migration of cancer cells.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Ophthalmology
Joo-Hee Park, Choul Yong Park
Summary: This study investigates the combined use of nitric oxide donors and hypochlorite to enhance the anti-Acanthamoeba effects while minimizing damage to human corneal epithelial cells. The results show that the combination of NaOCl and NO donors has a stronger anti-Acanthamoeba effect compared to single drug treatments.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Article
Plant Sciences
Weronika Kozlowska, Adam Matkowski, Sylwia Zielinska
Summary: Plant in vitro culture is a feasible system for studying the effect of environmental factors on the accumulation and chemodiversity of specialized metabolites in medicinal plants. This study examined the response of Salvia yangii to different light intensities and temperatures, and found that both factors significantly influenced the metabolic response of the plant. The study provides new insights into the plasticity of the metabolic profile of S. yangii and contributes to our understanding of chemical adaptations in plants.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Physical
Ewa Sobolewska, Piotr Makowiecki, Justyna Drozdowska, Ireneusz Dziuba, Alicja Nowicka, Marzena Wyganowska-Swiatkowska, Joanna Janiszewska-Olszowska, Katarzyna Grocholewicz
Summary: This study assessed the cytotoxicity of three denture adhesives on human fibroblasts. The results showed that these adhesives demonstrated toxic effects on cells in vitro.
Article
Environmental Sciences
Cengiz Sarikurkcu, Ilgaz Akata, Gulsen Guven, Bektas Tepe
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Cengiz Sarikurkcu, Marcello Locatelli, Angela Tartaglia, Vincenzo Ferrone, Aleksandra M. Juszczak, Mehmet Sabih Ozer, Bektas Tepe, Michal Tomczyk
Article
Environmental Sciences
Cengiz Sarikurkcu, Rifat Tayyib Sarikurkcu, Ilgaz Akata, Bektas Tepe
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Agricultural Engineering
Cengiz Sarikurkcu, Saliha Seyma Sahinler, Bektas Tepe
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Article
Agricultural Engineering
Cengiz Sarikurkcu, Saliha Seyma Sahinler, Olcay Ceylan, Bektas Tepe
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Article
Agricultural Engineering
Cengiz Sarikurkcu, Saliha Seyma Sahinler, Olcay Ceylan, Bektas Tepe
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Article
Environmental Sciences
Cengiz Sarikurkcu, Ilgaz Akata, Bektas Tepe
Summary: This study aimed to determine the essential and non-essential element contents of eight different Russula species collected from Soguksu National Park in Turkey. Most elements were within safe consumption limits, but some showed potential health risks. Additionally, principal component analysis and hierarchical cluster analysis were used to analyze mineral composition variability.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Cengiz Sarikurkcu, Rifat Tayyib Sarikurkcu, Bektas Tepe
Summary: This study evaluated the phytochemical composition, antioxidant, and enzyme inhibitory activities of Campanula macrostachya extracts. Methanol extract showed higher antioxidant activity, while ethyl acetate and methanol extracts exhibited higher alpha-amylase and tyrosinase inhibitory activity. Flavonoids, chlorogenic acid, hesperidin, and hyperoside were found to be key compounds contributing to the observed activities.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Cengiz Sarikurkcu, Dilek Yildiz, Ilgaz Akata, Bektas Tepe
Summary: This study investigated the metal contents, daily intake of metal, and health risk index values of nineteen different mushroom species collected from Uzungol, Trabzon, Turkey. The results showed that while some mushroom species are safe to consume, others exceeded the legal limits for cadmium content. Additionally, significant correlations were found between various metal pairs in the mushrooms. It was suggested that measures should be taken by the competent authorities to address potential environmental pollution in the area.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Feyyaz Keskin, Cengiz Sarikurkcu, Ilgaz Akata, Bektas Tepe
Summary: The study investigated the element concentrations of wild edible and non-edible mushrooms collected from Belgrad forest and calculated their potential health risks for human consumption. The results suggest that long-term consumption of certain mushroom species from this region may have negative impacts on human health, emphasizing the need for periodic monitoring of element concentrations in wild mushrooms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Feyyaz Keskin, Cengiz Sarikurkcu, Ilgaz Akata, Bektas Tepe
Summary: The study aimed to determine the element content of wild edible and inedible mushroom species and calculated the daily metal intake and health risk index of edible mushrooms. Some mushrooms were found to contain metal elements exceeding legal limits, suggesting consumption should be controlled.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Erman Salih Istiflia, Paulo A. Netz, Arzuhan Sihoglu Tepe, Cengiz Sarikurkcu, Bektas Tepe
Summary: This study compared the interaction between the RBD of E484K, N501Y and South Africa triple spike variants with ACE2, and found that these mutants interacted more strongly with ACE2 than the wild-type spike. Molecular dynamics and MM-PBSA results showed that E484K and spike triple mutant complexes were more stable than the N501Y variant, with E484K and South Africa triple mutants triggering greater conformational changes in the spike glycoprotein.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Erman Salih Istifli, Paulo A. Netz, Arzuhan Sihoglu Tepe, Mehmet Tahir Husunet, Cengiz Sarikurkcu, Bektas Tepe
Summary: This study investigated the interactions between twenty-three phytochemicals belonging to different flavonoid subgroups and the spike glycoprotein of 2019-nCoV. The results showed that (-)-epicatechin gallate had strong interactions with all the proteins studied.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biology
Erman Salih Istifli, Arzuhan Sihoglu Tepe, Paulo A. Netz, Cengiz Sarikurkcu, Ibrahim Halil Kilic, Bektas Tepe
Summary: The study found that robinin and gossypetin have significant binding capacity to the targets of the novel coronavirus and could be potential therapeutic agents. However, further verification of their inhibitory effects on cytochromes and minimizing adverse effects on cellular energy metabolism through molecular modifications are necessary.
TURKISH JOURNAL OF BIOLOGY
(2021)
Article
Biology
Erman Salih Istifli, Arzuhan Sihoglu Tepe, Cengiz Sarikurkcu, Bektas Tepe
TURKISH JOURNAL OF BIOLOGY
(2020)